Neonatal outcomes AI prediction using multimodal trajectory database
Herdiantri Sufriyana, Yung-Chieh Lin, Chien-Jung Ho, Ting-Chun Yeh, Chao-Ching Huang, Emily Chia-Yu Su
2024-09-10
Programming environment
Load raw data
| dataset | name | path |
|---|---|---|
| Modeling | demographic_surfactant_growth | inst/extdata/2011-202312_GA_22-30_838/0_Demographic+surfactant+Growth_838_DR_Su_20240813.xlsx |
| ventilation_breathing_o2_daily_42d | inst/extdata/2011-202312_GA_22-30_838/1_Ventilation 1_呼吸與氧氣_42d_daily_838_DR_Su_20240813.xlsx | |
| ventilation_breathing_o2_steroid_6w | inst/extdata/2011-202312_GA_22-30_838/1_Ventilation 2_呼吸與氧氣_steroid_6w_838_DR_Su_20240813.xlsx | |
| hemodynamics_42d | inst/extdata/2011-202312_GA_22-30_838/2_Hemodynamics_42d_838_DR_Su_20240813.xlsx | |
| infection_42d | inst/extdata/2011-202312_GA_22-30_838/3_Infection 1_42d_838_DR_Su_20240813.xlsx | |
| gi_tract_feeding_42d | inst/extdata/2011-202312_GA_22-30_838/4_Gl_tract1_feeding_42d_DR_Su_20240813.xlsx | |
| growth_hc_bw_6w | inst/extdata/2011-202312_GA_22-30_838/5_Growth2_HC_BW_6w_838_DR_Su_20240813.xlsx | |
| morbidities_42d | inst/extdata/2011-202312_GA_22-30_838/6_Morbidities1_42day_838_DR_Su_20240813.xlsx | |
| outcomes | inst/extdata/2011-202312_GA_22-30_838/7_Outcome_Morbidity_Outcomes_838_DR_Su_20240813.xlsx | |
| Independent test | demographic_surfactant_growth | inst/extdata/2011-202312_GA_22-30_838/0_Demographic+surfactant+Growth_838_DR_Su_20240813.xlsx |
| ventilation_breathing_o2_daily_42d | inst/extdata/2011-202312_GA_22-30_838/1_Ventilation 1_呼吸與氧氣_42d_daily_838_DR_Su_20240813.xlsx | |
| ventilation_breathing_o2_steroid_6w | inst/extdata/2011-202312_GA_22-30_838/1_Ventilation 2_呼吸與氧氣_steroid_6w_838_DR_Su_20240813.xlsx | |
| hemodynamics_42d | inst/extdata/2011-202312_GA_22-30_838/2_Hemodynamics_42d_838_DR_Su_20240813.xlsx | |
| infection_42d | inst/extdata/2011-202312_GA_22-30_838/3_Infection 1_42d_838_DR_Su_20240813.xlsx | |
| gi_tract_feeding_42d | inst/extdata/2011-202312_GA_22-30_838/4_Gl_tract1_feeding_42d_DR_Su_20240813.xlsx | |
| growth_hc_bw_6w | inst/extdata/2011-202312_GA_22-30_838/5_Growth2_HC_BW_6w_838_DR_Su_20240813.xlsx | |
| morbidities_42d | inst/extdata/2011-202312_GA_22-30_838/6_Morbidities1_42day_838_DR_Su_20240813.xlsx | |
| outcomes | inst/extdata/2011-202312_GA_22-30_838/7_Outcome_Morbidity_Outcomes_838_DR_Su_20240813.xlsx |
Data preprocessing
Data cleaning
| dataset | table | old_colname | new_colname |
|---|---|---|---|
| Modeling | demographic_surfactant_growth | ID | id |
| Family_Socioeconomic_status | socioeconomic_status | ||
| Maternal_education_level | education_status | ||
| Maternal_age | maternal_age | ||
| IVF | ivf | ||
| Preeclampsia | pe | ||
| Gestational_diabetes | gdm | ||
| CS | cs | ||
| Gravida | gravida | ||
| BBW | bbw_g | ||
| GA | ga_wk | ||
| Male | sex | ||
| Multiple_gestation | multiple_gestation | ||
| AS1 | as1 | ||
| AS5 | as5 | ||
| Resuscitation_at_birth | resuscitation_at_birth | ||
| birthtime_scoring | birthtime_scoring | ||
| Antenatal_steroid | steroid_antenatal | ||
| Chorioamnionitis | chorioamnionitis | ||
| surfactant | surfactant | ||
| BBWZ | bbw_z | ||
| BHCZ | bhc_z | ||
| ventilation_breathing_o2_daily_42d | ID | id | |
| Age_D | t_day | ||
| Resp_Support_raw | resp_supp_raw | ||
| FiO2_raw | fio2_raw | ||
| ventilation_breathing_o2_steroid_6w | ID | id | |
| GA | ga_wk | ||
| Age_W | t_wk | ||
| Cumulative_Aggressive_Resp_Support_days_QW | resp_supp_agg_cum_day_qw | ||
| Cumulative_FiO2_Support_days_QW | fio2_cum_day_qw | ||
| Cumulative_FiO2_Support_concentration_QW | fio2_cum_level_qw | ||
| Cumulative_Aggressive_Resp_Support_percentile | resp_supp_agg_cum_day_pct | ||
| Cumulative_FiO2_days_percentile | fio2_cum_day_pct | ||
| Cumulative_FiO2_concentration_percentile | fio2_cum_level_pct | ||
| postnatal_steroid | steroid_postnatal | ||
| hemodynamics_42d | ID | id | |
| Age_D | t_day | ||
| Inotropic | inotropic | ||
| Blood_Volume | blood_volume | ||
| Transfusion | transfusion | ||
| infection_42d | ID | id | |
| Age_D | t_day | ||
| blood_culture | blood_culture | ||
| Thrombocytopenia_severity | plt | ||
| Leukopenia_severity | wbc | ||
| gi_tract_feeding_42d | ID | id | |
| Age_D | t_day | ||
| Feeding | feeding | ||
| growth_hc_bw_6w | ID | id | |
| Age_W | t_wk | ||
| Postnatal_BW_z_score_QW | bw_z_qw | ||
| Postnatal_HC_z_score_QW | hc_z_qw | ||
| morbidities_42d | ID | id | |
| Age_D | t_day | ||
| IVH | ivh | ||
| PVL | pvl | ||
| cerebellar_hemorrhage | cerebellar_hemorrhage | ||
| ischaemic_stroke | ischaemic_stroke | ||
| hs-PDArequiring_intervention | hs_pda_iv | ||
| NEC | nec | ||
| NonNEC_surgical_abdomen | non_nec_surg_abd | ||
| AKI | aki | ||
| outcomes | ID | id | |
| Survival_at_discharge | survive | ||
| age_of_death | death_age | ||
| severe_ROP | rop_severe | ||
| BPD_grade | bpd_grade | ||
| EUGR_HC | eugr_hc | ||
| EUGR_BW | eugr_bw | ||
| discharge_hearing_outcome | hearing | ||
| Independent test | demographic_surfactant_growth | ID | id |
| Family_Socioeconomic_status | socioeconomic_status | ||
| Maternal_education_level | education_status | ||
| Maternal_age | maternal_age | ||
| IVF | ivf | ||
| Preeclampsia | pe | ||
| Gestational_diabetes | gdm | ||
| CS | cs | ||
| Gravida | gravida | ||
| BBW | bbw_g | ||
| GA | ga_wk | ||
| Male | sex | ||
| Multiple_gestation | multiple_gestation | ||
| AS1 | as1 | ||
| AS5 | as5 | ||
| Resuscitation_at_birth | resuscitation_at_birth | ||
| birthtime_scoring | birthtime_scoring | ||
| Antenatal_steroid | steroid_antenatal | ||
| Chorioamnionitis | chorioamnionitis | ||
| surfactant | surfactant | ||
| BBWZ | bbw_z | ||
| BHCZ | bhc_z | ||
| ventilation_breathing_o2_daily_42d | ID | id | |
| Age_D | t_day | ||
| Resp_Support_raw | resp_supp_raw | ||
| FiO2_raw | fio2_raw | ||
| ventilation_breathing_o2_steroid_6w | ID | id | |
| GA | ga_wk | ||
| Age_W | t_wk | ||
| Cumulative_Aggressive_Resp_Support_days_QW | resp_supp_agg_cum_day_qw | ||
| Cumulative_FiO2_Support_days_QW | fio2_cum_day_qw | ||
| Cumulative_FiO2_Support_concentration_QW | fio2_cum_level_qw | ||
| Cumulative_Aggressive_Resp_Support_percentile | resp_supp_agg_cum_day_pct | ||
| Cumulative_FiO2_days_percentile | fio2_cum_day_pct | ||
| Cumulative_FiO2_concentration_percentile | fio2_cum_level_pct | ||
| postnatal_steroid | steroid_postnatal | ||
| hemodynamics_42d | ID | id | |
| Age_D | t_day | ||
| Inotropic | inotropic | ||
| Blood_Volume | blood_volume | ||
| Transfusion | transfusion | ||
| infection_42d | ID | id | |
| Age_D | t_day | ||
| blood_culture | blood_culture | ||
| Thrombocytopenia_severity | plt | ||
| Leukopenia_severity | wbc | ||
| gi_tract_feeding_42d | ID | id | |
| Age_D | t_day | ||
| Feeding | feeding | ||
| growth_hc_bw_6w | ID | id | |
| Age_W | t_wk | ||
| Postnatal_BW_z_score_QW | bw_z_qw | ||
| Postnatal_HC_z_score_QW | hc_z_qw | ||
| morbidities_42d | ID | id | |
| Age_D | t_day | ||
| IVH | ivh | ||
| PVL | pvl | ||
| cerebellar_hemorrhage | cerebellar_hemorrhage | ||
| ischaemic_stroke | ischaemic_stroke | ||
| hs-PDArequiring_intervention | hs_pda_iv | ||
| NEC | nec | ||
| NonNEC_surgical_abdomen | non_nec_surg_abd | ||
| AKI | aki | ||
| outcomes | ID | id | |
| Survival_at_discharge | survive | ||
| age_of_death | death_age | ||
| severe_ROP | rop_severe | ||
| BPD_grade | bpd_grade | ||
| EUGR_HC | eugr_hc | ||
| EUGR_BW | eugr_bw | ||
| discharge_hearing_outcome | hearing |
| variable | old_type | new_type |
|---|---|---|
| id | numeric | character |
| t | numeric | numeric |
| socioeconomic_status | numeric | factor |
| education_status | numeric | factor |
| maternal_age | numeric | numeric |
| ivf | numeric | factor |
| pe | numeric | factor |
| gdm | numeric | factor |
| cs | numeric | factor |
| gravida | numeric | numeric |
| bbw_g | numeric | numeric |
| ga_wk | numeric | numeric |
| sex | numeric | factor |
| multiple_gestation | numeric | factor |
| as1 | numeric | numeric |
| as5 | numeric | numeric |
| resuscitation_at_birth | numeric | numeric |
| birthtime_scoring | numeric | factor |
| steroid_antenatal | numeric | numeric |
| chorioamnionitis | numeric | factor |
| surfactant | numeric | numeric |
| bbw_z | numeric | numeric |
| bhc_z | numeric | numeric |
| survive | numeric | factor |
| death_age | numeric | numeric |
| rop_severe | numeric | factor |
| bpd_grade | numeric | factor |
| eugr_hc | numeric | factor |
| eugr_bw | numeric | factor |
| hearing | numeric | factor |
| resp_supp_agg_cum_day_qw | numeric | numeric |
| fio2_cum_day_qw | numeric | numeric |
| fio2_cum_level_qw | numeric | numeric |
| resp_supp_agg_cum_day_pct | numeric | numeric |
| fio2_cum_day_pct | numeric | numeric |
| fio2_cum_level_pct | numeric | numeric |
| steroid_postnatal | numeric | numeric |
| bw_z_qw | numeric | factor |
| hc_z_qw | numeric | factor |
| resp_supp_raw | numeric | factor |
| fio2_raw | numeric | numeric |
| inotropic | numeric | numeric |
| blood_volume | numeric | numeric |
| transfusion | numeric | numeric |
| blood_culture | numeric | numeric |
| plt | numeric | numeric |
| wbc | numeric | numeric |
| feeding | numeric | numeric |
| ivh | numeric | factor |
| pvl | numeric | factor |
| cerebellar_hemorrhage | numeric | factor |
| ischaemic_stroke | numeric | factor |
| hs_pda_iv | numeric | factor |
| nec | numeric | numeric |
| non_nec_surg_abd | numeric | factor |
| aki | numeric | numeric |
| colname | old_cat | new_cat |
|---|---|---|
| socioeconomic_status | 1 | 5-lowest |
| socioeconomic_status | 2 | 4-second lowest |
| socioeconomic_status | 3 | 3-medium |
| socioeconomic_status | 4 | 2-second highest |
| socioeconomic_status | 5 | 1-highest |
| education_status | 1 | 7-elementary school |
| education_status | 2 | 6-junior high school |
| education_status | 3 | 5-high school, vocational |
| education_status | 4 | 4-high school |
| education_status | 5 | 3-college, vocational |
| education_status | 6 | 2-college |
| education_status | 7 | 1-postgraduate |
| ivf | 0 | 0-no |
| ivf | 1 | 1-yes |
| pe | 0 | 0-no |
| pe | 1 | 1-yes |
| gdm | 0 | 0-no |
| gdm | 1 | 1-yes |
| cs | 0 | 0-no |
| cs | 1 | 1-yes |
| sex | 0 | 0-female |
| sex | 1 | 1-male |
| multiple_gestation | 0 | 0-no |
| multiple_gestation | 1 | 1-yes |
| birthtime_scoring | 1 | 1-born 08:00-16:59 |
| birthtime_scoring | 2 | 2-born 17:00-23:59 |
| birthtime_scoring | 3 | 3-born 00:00-07:59 |
| chorioamnionitis | 0 | 0-no |
| chorioamnionitis | 1 | 1-yes |
| survive | 0 | 0-no |
| survive | 1 | 1-yes |
| rop_severe | 0 | 0-none/stage I/stage II |
| rop_severe | 1 | 1-stage II+ |
| bpd_grade | 0 | 0-no BPD |
| bpd_grade | 1 | 1-mild BPD |
| bpd_grade | 2 | 2-moderate/severe BPD |
| eugr_hc | 0 | 0-HC z-score at birth >=-1.5 |
| eugr_hc | 1 | 1-HC z-score at birth <-1.5 |
| eugr_bw | 0 | 0-BW z-score at birth >=-1.5 |
| eugr_bw | 1 | 1-BW z-score at birth <-1.5 |
| hearing | 0 | 0-passed |
| hearing | 1 | 1-failed |
| bw_z_qw | 0 | 4-BW z-score <=-3 |
| bw_z_qw | 1 | 3-BW z-score >-3 & <=-2 |
| bw_z_qw | 2 | 2-BW z-score >-2 & <=-1 |
| bw_z_qw | 3 | 1-BW z-score >-1 |
| hc_z_qw | 0 | 4-HC z-score <=-3 |
| hc_z_qw | 1 | 3-HC z-score >-3 & <=-2 |
| hc_z_qw | 2 | 2-HC z-score >-2 & <=-1 |
| hc_z_qw | 3 | 1-HC z-score >-1 |
| resp_supp_raw | 1 | 1-room air |
| resp_supp_raw | 2 | 2-nasal canula with oxygen |
| resp_supp_raw | 3 | 3-CPAP |
| resp_supp_raw | 4 | 4-N-IPPV |
| resp_supp_raw | 5 | 5-IMV |
| resp_supp_raw | 6 | 6-IMV+iNO/HFOV/HFOV+iNO |
| ivh | 0 | 1-no IVH |
| ivh | 1 | 2-IVH grade I |
| ivh | 2 | 3-IVH grade II |
| ivh | 4 | 4-IVH grade III |
| ivh | 5 | 5-IVH grade IV, unilateral |
| ivh | 6 | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus |
| pvl | 0 | 1-no PVL |
| pvl | 2 | 2-PVL focal, unilateral |
| pvl | 4 | 3-PVL focal, bilateral |
| pvl | 6 | 4-PVL extensive, bilateral |
| cerebellar_hemorrhage | 0 | 1-no bleeding |
| cerebellar_hemorrhage | 1 | 2-minimal bleeding |
| cerebellar_hemorrhage | 2 | 3-severe bleeding |
| ischaemic_stroke | 0 | 1-no ischemia |
| ischaemic_stroke | 1 | 2-ischemia, unilateral |
| ischaemic_stroke | 2 | 3-ischemia, bilateral |
| ischaemic_stroke | 3 | 4-ischemia, multiple |
| hs_pda_iv | 0 | 1-no PDA/PDA, no intervention |
| hs_pda_iv | 1 | 2-PDA, medical intervention |
| hs_pda_iv | 2 | 3-PDA, surgical intervention |
| non_nec_surg_abd | 0 | 1-no NEC/NEC, no surgery |
| non_nec_surg_abd | 4 | 2-SIP/meconium ileus/volvulus/obstruction |
| non_nec_surg_abd | 6 | 3-SIP/meconium ileus/volvulus/obstruction with stomy |
| dataset | survive | ms_death_age | n |
|---|---|---|---|
| Modeling | 0-no | FALSE | 119 |
| 1-yes | TRUE | 719 | |
| Independent test | 0-no | FALSE | 12 |
| 1-yes | TRUE | 75 |
| dataset | ms_death_age | variable | missing | non-missing |
|---|---|---|---|---|
| Modeling | missing | ms_bpd_grade | 0 | 719 |
| ms_eugr_bw | 0 | 719 | ||
| ms_eugr_hc | 0 | 719 | ||
| ms_hearing | 14 | 705 | ||
| ms_rop_severe | 0 | 719 | ||
| non-missing | ms_bpd_grade | 109 | 10 | |
| ms_eugr_bw | 110 | 9 | ||
| ms_eugr_hc | 110 | 9 | ||
| ms_hearing | 119 | 0 | ||
| ms_rop_severe | 109 | 10 | ||
| Independent test | missing | ms_bpd_grade | 0 | 75 |
| ms_eugr_bw | 0 | 75 | ||
| ms_eugr_hc | 0 | 75 | ||
| ms_hearing | 0 | 75 | ||
| ms_rop_severe | 0 | 75 | ||
| non-missing | ms_bpd_grade | 12 | 0 | |
| ms_eugr_bw | 12 | 0 | ||
| ms_eugr_hc | 12 | 0 | ||
| ms_hearing | 12 | 0 | ||
| ms_rop_severe | 12 | 0 |
| t_death_age_def | t_alive | variable | missing | non-missing |
|---|---|---|---|---|
| ceiled | 0-no | ms_resp_supp_agg_cum_day_qw | 458 | 4 |
| ms_fio2_cum_day_qw | 458 | 4 | ||
| ms_fio2_cum_level_qw | 458 | 4 | ||
| ms_resp_supp_agg_cum_day_pct | 458 | 4 | ||
| ms_fio2_cum_day_pct | 458 | 4 | ||
| ms_fio2_cum_level_pct | 458 | 4 | ||
| ms_steroid_postnatal | 458 | 4 | ||
| ms_bw_z_qw | 460 | 2 | ||
| ms_hc_z_qw | 460 | 2 | ||
| ms_resp_supp_raw | 3648 | 33 | ||
| ms_fio2_raw | 3648 | 33 | ||
| ms_inotropic | 3648 | 33 | ||
| ms_blood_volume | 3648 | 33 | ||
| ms_transfusion | 3648 | 33 | ||
| ms_blood_culture | 3648 | 33 | ||
| ms_plt | 3675 | 6 | ||
| ms_wbc | 3675 | 6 | ||
| ms_feeding | 3648 | 33 | ||
| 1-yes | ms_resp_supp_agg_cum_day_qw | 1 | 251 | |
| ms_fio2_cum_day_qw | 1 | 251 | ||
| ms_fio2_cum_level_qw | 1 | 251 | ||
| ms_resp_supp_agg_cum_day_pct | 1 | 251 | ||
| ms_fio2_cum_day_pct | 1 | 251 | ||
| ms_fio2_cum_level_pct | 1 | 251 | ||
| ms_steroid_postnatal | 0 | 252 | ||
| ms_bw_z_qw | 5 | 247 | ||
| ms_hc_z_qw | 23 | 229 | ||
| ms_resp_supp_raw | 5 | 1312 | ||
| ms_fio2_raw | 5 | 1312 | ||
| ms_inotropic | 0 | 1317 | ||
| ms_blood_volume | 0 | 1317 | ||
| ms_transfusion | 0 | 1317 | ||
| ms_blood_culture | 0 | 1317 | ||
| ms_plt | 986 | 331 | ||
| ms_wbc | 995 | 322 | ||
| ms_feeding | 0 | 1317 | ||
| rounded_plus1 | 0-no | ms_resp_supp_agg_cum_day_qw | 458 | 1 |
| ms_fio2_cum_day_qw | 458 | 1 | ||
| ms_fio2_cum_level_qw | 458 | 1 | ||
| ms_resp_supp_agg_cum_day_pct | 458 | 1 | ||
| ms_fio2_cum_day_pct | 458 | 1 | ||
| ms_fio2_cum_level_pct | 458 | 1 | ||
| ms_steroid_postnatal | 458 | 1 | ||
| ms_bw_z_qw | 459 | 0 | ||
| ms_hc_z_qw | 459 | 0 | ||
| ms_resp_supp_raw | 3633 | 8 | ||
| ms_fio2_raw | 3633 | 8 | ||
| ms_inotropic | 3633 | 8 | ||
| ms_blood_volume | 3633 | 8 | ||
| ms_transfusion | 3633 | 8 | ||
| ms_blood_culture | 3633 | 8 | ||
| ms_plt | 3641 | 0 | ||
| ms_wbc | 3641 | 0 | ||
| ms_feeding | 3633 | 8 | ||
| 1-yes | ms_resp_supp_agg_cum_day_qw | 1 | 254 | |
| ms_fio2_cum_day_qw | 1 | 254 | ||
| ms_fio2_cum_level_qw | 1 | 254 | ||
| ms_resp_supp_agg_cum_day_pct | 1 | 254 | ||
| ms_fio2_cum_day_pct | 1 | 254 | ||
| ms_fio2_cum_level_pct | 1 | 254 | ||
| ms_steroid_postnatal | 0 | 255 | ||
| ms_bw_z_qw | 6 | 249 | ||
| ms_hc_z_qw | 24 | 231 | ||
| ms_resp_supp_raw | 20 | 1337 | ||
| ms_fio2_raw | 20 | 1337 | ||
| ms_inotropic | 15 | 1342 | ||
| ms_blood_volume | 15 | 1342 | ||
| ms_transfusion | 15 | 1342 | ||
| ms_blood_culture | 15 | 1342 | ||
| ms_plt | 1020 | 337 | ||
| ms_wbc | 1029 | 328 | ||
| ms_feeding | 15 | 1342 | ||
| floored_plus1 | 0-no | ms_resp_supp_agg_cum_day_qw | 458 | 4 |
| ms_fio2_cum_day_qw | 458 | 4 | ||
| ms_fio2_cum_level_qw | 458 | 4 | ||
| ms_resp_supp_agg_cum_day_pct | 458 | 4 | ||
| ms_fio2_cum_day_pct | 458 | 4 | ||
| ms_fio2_cum_level_pct | 458 | 4 | ||
| ms_steroid_postnatal | 458 | 4 | ||
| ms_bw_z_qw | 460 | 2 | ||
| ms_hc_z_qw | 460 | 2 | ||
| ms_resp_supp_raw | 3648 | 33 | ||
| ms_fio2_raw | 3648 | 33 | ||
| ms_inotropic | 3648 | 33 | ||
| ms_blood_volume | 3648 | 33 | ||
| ms_transfusion | 3648 | 33 | ||
| ms_blood_culture | 3648 | 33 | ||
| ms_plt | 3675 | 6 | ||
| ms_wbc | 3675 | 6 | ||
| ms_feeding | 3648 | 33 | ||
| 1-yes | ms_resp_supp_agg_cum_day_qw | 1 | 251 | |
| ms_fio2_cum_day_qw | 1 | 251 | ||
| ms_fio2_cum_level_qw | 1 | 251 | ||
| ms_resp_supp_agg_cum_day_pct | 1 | 251 | ||
| ms_fio2_cum_day_pct | 1 | 251 | ||
| ms_fio2_cum_level_pct | 1 | 251 | ||
| ms_steroid_postnatal | 0 | 252 | ||
| ms_bw_z_qw | 5 | 247 | ||
| ms_hc_z_qw | 23 | 229 | ||
| ms_resp_supp_raw | 5 | 1312 | ||
| ms_fio2_raw | 5 | 1312 | ||
| ms_inotropic | 0 | 1317 | ||
| ms_blood_volume | 0 | 1317 | ||
| ms_transfusion | 0 | 1317 | ||
| ms_blood_culture | 0 | 1317 | ||
| ms_plt | 986 | 331 | ||
| ms_wbc | 995 | 322 | ||
| ms_feeding | 0 | 1317 |
Data partition
Figure 1. GA (week) distribution for each partition and independent test. GA, gestational week.
Numerical data transformation
Figure 2. QQ plot of numerical variables. QQ, quantile-to-quantile.
## t, maternal_age, gravida, ga_wk, as1, as5, resuscitation_at_birth, steroid_antenatal, surfactant, bbw_z, bhc_z, resp_supp_agg_cum_day_qw, fio2_cum_day_qw, fio2_cum_level_qw, resp_supp_agg_cum_day_pct, fio2_cum_day_pct, fio2_cum_level_pct, steroid_postnatal, inotropic, blood_volume, transfusion, blood_culture, plt, wbc, feeding, nec, aki| variable | statistic | p.value | alternative |
|---|---|---|---|
| death_age* | 0.261 | <0.001 | two-sided |
| Note: | |||
| *, p-value <=0.05, Shapiro-Wilk normality test. |
## death_age## log, sqrt, inv, log2, exp, asinh, bct| variable | best_trans | p.value | log | sqrt | inv | log2 | exp | asinh | bct |
|---|---|---|---|---|---|---|---|---|---|
| death_age* | bct | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
| Note: | |||||||||
| *, p-value <=0.05, Shapiro-Wilk normality test. |
## death_ageOutlier analysis
Correlation matrix
## ms_fio2_cum_day_pct, ms_fio2_cum_day_qw, ms_fio2_cum_level_pct, ms_fio2_cum_level_qw, ms_resp_supp_agg_cum_day_pct, ms_resp_supp_agg_cum_day_qw, pvl| V1 | V1_value | V2 | V2_value | n |
|---|---|---|---|---|
| ms_death_age | yes | ms_rop_severe | yes | 0 |
| ms_death_age | yes | ms_bpd_grade | yes | 0 |
| ms_death_age | yes | ms_eugr_hc | yes | 0 |
| ms_death_age | yes | ms_eugr_bw | yes | 0 |
| ms_death_age | no | ms_hearing | no | 0 |
| ms_death_age | yes | ms_inotropic | yes | 0 |
| ms_death_age | yes | ms_blood_volume | yes | 0 |
| ms_death_age | yes | ms_transfusion | yes | 0 |
| ms_death_age | yes | ms_blood_culture | yes | 0 |
| ms_death_age | yes | ms_feeding | yes | 0 |
| ms_death_age | yes | ms_ivh | yes | 0 |
| ms_death_age | yes | ms_pvl | yes | 0 |
| ms_death_age | yes | ms_cerebellar_hemorrhage | yes | 0 |
| ms_death_age | yes | ms_ischaemic_stroke | yes | 0 |
| ms_death_age | yes | ms_hs_pda_iv | yes | 0 |
| ms_death_age | yes | ms_nec | yes | 0 |
| ms_death_age | yes | ms_non_nec_surg_abd | yes | 0 |
| ms_death_age | yes | ms_aki | yes | 0 |
| ms_death_age | yes | survive | 0-no | 0 |
| ms_death_age | no | survive | 1-yes | 0 |
| ms_death_age | yes | rop_severe | NA | 0 |
| ms_death_age | yes | bpd_grade | NA | 0 |
| ms_death_age | no | bpd_grade | 1-mild BPD | 0 |
| ms_death_age | yes | eugr_hc | NA | 0 |
| ms_death_age | yes | eugr_bw | NA | 0 |
| ms_death_age | no | hearing | 0-passed | 0 |
| ms_death_age | no | hearing | 1-failed | 0 |
| ms_death_age | no | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_death_age | yes | ivh | NA | 0 |
| ms_death_age | yes | cerebellar_hemorrhage | NA | 0 |
| ms_death_age | yes | ischaemic_stroke | NA | 0 |
| ms_death_age | no | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_death_age | yes | hs_pda_iv | NA | 0 |
| ms_death_age | yes | non_nec_surg_abd | NA | 0 |
| ms_death_age | no | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_rop_severe | yes | ms_bpd_grade | no | 0 |
| ms_rop_severe | no | ms_bpd_grade | yes | 0 |
| ms_rop_severe | yes | ms_eugr_hc | no | 0 |
| ms_rop_severe | yes | ms_eugr_bw | no | 0 |
| ms_rop_severe | yes | ms_hearing | no | 0 |
| ms_rop_severe | no | ms_inotropic | yes | 0 |
| ms_rop_severe | no | ms_blood_volume | yes | 0 |
| ms_rop_severe | no | ms_transfusion | yes | 0 |
| ms_rop_severe | no | ms_blood_culture | yes | 0 |
| ms_rop_severe | no | ms_feeding | yes | 0 |
| ms_rop_severe | no | ms_ivh | yes | 0 |
| ms_rop_severe | no | ms_pvl | yes | 0 |
| ms_rop_severe | no | ms_cerebellar_hemorrhage | yes | 0 |
| ms_rop_severe | no | ms_ischaemic_stroke | yes | 0 |
| ms_rop_severe | no | ms_hs_pda_iv | yes | 0 |
| ms_rop_severe | no | ms_nec | yes | 0 |
| ms_rop_severe | no | ms_non_nec_surg_abd | yes | 0 |
| ms_rop_severe | no | ms_aki | yes | 0 |
| ms_rop_severe | yes | survive | 1-yes | 0 |
| ms_rop_severe | yes | rop_severe | 0-none/stage I/stage II | 0 |
| ms_rop_severe | yes | rop_severe | 1-stage II+ | 0 |
| ms_rop_severe | no | rop_severe | NA | 0 |
| ms_rop_severe | yes | bpd_grade | 0-no BPD | 0 |
| ms_rop_severe | yes | bpd_grade | 1-mild BPD | 0 |
| ms_rop_severe | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_rop_severe | no | bpd_grade | NA | 0 |
| ms_rop_severe | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_rop_severe | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_rop_severe | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_rop_severe | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_rop_severe | yes | hearing | 0-passed | 0 |
| ms_rop_severe | yes | hearing | 1-failed | 0 |
| ms_rop_severe | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_rop_severe | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_rop_severe | yes | ivh | 2-IVH grade I | 0 |
| ms_rop_severe | no | ivh | NA | 0 |
| ms_rop_severe | no | cerebellar_hemorrhage | NA | 0 |
| ms_rop_severe | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_rop_severe | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_rop_severe | no | ischaemic_stroke | NA | 0 |
| ms_rop_severe | no | hs_pda_iv | NA | 0 |
| ms_rop_severe | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_rop_severe | no | non_nec_surg_abd | NA | 0 |
| ms_bpd_grade | yes | ms_eugr_hc | no | 0 |
| ms_bpd_grade | yes | ms_eugr_bw | no | 0 |
| ms_bpd_grade | yes | ms_hearing | no | 0 |
| ms_bpd_grade | no | ms_inotropic | yes | 0 |
| ms_bpd_grade | no | ms_blood_volume | yes | 0 |
| ms_bpd_grade | no | ms_transfusion | yes | 0 |
| ms_bpd_grade | no | ms_blood_culture | yes | 0 |
| ms_bpd_grade | no | ms_feeding | yes | 0 |
| ms_bpd_grade | no | ms_ivh | yes | 0 |
| ms_bpd_grade | no | ms_pvl | yes | 0 |
| ms_bpd_grade | no | ms_cerebellar_hemorrhage | yes | 0 |
| ms_bpd_grade | no | ms_ischaemic_stroke | yes | 0 |
| ms_bpd_grade | no | ms_hs_pda_iv | yes | 0 |
| ms_bpd_grade | no | ms_nec | yes | 0 |
| ms_bpd_grade | no | ms_non_nec_surg_abd | yes | 0 |
| ms_bpd_grade | no | ms_aki | yes | 0 |
| ms_bpd_grade | yes | survive | 1-yes | 0 |
| ms_bpd_grade | yes | rop_severe | 0-none/stage I/stage II | 0 |
| ms_bpd_grade | yes | rop_severe | 1-stage II+ | 0 |
| ms_bpd_grade | no | rop_severe | NA | 0 |
| ms_bpd_grade | yes | bpd_grade | 0-no BPD | 0 |
| ms_bpd_grade | yes | bpd_grade | 1-mild BPD | 0 |
| ms_bpd_grade | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_bpd_grade | no | bpd_grade | NA | 0 |
| ms_bpd_grade | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_bpd_grade | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_bpd_grade | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_bpd_grade | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_bpd_grade | yes | hearing | 0-passed | 0 |
| ms_bpd_grade | yes | hearing | 1-failed | 0 |
| ms_bpd_grade | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_bpd_grade | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_bpd_grade | yes | ivh | 2-IVH grade I | 0 |
| ms_bpd_grade | no | ivh | NA | 0 |
| ms_bpd_grade | no | cerebellar_hemorrhage | NA | 0 |
| ms_bpd_grade | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_bpd_grade | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_bpd_grade | no | ischaemic_stroke | NA | 0 |
| ms_bpd_grade | no | hs_pda_iv | NA | 0 |
| ms_bpd_grade | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_bpd_grade | no | non_nec_surg_abd | NA | 0 |
| ms_eugr_hc | yes | ms_eugr_bw | no | 0 |
| ms_eugr_hc | no | ms_eugr_bw | yes | 0 |
| ms_eugr_hc | yes | ms_hearing | no | 0 |
| ms_eugr_hc | no | ms_inotropic | yes | 0 |
| ms_eugr_hc | no | ms_blood_volume | yes | 0 |
| ms_eugr_hc | no | ms_transfusion | yes | 0 |
| ms_eugr_hc | no | ms_blood_culture | yes | 0 |
| ms_eugr_hc | no | ms_feeding | yes | 0 |
| ms_eugr_hc | no | ms_ivh | yes | 0 |
| ms_eugr_hc | no | ms_pvl | yes | 0 |
| ms_eugr_hc | no | ms_cerebellar_hemorrhage | yes | 0 |
| ms_eugr_hc | no | ms_ischaemic_stroke | yes | 0 |
| ms_eugr_hc | no | ms_hs_pda_iv | yes | 0 |
| ms_eugr_hc | no | ms_nec | yes | 0 |
| ms_eugr_hc | no | ms_non_nec_surg_abd | yes | 0 |
| ms_eugr_hc | no | ms_aki | yes | 0 |
| ms_eugr_hc | yes | survive | 1-yes | 0 |
| ms_eugr_hc | yes | rop_severe | 1-stage II+ | 0 |
| ms_eugr_hc | no | rop_severe | NA | 0 |
| ms_eugr_hc | yes | bpd_grade | 1-mild BPD | 0 |
| ms_eugr_hc | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_eugr_hc | no | bpd_grade | NA | 0 |
| ms_eugr_hc | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_eugr_hc | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_eugr_hc | no | eugr_hc | NA | 0 |
| ms_eugr_hc | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_eugr_hc | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_eugr_hc | no | eugr_bw | NA | 0 |
| ms_eugr_hc | yes | hearing | 0-passed | 0 |
| ms_eugr_hc | yes | hearing | 1-failed | 0 |
| ms_eugr_hc | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_eugr_hc | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_eugr_hc | yes | ivh | 2-IVH grade I | 0 |
| ms_eugr_hc | no | ivh | NA | 0 |
| ms_eugr_hc | no | cerebellar_hemorrhage | NA | 0 |
| ms_eugr_hc | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_eugr_hc | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_eugr_hc | no | ischaemic_stroke | NA | 0 |
| ms_eugr_hc | no | hs_pda_iv | NA | 0 |
| ms_eugr_hc | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_eugr_hc | no | non_nec_surg_abd | NA | 0 |
| ms_eugr_bw | yes | ms_hearing | no | 0 |
| ms_eugr_bw | no | ms_inotropic | yes | 0 |
| ms_eugr_bw | no | ms_blood_volume | yes | 0 |
| ms_eugr_bw | no | ms_transfusion | yes | 0 |
| ms_eugr_bw | no | ms_blood_culture | yes | 0 |
| ms_eugr_bw | no | ms_feeding | yes | 0 |
| ms_eugr_bw | no | ms_ivh | yes | 0 |
| ms_eugr_bw | no | ms_pvl | yes | 0 |
| ms_eugr_bw | no | ms_cerebellar_hemorrhage | yes | 0 |
| ms_eugr_bw | no | ms_ischaemic_stroke | yes | 0 |
| ms_eugr_bw | no | ms_hs_pda_iv | yes | 0 |
| ms_eugr_bw | no | ms_nec | yes | 0 |
| ms_eugr_bw | no | ms_non_nec_surg_abd | yes | 0 |
| ms_eugr_bw | no | ms_aki | yes | 0 |
| ms_eugr_bw | yes | survive | 1-yes | 0 |
| ms_eugr_bw | yes | rop_severe | 1-stage II+ | 0 |
| ms_eugr_bw | no | rop_severe | NA | 0 |
| ms_eugr_bw | yes | bpd_grade | 1-mild BPD | 0 |
| ms_eugr_bw | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_eugr_bw | no | bpd_grade | NA | 0 |
| ms_eugr_bw | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_eugr_bw | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_eugr_bw | no | eugr_hc | NA | 0 |
| ms_eugr_bw | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_eugr_bw | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_eugr_bw | no | eugr_bw | NA | 0 |
| ms_eugr_bw | yes | hearing | 0-passed | 0 |
| ms_eugr_bw | yes | hearing | 1-failed | 0 |
| ms_eugr_bw | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_eugr_bw | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_eugr_bw | yes | ivh | 2-IVH grade I | 0 |
| ms_eugr_bw | no | ivh | NA | 0 |
| ms_eugr_bw | no | cerebellar_hemorrhage | NA | 0 |
| ms_eugr_bw | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_eugr_bw | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_eugr_bw | no | ischaemic_stroke | NA | 0 |
| ms_eugr_bw | no | hs_pda_iv | NA | 0 |
| ms_eugr_bw | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_eugr_bw | no | non_nec_surg_abd | NA | 0 |
| ms_hearing | no | ms_inotropic | yes | 0 |
| ms_hearing | no | ms_blood_volume | yes | 0 |
| ms_hearing | no | ms_transfusion | yes | 0 |
| ms_hearing | no | ms_blood_culture | yes | 0 |
| ms_hearing | no | ms_feeding | yes | 0 |
| ms_hearing | no | ms_ivh | yes | 0 |
| ms_hearing | no | ms_pvl | yes | 0 |
| ms_hearing | no | ms_cerebellar_hemorrhage | yes | 0 |
| ms_hearing | no | ms_ischaemic_stroke | yes | 0 |
| ms_hearing | no | ms_hs_pda_iv | yes | 0 |
| ms_hearing | no | ms_nec | yes | 0 |
| ms_hearing | no | ms_non_nec_surg_abd | yes | 0 |
| ms_hearing | no | ms_aki | yes | 0 |
| ms_hearing | no | survive | 0-no | 0 |
| ms_hearing | no | rop_severe | NA | 0 |
| ms_hearing | yes | bpd_grade | 1-mild BPD | 0 |
| ms_hearing | no | bpd_grade | NA | 0 |
| ms_hearing | no | eugr_hc | NA | 0 |
| ms_hearing | no | eugr_bw | NA | 0 |
| ms_hearing | yes | hearing | 0-passed | 0 |
| ms_hearing | yes | hearing | 1-failed | 0 |
| ms_hearing | no | hearing | NA | 0 |
| ms_hearing | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_hearing | no | ivh | NA | 0 |
| ms_hearing | no | cerebellar_hemorrhage | NA | 0 |
| ms_hearing | no | ischaemic_stroke | NA | 0 |
| ms_hearing | no | hs_pda_iv | NA | 0 |
| ms_hearing | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_hearing | no | non_nec_surg_abd | NA | 0 |
| ms_bw_z_qw | yes | socioeconomic_status | 1-highest | 0 |
| ms_bw_z_qw | yes | education_status | 4-high school | 0 |
| ms_bw_z_qw | yes | education_status | 7-elementary school | 0 |
| ms_bw_z_qw | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_bw_z_qw | yes | bw_z_qw | 1-BW z-score >-1 | 0 |
| ms_bw_z_qw | yes | bw_z_qw | 2-BW z-score >-2 & <=-1 | 0 |
| ms_bw_z_qw | yes | bw_z_qw | 3-BW z-score >-3 & <=-2 | 0 |
| ms_bw_z_qw | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_bw_z_qw | no | bw_z_qw | NA | 0 |
| ms_bw_z_qw | yes | hc_z_qw | 1-HC z-score >-1 | 0 |
| ms_bw_z_qw | yes | hc_z_qw | 2-HC z-score >-2 & <=-1 | 0 |
| ms_bw_z_qw | yes | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| ms_bw_z_qw | yes | ivh | 2-IVH grade I | 0 |
| ms_bw_z_qw | yes | ivh | 3-IVH grade II | 0 |
| ms_bw_z_qw | yes | ivh | 4-IVH grade III | 0 |
| ms_bw_z_qw | yes | ivh | 5-IVH grade IV, unilateral | 0 |
| ms_bw_z_qw | yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| ms_bw_z_qw | yes | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ms_bw_z_qw | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_bw_z_qw | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_bw_z_qw | yes | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ms_bw_z_qw | yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ms_bw_z_qw | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_hc_z_qw | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_hc_z_qw | yes | hc_z_qw | 1-HC z-score >-1 | 0 |
| ms_hc_z_qw | yes | hc_z_qw | 2-HC z-score >-2 & <=-1 | 0 |
| ms_hc_z_qw | yes | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| ms_hc_z_qw | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_hc_z_qw | no | hc_z_qw | NA | 0 |
| ms_hc_z_qw | yes | ivh | 2-IVH grade I | 0 |
| ms_hc_z_qw | yes | ivh | 3-IVH grade II | 0 |
| ms_hc_z_qw | yes | ivh | 4-IVH grade III | 0 |
| ms_hc_z_qw | yes | ivh | 5-IVH grade IV, unilateral | 0 |
| ms_hc_z_qw | yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| ms_hc_z_qw | yes | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ms_hc_z_qw | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_hc_z_qw | yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ms_hc_z_qw | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_inotropic | yes | ms_blood_volume | no | 0 |
| ms_inotropic | no | ms_blood_volume | yes | 0 |
| ms_inotropic | yes | ms_transfusion | no | 0 |
| ms_inotropic | no | ms_transfusion | yes | 0 |
| ms_inotropic | yes | ms_blood_culture | no | 0 |
| ms_inotropic | no | ms_blood_culture | yes | 0 |
| ms_inotropic | yes | ms_plt | no | 0 |
| ms_inotropic | yes | ms_wbc | no | 0 |
| ms_inotropic | yes | ms_feeding | no | 0 |
| ms_inotropic | no | ms_feeding | yes | 0 |
| ms_inotropic | yes | ms_ivh | no | 0 |
| ms_inotropic | no | ms_ivh | yes | 0 |
| ms_inotropic | yes | ms_pvl | no | 0 |
| ms_inotropic | no | ms_pvl | yes | 0 |
| ms_inotropic | yes | ms_cerebellar_hemorrhage | no | 0 |
| ms_inotropic | no | ms_cerebellar_hemorrhage | yes | 0 |
| ms_inotropic | yes | ms_ischaemic_stroke | no | 0 |
| ms_inotropic | no | ms_ischaemic_stroke | yes | 0 |
| ms_inotropic | yes | ms_hs_pda_iv | no | 0 |
| ms_inotropic | no | ms_hs_pda_iv | yes | 0 |
| ms_inotropic | yes | ms_nec | no | 0 |
| ms_inotropic | no | ms_nec | yes | 0 |
| ms_inotropic | yes | ms_non_nec_surg_abd | no | 0 |
| ms_inotropic | no | ms_non_nec_surg_abd | yes | 0 |
| ms_inotropic | yes | ms_aki | no | 0 |
| ms_inotropic | no | ms_aki | yes | 0 |
| ms_inotropic | yes | socioeconomic_status | 1-highest | 0 |
| ms_inotropic | yes | education_status | 1-postgraduate | 0 |
| ms_inotropic | yes | education_status | 4-high school | 0 |
| ms_inotropic | yes | education_status | 6-junior high school | 0 |
| ms_inotropic | yes | education_status | 7-elementary school | 0 |
| ms_inotropic | yes | birthtime_scoring | 2-born 17:00-23:59 | 0 |
| ms_inotropic | yes | survive | 1-yes | 0 |
| ms_inotropic | yes | rop_severe | 0-none/stage I/stage II | 0 |
| ms_inotropic | yes | rop_severe | 1-stage II+ | 0 |
| ms_inotropic | yes | bpd_grade | 0-no BPD | 0 |
| ms_inotropic | yes | bpd_grade | 1-mild BPD | 0 |
| ms_inotropic | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_inotropic | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_inotropic | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_inotropic | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_inotropic | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_inotropic | yes | hearing | 0-passed | 0 |
| ms_inotropic | yes | hearing | 1-failed | 0 |
| ms_inotropic | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_inotropic | yes | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| ms_inotropic | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_inotropic | yes | ivh | 1-no IVH | 0 |
| ms_inotropic | yes | ivh | 2-IVH grade I | 0 |
| ms_inotropic | yes | ivh | 3-IVH grade II | 0 |
| ms_inotropic | yes | ivh | 4-IVH grade III | 0 |
| ms_inotropic | yes | ivh | 5-IVH grade IV, unilateral | 0 |
| ms_inotropic | yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| ms_inotropic | no | ivh | NA | 0 |
| ms_inotropic | yes | cerebellar_hemorrhage | 1-no bleeding | 0 |
| ms_inotropic | yes | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ms_inotropic | no | cerebellar_hemorrhage | NA | 0 |
| ms_inotropic | yes | ischaemic_stroke | 1-no ischemia | 0 |
| ms_inotropic | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_inotropic | yes | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ms_inotropic | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_inotropic | no | ischaemic_stroke | NA | 0 |
| ms_inotropic | yes | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| ms_inotropic | yes | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ms_inotropic | yes | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ms_inotropic | no | hs_pda_iv | NA | 0 |
| ms_inotropic | yes | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| ms_inotropic | yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ms_inotropic | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_inotropic | no | non_nec_surg_abd | NA | 0 |
| ms_blood_volume | yes | ms_transfusion | no | 0 |
| ms_blood_volume | no | ms_transfusion | yes | 0 |
| ms_blood_volume | yes | ms_blood_culture | no | 0 |
| ms_blood_volume | no | ms_blood_culture | yes | 0 |
| ms_blood_volume | yes | ms_plt | no | 0 |
| ms_blood_volume | yes | ms_wbc | no | 0 |
| ms_blood_volume | yes | ms_feeding | no | 0 |
| ms_blood_volume | no | ms_feeding | yes | 0 |
| ms_blood_volume | yes | ms_ivh | no | 0 |
| ms_blood_volume | no | ms_ivh | yes | 0 |
| ms_blood_volume | yes | ms_pvl | no | 0 |
| ms_blood_volume | no | ms_pvl | yes | 0 |
| ms_blood_volume | yes | ms_cerebellar_hemorrhage | no | 0 |
| ms_blood_volume | no | ms_cerebellar_hemorrhage | yes | 0 |
| ms_blood_volume | yes | ms_ischaemic_stroke | no | 0 |
| ms_blood_volume | no | ms_ischaemic_stroke | yes | 0 |
| ms_blood_volume | yes | ms_hs_pda_iv | no | 0 |
| ms_blood_volume | no | ms_hs_pda_iv | yes | 0 |
| ms_blood_volume | yes | ms_nec | no | 0 |
| ms_blood_volume | no | ms_nec | yes | 0 |
| ms_blood_volume | yes | ms_non_nec_surg_abd | no | 0 |
| ms_blood_volume | no | ms_non_nec_surg_abd | yes | 0 |
| ms_blood_volume | yes | ms_aki | no | 0 |
| ms_blood_volume | no | ms_aki | yes | 0 |
| ms_blood_volume | yes | socioeconomic_status | 1-highest | 0 |
| ms_blood_volume | yes | education_status | 1-postgraduate | 0 |
| ms_blood_volume | yes | education_status | 4-high school | 0 |
| ms_blood_volume | yes | education_status | 6-junior high school | 0 |
| ms_blood_volume | yes | education_status | 7-elementary school | 0 |
| ms_blood_volume | yes | birthtime_scoring | 2-born 17:00-23:59 | 0 |
| ms_blood_volume | yes | survive | 1-yes | 0 |
| ms_blood_volume | yes | rop_severe | 0-none/stage I/stage II | 0 |
| ms_blood_volume | yes | rop_severe | 1-stage II+ | 0 |
| ms_blood_volume | yes | bpd_grade | 0-no BPD | 0 |
| ms_blood_volume | yes | bpd_grade | 1-mild BPD | 0 |
| ms_blood_volume | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_blood_volume | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_blood_volume | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_blood_volume | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_blood_volume | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_blood_volume | yes | hearing | 0-passed | 0 |
| ms_blood_volume | yes | hearing | 1-failed | 0 |
| ms_blood_volume | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_blood_volume | yes | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| ms_blood_volume | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_blood_volume | yes | ivh | 1-no IVH | 0 |
| ms_blood_volume | yes | ivh | 2-IVH grade I | 0 |
| ms_blood_volume | yes | ivh | 3-IVH grade II | 0 |
| ms_blood_volume | yes | ivh | 4-IVH grade III | 0 |
| ms_blood_volume | yes | ivh | 5-IVH grade IV, unilateral | 0 |
| ms_blood_volume | yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| ms_blood_volume | no | ivh | NA | 0 |
| ms_blood_volume | yes | cerebellar_hemorrhage | 1-no bleeding | 0 |
| ms_blood_volume | yes | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ms_blood_volume | no | cerebellar_hemorrhage | NA | 0 |
| ms_blood_volume | yes | ischaemic_stroke | 1-no ischemia | 0 |
| ms_blood_volume | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_blood_volume | yes | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ms_blood_volume | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_blood_volume | no | ischaemic_stroke | NA | 0 |
| ms_blood_volume | yes | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| ms_blood_volume | yes | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ms_blood_volume | yes | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ms_blood_volume | no | hs_pda_iv | NA | 0 |
| ms_blood_volume | yes | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| ms_blood_volume | yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ms_blood_volume | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_blood_volume | no | non_nec_surg_abd | NA | 0 |
| ms_transfusion | yes | ms_blood_culture | no | 0 |
| ms_transfusion | no | ms_blood_culture | yes | 0 |
| ms_transfusion | yes | ms_plt | no | 0 |
| ms_transfusion | yes | ms_wbc | no | 0 |
| ms_transfusion | yes | ms_feeding | no | 0 |
| ms_transfusion | no | ms_feeding | yes | 0 |
| ms_transfusion | yes | ms_ivh | no | 0 |
| ms_transfusion | no | ms_ivh | yes | 0 |
| ms_transfusion | yes | ms_pvl | no | 0 |
| ms_transfusion | no | ms_pvl | yes | 0 |
| ms_transfusion | yes | ms_cerebellar_hemorrhage | no | 0 |
| ms_transfusion | no | ms_cerebellar_hemorrhage | yes | 0 |
| ms_transfusion | yes | ms_ischaemic_stroke | no | 0 |
| ms_transfusion | no | ms_ischaemic_stroke | yes | 0 |
| ms_transfusion | yes | ms_hs_pda_iv | no | 0 |
| ms_transfusion | no | ms_hs_pda_iv | yes | 0 |
| ms_transfusion | yes | ms_nec | no | 0 |
| ms_transfusion | no | ms_nec | yes | 0 |
| ms_transfusion | yes | ms_non_nec_surg_abd | no | 0 |
| ms_transfusion | no | ms_non_nec_surg_abd | yes | 0 |
| ms_transfusion | yes | ms_aki | no | 0 |
| ms_transfusion | no | ms_aki | yes | 0 |
| ms_transfusion | yes | socioeconomic_status | 1-highest | 0 |
| ms_transfusion | yes | education_status | 1-postgraduate | 0 |
| ms_transfusion | yes | education_status | 4-high school | 0 |
| ms_transfusion | yes | education_status | 6-junior high school | 0 |
| ms_transfusion | yes | education_status | 7-elementary school | 0 |
| ms_transfusion | yes | birthtime_scoring | 2-born 17:00-23:59 | 0 |
| ms_transfusion | yes | survive | 1-yes | 0 |
| ms_transfusion | yes | rop_severe | 0-none/stage I/stage II | 0 |
| ms_transfusion | yes | rop_severe | 1-stage II+ | 0 |
| ms_transfusion | yes | bpd_grade | 0-no BPD | 0 |
| ms_transfusion | yes | bpd_grade | 1-mild BPD | 0 |
| ms_transfusion | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_transfusion | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_transfusion | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_transfusion | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_transfusion | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_transfusion | yes | hearing | 0-passed | 0 |
| ms_transfusion | yes | hearing | 1-failed | 0 |
| ms_transfusion | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_transfusion | yes | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| ms_transfusion | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_transfusion | yes | ivh | 1-no IVH | 0 |
| ms_transfusion | yes | ivh | 2-IVH grade I | 0 |
| ms_transfusion | yes | ivh | 3-IVH grade II | 0 |
| ms_transfusion | yes | ivh | 4-IVH grade III | 0 |
| ms_transfusion | yes | ivh | 5-IVH grade IV, unilateral | 0 |
| ms_transfusion | yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| ms_transfusion | no | ivh | NA | 0 |
| ms_transfusion | yes | cerebellar_hemorrhage | 1-no bleeding | 0 |
| ms_transfusion | yes | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ms_transfusion | no | cerebellar_hemorrhage | NA | 0 |
| ms_transfusion | yes | ischaemic_stroke | 1-no ischemia | 0 |
| ms_transfusion | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_transfusion | yes | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ms_transfusion | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_transfusion | no | ischaemic_stroke | NA | 0 |
| ms_transfusion | yes | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| ms_transfusion | yes | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ms_transfusion | yes | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ms_transfusion | no | hs_pda_iv | NA | 0 |
| ms_transfusion | yes | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| ms_transfusion | yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ms_transfusion | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_transfusion | no | non_nec_surg_abd | NA | 0 |
| ms_blood_culture | yes | ms_plt | no | 0 |
| ms_blood_culture | yes | ms_wbc | no | 0 |
| ms_blood_culture | yes | ms_feeding | no | 0 |
| ms_blood_culture | no | ms_feeding | yes | 0 |
| ms_blood_culture | yes | ms_ivh | no | 0 |
| ms_blood_culture | no | ms_ivh | yes | 0 |
| ms_blood_culture | yes | ms_pvl | no | 0 |
| ms_blood_culture | no | ms_pvl | yes | 0 |
| ms_blood_culture | yes | ms_cerebellar_hemorrhage | no | 0 |
| ms_blood_culture | no | ms_cerebellar_hemorrhage | yes | 0 |
| ms_blood_culture | yes | ms_ischaemic_stroke | no | 0 |
| ms_blood_culture | no | ms_ischaemic_stroke | yes | 0 |
| ms_blood_culture | yes | ms_hs_pda_iv | no | 0 |
| ms_blood_culture | no | ms_hs_pda_iv | yes | 0 |
| ms_blood_culture | yes | ms_nec | no | 0 |
| ms_blood_culture | no | ms_nec | yes | 0 |
| ms_blood_culture | yes | ms_non_nec_surg_abd | no | 0 |
| ms_blood_culture | no | ms_non_nec_surg_abd | yes | 0 |
| ms_blood_culture | yes | ms_aki | no | 0 |
| ms_blood_culture | no | ms_aki | yes | 0 |
| ms_blood_culture | yes | socioeconomic_status | 1-highest | 0 |
| ms_blood_culture | yes | education_status | 1-postgraduate | 0 |
| ms_blood_culture | yes | education_status | 4-high school | 0 |
| ms_blood_culture | yes | education_status | 6-junior high school | 0 |
| ms_blood_culture | yes | education_status | 7-elementary school | 0 |
| ms_blood_culture | yes | birthtime_scoring | 2-born 17:00-23:59 | 0 |
| ms_blood_culture | yes | survive | 1-yes | 0 |
| ms_blood_culture | yes | rop_severe | 0-none/stage I/stage II | 0 |
| ms_blood_culture | yes | rop_severe | 1-stage II+ | 0 |
| ms_blood_culture | yes | bpd_grade | 0-no BPD | 0 |
| ms_blood_culture | yes | bpd_grade | 1-mild BPD | 0 |
| ms_blood_culture | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_blood_culture | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_blood_culture | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_blood_culture | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_blood_culture | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_blood_culture | yes | hearing | 0-passed | 0 |
| ms_blood_culture | yes | hearing | 1-failed | 0 |
| ms_blood_culture | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_blood_culture | yes | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| ms_blood_culture | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_blood_culture | yes | ivh | 1-no IVH | 0 |
| ms_blood_culture | yes | ivh | 2-IVH grade I | 0 |
| ms_blood_culture | yes | ivh | 3-IVH grade II | 0 |
| ms_blood_culture | yes | ivh | 4-IVH grade III | 0 |
| ms_blood_culture | yes | ivh | 5-IVH grade IV, unilateral | 0 |
| ms_blood_culture | yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| ms_blood_culture | no | ivh | NA | 0 |
| ms_blood_culture | yes | cerebellar_hemorrhage | 1-no bleeding | 0 |
| ms_blood_culture | yes | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ms_blood_culture | no | cerebellar_hemorrhage | NA | 0 |
| ms_blood_culture | yes | ischaemic_stroke | 1-no ischemia | 0 |
| ms_blood_culture | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_blood_culture | yes | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ms_blood_culture | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_blood_culture | no | ischaemic_stroke | NA | 0 |
| ms_blood_culture | yes | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| ms_blood_culture | yes | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ms_blood_culture | yes | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ms_blood_culture | no | hs_pda_iv | NA | 0 |
| ms_blood_culture | yes | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| ms_blood_culture | yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ms_blood_culture | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_blood_culture | no | non_nec_surg_abd | NA | 0 |
| ms_plt | yes | ms_wbc | no | 0 |
| ms_plt | no | ms_feeding | yes | 0 |
| ms_plt | no | ms_ivh | yes | 0 |
| ms_plt | no | ms_pvl | yes | 0 |
| ms_plt | no | ms_cerebellar_hemorrhage | yes | 0 |
| ms_plt | no | ms_ischaemic_stroke | yes | 0 |
| ms_plt | no | ms_hs_pda_iv | yes | 0 |
| ms_plt | no | ms_nec | yes | 0 |
| ms_plt | no | ms_non_nec_surg_abd | yes | 0 |
| ms_plt | no | ms_aki | yes | 0 |
| ms_plt | no | ivh | NA | 0 |
| ms_plt | no | cerebellar_hemorrhage | NA | 0 |
| ms_plt | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_plt | no | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_plt | no | ischaemic_stroke | NA | 0 |
| ms_plt | no | hs_pda_iv | NA | 0 |
| ms_plt | no | non_nec_surg_abd | NA | 0 |
| ms_wbc | no | ms_feeding | yes | 0 |
| ms_wbc | no | ms_ivh | yes | 0 |
| ms_wbc | no | ms_pvl | yes | 0 |
| ms_wbc | no | ms_cerebellar_hemorrhage | yes | 0 |
| ms_wbc | no | ms_ischaemic_stroke | yes | 0 |
| ms_wbc | no | ms_hs_pda_iv | yes | 0 |
| ms_wbc | no | ms_nec | yes | 0 |
| ms_wbc | no | ms_non_nec_surg_abd | yes | 0 |
| ms_wbc | no | ms_aki | yes | 0 |
| ms_wbc | no | ivh | NA | 0 |
| ms_wbc | no | cerebellar_hemorrhage | NA | 0 |
| ms_wbc | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_wbc | no | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_wbc | no | ischaemic_stroke | NA | 0 |
| ms_wbc | no | hs_pda_iv | NA | 0 |
| ms_wbc | no | non_nec_surg_abd | NA | 0 |
| ms_feeding | yes | ms_ivh | no | 0 |
| ms_feeding | no | ms_ivh | yes | 0 |
| ms_feeding | yes | ms_pvl | no | 0 |
| ms_feeding | no | ms_pvl | yes | 0 |
| ms_feeding | yes | ms_cerebellar_hemorrhage | no | 0 |
| ms_feeding | no | ms_cerebellar_hemorrhage | yes | 0 |
| ms_feeding | yes | ms_ischaemic_stroke | no | 0 |
| ms_feeding | no | ms_ischaemic_stroke | yes | 0 |
| ms_feeding | yes | ms_hs_pda_iv | no | 0 |
| ms_feeding | no | ms_hs_pda_iv | yes | 0 |
| ms_feeding | yes | ms_nec | no | 0 |
| ms_feeding | no | ms_nec | yes | 0 |
| ms_feeding | yes | ms_non_nec_surg_abd | no | 0 |
| ms_feeding | no | ms_non_nec_surg_abd | yes | 0 |
| ms_feeding | yes | ms_aki | no | 0 |
| ms_feeding | no | ms_aki | yes | 0 |
| ms_feeding | yes | socioeconomic_status | 1-highest | 0 |
| ms_feeding | yes | education_status | 1-postgraduate | 0 |
| ms_feeding | yes | education_status | 4-high school | 0 |
| ms_feeding | yes | education_status | 6-junior high school | 0 |
| ms_feeding | yes | education_status | 7-elementary school | 0 |
| ms_feeding | yes | birthtime_scoring | 2-born 17:00-23:59 | 0 |
| ms_feeding | yes | survive | 1-yes | 0 |
| ms_feeding | yes | rop_severe | 0-none/stage I/stage II | 0 |
| ms_feeding | yes | rop_severe | 1-stage II+ | 0 |
| ms_feeding | yes | bpd_grade | 0-no BPD | 0 |
| ms_feeding | yes | bpd_grade | 1-mild BPD | 0 |
| ms_feeding | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_feeding | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_feeding | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_feeding | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_feeding | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_feeding | yes | hearing | 0-passed | 0 |
| ms_feeding | yes | hearing | 1-failed | 0 |
| ms_feeding | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_feeding | yes | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| ms_feeding | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_feeding | yes | ivh | 1-no IVH | 0 |
| ms_feeding | yes | ivh | 2-IVH grade I | 0 |
| ms_feeding | yes | ivh | 3-IVH grade II | 0 |
| ms_feeding | yes | ivh | 4-IVH grade III | 0 |
| ms_feeding | yes | ivh | 5-IVH grade IV, unilateral | 0 |
| ms_feeding | yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| ms_feeding | no | ivh | NA | 0 |
| ms_feeding | yes | cerebellar_hemorrhage | 1-no bleeding | 0 |
| ms_feeding | yes | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ms_feeding | no | cerebellar_hemorrhage | NA | 0 |
| ms_feeding | yes | ischaemic_stroke | 1-no ischemia | 0 |
| ms_feeding | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_feeding | yes | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ms_feeding | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_feeding | no | ischaemic_stroke | NA | 0 |
| ms_feeding | yes | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| ms_feeding | yes | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ms_feeding | yes | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ms_feeding | no | hs_pda_iv | NA | 0 |
| ms_feeding | yes | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| ms_feeding | yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ms_feeding | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_feeding | no | non_nec_surg_abd | NA | 0 |
| ms_ivh | yes | ms_pvl | no | 0 |
| ms_ivh | no | ms_pvl | yes | 0 |
| ms_ivh | yes | ms_cerebellar_hemorrhage | no | 0 |
| ms_ivh | no | ms_cerebellar_hemorrhage | yes | 0 |
| ms_ivh | yes | ms_ischaemic_stroke | no | 0 |
| ms_ivh | no | ms_ischaemic_stroke | yes | 0 |
| ms_ivh | yes | ms_hs_pda_iv | no | 0 |
| ms_ivh | no | ms_hs_pda_iv | yes | 0 |
| ms_ivh | yes | ms_nec | no | 0 |
| ms_ivh | no | ms_nec | yes | 0 |
| ms_ivh | yes | ms_non_nec_surg_abd | no | 0 |
| ms_ivh | no | ms_non_nec_surg_abd | yes | 0 |
| ms_ivh | yes | ms_aki | no | 0 |
| ms_ivh | no | ms_aki | yes | 0 |
| ms_ivh | yes | socioeconomic_status | 1-highest | 0 |
| ms_ivh | yes | education_status | 1-postgraduate | 0 |
| ms_ivh | yes | education_status | 4-high school | 0 |
| ms_ivh | yes | education_status | 6-junior high school | 0 |
| ms_ivh | yes | education_status | 7-elementary school | 0 |
| ms_ivh | yes | birthtime_scoring | 2-born 17:00-23:59 | 0 |
| ms_ivh | yes | survive | 1-yes | 0 |
| ms_ivh | yes | rop_severe | 0-none/stage I/stage II | 0 |
| ms_ivh | yes | rop_severe | 1-stage II+ | 0 |
| ms_ivh | yes | bpd_grade | 0-no BPD | 0 |
| ms_ivh | yes | bpd_grade | 1-mild BPD | 0 |
| ms_ivh | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_ivh | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_ivh | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_ivh | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_ivh | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_ivh | yes | hearing | 0-passed | 0 |
| ms_ivh | yes | hearing | 1-failed | 0 |
| ms_ivh | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_ivh | yes | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| ms_ivh | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_ivh | yes | ivh | 1-no IVH | 0 |
| ms_ivh | yes | ivh | 2-IVH grade I | 0 |
| ms_ivh | yes | ivh | 3-IVH grade II | 0 |
| ms_ivh | yes | ivh | 4-IVH grade III | 0 |
| ms_ivh | yes | ivh | 5-IVH grade IV, unilateral | 0 |
| ms_ivh | yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| ms_ivh | no | ivh | NA | 0 |
| ms_ivh | yes | cerebellar_hemorrhage | 1-no bleeding | 0 |
| ms_ivh | yes | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ms_ivh | no | cerebellar_hemorrhage | NA | 0 |
| ms_ivh | yes | ischaemic_stroke | 1-no ischemia | 0 |
| ms_ivh | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_ivh | yes | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ms_ivh | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_ivh | no | ischaemic_stroke | NA | 0 |
| ms_ivh | yes | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| ms_ivh | yes | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ms_ivh | yes | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ms_ivh | no | hs_pda_iv | NA | 0 |
| ms_ivh | yes | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| ms_ivh | yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ms_ivh | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_ivh | no | non_nec_surg_abd | NA | 0 |
| ms_pvl | yes | ms_cerebellar_hemorrhage | no | 0 |
| ms_pvl | no | ms_cerebellar_hemorrhage | yes | 0 |
| ms_pvl | yes | ms_ischaemic_stroke | no | 0 |
| ms_pvl | no | ms_ischaemic_stroke | yes | 0 |
| ms_pvl | yes | ms_hs_pda_iv | no | 0 |
| ms_pvl | no | ms_hs_pda_iv | yes | 0 |
| ms_pvl | yes | ms_nec | no | 0 |
| ms_pvl | no | ms_nec | yes | 0 |
| ms_pvl | yes | ms_non_nec_surg_abd | no | 0 |
| ms_pvl | no | ms_non_nec_surg_abd | yes | 0 |
| ms_pvl | yes | ms_aki | no | 0 |
| ms_pvl | no | ms_aki | yes | 0 |
| ms_pvl | yes | socioeconomic_status | 1-highest | 0 |
| ms_pvl | yes | education_status | 1-postgraduate | 0 |
| ms_pvl | yes | education_status | 4-high school | 0 |
| ms_pvl | yes | education_status | 6-junior high school | 0 |
| ms_pvl | yes | education_status | 7-elementary school | 0 |
| ms_pvl | yes | birthtime_scoring | 2-born 17:00-23:59 | 0 |
| ms_pvl | yes | survive | 1-yes | 0 |
| ms_pvl | yes | rop_severe | 0-none/stage I/stage II | 0 |
| ms_pvl | yes | rop_severe | 1-stage II+ | 0 |
| ms_pvl | yes | bpd_grade | 0-no BPD | 0 |
| ms_pvl | yes | bpd_grade | 1-mild BPD | 0 |
| ms_pvl | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_pvl | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_pvl | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_pvl | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_pvl | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_pvl | yes | hearing | 0-passed | 0 |
| ms_pvl | yes | hearing | 1-failed | 0 |
| ms_pvl | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_pvl | yes | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| ms_pvl | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_pvl | yes | ivh | 1-no IVH | 0 |
| ms_pvl | yes | ivh | 2-IVH grade I | 0 |
| ms_pvl | yes | ivh | 3-IVH grade II | 0 |
| ms_pvl | yes | ivh | 4-IVH grade III | 0 |
| ms_pvl | yes | ivh | 5-IVH grade IV, unilateral | 0 |
| ms_pvl | yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| ms_pvl | no | ivh | NA | 0 |
| ms_pvl | yes | cerebellar_hemorrhage | 1-no bleeding | 0 |
| ms_pvl | yes | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ms_pvl | no | cerebellar_hemorrhage | NA | 0 |
| ms_pvl | yes | ischaemic_stroke | 1-no ischemia | 0 |
| ms_pvl | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_pvl | yes | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ms_pvl | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_pvl | no | ischaemic_stroke | NA | 0 |
| ms_pvl | yes | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| ms_pvl | yes | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ms_pvl | yes | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ms_pvl | no | hs_pda_iv | NA | 0 |
| ms_pvl | yes | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| ms_pvl | yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ms_pvl | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_pvl | no | non_nec_surg_abd | NA | 0 |
| ms_cerebellar_hemorrhage | yes | ms_ischaemic_stroke | no | 0 |
| ms_cerebellar_hemorrhage | no | ms_ischaemic_stroke | yes | 0 |
| ms_cerebellar_hemorrhage | yes | ms_hs_pda_iv | no | 0 |
| ms_cerebellar_hemorrhage | no | ms_hs_pda_iv | yes | 0 |
| ms_cerebellar_hemorrhage | yes | ms_nec | no | 0 |
| ms_cerebellar_hemorrhage | no | ms_nec | yes | 0 |
| ms_cerebellar_hemorrhage | yes | ms_non_nec_surg_abd | no | 0 |
| ms_cerebellar_hemorrhage | no | ms_non_nec_surg_abd | yes | 0 |
| ms_cerebellar_hemorrhage | yes | ms_aki | no | 0 |
| ms_cerebellar_hemorrhage | no | ms_aki | yes | 0 |
| ms_cerebellar_hemorrhage | yes | socioeconomic_status | 1-highest | 0 |
| ms_cerebellar_hemorrhage | yes | education_status | 1-postgraduate | 0 |
| ms_cerebellar_hemorrhage | yes | education_status | 4-high school | 0 |
| ms_cerebellar_hemorrhage | yes | education_status | 6-junior high school | 0 |
| ms_cerebellar_hemorrhage | yes | education_status | 7-elementary school | 0 |
| ms_cerebellar_hemorrhage | yes | birthtime_scoring | 2-born 17:00-23:59 | 0 |
| ms_cerebellar_hemorrhage | yes | survive | 1-yes | 0 |
| ms_cerebellar_hemorrhage | yes | rop_severe | 0-none/stage I/stage II | 0 |
| ms_cerebellar_hemorrhage | yes | rop_severe | 1-stage II+ | 0 |
| ms_cerebellar_hemorrhage | yes | bpd_grade | 0-no BPD | 0 |
| ms_cerebellar_hemorrhage | yes | bpd_grade | 1-mild BPD | 0 |
| ms_cerebellar_hemorrhage | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_cerebellar_hemorrhage | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_cerebellar_hemorrhage | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_cerebellar_hemorrhage | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_cerebellar_hemorrhage | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_cerebellar_hemorrhage | yes | hearing | 0-passed | 0 |
| ms_cerebellar_hemorrhage | yes | hearing | 1-failed | 0 |
| ms_cerebellar_hemorrhage | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_cerebellar_hemorrhage | yes | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| ms_cerebellar_hemorrhage | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_cerebellar_hemorrhage | yes | ivh | 1-no IVH | 0 |
| ms_cerebellar_hemorrhage | yes | ivh | 2-IVH grade I | 0 |
| ms_cerebellar_hemorrhage | yes | ivh | 3-IVH grade II | 0 |
| ms_cerebellar_hemorrhage | yes | ivh | 4-IVH grade III | 0 |
| ms_cerebellar_hemorrhage | yes | ivh | 5-IVH grade IV, unilateral | 0 |
| ms_cerebellar_hemorrhage | yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| ms_cerebellar_hemorrhage | no | ivh | NA | 0 |
| ms_cerebellar_hemorrhage | yes | cerebellar_hemorrhage | 1-no bleeding | 0 |
| ms_cerebellar_hemorrhage | yes | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ms_cerebellar_hemorrhage | no | cerebellar_hemorrhage | NA | 0 |
| ms_cerebellar_hemorrhage | yes | ischaemic_stroke | 1-no ischemia | 0 |
| ms_cerebellar_hemorrhage | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_cerebellar_hemorrhage | yes | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ms_cerebellar_hemorrhage | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_cerebellar_hemorrhage | no | ischaemic_stroke | NA | 0 |
| ms_cerebellar_hemorrhage | yes | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| ms_cerebellar_hemorrhage | yes | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ms_cerebellar_hemorrhage | yes | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ms_cerebellar_hemorrhage | no | hs_pda_iv | NA | 0 |
| ms_cerebellar_hemorrhage | yes | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| ms_cerebellar_hemorrhage | yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ms_cerebellar_hemorrhage | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_cerebellar_hemorrhage | no | non_nec_surg_abd | NA | 0 |
| ms_ischaemic_stroke | yes | ms_hs_pda_iv | no | 0 |
| ms_ischaemic_stroke | no | ms_hs_pda_iv | yes | 0 |
| ms_ischaemic_stroke | yes | ms_nec | no | 0 |
| ms_ischaemic_stroke | no | ms_nec | yes | 0 |
| ms_ischaemic_stroke | yes | ms_non_nec_surg_abd | no | 0 |
| ms_ischaemic_stroke | no | ms_non_nec_surg_abd | yes | 0 |
| ms_ischaemic_stroke | yes | ms_aki | no | 0 |
| ms_ischaemic_stroke | no | ms_aki | yes | 0 |
| ms_ischaemic_stroke | yes | socioeconomic_status | 1-highest | 0 |
| ms_ischaemic_stroke | yes | education_status | 1-postgraduate | 0 |
| ms_ischaemic_stroke | yes | education_status | 4-high school | 0 |
| ms_ischaemic_stroke | yes | education_status | 6-junior high school | 0 |
| ms_ischaemic_stroke | yes | education_status | 7-elementary school | 0 |
| ms_ischaemic_stroke | yes | birthtime_scoring | 2-born 17:00-23:59 | 0 |
| ms_ischaemic_stroke | yes | survive | 1-yes | 0 |
| ms_ischaemic_stroke | yes | rop_severe | 0-none/stage I/stage II | 0 |
| ms_ischaemic_stroke | yes | rop_severe | 1-stage II+ | 0 |
| ms_ischaemic_stroke | yes | bpd_grade | 0-no BPD | 0 |
| ms_ischaemic_stroke | yes | bpd_grade | 1-mild BPD | 0 |
| ms_ischaemic_stroke | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_ischaemic_stroke | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_ischaemic_stroke | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_ischaemic_stroke | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_ischaemic_stroke | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_ischaemic_stroke | yes | hearing | 0-passed | 0 |
| ms_ischaemic_stroke | yes | hearing | 1-failed | 0 |
| ms_ischaemic_stroke | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_ischaemic_stroke | yes | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| ms_ischaemic_stroke | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_ischaemic_stroke | yes | ivh | 1-no IVH | 0 |
| ms_ischaemic_stroke | yes | ivh | 2-IVH grade I | 0 |
| ms_ischaemic_stroke | yes | ivh | 3-IVH grade II | 0 |
| ms_ischaemic_stroke | yes | ivh | 4-IVH grade III | 0 |
| ms_ischaemic_stroke | yes | ivh | 5-IVH grade IV, unilateral | 0 |
| ms_ischaemic_stroke | yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| ms_ischaemic_stroke | no | ivh | NA | 0 |
| ms_ischaemic_stroke | yes | cerebellar_hemorrhage | 1-no bleeding | 0 |
| ms_ischaemic_stroke | yes | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ms_ischaemic_stroke | no | cerebellar_hemorrhage | NA | 0 |
| ms_ischaemic_stroke | yes | ischaemic_stroke | 1-no ischemia | 0 |
| ms_ischaemic_stroke | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_ischaemic_stroke | yes | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ms_ischaemic_stroke | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_ischaemic_stroke | no | ischaemic_stroke | NA | 0 |
| ms_ischaemic_stroke | yes | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| ms_ischaemic_stroke | yes | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ms_ischaemic_stroke | yes | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ms_ischaemic_stroke | no | hs_pda_iv | NA | 0 |
| ms_ischaemic_stroke | yes | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| ms_ischaemic_stroke | yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ms_ischaemic_stroke | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_ischaemic_stroke | no | non_nec_surg_abd | NA | 0 |
| ms_hs_pda_iv | yes | ms_nec | no | 0 |
| ms_hs_pda_iv | no | ms_nec | yes | 0 |
| ms_hs_pda_iv | yes | ms_non_nec_surg_abd | no | 0 |
| ms_hs_pda_iv | no | ms_non_nec_surg_abd | yes | 0 |
| ms_hs_pda_iv | yes | ms_aki | no | 0 |
| ms_hs_pda_iv | no | ms_aki | yes | 0 |
| ms_hs_pda_iv | yes | socioeconomic_status | 1-highest | 0 |
| ms_hs_pda_iv | yes | education_status | 1-postgraduate | 0 |
| ms_hs_pda_iv | yes | education_status | 4-high school | 0 |
| ms_hs_pda_iv | yes | education_status | 6-junior high school | 0 |
| ms_hs_pda_iv | yes | education_status | 7-elementary school | 0 |
| ms_hs_pda_iv | yes | birthtime_scoring | 2-born 17:00-23:59 | 0 |
| ms_hs_pda_iv | yes | survive | 1-yes | 0 |
| ms_hs_pda_iv | yes | rop_severe | 0-none/stage I/stage II | 0 |
| ms_hs_pda_iv | yes | rop_severe | 1-stage II+ | 0 |
| ms_hs_pda_iv | yes | bpd_grade | 0-no BPD | 0 |
| ms_hs_pda_iv | yes | bpd_grade | 1-mild BPD | 0 |
| ms_hs_pda_iv | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_hs_pda_iv | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_hs_pda_iv | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_hs_pda_iv | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_hs_pda_iv | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_hs_pda_iv | yes | hearing | 0-passed | 0 |
| ms_hs_pda_iv | yes | hearing | 1-failed | 0 |
| ms_hs_pda_iv | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_hs_pda_iv | yes | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| ms_hs_pda_iv | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_hs_pda_iv | yes | ivh | 1-no IVH | 0 |
| ms_hs_pda_iv | yes | ivh | 2-IVH grade I | 0 |
| ms_hs_pda_iv | yes | ivh | 3-IVH grade II | 0 |
| ms_hs_pda_iv | yes | ivh | 4-IVH grade III | 0 |
| ms_hs_pda_iv | yes | ivh | 5-IVH grade IV, unilateral | 0 |
| ms_hs_pda_iv | yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| ms_hs_pda_iv | no | ivh | NA | 0 |
| ms_hs_pda_iv | yes | cerebellar_hemorrhage | 1-no bleeding | 0 |
| ms_hs_pda_iv | yes | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ms_hs_pda_iv | no | cerebellar_hemorrhage | NA | 0 |
| ms_hs_pda_iv | yes | ischaemic_stroke | 1-no ischemia | 0 |
| ms_hs_pda_iv | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_hs_pda_iv | yes | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ms_hs_pda_iv | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_hs_pda_iv | no | ischaemic_stroke | NA | 0 |
| ms_hs_pda_iv | yes | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| ms_hs_pda_iv | yes | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ms_hs_pda_iv | yes | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ms_hs_pda_iv | no | hs_pda_iv | NA | 0 |
| ms_hs_pda_iv | yes | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| ms_hs_pda_iv | yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ms_hs_pda_iv | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_hs_pda_iv | no | non_nec_surg_abd | NA | 0 |
| ms_nec | yes | ms_non_nec_surg_abd | no | 0 |
| ms_nec | no | ms_non_nec_surg_abd | yes | 0 |
| ms_nec | yes | ms_aki | no | 0 |
| ms_nec | no | ms_aki | yes | 0 |
| ms_nec | yes | socioeconomic_status | 1-highest | 0 |
| ms_nec | yes | education_status | 1-postgraduate | 0 |
| ms_nec | yes | education_status | 4-high school | 0 |
| ms_nec | yes | education_status | 6-junior high school | 0 |
| ms_nec | yes | education_status | 7-elementary school | 0 |
| ms_nec | yes | birthtime_scoring | 2-born 17:00-23:59 | 0 |
| ms_nec | yes | survive | 1-yes | 0 |
| ms_nec | yes | rop_severe | 0-none/stage I/stage II | 0 |
| ms_nec | yes | rop_severe | 1-stage II+ | 0 |
| ms_nec | yes | bpd_grade | 0-no BPD | 0 |
| ms_nec | yes | bpd_grade | 1-mild BPD | 0 |
| ms_nec | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_nec | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_nec | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_nec | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_nec | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_nec | yes | hearing | 0-passed | 0 |
| ms_nec | yes | hearing | 1-failed | 0 |
| ms_nec | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_nec | yes | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| ms_nec | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_nec | yes | ivh | 1-no IVH | 0 |
| ms_nec | yes | ivh | 2-IVH grade I | 0 |
| ms_nec | yes | ivh | 3-IVH grade II | 0 |
| ms_nec | yes | ivh | 4-IVH grade III | 0 |
| ms_nec | yes | ivh | 5-IVH grade IV, unilateral | 0 |
| ms_nec | yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| ms_nec | no | ivh | NA | 0 |
| ms_nec | yes | cerebellar_hemorrhage | 1-no bleeding | 0 |
| ms_nec | yes | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ms_nec | no | cerebellar_hemorrhage | NA | 0 |
| ms_nec | yes | ischaemic_stroke | 1-no ischemia | 0 |
| ms_nec | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_nec | yes | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ms_nec | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_nec | no | ischaemic_stroke | NA | 0 |
| ms_nec | yes | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| ms_nec | yes | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ms_nec | yes | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ms_nec | no | hs_pda_iv | NA | 0 |
| ms_nec | yes | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| ms_nec | yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ms_nec | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_nec | no | non_nec_surg_abd | NA | 0 |
| ms_non_nec_surg_abd | yes | ms_aki | no | 0 |
| ms_non_nec_surg_abd | no | ms_aki | yes | 0 |
| ms_non_nec_surg_abd | yes | socioeconomic_status | 1-highest | 0 |
| ms_non_nec_surg_abd | yes | education_status | 1-postgraduate | 0 |
| ms_non_nec_surg_abd | yes | education_status | 4-high school | 0 |
| ms_non_nec_surg_abd | yes | education_status | 6-junior high school | 0 |
| ms_non_nec_surg_abd | yes | education_status | 7-elementary school | 0 |
| ms_non_nec_surg_abd | yes | birthtime_scoring | 2-born 17:00-23:59 | 0 |
| ms_non_nec_surg_abd | yes | survive | 1-yes | 0 |
| ms_non_nec_surg_abd | yes | rop_severe | 0-none/stage I/stage II | 0 |
| ms_non_nec_surg_abd | yes | rop_severe | 1-stage II+ | 0 |
| ms_non_nec_surg_abd | yes | bpd_grade | 0-no BPD | 0 |
| ms_non_nec_surg_abd | yes | bpd_grade | 1-mild BPD | 0 |
| ms_non_nec_surg_abd | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_non_nec_surg_abd | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_non_nec_surg_abd | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_non_nec_surg_abd | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_non_nec_surg_abd | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_non_nec_surg_abd | yes | hearing | 0-passed | 0 |
| ms_non_nec_surg_abd | yes | hearing | 1-failed | 0 |
| ms_non_nec_surg_abd | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_non_nec_surg_abd | yes | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| ms_non_nec_surg_abd | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_non_nec_surg_abd | yes | ivh | 1-no IVH | 0 |
| ms_non_nec_surg_abd | yes | ivh | 2-IVH grade I | 0 |
| ms_non_nec_surg_abd | yes | ivh | 3-IVH grade II | 0 |
| ms_non_nec_surg_abd | yes | ivh | 4-IVH grade III | 0 |
| ms_non_nec_surg_abd | yes | ivh | 5-IVH grade IV, unilateral | 0 |
| ms_non_nec_surg_abd | yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| ms_non_nec_surg_abd | no | ivh | NA | 0 |
| ms_non_nec_surg_abd | yes | cerebellar_hemorrhage | 1-no bleeding | 0 |
| ms_non_nec_surg_abd | yes | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ms_non_nec_surg_abd | no | cerebellar_hemorrhage | NA | 0 |
| ms_non_nec_surg_abd | yes | ischaemic_stroke | 1-no ischemia | 0 |
| ms_non_nec_surg_abd | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_non_nec_surg_abd | yes | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ms_non_nec_surg_abd | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_non_nec_surg_abd | no | ischaemic_stroke | NA | 0 |
| ms_non_nec_surg_abd | yes | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| ms_non_nec_surg_abd | yes | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ms_non_nec_surg_abd | yes | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ms_non_nec_surg_abd | no | hs_pda_iv | NA | 0 |
| ms_non_nec_surg_abd | yes | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| ms_non_nec_surg_abd | yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ms_non_nec_surg_abd | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_non_nec_surg_abd | no | non_nec_surg_abd | NA | 0 |
| ms_aki | yes | socioeconomic_status | 1-highest | 0 |
| ms_aki | yes | education_status | 1-postgraduate | 0 |
| ms_aki | yes | education_status | 4-high school | 0 |
| ms_aki | yes | education_status | 6-junior high school | 0 |
| ms_aki | yes | education_status | 7-elementary school | 0 |
| ms_aki | yes | birthtime_scoring | 2-born 17:00-23:59 | 0 |
| ms_aki | yes | survive | 1-yes | 0 |
| ms_aki | yes | rop_severe | 0-none/stage I/stage II | 0 |
| ms_aki | yes | rop_severe | 1-stage II+ | 0 |
| ms_aki | yes | bpd_grade | 0-no BPD | 0 |
| ms_aki | yes | bpd_grade | 1-mild BPD | 0 |
| ms_aki | yes | bpd_grade | 2-moderate/severe BPD | 0 |
| ms_aki | yes | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| ms_aki | yes | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| ms_aki | yes | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| ms_aki | yes | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| ms_aki | yes | hearing | 0-passed | 0 |
| ms_aki | yes | hearing | 1-failed | 0 |
| ms_aki | yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| ms_aki | yes | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| ms_aki | yes | hc_z_qw | 4-HC z-score <=-3 | 0 |
| ms_aki | yes | ivh | 1-no IVH | 0 |
| ms_aki | yes | ivh | 2-IVH grade I | 0 |
| ms_aki | yes | ivh | 3-IVH grade II | 0 |
| ms_aki | yes | ivh | 4-IVH grade III | 0 |
| ms_aki | yes | ivh | 5-IVH grade IV, unilateral | 0 |
| ms_aki | yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| ms_aki | no | ivh | NA | 0 |
| ms_aki | yes | cerebellar_hemorrhage | 1-no bleeding | 0 |
| ms_aki | yes | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ms_aki | no | cerebellar_hemorrhage | NA | 0 |
| ms_aki | yes | ischaemic_stroke | 1-no ischemia | 0 |
| ms_aki | yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ms_aki | yes | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ms_aki | yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ms_aki | no | ischaemic_stroke | NA | 0 |
| ms_aki | yes | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| ms_aki | yes | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ms_aki | yes | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ms_aki | no | hs_pda_iv | NA | 0 |
| ms_aki | yes | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| ms_aki | yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ms_aki | yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ms_aki | no | non_nec_surg_abd | NA | 0 |
| socioeconomic_status | 4-second lowest | education_status | 1-postgraduate | 0 |
| socioeconomic_status | 5-lowest | education_status | 1-postgraduate | 0 |
| socioeconomic_status | 5-lowest | education_status | 2-college | 0 |
| socioeconomic_status | 1-highest | education_status | 3-college, vocational | 0 |
| socioeconomic_status | 5-lowest | education_status | 3-college, vocational | 0 |
| socioeconomic_status | 1-highest | education_status | 4-high school | 0 |
| socioeconomic_status | 1-highest | education_status | 5-high school, vocational | 0 |
| socioeconomic_status | 1-highest | education_status | 6-junior high school | 0 |
| socioeconomic_status | 1-highest | education_status | 7-elementary school | 0 |
| socioeconomic_status | 2-second highest | education_status | 7-elementary school | 0 |
| socioeconomic_status | 5-lowest | ivf | 1-yes | 0 |
| socioeconomic_status | 1-highest | pe | 1-yes | 0 |
| socioeconomic_status | 1-highest | gdm | 1-yes | 0 |
| socioeconomic_status | 5-lowest | gdm | 1-yes | 0 |
| socioeconomic_status | 1-highest | chorioamnionitis | 1-yes | 0 |
| socioeconomic_status | 5-lowest | chorioamnionitis | 1-yes | 0 |
| socioeconomic_status | 1-highest | bpd_grade | 1-mild BPD | 0 |
| socioeconomic_status | 5-lowest | bpd_grade | 1-mild BPD | 0 |
| socioeconomic_status | 1-highest | bw_z_qw | 3-BW z-score >-3 & <=-2 | 0 |
| socioeconomic_status | 1-highest | bw_z_qw | NA | 0 |
| socioeconomic_status | 1-highest | bw_z_qw | 4-BW z-score <=-3 | 0 |
| socioeconomic_status | 2-second highest | bw_z_qw | 4-BW z-score <=-3 | 0 |
| socioeconomic_status | 5-lowest | bw_z_qw | 4-BW z-score <=-3 | 0 |
| socioeconomic_status | 1-highest | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| socioeconomic_status | 1-highest | hc_z_qw | 4-HC z-score <=-3 | 0 |
| socioeconomic_status | 4-second lowest | ivh | 4-IVH grade III | 0 |
| socioeconomic_status | 5-lowest | ivh | 4-IVH grade III | 0 |
| socioeconomic_status | 1-highest | ivh | 5-IVH grade IV, unilateral | 0 |
| socioeconomic_status | 1-highest | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| socioeconomic_status | 5-lowest | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| socioeconomic_status | 1-highest | ivh | NA | 0 |
| socioeconomic_status | 1-highest | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| socioeconomic_status | 4-second lowest | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| socioeconomic_status | 5-lowest | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| socioeconomic_status | 1-highest | cerebellar_hemorrhage | NA | 0 |
| socioeconomic_status | 1-highest | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| socioeconomic_status | 3-medium | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| socioeconomic_status | 5-lowest | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| socioeconomic_status | 1-highest | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| socioeconomic_status | 5-lowest | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| socioeconomic_status | 1-highest | ischaemic_stroke | NA | 0 |
| socioeconomic_status | 1-highest | ischaemic_stroke | 4-ischemia, multiple | 0 |
| socioeconomic_status | 2-second highest | ischaemic_stroke | 4-ischemia, multiple | 0 |
| socioeconomic_status | 3-medium | ischaemic_stroke | 4-ischemia, multiple | 0 |
| socioeconomic_status | 1-highest | hs_pda_iv | NA | 0 |
| socioeconomic_status | 1-highest | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| socioeconomic_status | 1-highest | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| socioeconomic_status | 4-second lowest | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| socioeconomic_status | 5-lowest | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| socioeconomic_status | 1-highest | non_nec_surg_abd | NA | 0 |
| education_status | 7-elementary school | ivf | 1-yes | 0 |
| education_status | 7-elementary school | pe | 1-yes | 0 |
| education_status | 6-junior high school | gdm | 1-yes | 0 |
| education_status | 7-elementary school | gdm | 1-yes | 0 |
| education_status | 7-elementary school | birthtime_scoring | 3-born 00:00-07:59 | 0 |
| education_status | 7-elementary school | chorioamnionitis | 1-yes | 0 |
| education_status | 7-elementary school | rop_severe | 1-stage II+ | 0 |
| education_status | 7-elementary school | bpd_grade | 1-mild BPD | 0 |
| education_status | 7-elementary school | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| education_status | 7-elementary school | hearing | 1-failed | 0 |
| education_status | 7-elementary school | bw_z_qw | 3-BW z-score >-3 & <=-2 | 0 |
| education_status | 4-high school | bw_z_qw | NA | 0 |
| education_status | 7-elementary school | bw_z_qw | NA | 0 |
| education_status | 1-postgraduate | bw_z_qw | 4-BW z-score <=-3 | 0 |
| education_status | 4-high school | bw_z_qw | 4-BW z-score <=-3 | 0 |
| education_status | 6-junior high school | bw_z_qw | 4-BW z-score <=-3 | 0 |
| education_status | 7-elementary school | bw_z_qw | 4-BW z-score <=-3 | 0 |
| education_status | 7-elementary school | hc_z_qw | 4-HC z-score <=-3 | 0 |
| education_status | 7-elementary school | ivh | 2-IVH grade I | 0 |
| education_status | 4-high school | ivh | 4-IVH grade III | 0 |
| education_status | 5-high school, vocational | ivh | 4-IVH grade III | 0 |
| education_status | 6-junior high school | ivh | 4-IVH grade III | 0 |
| education_status | 7-elementary school | ivh | 4-IVH grade III | 0 |
| education_status | 5-high school, vocational | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| education_status | 6-junior high school | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| education_status | 7-elementary school | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| education_status | 1-postgraduate | ivh | 5-IVH grade IV, unilateral | 0 |
| education_status | 3-college, vocational | ivh | 5-IVH grade IV, unilateral | 0 |
| education_status | 1-postgraduate | ivh | NA | 0 |
| education_status | 4-high school | ivh | NA | 0 |
| education_status | 6-junior high school | ivh | NA | 0 |
| education_status | 7-elementary school | ivh | NA | 0 |
| education_status | 3-college, vocational | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| education_status | 4-high school | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| education_status | 6-junior high school | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| education_status | 7-elementary school | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| education_status | 1-postgraduate | cerebellar_hemorrhage | NA | 0 |
| education_status | 4-high school | cerebellar_hemorrhage | NA | 0 |
| education_status | 6-junior high school | cerebellar_hemorrhage | NA | 0 |
| education_status | 7-elementary school | cerebellar_hemorrhage | NA | 0 |
| education_status | 1-postgraduate | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| education_status | 3-college, vocational | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| education_status | 4-high school | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| education_status | 6-junior high school | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| education_status | 7-elementary school | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| education_status | 1-postgraduate | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| education_status | 3-college, vocational | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| education_status | 4-high school | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| education_status | 6-junior high school | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| education_status | 7-elementary school | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| education_status | 1-postgraduate | ischaemic_stroke | NA | 0 |
| education_status | 4-high school | ischaemic_stroke | NA | 0 |
| education_status | 6-junior high school | ischaemic_stroke | NA | 0 |
| education_status | 7-elementary school | ischaemic_stroke | NA | 0 |
| education_status | 1-postgraduate | ischaemic_stroke | 4-ischemia, multiple | 0 |
| education_status | 2-college | ischaemic_stroke | 4-ischemia, multiple | 0 |
| education_status | 3-college, vocational | ischaemic_stroke | 4-ischemia, multiple | 0 |
| education_status | 6-junior high school | ischaemic_stroke | 4-ischemia, multiple | 0 |
| education_status | 7-elementary school | ischaemic_stroke | 4-ischemia, multiple | 0 |
| education_status | 7-elementary school | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| education_status | 1-postgraduate | hs_pda_iv | NA | 0 |
| education_status | 4-high school | hs_pda_iv | NA | 0 |
| education_status | 6-junior high school | hs_pda_iv | NA | 0 |
| education_status | 7-elementary school | hs_pda_iv | NA | 0 |
| education_status | 1-postgraduate | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| education_status | 4-high school | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| education_status | 6-junior high school | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| education_status | 7-elementary school | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| education_status | 1-postgraduate | non_nec_surg_abd | NA | 0 |
| education_status | 4-high school | non_nec_surg_abd | NA | 0 |
| education_status | 6-junior high school | non_nec_surg_abd | NA | 0 |
| education_status | 7-elementary school | non_nec_surg_abd | NA | 0 |
| ivf | 1-yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ivf | 1-yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| pe | 1-yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| gdm | 1-yes | bpd_grade | 1-mild BPD | 0 |
| gdm | 1-yes | bw_z_qw | 3-BW z-score >-3 & <=-2 | 0 |
| gdm | 1-yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| gdm | 1-yes | ivh | 4-IVH grade III | 0 |
| gdm | 1-yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| gdm | 1-yes | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| gdm | 1-yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| gdm | 1-yes | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| gdm | 1-yes | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| cs | 0-no | bw_z_qw | 4-BW z-score <=-3 | 0 |
| cs | 0-no | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| cs | 0-no | ischaemic_stroke | 4-ischemia, multiple | 0 |
| sex | 0-female | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| sex | 0-female | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| multiple_gestation | 1-yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| multiple_gestation | 0-no | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| birthtime_scoring | 2-born 17:00-23:59 | ivh | NA | 0 |
| birthtime_scoring | 2-born 17:00-23:59 | cerebellar_hemorrhage | NA | 0 |
| birthtime_scoring | 3-born 00:00-07:59 | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| birthtime_scoring | 3-born 00:00-07:59 | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| birthtime_scoring | 2-born 17:00-23:59 | ischaemic_stroke | NA | 0 |
| birthtime_scoring | 1-born 08:00-16:59 | ischaemic_stroke | 4-ischemia, multiple | 0 |
| birthtime_scoring | 3-born 00:00-07:59 | ischaemic_stroke | 4-ischemia, multiple | 0 |
| birthtime_scoring | 2-born 17:00-23:59 | hs_pda_iv | NA | 0 |
| birthtime_scoring | 2-born 17:00-23:59 | non_nec_surg_abd | NA | 0 |
| chorioamnionitis | 1-yes | bw_z_qw | 4-BW z-score <=-3 | 0 |
| chorioamnionitis | 1-yes | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| chorioamnionitis | 1-yes | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| chorioamnionitis | 1-yes | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| chorioamnionitis | 1-yes | ischaemic_stroke | 4-ischemia, multiple | 0 |
| survive | 1-yes | rop_severe | NA | 0 |
| survive | 1-yes | bpd_grade | NA | 0 |
| survive | 0-no | bpd_grade | 1-mild BPD | 0 |
| survive | 1-yes | eugr_hc | NA | 0 |
| survive | 1-yes | eugr_bw | NA | 0 |
| survive | 0-no | hearing | 0-passed | 0 |
| survive | 0-no | hearing | 1-failed | 0 |
| survive | 0-no | bw_z_qw | 4-BW z-score <=-3 | 0 |
| survive | 1-yes | ivh | NA | 0 |
| survive | 1-yes | cerebellar_hemorrhage | NA | 0 |
| survive | 1-yes | ischaemic_stroke | NA | 0 |
| survive | 0-no | ischaemic_stroke | 4-ischemia, multiple | 0 |
| survive | 1-yes | hs_pda_iv | NA | 0 |
| survive | 1-yes | non_nec_surg_abd | NA | 0 |
| survive | 0-no | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| rop_severe | NA | bpd_grade | 0-no BPD | 0 |
| rop_severe | NA | bpd_grade | 1-mild BPD | 0 |
| rop_severe | NA | bpd_grade | 2-moderate/severe BPD | 0 |
| rop_severe | 0-none/stage I/stage II | bpd_grade | NA | 0 |
| rop_severe | 1-stage II+ | bpd_grade | NA | 0 |
| rop_severe | NA | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| rop_severe | NA | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| rop_severe | 1-stage II+ | eugr_hc | NA | 0 |
| rop_severe | NA | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| rop_severe | NA | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| rop_severe | 1-stage II+ | eugr_bw | NA | 0 |
| rop_severe | NA | hearing | 0-passed | 0 |
| rop_severe | NA | hearing | 1-failed | 0 |
| rop_severe | 1-stage II+ | bw_z_qw | 4-BW z-score <=-3 | 0 |
| rop_severe | NA | bw_z_qw | 4-BW z-score <=-3 | 0 |
| rop_severe | NA | hc_z_qw | 4-HC z-score <=-3 | 0 |
| rop_severe | NA | ivh | 2-IVH grade I | 0 |
| rop_severe | 0-none/stage I/stage II | ivh | NA | 0 |
| rop_severe | 1-stage II+ | ivh | NA | 0 |
| rop_severe | 1-stage II+ | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| rop_severe | 0-none/stage I/stage II | cerebellar_hemorrhage | NA | 0 |
| rop_severe | 1-stage II+ | cerebellar_hemorrhage | NA | 0 |
| rop_severe | 1-stage II+ | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| rop_severe | NA | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| rop_severe | 1-stage II+ | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| rop_severe | NA | ischaemic_stroke | 4-ischemia, multiple | 0 |
| rop_severe | 0-none/stage I/stage II | ischaemic_stroke | NA | 0 |
| rop_severe | 1-stage II+ | ischaemic_stroke | NA | 0 |
| rop_severe | 0-none/stage I/stage II | hs_pda_iv | NA | 0 |
| rop_severe | 1-stage II+ | hs_pda_iv | NA | 0 |
| rop_severe | NA | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| rop_severe | 0-none/stage I/stage II | non_nec_surg_abd | NA | 0 |
| rop_severe | 1-stage II+ | non_nec_surg_abd | NA | 0 |
| bpd_grade | NA | eugr_hc | 0-HC z-score at birth >=-1.5 | 0 |
| bpd_grade | NA | eugr_hc | 1-HC z-score at birth <-1.5 | 0 |
| bpd_grade | 1-mild BPD | eugr_hc | NA | 0 |
| bpd_grade | 2-moderate/severe BPD | eugr_hc | NA | 0 |
| bpd_grade | NA | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| bpd_grade | NA | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| bpd_grade | 1-mild BPD | eugr_bw | NA | 0 |
| bpd_grade | 2-moderate/severe BPD | eugr_bw | NA | 0 |
| bpd_grade | NA | hearing | 0-passed | 0 |
| bpd_grade | NA | hearing | 1-failed | 0 |
| bpd_grade | 1-mild BPD | hearing | NA | 0 |
| bpd_grade | 1-mild BPD | bw_z_qw | 4-BW z-score <=-3 | 0 |
| bpd_grade | NA | bw_z_qw | 4-BW z-score <=-3 | 0 |
| bpd_grade | NA | hc_z_qw | 4-HC z-score <=-3 | 0 |
| bpd_grade | 1-mild BPD | ivh | 2-IVH grade I | 0 |
| bpd_grade | NA | ivh | 2-IVH grade I | 0 |
| bpd_grade | 1-mild BPD | ivh | 5-IVH grade IV, unilateral | 0 |
| bpd_grade | 1-mild BPD | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| bpd_grade | 0-no BPD | ivh | NA | 0 |
| bpd_grade | 1-mild BPD | ivh | NA | 0 |
| bpd_grade | 2-moderate/severe BPD | ivh | NA | 0 |
| bpd_grade | 0-no BPD | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| bpd_grade | 1-mild BPD | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| bpd_grade | 0-no BPD | cerebellar_hemorrhage | NA | 0 |
| bpd_grade | 1-mild BPD | cerebellar_hemorrhage | NA | 0 |
| bpd_grade | 2-moderate/severe BPD | cerebellar_hemorrhage | NA | 0 |
| bpd_grade | 1-mild BPD | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| bpd_grade | NA | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| bpd_grade | 1-mild BPD | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| bpd_grade | 0-no BPD | ischaemic_stroke | 4-ischemia, multiple | 0 |
| bpd_grade | 1-mild BPD | ischaemic_stroke | 4-ischemia, multiple | 0 |
| bpd_grade | NA | ischaemic_stroke | 4-ischemia, multiple | 0 |
| bpd_grade | 0-no BPD | ischaemic_stroke | NA | 0 |
| bpd_grade | 1-mild BPD | ischaemic_stroke | NA | 0 |
| bpd_grade | 2-moderate/severe BPD | ischaemic_stroke | NA | 0 |
| bpd_grade | 0-no BPD | hs_pda_iv | NA | 0 |
| bpd_grade | 1-mild BPD | hs_pda_iv | NA | 0 |
| bpd_grade | 2-moderate/severe BPD | hs_pda_iv | NA | 0 |
| bpd_grade | 1-mild BPD | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| bpd_grade | 1-mild BPD | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| bpd_grade | NA | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| bpd_grade | 0-no BPD | non_nec_surg_abd | NA | 0 |
| bpd_grade | 1-mild BPD | non_nec_surg_abd | NA | 0 |
| bpd_grade | 2-moderate/severe BPD | non_nec_surg_abd | NA | 0 |
| eugr_hc | NA | eugr_bw | 0-BW z-score at birth >=-1.5 | 0 |
| eugr_hc | NA | eugr_bw | 1-BW z-score at birth <-1.5 | 0 |
| eugr_hc | 0-HC z-score at birth >=-1.5 | eugr_bw | NA | 0 |
| eugr_hc | 1-HC z-score at birth <-1.5 | eugr_bw | NA | 0 |
| eugr_hc | NA | hearing | 0-passed | 0 |
| eugr_hc | NA | hearing | 1-failed | 0 |
| eugr_hc | NA | bw_z_qw | 4-BW z-score <=-3 | 0 |
| eugr_hc | NA | hc_z_qw | 4-HC z-score <=-3 | 0 |
| eugr_hc | NA | ivh | 2-IVH grade I | 0 |
| eugr_hc | 0-HC z-score at birth >=-1.5 | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| eugr_hc | 0-HC z-score at birth >=-1.5 | ivh | NA | 0 |
| eugr_hc | 1-HC z-score at birth <-1.5 | ivh | NA | 0 |
| eugr_hc | 0-HC z-score at birth >=-1.5 | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| eugr_hc | 0-HC z-score at birth >=-1.5 | cerebellar_hemorrhage | NA | 0 |
| eugr_hc | 1-HC z-score at birth <-1.5 | cerebellar_hemorrhage | NA | 0 |
| eugr_hc | NA | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| eugr_hc | 0-HC z-score at birth >=-1.5 | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| eugr_hc | 0-HC z-score at birth >=-1.5 | ischaemic_stroke | 4-ischemia, multiple | 0 |
| eugr_hc | NA | ischaemic_stroke | 4-ischemia, multiple | 0 |
| eugr_hc | 0-HC z-score at birth >=-1.5 | ischaemic_stroke | NA | 0 |
| eugr_hc | 1-HC z-score at birth <-1.5 | ischaemic_stroke | NA | 0 |
| eugr_hc | 0-HC z-score at birth >=-1.5 | hs_pda_iv | NA | 0 |
| eugr_hc | 1-HC z-score at birth <-1.5 | hs_pda_iv | NA | 0 |
| eugr_hc | NA | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| eugr_hc | 0-HC z-score at birth >=-1.5 | non_nec_surg_abd | NA | 0 |
| eugr_hc | 1-HC z-score at birth <-1.5 | non_nec_surg_abd | NA | 0 |
| eugr_bw | NA | hearing | 0-passed | 0 |
| eugr_bw | NA | hearing | 1-failed | 0 |
| eugr_bw | NA | bw_z_qw | 4-BW z-score <=-3 | 0 |
| eugr_bw | 1-BW z-score at birth <-1.5 | bw_z_qw | NA | 0 |
| eugr_bw | NA | hc_z_qw | 4-HC z-score <=-3 | 0 |
| eugr_bw | NA | ivh | 2-IVH grade I | 0 |
| eugr_bw | 0-BW z-score at birth >=-1.5 | ivh | NA | 0 |
| eugr_bw | 1-BW z-score at birth <-1.5 | ivh | NA | 0 |
| eugr_bw | 0-BW z-score at birth >=-1.5 | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| eugr_bw | 0-BW z-score at birth >=-1.5 | cerebellar_hemorrhage | NA | 0 |
| eugr_bw | 1-BW z-score at birth <-1.5 | cerebellar_hemorrhage | NA | 0 |
| eugr_bw | NA | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| eugr_bw | 1-BW z-score at birth <-1.5 | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| eugr_bw | 1-BW z-score at birth <-1.5 | ischaemic_stroke | 4-ischemia, multiple | 0 |
| eugr_bw | NA | ischaemic_stroke | 4-ischemia, multiple | 0 |
| eugr_bw | 0-BW z-score at birth >=-1.5 | ischaemic_stroke | NA | 0 |
| eugr_bw | 1-BW z-score at birth <-1.5 | ischaemic_stroke | NA | 0 |
| eugr_bw | 0-BW z-score at birth >=-1.5 | hs_pda_iv | NA | 0 |
| eugr_bw | 1-BW z-score at birth <-1.5 | hs_pda_iv | NA | 0 |
| eugr_bw | NA | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| eugr_bw | 0-BW z-score at birth >=-1.5 | non_nec_surg_abd | NA | 0 |
| eugr_bw | 1-BW z-score at birth <-1.5 | non_nec_surg_abd | NA | 0 |
| hearing | NA | bw_z_qw | 4-BW z-score <=-3 | 0 |
| hearing | 0-passed | ivh | NA | 0 |
| hearing | 1-failed | ivh | NA | 0 |
| hearing | 1-failed | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| hearing | 0-passed | cerebellar_hemorrhage | NA | 0 |
| hearing | 1-failed | cerebellar_hemorrhage | NA | 0 |
| hearing | 1-failed | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| hearing | 1-failed | ischaemic_stroke | 4-ischemia, multiple | 0 |
| hearing | 0-passed | ischaemic_stroke | NA | 0 |
| hearing | 1-failed | ischaemic_stroke | NA | 0 |
| hearing | 0-passed | hs_pda_iv | NA | 0 |
| hearing | 1-failed | hs_pda_iv | NA | 0 |
| hearing | NA | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| hearing | 0-passed | non_nec_surg_abd | NA | 0 |
| hearing | 1-failed | non_nec_surg_abd | NA | 0 |
| bw_z_qw | 4-BW z-score <=-3 | hc_z_qw | 1-HC z-score >-1 | 0 |
| bw_z_qw | NA | hc_z_qw | 1-HC z-score >-1 | 0 |
| bw_z_qw | 4-BW z-score <=-3 | hc_z_qw | 2-HC z-score >-2 & <=-1 | 0 |
| bw_z_qw | NA | hc_z_qw | 2-HC z-score >-2 & <=-1 | 0 |
| bw_z_qw | 4-BW z-score <=-3 | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| bw_z_qw | NA | hc_z_qw | 3-HC z-score >-3 & <=-2 | 0 |
| bw_z_qw | 4-BW z-score <=-3 | hc_z_qw | NA | 0 |
| bw_z_qw | 4-BW z-score <=-3 | ivh | 2-IVH grade I | 0 |
| bw_z_qw | NA | ivh | 2-IVH grade I | 0 |
| bw_z_qw | 4-BW z-score <=-3 | ivh | 3-IVH grade II | 0 |
| bw_z_qw | NA | ivh | 3-IVH grade II | 0 |
| bw_z_qw | 4-BW z-score <=-3 | ivh | 4-IVH grade III | 0 |
| bw_z_qw | NA | ivh | 4-IVH grade III | 0 |
| bw_z_qw | 4-BW z-score <=-3 | ivh | 5-IVH grade IV, unilateral | 0 |
| bw_z_qw | NA | ivh | 5-IVH grade IV, unilateral | 0 |
| bw_z_qw | 4-BW z-score <=-3 | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| bw_z_qw | NA | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| bw_z_qw | 4-BW z-score <=-3 | ivh | NA | 0 |
| bw_z_qw | 3-BW z-score >-3 & <=-2 | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| bw_z_qw | 4-BW z-score <=-3 | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| bw_z_qw | NA | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| bw_z_qw | 4-BW z-score <=-3 | cerebellar_hemorrhage | NA | 0 |
| bw_z_qw | 4-BW z-score <=-3 | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| bw_z_qw | NA | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| bw_z_qw | 2-BW z-score >-2 & <=-1 | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| bw_z_qw | 3-BW z-score >-3 & <=-2 | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| bw_z_qw | 4-BW z-score <=-3 | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| bw_z_qw | 2-BW z-score >-2 & <=-1 | ischaemic_stroke | 4-ischemia, multiple | 0 |
| bw_z_qw | 3-BW z-score >-3 & <=-2 | ischaemic_stroke | 4-ischemia, multiple | 0 |
| bw_z_qw | 4-BW z-score <=-3 | ischaemic_stroke | 4-ischemia, multiple | 0 |
| bw_z_qw | NA | ischaemic_stroke | 4-ischemia, multiple | 0 |
| bw_z_qw | 4-BW z-score <=-3 | ischaemic_stroke | NA | 0 |
| bw_z_qw | 4-BW z-score <=-3 | hs_pda_iv | 2-PDA, medical intervention | 0 |
| bw_z_qw | 4-BW z-score <=-3 | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| bw_z_qw | NA | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| bw_z_qw | 4-BW z-score <=-3 | hs_pda_iv | NA | 0 |
| bw_z_qw | 4-BW z-score <=-3 | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| bw_z_qw | NA | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| bw_z_qw | 4-BW z-score <=-3 | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| bw_z_qw | NA | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| bw_z_qw | 4-BW z-score <=-3 | non_nec_surg_abd | NA | 0 |
| hc_z_qw | 4-HC z-score <=-3 | ivh | 2-IVH grade I | 0 |
| hc_z_qw | NA | ivh | 2-IVH grade I | 0 |
| hc_z_qw | NA | ivh | 3-IVH grade II | 0 |
| hc_z_qw | 4-HC z-score <=-3 | ivh | 4-IVH grade III | 0 |
| hc_z_qw | NA | ivh | 4-IVH grade III | 0 |
| hc_z_qw | 4-HC z-score <=-3 | ivh | 5-IVH grade IV, unilateral | 0 |
| hc_z_qw | NA | ivh | 5-IVH grade IV, unilateral | 0 |
| hc_z_qw | 4-HC z-score <=-3 | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| hc_z_qw | NA | ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 0 |
| hc_z_qw | 3-HC z-score >-3 & <=-2 | ivh | NA | 0 |
| hc_z_qw | 4-HC z-score <=-3 | ivh | NA | 0 |
| hc_z_qw | 2-HC z-score >-2 & <=-1 | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| hc_z_qw | 3-HC z-score >-3 & <=-2 | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| hc_z_qw | 4-HC z-score <=-3 | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| hc_z_qw | NA | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| hc_z_qw | 3-HC z-score >-3 & <=-2 | cerebellar_hemorrhage | NA | 0 |
| hc_z_qw | 4-HC z-score <=-3 | cerebellar_hemorrhage | NA | 0 |
| hc_z_qw | 2-HC z-score >-2 & <=-1 | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| hc_z_qw | 3-HC z-score >-3 & <=-2 | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| hc_z_qw | 4-HC z-score <=-3 | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| hc_z_qw | 3-HC z-score >-3 & <=-2 | ischaemic_stroke | 4-ischemia, multiple | 0 |
| hc_z_qw | 4-HC z-score <=-3 | ischaemic_stroke | 4-ischemia, multiple | 0 |
| hc_z_qw | NA | ischaemic_stroke | 4-ischemia, multiple | 0 |
| hc_z_qw | 3-HC z-score >-3 & <=-2 | ischaemic_stroke | NA | 0 |
| hc_z_qw | 4-HC z-score <=-3 | ischaemic_stroke | NA | 0 |
| hc_z_qw | 1-HC z-score >-1 | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| hc_z_qw | 3-HC z-score >-3 & <=-2 | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| hc_z_qw | 3-HC z-score >-3 & <=-2 | hs_pda_iv | NA | 0 |
| hc_z_qw | 4-HC z-score <=-3 | hs_pda_iv | NA | 0 |
| hc_z_qw | 4-HC z-score <=-3 | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| hc_z_qw | NA | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| hc_z_qw | 3-HC z-score >-3 & <=-2 | non_nec_surg_abd | NA | 0 |
| hc_z_qw | 4-HC z-score <=-3 | non_nec_surg_abd | NA | 0 |
| hc_z_qw | 1-HC z-score >-1 | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| hc_z_qw | NA | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ivh | NA | cerebellar_hemorrhage | 1-no bleeding | 0 |
| ivh | 2-IVH grade I | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ivh | 3-IVH grade II | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ivh | 4-IVH grade III | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ivh | 5-IVH grade IV, unilateral | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ivh | NA | cerebellar_hemorrhage | 3-severe bleeding | 0 |
| ivh | 1-no IVH | cerebellar_hemorrhage | NA | 0 |
| ivh | 2-IVH grade I | cerebellar_hemorrhage | NA | 0 |
| ivh | 3-IVH grade II | cerebellar_hemorrhage | NA | 0 |
| ivh | 4-IVH grade III | cerebellar_hemorrhage | NA | 0 |
| ivh | 5-IVH grade IV, unilateral | cerebellar_hemorrhage | NA | 0 |
| ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | cerebellar_hemorrhage | NA | 0 |
| ivh | NA | ischaemic_stroke | 1-no ischemia | 0 |
| ivh | 2-IVH grade I | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ivh | 3-IVH grade II | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ivh | 4-IVH grade III | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ivh | 5-IVH grade IV, unilateral | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ivh | NA | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| ivh | 2-IVH grade I | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ivh | 3-IVH grade II | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ivh | 4-IVH grade III | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ivh | NA | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| ivh | 2-IVH grade I | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ivh | 3-IVH grade II | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ivh | 4-IVH grade III | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ivh | 5-IVH grade IV, unilateral | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ivh | NA | ischaemic_stroke | 4-ischemia, multiple | 0 |
| ivh | 1-no IVH | ischaemic_stroke | NA | 0 |
| ivh | 2-IVH grade I | ischaemic_stroke | NA | 0 |
| ivh | 3-IVH grade II | ischaemic_stroke | NA | 0 |
| ivh | 4-IVH grade III | ischaemic_stroke | NA | 0 |
| ivh | 5-IVH grade IV, unilateral | ischaemic_stroke | NA | 0 |
| ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | ischaemic_stroke | NA | 0 |
| ivh | NA | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| ivh | 4-IVH grade III | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ivh | NA | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ivh | 2-IVH grade I | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ivh | 3-IVH grade II | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ivh | 4-IVH grade III | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ivh | NA | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ivh | 1-no IVH | hs_pda_iv | NA | 0 |
| ivh | 2-IVH grade I | hs_pda_iv | NA | 0 |
| ivh | 3-IVH grade II | hs_pda_iv | NA | 0 |
| ivh | 4-IVH grade III | hs_pda_iv | NA | 0 |
| ivh | 5-IVH grade IV, unilateral | hs_pda_iv | NA | 0 |
| ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | hs_pda_iv | NA | 0 |
| ivh | NA | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| ivh | 2-IVH grade I | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ivh | 3-IVH grade II | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ivh | 4-IVH grade III | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ivh | 5-IVH grade IV, unilateral | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ivh | NA | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ivh | 2-IVH grade I | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ivh | 3-IVH grade II | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ivh | 4-IVH grade III | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ivh | 5-IVH grade IV, unilateral | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ivh | NA | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ivh | 1-no IVH | non_nec_surg_abd | NA | 0 |
| ivh | 2-IVH grade I | non_nec_surg_abd | NA | 0 |
| ivh | 3-IVH grade II | non_nec_surg_abd | NA | 0 |
| ivh | 4-IVH grade III | non_nec_surg_abd | NA | 0 |
| ivh | 5-IVH grade IV, unilateral | non_nec_surg_abd | NA | 0 |
| ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | non_nec_surg_abd | NA | 0 |
| cerebellar_hemorrhage | NA | ischaemic_stroke | 1-no ischemia | 0 |
| cerebellar_hemorrhage | 3-severe bleeding | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| cerebellar_hemorrhage | NA | ischaemic_stroke | 2-ischemia, unilateral | 0 |
| cerebellar_hemorrhage | 3-severe bleeding | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| cerebellar_hemorrhage | NA | ischaemic_stroke | 3-ischemia, bilateral | 0 |
| cerebellar_hemorrhage | 3-severe bleeding | ischaemic_stroke | 4-ischemia, multiple | 0 |
| cerebellar_hemorrhage | NA | ischaemic_stroke | 4-ischemia, multiple | 0 |
| cerebellar_hemorrhage | 1-no bleeding | ischaemic_stroke | NA | 0 |
| cerebellar_hemorrhage | 3-severe bleeding | ischaemic_stroke | NA | 0 |
| cerebellar_hemorrhage | NA | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| cerebellar_hemorrhage | 3-severe bleeding | hs_pda_iv | 2-PDA, medical intervention | 0 |
| cerebellar_hemorrhage | NA | hs_pda_iv | 2-PDA, medical intervention | 0 |
| cerebellar_hemorrhage | 3-severe bleeding | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| cerebellar_hemorrhage | NA | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| cerebellar_hemorrhage | 1-no bleeding | hs_pda_iv | NA | 0 |
| cerebellar_hemorrhage | 3-severe bleeding | hs_pda_iv | NA | 0 |
| cerebellar_hemorrhage | NA | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| cerebellar_hemorrhage | 3-severe bleeding | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| cerebellar_hemorrhage | NA | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| cerebellar_hemorrhage | 3-severe bleeding | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| cerebellar_hemorrhage | NA | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| cerebellar_hemorrhage | 1-no bleeding | non_nec_surg_abd | NA | 0 |
| cerebellar_hemorrhage | 3-severe bleeding | non_nec_surg_abd | NA | 0 |
| ischaemic_stroke | NA | hs_pda_iv | 1-no PDA/PDA, no intervention | 0 |
| ischaemic_stroke | 2-ischemia, unilateral | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ischaemic_stroke | 3-ischemia, bilateral | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ischaemic_stroke | 4-ischemia, multiple | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ischaemic_stroke | NA | hs_pda_iv | 2-PDA, medical intervention | 0 |
| ischaemic_stroke | 2-ischemia, unilateral | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ischaemic_stroke | 3-ischemia, bilateral | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ischaemic_stroke | 4-ischemia, multiple | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ischaemic_stroke | NA | hs_pda_iv | 3-PDA, surgical intervention | 0 |
| ischaemic_stroke | 1-no ischemia | hs_pda_iv | NA | 0 |
| ischaemic_stroke | 2-ischemia, unilateral | hs_pda_iv | NA | 0 |
| ischaemic_stroke | 3-ischemia, bilateral | hs_pda_iv | NA | 0 |
| ischaemic_stroke | 4-ischemia, multiple | hs_pda_iv | NA | 0 |
| ischaemic_stroke | NA | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| ischaemic_stroke | 2-ischemia, unilateral | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ischaemic_stroke | 3-ischemia, bilateral | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ischaemic_stroke | 4-ischemia, multiple | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ischaemic_stroke | NA | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| ischaemic_stroke | 2-ischemia, unilateral | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ischaemic_stroke | 3-ischemia, bilateral | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ischaemic_stroke | 4-ischemia, multiple | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ischaemic_stroke | NA | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| ischaemic_stroke | 1-no ischemia | non_nec_surg_abd | NA | 0 |
| ischaemic_stroke | 2-ischemia, unilateral | non_nec_surg_abd | NA | 0 |
| ischaemic_stroke | 3-ischemia, bilateral | non_nec_surg_abd | NA | 0 |
| ischaemic_stroke | 4-ischemia, multiple | non_nec_surg_abd | NA | 0 |
| hs_pda_iv | NA | non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0 |
| hs_pda_iv | 2-PDA, medical intervention | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| hs_pda_iv | 3-PDA, surgical intervention | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| hs_pda_iv | NA | non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 0 |
| hs_pda_iv | 3-PDA, surgical intervention | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| hs_pda_iv | NA | non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 0 |
| hs_pda_iv | 1-no PDA/PDA, no intervention | non_nec_surg_abd | NA | 0 |
| hs_pda_iv | 2-PDA, medical intervention | non_nec_surg_abd | NA | 0 |
| hs_pda_iv | 3-PDA, surgical intervention | non_nec_surg_abd | NA | 0 |
Figure 3. Correlation matrix. *, based on p-value (frequentist) or 95% CI (Bayesian); †, pair of variable and its missingness; ‡, at least 1 variable was a categorical variable with a category of 1 value; §, insufficient sample size.
Missing value imputation
Descriptive statistics
| unit | N | variable | value | survive 0-no | survive 1-yes | cor.p.value |
|---|---|---|---|---|---|---|
| id|t | 20551 | total (prevalence) | n (%) | 811 (3.95) | 19740 (96.05) | |
| resp_supp_agg_cum_day_qw | average (SD) | 9.24 (8.86) | 3.44 (6.83) | <0.001 | ||
| fio2_cum_day_qw | average (SD) | 15.68 (11.54) | 8.53 (10.87) | <0.001 | ||
| fio2_cum_level_qw | average (SD) | 290.99 (257.82) | 91.98 (183.55) | <0.001 | ||
| resp_supp_agg_cum_day_pct | average (SD) | 62.36 (32.78) | 49.99 (23.82) | <0.001 | ||
| fio2_cum_day_pct | average (SD) | 65.22 (31.36) | 50.47 (28.21) | <0.001 | ||
| fio2_cum_level_pct | average (SD) | 73.29 (29.8) | 49.36 (28.33) | <0.001 | ||
| steroid_postnatal | 0 % (n) | 96 (776) | 99 (19446) | <0.001 | ||
| 2 % (n) | 4 (35) | 1 (294) | ||||
| bw_z_qw | 1-BW z-score >-1 % (n) | 55 (445) | 58 (11459) | <0.001 | ||
| 2-BW z-score >-2 & <=-1 % (n) | 29 (237) | 37 (7358) | ||||
| 3-BW z-score >-3 & <=-2 % (n) | 16 (126) | 4 (839) | ||||
| 4-BW z-score <=-3 % (n) | 0 (3) | 0 (84) | ||||
| hc_z_qw | 1-HC z-score >-1 % (n) | 40 (325) | 42 (8356) | <0.001 | ||
| 2-HC z-score >-2 & <=-1 % (n) | 34 (279) | 37 (7346) | ||||
| 3-HC z-score >-3 & <=-2 % (n) | 13 (106) | 16 (3112) | ||||
| 4-HC z-score <=-3 % (n) | 12 (101) | 5 (926) | ||||
| inotropic | 0 % (n) | 63 (511) | 93 (18360) | <0.001 | ||
| 2 % (n) | 15 (121) | 4 (799) | ||||
| 4 % (n) | 10 (83) | 2 (443) | ||||
| 6 % (n) | 12 (96) | 1 (138) | ||||
| blood_volume | 0 % (n) | 81 (659) | 98 (19291) | <0.001 | ||
| 4 % (n) | 16 (130) | 2 (427) | ||||
| 6 % (n) | 3 (22) | 0 (22) | ||||
| transfusion | 0 % (n) | 80 (645) | 95 (18673) | <0.001 | ||
| 2 % (n) | 20 (166) | 5 (1067) | ||||
| blood_culture | 0 % (n) | 89 (718) | 95 (18724) | <0.001 | ||
| 2 % (n) | 9 (76) | 5 (901) | ||||
| 6 % (n) | 2 (17) | 1 (115) | ||||
| plt | 0 % (n) | 62 (505) | 88 (17324) | <0.001 | ||
| 1 % (n) | 16 (126) | 7 (1306) | ||||
| 2 % (n) | 14 (112) | 4 (704) | ||||
| 4 % (n) | 8 (67) | 2 (364) | ||||
| 6 % (n) | 0 (1) | 0 (42) | ||||
| wbc | 0 % (n) | 94 (766) | 97 (19105) | >0.05 | ||
| 2 % (n) | 4 (35) | 2 (478) | ||||
| 4 % (n) | 1 (10) | 1 (157) | ||||
| feeding | 0 % (n) | 50 (406) | 14 (2824) | <0.001 | ||
| 1 % (n) | 31 (252) | 24 (4834) | ||||
| 2 % (n) | 6 (46) | 8 (1586) | ||||
| 3 % (n) | 7 (58) | 8 (1489) | ||||
| 4 % (n) | 2 (20) | 4 (754) | ||||
| 5 % (n) | 1 (11) | 4 (716) | ||||
| 6 % (n) | 2 (18) | 38 (7537) | ||||
| ivh | 1-no IVH % (n) | 97 (783) | 99 (19617) | <0.001 | ||
| 2-IVH grade I % (n) | 0 (1) | 0 (43) | ||||
| 3-IVH grade II % (n) | 1 (9) | 0 (60) | ||||
| 4-IVH grade III % (n) | 0 (4) | 0 (8) | ||||
| 5-IVH grade IV, unilateral % (n) | 1 (9) | 0 (8) | ||||
| 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus % (n) | 1 (5) | 0 (4) | ||||
| cerebellar_hemorrhage | 1-no bleeding % (n) | 100 (808) | 100 (19739) | <0.001 | ||
| 3-severe bleeding % (n) | 0 (3) | 0 (1) | ||||
| ischaemic_stroke | 1-no ischemia % (n) | 100 (807) | 100 (19735) | <0.001 | ||
| 2-ischemia, unilateral % (n) | 0 (1) | 0 (2) | ||||
| 3-ischemia, bilateral % (n) | 0 (3) | 0 (1) | ||||
| 4-ischemia, multiple % (n) | 0 (0) | 0 (2) | ||||
| hs_pda_iv | 1-no PDA/PDA, no intervention % (n) | 95 (774) | 97 (19220) | <0.001 | ||
| 2-PDA, medical intervention % (n) | 4 (34) | 2 (466) | ||||
| 3-PDA, surgical intervention % (n) | 0 (3) | 0 (54) | ||||
| nec | 0 % (n) | 100 (811) | 100 (19684) | <0.001 | ||
| 2 % (n) | 0 (0) | 0 (38) | ||||
| 3 % (n) | 0 (0) | 0 (11) | ||||
| 4 % (n) | 0 (0) | 0 (4) | ||||
| 5 % (n) | 0 (0) | 0 (1) | ||||
| 6 % (n) | 0 (0) | 0 (2) | ||||
| non_nec_surg_abd | 1-no NEC/NEC, no surgery % (n) | 100 (808) | 100 (19722) | <0.001 | ||
| 2-SIP/meconium ileus/volvulus/obstruction % (n) | 0 (3) | 0 (10) | ||||
| 3-SIP/meconium ileus/volvulus/obstruction with stomy % (n) | 0 (0) | 0 (8) | ||||
| aki | 0 % (n) | 96 (780) | 100 (19681) | <0.001 | ||
| 2 % (n) | 1 (8) | 0 (33) | ||||
| 4 % (n) | 1 (5) | 0 (14) | ||||
| 6 % (n) | 2 (18) | 0 (12) | ||||
| id | 537 | total (prevalence) | n (%) | 67 (12.48) | 470 (87.52) | |
| socioeconomic_status | 1-highest % (n) | 3 (2) | 1 (7) | <0.001 | ||
| 2-second highest % (n) | 16 (11) | 23 (107) | ||||
| 3-medium % (n) | 42 (28) | 50 (236) | ||||
| 4-second lowest % (n) | 30 (20) | 23 (108) | ||||
| 5-lowest % (n) | 9 (6) | 3 (12) | ||||
| education_status | 1-postgraduate % (n) | 10 (7) | 8 (38) | <0.001 | ||
| 2-college % (n) | 36 (24) | 44 (208) | ||||
| 3-college, vocational % (n) | 12 (8) | 12 (57) | ||||
| 4-high school % (n) | 6 (4) | 6 (26) | ||||
| 5-high school, vocational % (n) | 27 (18) | 23 (110) | ||||
| 6-junior high school % (n) | 7 (5) | 6 (27) | ||||
| 7-elementary school % (n) | 1 (1) | 1 (4) | ||||
| maternal_age | average (SD) | 31.33 (5.75) | 33.05 (5.17) | >0.05 | ||
| ivf | 0-no % (n) | 82 (55) | 76 (355) | <0.001 | ||
| 1-yes % (n) | 18 (12) | 24 (115) | ||||
| pe | 0-no % (n) | 78 (52) | 79 (373) | <0.001 | ||
| 1-yes % (n) | 22 (15) | 21 (97) | ||||
| gdm | 0-no % (n) | 94 (63) | 95 (448) | <0.001 | ||
| 1-yes % (n) | 6 (4) | 5 (22) | ||||
| cs | 0-no % (n) | 40 (27) | 35 (166) | 0.025 | ||
| 1-yes % (n) | 60 (40) | 65 (304) | ||||
| gravida | average (SD) | 2.33 (1.45) | 2.4 (1.4) | <0.001 | ||
| ga_wk | average (SD) | 24.67 (2.08) | 27.39 (2.11) | <0.001 | ||
| sex | 0-female % (n) | 40 (27) | 44 (207) | >0.05 | ||
| 1-male % (n) | 60 (40) | 56 (263) | ||||
| multiple_gestation | 0-no % (n) | 67 (45) | 70 (327) | 0.004 | ||
| 1-yes % (n) | 33 (22) | 30 (143) | ||||
| as1 | 0 % (n) | 75 (50) | 21 (99) | <0.001 | ||
| 1 % (n) | 21 (14) | 30 (139) | ||||
| 2 % (n) | 4 (3) | 42 (197) | ||||
| 4 % (n) | 0 (0) | 7 (35) | ||||
| as5 | 0 % (n) | 31 (21) | 4 (20) | <0.001 | ||
| 1 % (n) | 24 (16) | 9 (41) | ||||
| 2 % (n) | 34 (23) | 29 (134) | ||||
| 4 % (n) | 10 (7) | 59 (275) | ||||
| resuscitation_at_birth | 0 % (n) | 40 (27) | 87 (407) | <0.001 | ||
| 6 % (n) | 60 (40) | 13 (63) | ||||
| birthtime_scoring | 1-born 08:00-16:59 % (n) | 52 (35) | 51 (239) | <0.001 | ||
| 2-born 17:00-23:59 % (n) | 18 (12) | 28 (131) | ||||
| 3-born 00:00-07:59 % (n) | 30 (20) | 21 (100) | ||||
| steroid_antenatal | 0 % (n) | 16 (11) | 5 (25) | <0.001 | ||
| 2 % (n) | 36 (24) | 28 (130) | ||||
| 4 % (n) | 48 (32) | 67 (315) | ||||
| chorioamnionitis | 0-no % (n) | 85 (57) | 88 (413) | <0.001 | ||
| 1-yes % (n) | 15 (10) | 12 (57) | ||||
| surfactant | 0 % (n) | 19 (13) | 66 (312) | <0.001 | ||
| 2 % (n) | 81 (54) | 34 (158) | ||||
| bbw_z | 0 % (n) | 7 (5) | 1 (6) | <0.001 | ||
| 2 % (n) | 15 (10) | 8 (37) | ||||
| 4 % (n) | 78 (52) | 91 (427) | ||||
| bhc_z | 0 % (n) | 9 (6) | 5 (24) | <0.001 | ||
| 2 % (n) | 13 (9) | 9 (41) | ||||
| 4 % (n) | 78 (52) | 86 (405) | ||||
| death_age | average (SD) | 19.95 (41.99) | N/A | |||
| 546 | total (prevalence) | n (%) | 67 (12.27) | 479 (87.73) | ||
| pvl | 1-no PVL % (n) | 100 (67) | 98 (470) | |||
| 2-PVL focal, unilateral % (n) | 0 (0) | 0 (1) | ||||
| 3-PVL focal, bilateral % (n) | 0 (0) | 1 (6) | ||||
| 4-PVL extensive, bilateral % (n) | 0 (0) | 0 (2) |
| unit | N | variable | value | rop_severe 0-none/stage I/stage II | rop_severe 1-stage II+ | rop_severe (missing) | bpd_grade 0-no BPD | bpd_grade 1-mild BPD | bpd_grade 2-moderate/severe BPD | bpd_grade (missing) | eugr_hc 0-HC z-score at birth >=-1.5 | eugr_hc 1-HC z-score at birth <-1.5 | eugr_hc (missing) | eugr_bw 0-BW z-score at birth >=-1.5 | eugr_bw 1-BW z-score at birth <-1.5 | eugr_bw (missing) | hearing 0-passed | hearing 1-failed | hearing (missing) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| id|t | 20551 | total (prevalence) | n (%) | 17598 (85.63) | 2394 (11.65) | 559 (2.72) | 13272 (64.58) | 714 (3.47) | 6006 (29.22) | 559 (2.72) | 15456 (75.21) | 4494 (21.87) | 601 (2.92) | 16044 (78.07) | 3906 (19.01) | 601 (2.92) | 17724 (86.24) | 1554 (7.56) | 1273 (6.19) |
| resp_supp_agg_cum_day_qw | average (SD) | 2.49 (5.41) | 10.82 (10.92) | 10.17 (8.35) | 0.99 (2.53) | 3.32 (4.95) | 9.03 (9.81) | 10.17 (8.35) | 2.22 (5.16) | 7.87 (9.73) | 9.6 (8.32) | 2.66 (6.08) | 6.93 (8.72) | 9.6 (8.32) | 3.06 (6.5) | 7.77 (8.89) | 7.12 (8.52) | ||
| fio2_cum_day_qw | average (SD) | 7.45 (10.11) | 17.99 (12.67) | 12.5 (9.74) | 4.76 (7.61) | 12.9 (11.21) | 16.95 (12.46) | 12.5 (9.74) | 6.97 (9.8) | 14.57 (12.65) | 13.13 (10.17) | 7.5 (10.39) | 13.53 (11.95) | 13.13 (10.17) | 7.97 (10.54) | 14.73 (12.57) | 13.36 (11.54) | ||
| fio2_cum_level_qw | average (SD) | 73.19 (160.55) | 257.73 (271.11) | 262.22 (244.45) | 31.88 (59.45) | 112.96 (133.38) | 233.3 (280.85) | 262.22 (244.45) | 63.49 (135.77) | 202.7 (277.05) | 265.17 (243.41) | 77.01 (165.14) | 168.14 (244.61) | 265.17 (243.41) | 84.91 (178.57) | 173.89 (229.85) | 217.15 (238.78) | ||
| resp_supp_agg_cum_day_pct | average (SD) | 49.54 (23.22) | 54.45 (28.82) | 63.07 (32.12) | 45.36 (19.7) | 53.86 (24.62) | 60.2 (28.92) | 63.07 (32.12) | 48.02 (21.77) | 57.1 (29.38) | 64.11 (31.21) | 48.33 (22.09) | 57.2 (29.58) | 64.11 (31.21) | 49.41 (22.99) | 56.25 (30.95) | 58.3 (30.56) | ||
| fio2_cum_day_pct | average (SD) | 50.54 (28.31) | 53.71 (29.09) | 55.98 (30.5) | 44.22 (26.83) | 67.3 (22.89) | 63.76 (27.2) | 55.98 (30.5) | 49.22 (27.88) | 56.36 (29.39) | 58.59 (30.95) | 49.63 (28.16) | 55.75 (28.75) | 58.59 (30.95) | 49.87 (28.5) | 53.29 (23.99) | 64.85 (29.54) | ||
| fio2_cum_level_pct | average (SD) | 49.68 (28.53) | 50.48 (28.27) | 69.37 (31.64) | 43.79 (27.07) | 64.54 (23.63) | 61.25 (27.96) | 69.37 (31.64) | 47.82 (27.84) | 56.11 (29.61) | 70.94 (31.27) | 48.03 (28.09) | 56.49 (28.96) | 70.94 (31.27) | 49.1 (28.47) | 47.97 (26.09) | 69.94 (28.94) | ||
| steroid_postnatal | 0 % (n) | 99 (17451) | 93 (2233) | 96 (538) | 100 (13244) | 99 (707) | 95 (5733) | 96 (538) | 99 (15288) | 97 (4354) | 97 (580) | 99 (15841) | 97 (3801) | 97 (580) | 99 (17472) | 97 (1512) | 97 (1238) | ||
| 2 % (n) | 1 (147) | 7 (161) | 4 (21) | 0 (28) | 1 (7) | 5 (273) | 4 (21) | 1 (168) | 3 (140) | 3 (21) | 1 (203) | 3 (105) | 3 (21) | 1 (252) | 3 (42) | 3 (35) | |||
| bw_z_qw | 1-BW z-score >-1 % (n) | 60 (10514) | 43 (1022) | 66 (368) | 65 (8674) | 68 (482) | 40 (2380) | 66 (368) | 59 (9165) | 52 (2350) | 65 (389) | 60 (9618) | 49 (1897) | 65 (389) | 60 (10603) | 38 (590) | 56 (711) | ||
| 2-BW z-score >-2 & <=-1 % (n) | 35 (6155) | 54 (1289) | 27 (151) | 32 (4199) | 28 (197) | 51 (3048) | 27 (151) | 36 (5531) | 42 (1899) | 27 (165) | 36 (5729) | 44 (1701) | 27 (165) | 36 (6352) | 53 (817) | 33 (426) | |||
| 3-BW z-score >-3 & <=-2 % (n) | 5 (842) | 3 (83) | 7 (40) | 3 (371) | 5 (35) | 9 (519) | 7 (40) | 4 (680) | 5 (238) | 8 (47) | 4 (666) | 6 (252) | 8 (47) | 4 (699) | 9 (133) | 10 (133) | |||
| 4-BW z-score <=-3 % (n) | 0 (87) | 0 (0) | 0 (0) | 0 (28) | 0 (0) | 1 (59) | 0 (0) | 1 (80) | 0 (7) | 0 (0) | 0 (31) | 1 (56) | 0 (0) | 0 (70) | 1 (14) | 0 (3) | |||
| hc_z_qw | 1-HC z-score >-1 % (n) | 45 (7857) | 23 (556) | 48 (268) | 51 (6755) | 27 (193) | 24 (1465) | 48 (268) | 44 (6826) | 35 (1551) | 51 (304) | 45 (7249) | 29 (1128) | 51 (304) | 44 (7785) | 23 (356) | 42 (540) | ||
| 2-HC z-score >-2 & <=-1 % (n) | 37 (6496) | 38 (919) | 38 (210) | 37 (4907) | 45 (324) | 36 (2184) | 38 (210) | 38 (5930) | 33 (1482) | 35 (213) | 37 (5971) | 37 (1441) | 35 (213) | 37 (6643) | 37 (571) | 32 (411) | |||
| 3-HC z-score >-3 & <=-2 % (n) | 14 (2438) | 29 (700) | 14 (80) | 10 (1319) | 26 (183) | 27 (1636) | 14 (80) | 13 (2050) | 24 (1085) | 14 (83) | 14 (2182) | 24 (953) | 14 (83) | 15 (2633) | 24 (368) | 17 (217) | |||
| 4-HC z-score <=-3 % (n) | 5 (807) | 9 (219) | 0 (1) | 2 (291) | 2 (14) | 12 (721) | 0 (1) | 4 (650) | 8 (376) | 0 (1) | 4 (642) | 10 (384) | 0 (1) | 4 (663) | 17 (259) | 8 (105) | |||
| inotropic | 0 % (n) | 94 (16629) | 81 (1943) | 53 (299) | 97 (12817) | 95 (679) | 85 (5076) | 53 (299) | 95 (14745) | 84 (3785) | 57 (341) | 95 (15187) | 86 (3343) | 57 (341) | 94 (16617) | 85 (1319) | 73 (935) | ||
| 2 % (n) | 3 (563) | 11 (261) | 17 (96) | 2 (282) | 3 (19) | 9 (523) | 17 (96) | 3 (464) | 8 (360) | 16 (96) | 3 (541) | 7 (283) | 16 (96) | 4 (633) | 9 (144) | 11 (143) | |||
| 4 % (n) | 2 (310) | 6 (143) | 13 (73) | 1 (150) | 2 (15) | 5 (288) | 13 (73) | 1 (201) | 6 (252) | 12 (73) | 2 (243) | 5 (210) | 12 (73) | 2 (370) | 4 (63) | 7 (93) | |||
| 6 % (n) | 1 (96) | 2 (47) | 16 (91) | 0 (23) | 0 (1) | 2 (119) | 16 (91) | 0 (46) | 2 (97) | 15 (91) | 0 (73) | 2 (70) | 15 (91) | 1 (104) | 2 (28) | 8 (102) | |||
| blood_volume | 0 % (n) | 98 (17276) | 94 (2261) | 74 (413) | 98 (13053) | 97 (696) | 96 (5788) | 74 (413) | 99 (15232) | 95 (4263) | 76 (455) | 98 (15803) | 95 (3692) | 76 (455) | 98 (17363) | 95 (1482) | 87 (1105) | ||
| 4 % (n) | 2 (313) | 5 (120) | 22 (124) | 2 (213) | 2 (17) | 3 (203) | 22 (124) | 1 (216) | 5 (217) | 21 (124) | 1 (231) | 5 (202) | 21 (124) | 2 (345) | 4 (66) | 11 (146) | |||
| 6 % (n) | 0 (9) | 1 (13) | 4 (22) | 0 (6) | 0 (1) | 0 (15) | 4 (22) | 0 (8) | 0 (14) | 4 (22) | 0 (10) | 0 (12) | 4 (22) | 0 (16) | 0 (6) | 2 (22) | |||
| transfusion | 0 % (n) | 95 (16800) | 88 (2098) | 75 (420) | 97 (12844) | 94 (668) | 90 (5386) | 75 (420) | 96 (14793) | 90 (4063) | 77 (462) | 95 (15309) | 91 (3547) | 77 (462) | 95 (16853) | 89 (1383) | 85 (1082) | ||
| 2 % (n) | 5 (798) | 12 (296) | 25 (139) | 3 (428) | 6 (46) | 10 (620) | 25 (139) | 4 (663) | 10 (431) | 23 (139) | 5 (735) | 9 (359) | 23 (139) | 5 (871) | 11 (171) | 15 (191) | |||
| blood_culture | 0 % (n) | 95 (16798) | 90 (2154) | 88 (490) | 96 (12783) | 93 (667) | 92 (5502) | 88 (490) | 96 (14824) | 91 (4089) | 88 (529) | 96 (15344) | 91 (3569) | 88 (529) | 95 (16887) | 90 (1395) | 91 (1160) | ||
| 2 % (n) | 4 (716) | 9 (207) | 10 (54) | 3 (445) | 6 (42) | 7 (436) | 10 (54) | 4 (580) | 8 (341) | 9 (56) | 4 (631) | 7 (290) | 9 (56) | 4 (754) | 8 (127) | 8 (96) | |||
| 6 % (n) | 0 (84) | 1 (33) | 3 (15) | 0 (44) | 1 (5) | 1 (68) | 3 (15) | 0 (52) | 1 (64) | 3 (16) | 0 (69) | 1 (47) | 3 (16) | 0 (83) | 2 (32) | 1 (17) | |||
| plt | 0 % (n) | 89 (15586) | 78 (1877) | 65 (366) | 91 (12055) | 91 (652) | 79 (4756) | 65 (366) | 91 (14018) | 76 (3411) | 67 (400) | 90 (14440) | 77 (2989) | 67 (400) | 89 (15776) | 72 (1122) | 73 (931) | ||
| 1 % (n) | 6 (1099) | 11 (257) | 14 (76) | 5 (722) | 4 (31) | 10 (603) | 14 (76) | 5 (838) | 11 (514) | 13 (80) | 6 (919) | 11 (433) | 13 (80) | 6 (1084) | 13 (198) | 12 (150) | |||
| 2 % (n) | 3 (584) | 7 (161) | 13 (71) | 2 (315) | 3 (19) | 7 (411) | 13 (71) | 3 (394) | 8 (348) | 12 (74) | 3 (443) | 8 (299) | 12 (74) | 3 (540) | 10 (157) | 9 (119) | |||
| 4 % (n) | 2 (291) | 4 (95) | 8 (45) | 1 (156) | 1 (9) | 4 (221) | 8 (45) | 1 (179) | 5 (206) | 8 (46) | 1 (213) | 4 (172) | 8 (46) | 2 (284) | 5 (75) | 6 (72) | |||
| 6 % (n) | 0 (38) | 0 (4) | 0 (1) | 0 (24) | 0 (3) | 0 (15) | 0 (1) | 0 (27) | 0 (15) | 0 (1) | 0 (29) | 0 (13) | 0 (1) | 0 (40) | 0 (2) | 0 (1) | |||
| wbc | 0 % (n) | 97 (17076) | 95 (2272) | 94 (523) | 98 (12954) | 93 (662) | 95 (5732) | 94 (523) | 97 (15017) | 95 (4291) | 94 (563) | 97 (15582) | 95 (3726) | 94 (563) | 97 (17192) | 95 (1469) | 95 (1210) | ||
| 2 % (n) | 2 (388) | 4 (96) | 5 (29) | 2 (239) | 5 (34) | 4 (211) | 5 (29) | 2 (331) | 3 (152) | 5 (30) | 2 (344) | 4 (139) | 5 (30) | 2 (398) | 4 (63) | 4 (52) | |||
| 4 % (n) | 1 (134) | 1 (26) | 1 (7) | 1 (79) | 3 (18) | 1 (63) | 1 (7) | 1 (108) | 1 (51) | 1 (8) | 1 (118) | 1 (41) | 1 (8) | 1 (134) | 1 (22) | 1 (11) | |||
| feeding | 0 % (n) | 13 (2252) | 26 (623) | 64 (355) | 10 (1393) | 15 (106) | 23 (1376) | 64 (355) | 11 (1695) | 26 (1173) | 60 (362) | 11 (1793) | 28 (1075) | 60 (362) | 13 (2322) | 29 (447) | 36 (461) | ||
| 1 % (n) | 23 (4035) | 37 (897) | 28 (154) | 22 (2901) | 30 (211) | 30 (1820) | 28 (154) | 23 (3503) | 31 (1405) | 30 (178) | 22 (3578) | 34 (1330) | 30 (178) | 24 (4209) | 34 (536) | 27 (341) | |||
| 2 % (n) | 8 (1405) | 9 (209) | 3 (18) | 8 (1019) | 11 (79) | 9 (516) | 3 (18) | 8 (1256) | 8 (354) | 4 (22) | 8 (1309) | 8 (301) | 4 (22) | 8 (1424) | 8 (131) | 6 (77) | |||
| 3 % (n) | 8 (1340) | 7 (178) | 5 (29) | 7 (965) | 10 (73) | 8 (480) | 5 (29) | 8 (1196) | 7 (317) | 6 (34) | 8 (1235) | 7 (278) | 6 (34) | 8 (1337) | 8 (131) | 6 (79) | |||
| 4 % (n) | 4 (695) | 3 (76) | 1 (3) | 4 (502) | 5 (36) | 4 (233) | 1 (3) | 4 (613) | 3 (156) | 1 (5) | 4 (660) | 3 (109) | 1 (5) | 4 (688) | 3 (53) | 3 (33) | |||
| 5 % (n) | 4 (662) | 3 (65) | 0 (0) | 4 (514) | 3 (19) | 3 (194) | 0 (0) | 4 (603) | 3 (124) | 0 (0) | 4 (611) | 3 (116) | 0 (0) | 4 (670) | 2 (36) | 2 (21) | |||
| 6 % (n) | 41 (7209) | 14 (346) | 0 (0) | 45 (5978) | 27 (190) | 23 (1387) | 0 (0) | 43 (6590) | 21 (965) | 0 (0) | 43 (6858) | 18 (697) | 0 (0) | 40 (7074) | 14 (220) | 21 (261) | |||
| ivh | 1-no IVH % (n) | 99 (17505) | 99 (2363) | 95 (532) | 100 (13216) | 99 (710) | 99 (5942) | 95 (532) | 99 (15376) | 99 (4450) | 96 (574) | 99 (15949) | 99 (3877) | 96 (574) | 99 (17617) | 99 (1539) | 98 (1244) | ||
| 2-IVH grade I % (n) | 0 (40) | 0 (4) | 0 (0) | 0 (33) | 0 (0) | 0 (11) | 0 (0) | 0 (34) | 0 (10) | 0 (0) | 0 (37) | 0 (7) | 0 (0) | 0 (42) | 0 (1) | 0 (1) | |||
| 3-IVH grade II % (n) | 0 (43) | 1 (17) | 2 (9) | 0 (20) | 0 (3) | 1 (37) | 2 (9) | 0 (41) | 0 (19) | 1 (9) | 0 (46) | 0 (14) | 1 (9) | 0 (52) | 1 (8) | 1 (9) | |||
| 4-IVH grade III % (n) | 0 (5) | 0 (3) | 1 (4) | 0 (1) | 0 (1) | 0 (6) | 1 (4) | 0 (4) | 0 (4) | 1 (4) | 0 (5) | 0 (3) | 1 (4) | 0 (6) | 0 (2) | 0 (4) | |||
| 5-IVH grade IV, unilateral % (n) | 0 (3) | 0 (5) | 2 (9) | 0 (1) | 0 (0) | 0 (7) | 2 (9) | 0 (1) | 0 (7) | 1 (9) | 0 (5) | 0 (3) | 1 (9) | 0 (5) | 0 (2) | 1 (10) | |||
| 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus % (n) | 0 (2) | 0 (2) | 1 (5) | 0 (1) | 0 (0) | 0 (3) | 1 (5) | 0 (0) | 0 (4) | 1 (5) | 0 (2) | 0 (2) | 1 (5) | 0 (2) | 0 (2) | 0 (5) | |||
| cerebellar_hemorrhage | 1-no bleeding % (n) | 100 (17597) | 100 (2394) | 99 (556) | 100 (13272) | 100 (714) | 100 (6005) | 99 (556) | 100 (15456) | 100 (4493) | 100 (598) | 100 (16044) | 100 (3905) | 100 (598) | 100 (17723) | 100 (1554) | 100 (1270) | ||
| 3-severe bleeding % (n) | 0 (1) | 0 (0) | 1 (3) | 0 (0) | 0 (0) | 0 (1) | 1 (3) | 0 (0) | 0 (1) | 0 (3) | 0 (0) | 0 (1) | 0 (3) | 0 (1) | 0 (0) | 0 (3) | |||
| ischaemic_stroke | 1-no ischemia % (n) | 100 (17592) | 100 (2393) | 100 (557) | 100 (13270) | 100 (714) | 100 (6001) | 100 (557) | 100 (15454) | 100 (4489) | 100 (599) | 100 (16038) | 100 (3905) | 100 (599) | 100 (17721) | 100 (1553) | 100 (1268) | ||
| 2-ischemia, unilateral % (n) | 0 (3) | 0 (0) | 0 (0) | 0 (1) | 0 (0) | 0 (2) | 0 (0) | 0 (2) | 0 (1) | 0 (0) | 0 (2) | 0 (1) | 0 (0) | 0 (1) | 0 (1) | 0 (1) | |||
| 3-ischemia, bilateral % (n) | 0 (2) | 0 (0) | 0 (2) | 0 (1) | 0 (0) | 0 (1) | 0 (2) | 0 (0) | 0 (2) | 0 (2) | 0 (2) | 0 (0) | 0 (2) | 0 (1) | 0 (0) | 0 (3) | |||
| 4-ischemia, multiple % (n) | 0 (1) | 0 (1) | 0 (0) | 0 (0) | 0 (0) | 0 (2) | 0 (0) | 0 (0) | 0 (2) | 0 (0) | 0 (2) | 0 (0) | 0 (0) | 0 (1) | 0 (0) | 0 (1) | |||
| hs_pda_iv | 1-no PDA/PDA, no intervention % (n) | 98 (17181) | 96 (2287) | 94 (526) | 98 (13061) | 98 (700) | 95 (5707) | 94 (526) | 98 (15102) | 96 (4324) | 95 (568) | 98 (15668) | 96 (3758) | 95 (568) | 98 (17289) | 95 (1474) | 97 (1231) | ||
| 2-PDA, medical intervention % (n) | 2 (377) | 4 (93) | 5 (30) | 1 (191) | 2 (13) | 4 (266) | 5 (30) | 2 (320) | 3 (150) | 5 (30) | 2 (340) | 3 (130) | 5 (30) | 2 (390) | 5 (72) | 3 (38) | |||
| 3-PDA, surgical intervention % (n) | 0 (40) | 1 (14) | 1 (3) | 0 (20) | 0 (1) | 1 (33) | 1 (3) | 0 (34) | 0 (20) | 0 (3) | 0 (36) | 0 (18) | 0 (3) | 0 (45) | 1 (8) | 0 (4) | |||
| nec | 0 % (n) | 100 (17548) | 100 (2388) | 100 (559) | 100 (13231) | 100 (712) | 100 (5993) | 100 (559) | 100 (15411) | 100 (4483) | 100 (601) | 100 (16002) | 100 (3892) | 100 (601) | 100 (17672) | 100 (1551) | 100 (1272) | ||
| 2 % (n) | 0 (34) | 0 (4) | 0 (0) | 0 (30) | 0 (2) | 0 (6) | 0 (0) | 0 (32) | 0 (6) | 0 (0) | 0 (30) | 0 (8) | 0 (0) | 0 (38) | 0 (0) | 0 (0) | |||
| 3 % (n) | 0 (10) | 0 (1) | 0 (0) | 0 (7) | 0 (0) | 0 (4) | 0 (0) | 0 (9) | 0 (2) | 0 (0) | 0 (9) | 0 (2) | 0 (0) | 0 (10) | 0 (1) | 0 (0) | |||
| 4 % (n) | 0 (3) | 0 (1) | 0 (0) | 0 (2) | 0 (0) | 0 (2) | 0 (0) | 0 (3) | 0 (1) | 0 (0) | 0 (2) | 0 (2) | 0 (0) | 0 (3) | 0 (0) | 0 (1) | |||
| 5 % (n) | 0 (1) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (1) | 0 (0) | 0 (0) | 0 (1) | 0 (0) | 0 (0) | 0 (1) | 0 (0) | 0 (0) | 0 (1) | 0 (0) | |||
| 6 % (n) | 0 (2) | 0 (0) | 0 (0) | 0 (2) | 0 (0) | 0 (0) | 0 (0) | 0 (1) | 0 (1) | 0 (0) | 0 (1) | 0 (1) | 0 (0) | 0 (1) | 0 (1) | 0 (0) | |||
| non_nec_surg_abd | 1-no NEC/NEC, no surgery % (n) | 100 (17586) | 100 (2388) | 99 (556) | 100 (13267) | 100 (714) | 100 (5993) | 99 (556) | 100 (15450) | 100 (4482) | 100 (598) | 100 (16035) | 100 (3897) | 100 (598) | 100 (17710) | 100 (1550) | 100 (1270) | ||
| 2-SIP/meconium ileus/volvulus/obstruction % (n) | 0 (7) | 0 (3) | 1 (3) | 0 (4) | 0 (0) | 0 (6) | 1 (3) | 0 (4) | 0 (6) | 0 (3) | 0 (5) | 0 (5) | 0 (3) | 0 (7) | 0 (3) | 0 (3) | |||
| 3-SIP/meconium ileus/volvulus/obstruction with stomy % (n) | 0 (5) | 0 (3) | 0 (0) | 0 (1) | 0 (0) | 0 (7) | 0 (0) | 0 (2) | 0 (6) | 0 (0) | 0 (4) | 0 (4) | 0 (0) | 0 (7) | 0 (1) | 0 (0) | |||
| aki | 0 % (n) | 100 (17554) | 99 (2378) | 95 (529) | 100 (13252) | 100 (711) | 99 (5969) | 95 (529) | 100 (15419) | 99 (4471) | 95 (571) | 100 (16007) | 99 (3883) | 95 (571) | 100 (17676) | 100 (1547) | 97 (1238) | ||
| 2 % (n) | 0 (26) | 0 (7) | 1 (8) | 0 (12) | 0 (1) | 0 (20) | 1 (8) | 0 (23) | 0 (10) | 1 (8) | 0 (23) | 0 (10) | 1 (8) | 0 (29) | 0 (3) | 1 (9) | |||
| 4 % (n) | 0 (11) | 0 (3) | 1 (5) | 0 (4) | 0 (2) | 0 (8) | 1 (5) | 0 (8) | 0 (6) | 1 (5) | 0 (6) | 0 (8) | 1 (5) | 0 (10) | 0 (3) | 0 (6) | |||
| 6 % (n) | 0 (7) | 0 (6) | 3 (17) | 0 (4) | 0 (0) | 0 (9) | 3 (17) | 0 (6) | 0 (7) | 3 (17) | 0 (8) | 0 (5) | 3 (17) | 0 (9) | 0 (1) | 2 (20) | |||
| id | 537 | total (prevalence) | n (%) | 419 (78.03) | 57 (10.61) | 61 (11.36) | 316 (58.85) | 17 (3.17) | 143 (26.63) | 61 (11.36) | 368 (68.53) | 107 (19.93) | 62 (11.55) | 382 (71.14) | 93 (17.32) | 62 (11.55) | 422 (78.58) | 37 (6.89) | 78 (14.53) |
| socioeconomic_status | 1-highest % (n) | 1 (6) | 2 (1) | 3 (2) | 2 (6) | 0 (0) | 1 (1) | 3 (2) | 2 (6) | 1 (1) | 3 (2) | 2 (6) | 1 (1) | 3 (2) | 1 (6) | 3 (1) | 3 (2) | ||
| 2-second highest % (n) | 21 (89) | 32 (18) | 18 (11) | 20 (64) | 29 (5) | 27 (38) | 18 (11) | 21 (76) | 29 (31) | 18 (11) | 22 (84) | 25 (23) | 18 (11) | 22 (94) | 27 (10) | 18 (14) | |||
| 3-medium % (n) | 50 (211) | 49 (28) | 41 (25) | 49 (154) | 41 (7) | 55 (78) | 41 (25) | 51 (189) | 46 (49) | 42 (26) | 52 (197) | 44 (41) | 42 (26) | 52 (218) | 49 (18) | 36 (28) | |||
| 4-second lowest % (n) | 25 (103) | 14 (8) | 28 (17) | 26 (82) | 29 (5) | 17 (24) | 28 (17) | 24 (87) | 22 (24) | 27 (17) | 22 (85) | 28 (26) | 27 (17) | 22 (93) | 19 (7) | 36 (28) | |||
| 5-lowest % (n) | 2 (10) | 4 (2) | 10 (6) | 3 (10) | 0 (0) | 1 (2) | 10 (6) | 3 (10) | 2 (2) | 10 (6) | 3 (10) | 2 (2) | 10 (6) | 3 (11) | 3 (1) | 8 (6) | |||
| education_status | 1-postgraduate % (n) | 8 (33) | 9 (5) | 11 (7) | 8 (25) | 6 (1) | 8 (12) | 11 (7) | 8 (28) | 9 (10) | 11 (7) | 8 (30) | 9 (8) | 11 (7) | 8 (34) | 8 (3) | 10 (8) | ||
| 2-college % (n) | 44 (183) | 47 (27) | 36 (22) | 43 (136) | 35 (6) | 48 (68) | 36 (22) | 44 (163) | 43 (46) | 37 (23) | 46 (174) | 38 (35) | 37 (23) | 46 (194) | 35 (13) | 32 (25) | |||
| 3-college, vocational % (n) | 12 (51) | 11 (6) | 13 (8) | 13 (41) | 6 (1) | 10 (15) | 13 (8) | 11 (41) | 15 (16) | 13 (8) | 12 (46) | 12 (11) | 13 (8) | 12 (50) | 16 (6) | 12 (9) | |||
| 4-high school % (n) | 5 (19) | 12 (7) | 7 (4) | 6 (18) | 12 (2) | 4 (6) | 7 (4) | 5 (20) | 6 (6) | 6 (4) | 5 (21) | 5 (5) | 6 (4) | 5 (19) | 16 (6) | 6 (5) | |||
| 5-high school, vocational % (n) | 25 (105) | 16 (9) | 23 (14) | 24 (76) | 35 (6) | 22 (32) | 23 (14) | 24 (89) | 23 (25) | 23 (14) | 23 (88) | 28 (26) | 23 (14) | 23 (97) | 22 (8) | 29 (23) | |||
| 6-junior high school % (n) | 6 (24) | 5 (3) | 8 (5) | 5 (17) | 6 (1) | 6 (9) | 8 (5) | 6 (23) | 4 (4) | 8 (5) | 5 (20) | 8 (7) | 8 (5) | 6 (25) | 3 (1) | 8 (6) | |||
| 7-elementary school % (n) | 1 (4) | 0 (0) | 2 (1) | 1 (3) | 0 (0) | 1 (1) | 2 (1) | 1 (4) | 0 (0) | 2 (1) | 1 (3) | 1 (1) | 2 (1) | 1 (3) | 0 (0) | 3 (2) | |||
| maternal_age | average (SD) | 33.14 (5.14) | 32.51 (5.41) | 31.08 (5.75) | 32.8 (5.2) | 33.41 (5.35) | 33.59 (5.08) | 31.08 (5.75) | 33.11 (5.17) | 32.95 (5.2) | 31.05 (5.71) | 33.05 (5.09) | 33.14 (5.5) | 31.05 (5.71) | 33.18 (5.18) | 32.16 (4.75) | 31.29 (5.71) | ||
| ivf | 0-no % (n) | 77 (323) | 65 (37) | 82 (50) | 77 (244) | 59 (10) | 74 (106) | 82 (50) | 76 (281) | 73 (78) | 82 (51) | 75 (288) | 76 (71) | 82 (51) | 76 (319) | 73 (27) | 82 (64) | ||
| 1-yes % (n) | 23 (96) | 35 (20) | 18 (11) | 23 (72) | 41 (7) | 26 (37) | 18 (11) | 24 (87) | 27 (29) | 18 (11) | 25 (94) | 24 (22) | 18 (11) | 24 (103) | 27 (10) | 18 (14) | |||
| pe | 0-no % (n) | 77 (322) | 93 (53) | 82 (50) | 76 (239) | 88 (15) | 85 (121) | 82 (50) | 78 (288) | 81 (87) | 81 (50) | 80 (305) | 75 (70) | 81 (50) | 79 (332) | 89 (33) | 77 (60) | ||
| 1-yes % (n) | 23 (97) | 7 (4) | 18 (11) | 24 (77) | 12 (2) | 15 (22) | 18 (11) | 22 (80) | 19 (20) | 19 (12) | 20 (77) | 25 (23) | 19 (12) | 21 (90) | 11 (4) | 23 (18) | |||
| gdm | 0-no % (n) | 95 (399) | 96 (55) | 93 (57) | 94 (298) | 100 (17) | 97 (139) | 93 (57) | 95 (350) | 96 (103) | 94 (58) | 95 (364) | 96 (89) | 94 (58) | 95 (403) | 92 (34) | 95 (74) | ||
| 1-yes % (n) | 5 (20) | 4 (2) | 7 (4) | 6 (18) | 0 (0) | 3 (4) | 7 (4) | 5 (18) | 4 (4) | 6 (4) | 5 (18) | 4 (4) | 6 (4) | 5 (19) | 8 (3) | 5 (4) | |||
| cs | 0-no % (n) | 35 (145) | 40 (23) | 41 (25) | 37 (116) | 24 (4) | 34 (48) | 41 (25) | 36 (132) | 34 (36) | 40 (25) | 35 (135) | 35 (33) | 40 (25) | 36 (151) | 35 (13) | 37 (29) | ||
| 1-yes % (n) | 65 (274) | 60 (34) | 59 (36) | 63 (200) | 76 (13) | 66 (95) | 59 (36) | 64 (236) | 66 (71) | 60 (37) | 65 (247) | 65 (60) | 60 (37) | 64 (271) | 65 (24) | 63 (49) | |||
| gravida | average (SD) | 2.4 (1.4) | 2.4 (1.49) | 2.31 (1.37) | 2.27 (1.35) | 2.35 (1.41) | 2.68 (1.52) | 2.31 (1.37) | 2.41 (1.44) | 2.36 (1.33) | 2.31 (1.36) | 2.4 (1.4) | 2.39 (1.47) | 2.31 (1.36) | 2.4 (1.44) | 2.22 (1.03) | 2.41 (1.39) | ||
| ga_wk | average (SD) | 27.75 (1.86) | 24.56 (1.64) | 24.52 (2.05) | 28.11 (1.63) | 27.24 (1.75) | 25.75 (2.17) | 24.52 (2.05) | 27.8 (1.94) | 25.87 (2) | 24.58 (2.08) | 27.66 (2) | 26.16 (2.13) | 24.58 (2.08) | 27.53 (2.03) | 25.59 (2.23) | 25.13 (2.32) | ||
| sex | 0-female % (n) | 47 (196) | 26 (15) | 38 (23) | 47 (149) | 41 (7) | 38 (55) | 38 (23) | 45 (164) | 44 (47) | 37 (23) | 46 (175) | 39 (36) | 37 (23) | 45 (189) | 41 (15) | 38 (30) | ||
| 1-male % (n) | 53 (223) | 74 (42) | 62 (38) | 53 (167) | 59 (10) | 62 (88) | 62 (38) | 55 (204) | 56 (60) | 63 (39) | 54 (207) | 61 (57) | 63 (39) | 55 (233) | 59 (22) | 62 (48) | |||
| multiple_gestation | 0-no % (n) | 70 (295) | 63 (36) | 67 (41) | 72 (227) | 47 (8) | 67 (96) | 67 (41) | 72 (264) | 62 (66) | 68 (42) | 70 (268) | 67 (62) | 68 (42) | 70 (295) | 68 (25) | 67 (52) | ||
| 1-yes % (n) | 30 (124) | 37 (21) | 33 (20) | 28 (89) | 53 (9) | 33 (47) | 33 (20) | 28 (104) | 38 (41) | 32 (20) | 30 (114) | 33 (31) | 32 (20) | 30 (127) | 32 (12) | 33 (26) | |||
| as1 | 0 % (n) | 19 (80) | 42 (24) | 74 (45) | 16 (49) | 41 (7) | 34 (48) | 74 (45) | 18 (67) | 34 (36) | 74 (46) | 20 (75) | 30 (28) | 74 (46) | 21 (87) | 27 (10) | 67 (52) | ||
| 1 % (n) | 30 (125) | 25 (14) | 23 (14) | 28 (90) | 18 (3) | 32 (46) | 23 (14) | 28 (104) | 33 (35) | 23 (14) | 29 (112) | 29 (27) | 23 (14) | 29 (122) | 35 (13) | 23 (18) | |||
| 2 % (n) | 43 (182) | 28 (16) | 3 (2) | 47 (148) | 41 (7) | 30 (43) | 3 (2) | 46 (168) | 28 (30) | 3 (2) | 43 (164) | 37 (34) | 3 (2) | 43 (180) | 32 (12) | 10 (8) | |||
| 4 % (n) | 8 (32) | 5 (3) | 0 (0) | 9 (29) | 0 (0) | 4 (6) | 0 (0) | 8 (29) | 6 (6) | 0 (0) | 8 (31) | 4 (4) | 0 (0) | 8 (33) | 5 (2) | 0 (0) | |||
| as5 | 0 % (n) | 4 (17) | 7 (4) | 33 (20) | 3 (11) | 0 (0) | 7 (10) | 33 (20) | 4 (14) | 7 (7) | 32 (20) | 3 (11) | 11 (10) | 32 (20) | 4 (17) | 8 (3) | 27 (21) | ||
| 1 % (n) | 7 (31) | 19 (11) | 25 (15) | 5 (17) | 6 (1) | 17 (24) | 25 (15) | 6 (23) | 18 (19) | 24 (15) | 8 (31) | 12 (11) | 24 (15) | 9 (37) | 11 (4) | 21 (16) | |||
| 2 % (n) | 27 (115) | 40 (23) | 31 (19) | 24 (77) | 41 (7) | 38 (54) | 31 (19) | 27 (98) | 36 (39) | 32 (20) | 28 (106) | 33 (31) | 32 (20) | 28 (120) | 27 (10) | 35 (27) | |||
| 4 % (n) | 61 (256) | 33 (19) | 11 (7) | 67 (211) | 53 (9) | 38 (55) | 11 (7) | 63 (233) | 39 (42) | 11 (7) | 61 (234) | 44 (41) | 11 (7) | 59 (248) | 54 (20) | 18 (14) | |||
| resuscitation_at_birth | 0 % (n) | 89 (371) | 70 (40) | 38 (23) | 90 (284) | 94 (16) | 78 (111) | 38 (23) | 88 (323) | 81 (87) | 39 (24) | 89 (340) | 75 (70) | 39 (24) | 87 (367) | 81 (30) | 47 (37) | ||
| 6 % (n) | 11 (48) | 30 (17) | 62 (38) | 10 (32) | 6 (1) | 22 (32) | 62 (38) | 12 (45) | 19 (20) | 61 (38) | 11 (42) | 25 (23) | 61 (38) | 13 (55) | 19 (7) | 53 (41) | |||
| birthtime_scoring | 1-born 08:00-16:59 % (n) | 52 (219) | 42 (24) | 51 (31) | 52 (163) | 47 (8) | 50 (72) | 51 (31) | 49 (182) | 56 (60) | 52 (32) | 51 (196) | 49 (46) | 52 (32) | 51 (215) | 51 (19) | 51 (40) | ||
| 2-born 17:00-23:59 % (n) | 27 (115) | 30 (17) | 18 (11) | 27 (84) | 41 (7) | 29 (41) | 18 (11) | 30 (109) | 21 (23) | 18 (11) | 27 (103) | 31 (29) | 18 (11) | 27 (115) | 27 (10) | 23 (18) | |||
| 3-born 00:00-07:59 % (n) | 20 (85) | 28 (16) | 31 (19) | 22 (69) | 12 (2) | 21 (30) | 31 (19) | 21 (77) | 22 (24) | 31 (19) | 22 (83) | 19 (18) | 31 (19) | 22 (92) | 22 (8) | 26 (20) | |||
| steroid_antenatal | 0 % (n) | 6 (24) | 4 (2) | 16 (10) | 7 (21) | 0 (0) | 3 (5) | 16 (10) | 5 (19) | 7 (7) | 16 (10) | 5 (20) | 6 (6) | 16 (10) | 5 (22) | 5 (2) | 15 (12) | ||
| 2 % (n) | 28 (118) | 25 (14) | 36 (22) | 29 (92) | 29 (5) | 24 (35) | 36 (22) | 26 (95) | 34 (36) | 37 (23) | 28 (106) | 27 (25) | 37 (23) | 27 (116) | 27 (10) | 36 (28) | |||
| 4 % (n) | 66 (277) | 72 (41) | 48 (29) | 64 (203) | 71 (12) | 72 (103) | 48 (29) | 69 (254) | 60 (64) | 47 (29) | 67 (256) | 67 (62) | 47 (29) | 67 (284) | 68 (25) | 49 (38) | |||
| chorioamnionitis | 0-no % (n) | 89 (372) | 82 (47) | 84 (51) | 90 (284) | 82 (14) | 85 (121) | 84 (51) | 87 (321) | 91 (97) | 84 (52) | 88 (335) | 89 (83) | 84 (52) | 87 (369) | 95 (35) | 85 (66) | ||
| 1-yes % (n) | 11 (47) | 18 (10) | 16 (10) | 10 (32) | 18 (3) | 15 (22) | 16 (10) | 13 (47) | 9 (10) | 16 (10) | 12 (47) | 11 (10) | 16 (10) | 13 (53) | 5 (2) | 15 (12) | |||
| surfactant | 0 % (n) | 69 (290) | 42 (24) | 18 (11) | 77 (244) | 59 (10) | 42 (60) | 18 (11) | 73 (269) | 41 (44) | 19 (12) | 70 (267) | 49 (46) | 19 (12) | 67 (284) | 54 (20) | 27 (21) | ||
| 2 % (n) | 31 (129) | 58 (33) | 82 (50) | 23 (72) | 41 (7) | 58 (83) | 82 (50) | 27 (99) | 59 (63) | 81 (50) | 30 (115) | 51 (47) | 81 (50) | 33 (138) | 46 (17) | 73 (57) | |||
| bbw_z | 0 % (n) | 2 (7) | 2 (1) | 5 (3) | 1 (2) | 0 (0) | 4 (6) | 5 (3) | 1 (5) | 3 (3) | 5 (3) | 1 (5) | 3 (3) | 5 (3) | 1 (4) | 5 (2) | 6 (5) | ||
| 2 % (n) | 8 (34) | 5 (3) | 16 (10) | 6 (20) | 6 (1) | 11 (16) | 16 (10) | 8 (29) | 7 (8) | 16 (10) | 8 (30) | 8 (7) | 16 (10) | 8 (32) | 14 (5) | 13 (10) | |||
| 4 % (n) | 90 (378) | 93 (53) | 79 (48) | 93 (294) | 94 (16) | 85 (121) | 79 (48) | 91 (334) | 90 (96) | 79 (49) | 91 (347) | 89 (83) | 79 (49) | 91 (386) | 81 (30) | 81 (63) | |||
| bhc_z | 0 % (n) | 6 (24) | 4 (2) | 7 (4) | 3 (11) | 6 (1) | 10 (14) | 7 (4) | 6 (22) | 4 (4) | 6 (4) | 4 (17) | 10 (9) | 6 (4) | 4 (18) | 16 (6) | 8 (6) | ||
| 2 % (n) | 8 (35) | 12 (7) | 13 (8) | 7 (23) | 12 (2) | 12 (17) | 13 (8) | 10 (36) | 6 (6) | 13 (8) | 9 (35) | 8 (7) | 13 (8) | 9 (37) | 11 (4) | 12 (9) | |||
| 4 % (n) | 86 (360) | 84 (48) | 80 (49) | 89 (282) | 82 (14) | 78 (112) | 80 (49) | 84 (310) | 91 (97) | 81 (50) | 86 (330) | 83 (77) | 81 (50) | 87 (367) | 73 (27) | 81 (63) | |||
| death_age | average (SD) | N/A | N/A | 8.79 (13.64) | N/A | N/A | N/A | 8.79 (13.64) | N/A | N/A | 9.5 (14.61) | N/A | N/A | 9.5 (14.61) | N/A | N/A | N/A | ||
| 546 | total (prevalence) | n (%) | 427 (78.21) | 58 (10.62) | 61 (11.17) | 322 (58.97) | 17 (3.11) | 146 (26.74) | 61 (11.17) | 375 (68.68) | 109 (19.96) | 62 (11.36) | 389 (71.25) | 95 (17.4) | 62 (11.36) | 429 (78.57) | 38 (6.96) | 79 (14.47) | |
| pvl | 1-no PVL % (n) | 98 (419) | 98 (57) | 100 (61) | 98 (316) | 100 (17) | 98 (143) | 100 (61) | 98 (368) | 98 (107) | 100 (62) | 98 (382) | 98 (93) | 100 (62) | 98 (422) | 97 (37) | 99 (78) | ||
| 2-PVL focal, unilateral % (n) | 0 (0) | 2 (1) | 0 (0) | 0 (0) | 0 (0) | 1 (1) | 0 (0) | 0 (0) | 1 (1) | 0 (0) | 0 (0) | 1 (1) | 0 (0) | 0 (0) | 3 (1) | 0 (0) | |||
| 3-PVL focal, bilateral % (n) | 1 (6) | 0 (0) | 0 (0) | 1 (4) | 0 (0) | 1 (2) | 0 (0) | 1 (5) | 1 (1) | 0 (0) | 1 (5) | 1 (1) | 0 (0) | 1 (5) | 0 (0) | 1 (1) | |||
| 4-PVL extensive, bilateral % (n) | 0 (2) | 0 (0) | 0 (0) | 1 (2) | 0 (0) | 0 (0) | 0 (0) | 1 (2) | 0 (0) | 0 (0) | 1 (2) | 0 (0) | 0 (0) | 0 (2) | 0 (0) | 0 (0) |
Feature extraction
| colname | old_cat | new_cat |
|---|---|---|
| socioeconomic_status | 1-highest | 1-high |
| socioeconomic_status | 2-second highest | 1-high |
| socioeconomic_status | 3-medium | 2-medium |
| socioeconomic_status | 4-second lowest | 3-low |
| socioeconomic_status | 5-lowest | 3-low |
| education_status | 1-postgraduate | 0-high |
| education_status | 2-college | 0-high |
| education_status | 3-college, vocational | 0-high |
| education_status | 4-high school | 1-low |
| education_status | 5-high school, vocational | 1-low |
| education_status | 6-junior high school | 1-low |
| education_status | 7-elementary school | 1-low |
| ivf | 0-no | 0-no |
| ivf | 1-yes | 1-yes |
| pe | 0-no | 0-no |
| pe | 1-yes | 1-yes |
| gdm | 0-no | 0-no |
| gdm | 1-yes | 1-yes |
| cs | 0-no | 0-no |
| cs | 1-yes | 1-yes |
| sex | 0-female | 0-female |
| sex | 1-male | 1-male |
| multiple_gestation | 0-no | 0-no |
| multiple_gestation | 1-yes | 1-yes |
| birthtime_scoring | 1-born 08:00-16:59 | birthtime_day |
| birthtime_scoring | 2-born 17:00-23:59 | birthtime_evening |
| birthtime_scoring | 3-born 00:00-07:59 | birthtime_night |
| chorioamnionitis | 0-no | 0-no |
| chorioamnionitis | 1-yes | 1-yes |
| survive | 0-no | 0-no |
| survive | 1-yes | 1-yes |
| rop_severe | 0-none/stage I/stage II | 0-none/stage I/stage II |
| rop_severe | 1-stage II+ | 1-stage II+ |
| rop_severe | NA | NA |
| bpd_grade | 0-no BPD | bpd* |
| bpd_grade | 1-mild BPD | (removed) |
| bpd_grade | 2-moderate/severe BPD | bpd_moderate_severe |
| bpd_grade | NA | (missing) |
| eugr_hc | 0-HC z-score at birth >=-1.5 | 0-HC z-score at birth >=-1.5 |
| eugr_hc | 1-HC z-score at birth <-1.5 | 1-HC z-score at birth <-1.5 |
| eugr_hc | NA | NA |
| eugr_bw | 0-BW z-score at birth >=-1.5 | 0-BW z-score at birth >=-1.5 |
| eugr_bw | 1-BW z-score at birth <-1.5 | 1-BW z-score at birth <-1.5 |
| eugr_bw | NA | NA |
| hearing | 0-passed | 0-passed |
| hearing | 1-failed | 1-failed |
| hearing | NA | NA |
| bw_z_qw | 1-BW z-score >-1 | 0-BW z-score >-1 |
| bw_z_qw | 2-BW z-score >-2 & <=-1 | 1-BW z-score <=-1 |
| bw_z_qw | 3-BW z-score >-3 & <=-2 | 1-BW z-score <=-1 |
| bw_z_qw | 4-BW z-score <=-3 | 1-BW z-score <=-1 |
| hc_z_qw | 1-HC z-score >-1 | 0-HC z-score >-1 |
| hc_z_qw | 2-HC z-score >-2 & <=-1 | 1-HC z-score <=-1 |
| hc_z_qw | 3-HC z-score >-3 & <=-2 | 1-HC z-score <=-1 |
| hc_z_qw | 4-HC z-score <=-3 | 1-HC z-score <=-1 |
| ivh | 1-no IVH | 0-no IVH |
| ivh | 2-IVH grade I | 1-IVH |
| ivh | 3-IVH grade II | 1-IVH |
| ivh | 4-IVH grade III | 1-IVH |
| ivh | 5-IVH grade IV, unilateral | 1-IVH |
| ivh | 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus | 1-IVH |
| pvl | 1-no PVL | 0-no PVL |
| pvl | 2-PVL focal, unilateral | 1-PVL |
| pvl | 3-PVL focal, bilateral | 1-PVL |
| pvl | 4-PVL extensive, bilateral | 1-PVL |
| cerebellar_hemorrhage | 1-no bleeding | 1-no bleeding |
| cerebellar_hemorrhage | 3-severe bleeding | 3-severe bleeding |
| ischaemic_stroke | 1-no ischemia | 0-no ischemia |
| ischaemic_stroke | 2-ischemia, unilateral | 1-ischemia |
| ischaemic_stroke | 3-ischemia, bilateral | 1-ischemia |
| ischaemic_stroke | 4-ischemia, multiple | 1-ischemia |
| hs_pda_iv | 1-no PDA/PDA, no intervention | (removed) |
| hs_pda_iv | 2-PDA, medical intervention | pda_medical |
| hs_pda_iv | 3-PDA, surgical intervention | pda_surgical |
| non_nec_surg_abd | 1-no NEC/NEC, no surgery | 0-no NEC/NEC, no surgery |
| non_nec_surg_abd | 2-SIP/meconium ileus/volvulus/obstruction | 1-NEC with surgery |
| non_nec_surg_abd | 3-SIP/meconium ileus/volvulus/obstruction with stomy | 1-NEC with surgery |
| Note: | ||
| *, inversed nominal category. |
Univariate regression analysis
| outcome | variable | term | OR | LB | UB | p.value |
|---|---|---|---|---|---|---|
| survive | fio2_cum_level_qw* | value | 1.002000e+00 | 1.001 | 1.003 | <0.001 |
| survive | ga_wk* | value | 1.740000e+00 | 1.518 | 1.995 | <0.001 |
| survive | as1* | value | 5.449000e+00 | 3.453 | 8.600 | <0.001 |
| survive | as5* | value | 2.507000e+00 | 1.996 | 3.149 | <0.001 |
| survive | resuscitation_at_birth* | value | 6.860000e-01 | 0.626 | 0.753 | <0.001 |
| survive | steroid_antenatal* | value | 1.416000e+00 | 1.177 | 1.704 | <0.001 |
| survive | surfactant* | value | 3.490000e-01 | 0.254 | 0.480 | <0.001 |
| survive | bbw_z* | value | 1.566000e+00 | 1.223 | 2.005 | <0.001 |
| survive | fio2_cum_day_qw* | value | 1.185000e+00 | 1.041 | 1.349 | 0.01 |
| survive | maternal_age* | value | 1.062000e+00 | 1.013 | 1.114 | 0.013 |
| survive | resp_supp_agg_cum_day_qw* | value | 1.054000e+00 | 1.010 | 1.101 | 0.017 |
| survive | fio2_cum_day_pct* | value | 1.029000e+00 | 1.001 | 1.058 | 0.039 |
| survive | fio2_cum_level_pct* | value | 1.027000e+00 | 1.000 | 1.055 | 0.046 |
| survive | plt | value | 1.684000e+00 | 0.971 | 2.919 | 0.064 |
| survive | bhc_z | value | 1.209000e+00 | 0.982 | 1.488 | 0.074 |
| survive | socioeconomic_status | 3-low | 5.260000e-01 | 0.258 | 1.074 | 0.078 |
| survive | birthtime_evening | 1-yes | 1.771000e+00 | 0.919 | 3.414 | 0.088 |
| survive | birthtime_night | 1-yes | 6.350000e-01 | 0.360 | 1.121 | 0.117 |
| survive | ivf | 1-yes | 1.485000e+00 | 0.768 | 2.869 | 0.24 |
| survive | feeding | value | 8.440000e-01 | 0.636 | 1.122 | 0.244 |
| survive | education_status | 1-low | 7.680000e-01 | 0.456 | 1.292 | 0.32 |
| survive | cs | 1-yes | 1.236000e+00 | 0.732 | 2.087 | 0.427 |
| survive | chorioamnionitis | 1-yes | 7.870000e-01 | 0.380 | 1.627 | 0.518 |
| survive | sex | 1-male | 8.580000e-01 | 0.509 | 1.444 | 0.563 |
| survive | transfusion | value | 1.325000e+00 | 0.469 | 3.748 | 0.595 |
| survive | resp_supp_agg_cum_day_pct | value | 1.007000e+00 | 0.981 | 1.033 | 0.601 |
| survive | gdm | 1-yes | 7.730000e-01 | 0.258 | 2.318 | 0.646 |
| survive | multiple_gestation | 1-yes | 8.940000e-01 | 0.518 | 1.545 | 0.689 |
| survive | gravida | value | 1.036000e+00 | 0.859 | 1.248 | 0.713 |
| survive | pe | 1-yes | 9.020000e-01 | 0.487 | 1.670 | 0.742 |
| survive | birthtime_day | 1-yes | 9.460000e-01 | 0.567 | 1.579 | 0.832 |
| survive | socioeconomic_status | 2-medium | 9.610000e-01 | 0.480 | 1.925 | 0.911 |
| survive | bw_z_qw | 1-BW z-score <=-1 | 1.036000e+00 | 0.278 | 3.857 | 0.958 |
| survive | pvl | 1-PVL | 2.231151e+06 | 0.000 | Inf | 0.985 |
| survive | steroid_postnatal | value | 0.000000e+00 | 0.000 | Inf | 0.998 |
| survive | hc_z_qw | 1-HC z-score <=-1 | 3.082449e+08 | 0.000 | Inf | 0.998 |
| survive | inotropic | value | 1.000000e-03 | 0.000 | Inf | 0.998 |
| survive | blood_culture | value | 0.000000e+00 | 0.000 | Inf | 0.998 |
| survive | wbc | value | 0.000000e+00 | 0.000 | Inf | 0.998 |
| survive | blood_volume | value | 3.000000e-02 | 0.000 | Inf | 0.999 |
| survive | pda_surgical | 1-yes | 0.000000e+00 | 0.000 | Inf | 0.999 |
| survive | ivhNA | 1-IVH | NA | NA | NA | NA |
| survive | cerebellar_hemorrhageNA | 3-severe bleeding | NA | NA | NA | NA |
| survive | ischaemic_strokeNA | 1-ischemia | NA | NA | NA | NA |
| survive | pda_medicalNA | 1-yes | NA | NA | NA | NA |
| survive | necNA | value | NA | NA | NA | NA |
| survive | non_nec_surg_abdNA | 1-NEC with surgery | NA | NA | NA | NA |
| survive | akiNA | value | NA | NA | NA | NA |
| rop_severe | resp_supp_agg_cum_day_qw* | value | 1.102000e+00 | 1.098 | 1.107 | <0.001 |
| rop_severe | fio2_cum_day_qw* | value | 1.120000e+00 | 1.114 | 1.127 | <0.001 |
| rop_severe | fio2_cum_level_qw* | value | 1.002000e+00 | 1.002 | 1.002 | <0.001 |
| rop_severe | steroid_postnatal* | value | 2.451000e+00 | 2.260 | 2.657 | <0.001 |
| rop_severe | ga_wk* | value | 4.360000e-01 | 0.359 | 0.528 | <0.001 |
| rop_severe | as5* | value | 6.590000e-01 | 0.536 | 0.811 | <0.001 |
| rop_severe | resuscitation_at_birth* | value | 1.219000e+00 | 1.095 | 1.357 | <0.001 |
| rop_severe | surfactant* | value | 1.758000e+00 | 1.325 | 2.332 | <0.001 |
| rop_severe | hc_z_qw* | 1-HC z-score <=-1 | 2.940000e+00 | 2.653 | 3.258 | <0.001 |
| rop_severe | inotropic* | value | 1.385000e+00 | 1.346 | 1.425 | <0.001 |
| rop_severe | blood_volume* | value | 1.318000e+00 | 1.261 | 1.378 | <0.001 |
| rop_severe | transfusion* | value | 1.643000e+00 | 1.545 | 1.747 | <0.001 |
| rop_severe | blood_culture* | value | 1.267000e+00 | 1.215 | 1.322 | <0.001 |
| rop_severe | plt* | value | 1.276000e+00 | 1.228 | 1.325 | <0.001 |
| rop_severe | wbc* | value | 1.182000e+00 | 1.105 | 1.265 | <0.001 |
| rop_severe | feeding* | value | 6.950000e-01 | 0.680 | 0.709 | <0.001 |
| rop_severe | ivh* | 1-IVH | 2.388000e+00 | 1.647 | 3.462 | <0.001 |
| rop_severe | cerebellar_hemorrhage | 3-severe bleeding | 0.000000e+00 | 0.000 | Inf | <0.001 |
| rop_severe | pda_medical* | 1-yes | 1.789000e+00 | 1.447 | 2.212 | <0.001 |
| rop_severe | pda_surgical* | 1-yes | 2.358000e+00 | 1.391 | 3.995 | <0.001 |
| rop_severe | aki* | value | 1.280000e+00 | 1.139 | 1.438 | <0.001 |
| rop_severe | as1* | value | 6.310000e-01 | 0.468 | 0.851 | 0.003 |
| rop_severe | bw_z_qw* | 1-BW z-score <=-1 | 1.964000e+00 | 1.808 | 2.134 | 0.003 |
| rop_severe | non_nec_surg_abd* | 1-NEC with surgery | 3.163000e+00 | 1.415 | 7.067 | 0.003 |
| rop_severe | sex* | 1-male | 2.461000e+00 | 1.324 | 4.575 | 0.004 |
| rop_severe | pe* | 1-yes | 2.510000e-01 | 0.088 | 0.710 | 0.009 |
| rop_severe | ivf* | 1-yes | 1.819000e+00 | 1.008 | 3.280 | 0.047 |
| rop_severe | socioeconomic_status* | 3-low | 4.420000e-01 | 0.196 | 0.998 | 0.049 |
| rop_severe | birthtime_day | 1-yes | 6.640000e-01 | 0.380 | 1.162 | 0.152 |
| rop_severe | resp_supp_agg_cum_day_pct | value | 1.008000e+00 | 1.006 | 1.009 | 0.16 |
| rop_severe | chorioamnionitis | 1-yes | 1.684000e+00 | 0.798 | 3.554 | 0.171 |
| rop_severe | birthtime_night | 1-yes | 1.533000e+00 | 0.821 | 2.864 | 0.18 |
| rop_severe | socioeconomic_status | 2-medium | 6.640000e-01 | 0.353 | 1.247 | 0.203 |
| rop_severe | multiple_gestation | 1-yes | 1.388000e+00 | 0.779 | 2.473 | 0.266 |
| rop_severe | steroid_antenatal | value | 1.133000e+00 | 0.879 | 1.460 | 0.335 |
| rop_severe | maternal_age | value | 9.770000e-01 | 0.926 | 1.030 | 0.388 |
| rop_severe | cs | 1-yes | 7.820000e-01 | 0.444 | 1.378 | 0.395 |
| rop_severe | fio2_cum_day_pct | value | 1.004000e+00 | 1.002 | 1.005 | 0.412 |
| rop_severe | bbw_z | value | 1.119000e+00 | 0.732 | 1.713 | 0.603 |
| rop_severe | education_status | 1-low | 8.780000e-01 | 0.489 | 1.577 | 0.664 |
| rop_severe | gdm | 1-yes | 7.250000e-01 | 0.165 | 3.188 | 0.671 |
| rop_severe | birthtime_evening | 1-yes | 1.123000e+00 | 0.612 | 2.061 | 0.707 |
| rop_severe | nec | value | 9.550000e-01 | 0.706 | 1.290 | 0.746 |
| rop_severe | fio2_cum_level_pct | value | 1.001000e+00 | 1.000 | 1.002 | 0.827 |
| rop_severe | ischaemic_stroke | 1-ischemia | 1.208000e+00 | 0.170 | 8.601 | 0.849 |
| rop_severe | pvl | 1-PVL | 9.190000e-01 | 0.113 | 7.482 | 0.937 |
| rop_severe | bhc_z | value | 1.010000e+00 | 0.771 | 1.323 | 0.944 |
| rop_severe | gravida | value | 1.004000e+00 | 0.825 | 1.221 | 0.971 |
| bpd | fio2_cum_level_qw* | value | 1.007000e+00 | 1.005 | 1.008 | <0.001 |
| bpd | fio2_cum_level_pct* | value | 1.009000e+00 | 1.005 | 1.013 | <0.001 |
| bpd | resp_supp_agg_cum_day_qw* | value | 1.082000e+00 | 1.024 | 1.143 | 0.005 |
| bpd | fio2_cum_day_pct | value | 1.004000e+00 | 1.000 | 1.009 | 0.074 |
| bpd | ga_wk | value | 8.350000e-01 | 0.542 | 1.287 | 0.415 |
| bpd | maternal_age | value | 1.018000e+00 | 0.955 | 1.085 | 0.583 |
| bpd | fio2_cum_day_qw | value | 1.007000e+00 | 0.972 | 1.043 | 0.713 |
| bpd | resp_supp_agg_cum_day_pct | value | 9.990000e-01 | 0.994 | 1.005 | 0.824 |
| bpd | nec | value | 9.440000e-01 | 0.485 | 1.837 | 0.866 |
| bpd | cerebellar_hemorrhage | 3-severe bleeding | 3.143660e+08 | 0.000 | Inf | 0.999 |
| bpd | steroid_postnatal | value | 1.000000e+00 | 0.141 | 7.099 | 1 |
| bpd | socioeconomic_status | 2-medium | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | socioeconomic_status | 3-low | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | education_status | 1-low | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | ivf | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | pe | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | gdm | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | cs | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | gravida | value | 1.000000e+00 | 0.592 | 1.688 | 1 |
| bpd | sex | 1-male | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | multiple_gestation | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | as1 | value | 1.000000e+00 | 0.392 | 2.552 | 1 |
| bpd | as5 | value | 1.000000e+00 | 0.392 | 2.552 | 1 |
| bpd | resuscitation_at_birth | value | 1.000000e+00 | 0.520 | 1.922 | 1 |
| bpd | birthtime_day | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | birthtime_evening | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | birthtime_night | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | steroid_antenatal | value | 1.000000e+00 | 0.375 | 2.664 | 1 |
| bpd | chorioamnionitis | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | surfactant | value | 1.000000e+00 | 0.141 | 7.099 | 1 |
| bpd | bbw_z | value | 1.000000e+00 | 0.375 | 2.664 | 1 |
| bpd | bhc_z | value | 1.000000e+00 | 0.375 | 2.664 | 1 |
| bpd | bw_z_qw | 1-BW z-score <=-1 | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | hc_z_qw | 1-HC z-score <=-1 | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | inotropic | value | 1.000000e+00 | 0.538 | 1.859 | 1 |
| bpd | blood_volume | value | 1.000000e+00 | 0.526 | 1.899 | 1 |
| bpd | transfusion | value | 1.000000e+00 | 0.141 | 7.099 | 1 |
| bpd | blood_culture | value | 1.000000e+00 | 0.526 | 1.899 | 1 |
| bpd | plt | value | 1.000000e+00 | 0.562 | 1.778 | 1 |
| bpd | wbc | value | 1.000000e+00 | 0.375 | 2.664 | 1 |
| bpd | feeding | value | 1.000000e+00 | 0.592 | 1.688 | 1 |
| bpd | ivh | 1-IVH | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | pvl | 1-PVL | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | ischaemic_stroke | 1-ischemia | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | pda_medical | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | pda_surgical | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | non_nec_surg_abd | 1-NEC with surgery | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd | aki | value | 1.000000e+00 | 0.538 | 1.859 | 1 |
| bpd_moderate_severe | fio2_cum_level_qw* | value | 1.005000e+00 | 1.004 | 1.007 | <0.001 |
| bpd_moderate_severe | fio2_cum_level_pct* | value | 1.008000e+00 | 1.004 | 1.012 | <0.001 |
| bpd_moderate_severe | resp_supp_agg_cum_day_qw* | value | 1.074000e+00 | 1.020 | 1.132 | 0.007 |
| bpd_moderate_severe | fio2_cum_day_pct | value | 1.002000e+00 | 0.998 | 1.007 | 0.327 |
| bpd_moderate_severe | ga_wk | value | 8.350000e-01 | 0.542 | 1.287 | 0.415 |
| bpd_moderate_severe | resp_supp_agg_cum_day_pct | value | 9.980000e-01 | 0.992 | 1.003 | 0.441 |
| bpd_moderate_severe | maternal_age | value | 1.018000e+00 | 0.955 | 1.085 | 0.583 |
| bpd_moderate_severe | fio2_cum_day_qw | value | 1.003000e+00 | 0.969 | 1.038 | 0.865 |
| bpd_moderate_severe | nec | value | 9.440000e-01 | 0.485 | 1.837 | 0.866 |
| bpd_moderate_severe | cerebellar_hemorrhage | 3-severe bleeding | 3.143660e+08 | 0.000 | Inf | 0.999 |
| bpd_moderate_severe | steroid_postnatal | value | 1.000000e+00 | 0.141 | 7.099 | 1 |
| bpd_moderate_severe | socioeconomic_status | 2-medium | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | socioeconomic_status | 3-low | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | education_status | 1-low | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | ivf | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | pe | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | gdm | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | cs | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | gravida | value | 1.000000e+00 | 0.592 | 1.688 | 1 |
| bpd_moderate_severe | sex | 1-male | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | multiple_gestation | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | as1 | value | 1.000000e+00 | 0.392 | 2.552 | 1 |
| bpd_moderate_severe | as5 | value | 1.000000e+00 | 0.392 | 2.552 | 1 |
| bpd_moderate_severe | resuscitation_at_birth | value | 1.000000e+00 | 0.520 | 1.922 | 1 |
| bpd_moderate_severe | birthtime_day | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | birthtime_evening | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | birthtime_night | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | steroid_antenatal | value | 1.000000e+00 | 0.375 | 2.664 | 1 |
| bpd_moderate_severe | chorioamnionitis | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | surfactant | value | 1.000000e+00 | 0.141 | 7.099 | 1 |
| bpd_moderate_severe | bbw_z | value | 1.000000e+00 | 0.375 | 2.664 | 1 |
| bpd_moderate_severe | bhc_z | value | 1.000000e+00 | 0.375 | 2.664 | 1 |
| bpd_moderate_severe | bw_z_qw | 1-BW z-score <=-1 | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | hc_z_qw | 1-HC z-score <=-1 | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | inotropic | value | 1.000000e+00 | 0.538 | 1.859 | 1 |
| bpd_moderate_severe | blood_volume | value | 1.000000e+00 | 0.526 | 1.899 | 1 |
| bpd_moderate_severe | transfusion | value | 1.000000e+00 | 0.141 | 7.099 | 1 |
| bpd_moderate_severe | blood_culture | value | 1.000000e+00 | 0.526 | 1.899 | 1 |
| bpd_moderate_severe | plt | value | 1.000000e+00 | 0.562 | 1.778 | 1 |
| bpd_moderate_severe | wbc | value | 1.000000e+00 | 0.375 | 2.664 | 1 |
| bpd_moderate_severe | feeding | value | 1.000000e+00 | 0.592 | 1.688 | 1 |
| bpd_moderate_severe | ivh | 1-IVH | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | pvl | 1-PVL | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | ischaemic_stroke | 1-ischemia | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | pda_medical | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | pda_surgical | 1-yes | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | non_nec_surg_abd | 1-NEC with surgery | 1.000000e+00 | 0.020 | 50.397 | 1 |
| bpd_moderate_severe | aki | value | 1.000000e+00 | 0.538 | 1.859 | 1 |
| eugr_hc | resp_supp_agg_cum_day_qw* | value | 1.076000e+00 | 1.072 | 1.079 | <0.001 |
| eugr_hc | fio2_cum_day_qw* | value | 1.070000e+00 | 1.066 | 1.073 | <0.001 |
| eugr_hc | fio2_cum_level_qw* | value | 1.002000e+00 | 1.002 | 1.002 | <0.001 |
| eugr_hc | steroid_postnatal* | value | 1.545000e+00 | 1.420 | 1.682 | <0.001 |
| eugr_hc | ga_wk* | value | 6.400000e-01 | 0.571 | 0.717 | <0.001 |
| eugr_hc | as5* | value | 6.820000e-01 | 0.578 | 0.804 | <0.001 |
| eugr_hc | surfactant* | value | 1.972000e+00 | 1.576 | 2.469 | <0.001 |
| eugr_hc | inotropic* | value | 1.386000e+00 | 1.356 | 1.418 | <0.001 |
| eugr_hc | blood_volume* | value | 1.310000e+00 | 1.267 | 1.355 | <0.001 |
| eugr_hc | transfusion* | value | 1.435000e+00 | 1.365 | 1.509 | <0.001 |
| eugr_hc | blood_culture* | value | 1.267000e+00 | 1.226 | 1.309 | <0.001 |
| eugr_hc | plt* | value | 1.390000e+00 | 1.355 | 1.425 | <0.001 |
| eugr_hc | wbc* | value | 1.155000e+00 | 1.097 | 1.217 | <0.001 |
| eugr_hc | feeding* | value | 7.470000e-01 | 0.736 | 0.758 | <0.001 |
| eugr_hc | ivh* | 1-IVH | 1.767000e+00 | 1.298 | 2.405 | <0.001 |
| eugr_hc | cerebellar_hemorrhage* | 3-severe bleeding | 8.200000e+00 | 1.142 | 58.898 | <0.001 |
| eugr_hc | ischaemic_stroke* | 1-ischemia | 4.469000e+00 | 1.853 | 10.777 | <0.001 |
| eugr_hc | non_nec_surg_abd* | 1-NEC with surgery | 4.023000e+00 | 2.277 | 7.106 | <0.001 |
| eugr_hc | aki* | value | 1.201000e+00 | 1.087 | 1.328 | <0.001 |
| eugr_hc | resp_supp_agg_cum_day_pct* | value | 1.014000e+00 | 1.013 | 1.015 | 0.001 |
| eugr_hc | as1* | value | 6.770000e-01 | 0.540 | 0.848 | 0.001 |
| eugr_hc | pda_medical* | 1-yes | 1.538000e+00 | 1.302 | 1.816 | 0.001 |
| eugr_hc | pda_surgical* | 1-yes | 1.805000e+00 | 1.162 | 2.804 | 0.004 |
| eugr_hc | hc_z_qw* | 1-HC z-score <=-1 | 1.508000e+00 | 1.411 | 1.611 | 0.006 |
| eugr_hc | fio2_cum_level_pct* | value | 1.009000e+00 | 1.008 | 1.010 | 0.007 |
| eugr_hc | fio2_cum_day_pct* | value | 1.008000e+00 | 1.007 | 1.009 | 0.02 |
| eugr_hc | multiple_gestation* | 1-yes | 1.577000e+00 | 1.005 | 2.476 | 0.048 |
| eugr_hc | resuscitation_at_birth | value | 1.087000e+00 | 0.987 | 1.197 | 0.089 |
| eugr_hc | birthtime_evening | 1-yes | 6.510000e-01 | 0.390 | 1.086 | 0.1 |
| eugr_hc | steroid_antenatal | value | 8.650000e-01 | 0.726 | 1.030 | 0.103 |
| eugr_hc | socioeconomic_status | 2-medium | 6.640000e-01 | 0.397 | 1.112 | 0.12 |
| eugr_hc | bw_z_qw | 1-BW z-score <=-1 | 1.296000e+00 | 1.221 | 1.376 | 0.12 |
| eugr_hc | bhc_z | value | 1.207000e+00 | 0.944 | 1.543 | 0.133 |
| eugr_hc | socioeconomic_status | 3-low | 6.870000e-01 | 0.379 | 1.246 | 0.216 |
| eugr_hc | birthtime_day | 1-yes | 1.305000e+00 | 0.846 | 2.012 | 0.229 |
| eugr_hc | chorioamnionitis | 1-yes | 7.040000e-01 | 0.343 | 1.446 | 0.339 |
| eugr_hc | education_status | 1-low | 8.290000e-01 | 0.526 | 1.308 | 0.421 |
| eugr_hc | ivf | 1-yes | 1.201000e+00 | 0.736 | 1.959 | 0.464 |
| eugr_hc | pe | 1-yes | 8.280000e-01 | 0.480 | 1.428 | 0.497 |
| eugr_hc | bbw_z | value | 9.150000e-01 | 0.692 | 1.211 | 0.536 |
| eugr_hc | gdm | 1-yes | 7.550000e-01 | 0.250 | 2.281 | 0.618 |
| eugr_hc | cs | 1-yes | 1.103000e+00 | 0.701 | 1.737 | 0.672 |
| eugr_hc | gravida | value | 9.720000e-01 | 0.833 | 1.135 | 0.722 |
| eugr_hc | birthtime_night | 1-yes | 1.093000e+00 | 0.650 | 1.836 | 0.738 |
| eugr_hc | maternal_age | value | 9.940000e-01 | 0.954 | 1.037 | 0.788 |
| eugr_hc | sex | 1-male | 1.026000e+00 | 0.665 | 1.583 | 0.907 |
| eugr_hc | nec | value | 1.013000e+00 | 0.826 | 1.242 | 0.907 |
| eugr_hc | pvl | 1-PVL | 9.830000e-01 | 0.201 | 4.800 | 0.983 |
| eugr_bw | resp_supp_agg_cum_day_qw* | value | 1.058000e+00 | 1.054 | 1.061 | <0.001 |
| eugr_bw | fio2_cum_day_qw* | value | 1.053000e+00 | 1.050 | 1.056 | <0.001 |
| eugr_bw | fio2_cum_level_qw* | value | 1.002000e+00 | 1.001 | 1.002 | <0.001 |
| eugr_bw | ga_wk* | value | 7.190000e-01 | 0.644 | 0.802 | <0.001 |
| eugr_bw | as5* | value | 7.300000e-01 | 0.615 | 0.867 | <0.001 |
| eugr_bw | surfactant* | value | 1.540000e+00 | 1.223 | 1.940 | <0.001 |
| eugr_bw | hc_z_qw* | 1-HC z-score <=-1 | 2.084000e+00 | 1.935 | 2.246 | <0.001 |
| eugr_bw | inotropic* | value | 1.317000e+00 | 1.285 | 1.350 | <0.001 |
| eugr_bw | blood_volume* | value | 1.328000e+00 | 1.282 | 1.375 | <0.001 |
| eugr_bw | transfusion* | value | 1.382000e+00 | 1.308 | 1.460 | <0.001 |
| eugr_bw | blood_culture* | value | 1.224000e+00 | 1.180 | 1.269 | <0.001 |
| eugr_bw | plt* | value | 1.362000e+00 | 1.325 | 1.400 | <0.001 |
| eugr_bw | wbc* | value | 1.151000e+00 | 1.089 | 1.217 | <0.001 |
| eugr_bw | feeding* | value | 7.080000e-01 | 0.696 | 0.719 | <0.001 |
| eugr_bw | cerebellar_hemorrhage* | 3-severe bleeding | 9.548000e+00 | 1.327 | 68.706 | <0.001 |
| eugr_bw | non_nec_surg_abd* | 1-NEC with surgery | 3.110000e+00 | 1.613 | 5.997 | <0.001 |
| eugr_bw | aki* | value | 1.223000e+00 | 1.105 | 1.353 | <0.001 |
| eugr_bw | resuscitation_at_birth* | value | 1.177000e+00 | 1.070 | 1.294 | 0.001 |
| eugr_bw | resp_supp_agg_cum_day_pct* | value | 1.014000e+00 | 1.012 | 1.015 | 0.002 |
| eugr_bw | pda_medical* | 1-yes | 1.517000e+00 | 1.270 | 1.814 | 0.002 |
| eugr_bw | pda_surgical* | 1-yes | 1.857000e+00 | 1.167 | 2.954 | 0.004 |
| eugr_bw | fio2_cum_level_pct* | value | 1.009000e+00 | 1.008 | 1.011 | 0.007 |
| eugr_bw | steroid_postnatal* | value | 1.390000e+00 | 1.261 | 1.532 | 0.012 |
| eugr_bw | bw_z_qw* | 1-BW z-score <=-1 | 1.534000e+00 | 1.439 | 1.636 | 0.014 |
| eugr_bw | as1* | value | 7.640000e-01 | 0.608 | 0.961 | 0.022 |
| eugr_bw | fio2_cum_day_pct* | value | 1.007000e+00 | 1.006 | 1.008 | 0.05 |
| eugr_bw | nec | value | 1.165000e+00 | 0.977 | 1.390 | 0.074 |
| eugr_bw | bhc_z | value | 8.630000e-01 | 0.708 | 1.052 | 0.144 |
| eugr_bw | education_status | 1-low | 1.368000e+00 | 0.861 | 2.173 | 0.185 |
| eugr_bw | ivh | 1-IVH | 1.235000e+00 | 0.849 | 1.796 | 0.199 |
| eugr_bw | sex | 1-male | 1.339000e+00 | 0.842 | 2.127 | 0.217 |
| eugr_bw | pe | 1-yes | 1.301000e+00 | 0.764 | 2.218 | 0.333 |
| eugr_bw | socioeconomic_status | 2-medium | 7.800000e-01 | 0.445 | 1.369 | 0.387 |
| eugr_bw | bbw_z | value | 8.860000e-01 | 0.665 | 1.180 | 0.407 |
| eugr_bw | birthtime_evening | 1-yes | 1.227000e+00 | 0.749 | 2.011 | 0.416 |
| eugr_bw | multiple_gestation | 1-yes | 1.175000e+00 | 0.725 | 1.907 | 0.512 |
| eugr_bw | birthtime_night | 1-yes | 8.650000e-01 | 0.489 | 1.527 | 0.616 |
| eugr_bw | chorioamnionitis | 1-yes | 8.590000e-01 | 0.416 | 1.771 | 0.68 |
| eugr_bw | ischaemic_stroke | 1-ischemia | 7.080000e-01 | 0.100 | 5.033 | 0.728 |
| eugr_bw | birthtime_day | 1-yes | 9.290000e-01 | 0.590 | 1.461 | 0.749 |
| eugr_bw | socioeconomic_status | 3-low | 1.105000e+00 | 0.597 | 2.048 | 0.75 |
| eugr_bw | steroid_antenatal | value | 9.780000e-01 | 0.808 | 1.183 | 0.818 |
| eugr_bw | pvl | 1-PVL | 1.174000e+00 | 0.240 | 5.742 | 0.843 |
| eugr_bw | ivf | 1-yes | 9.490000e-01 | 0.558 | 1.616 | 0.848 |
| eugr_bw | gdm | 1-yes | 9.090000e-01 | 0.300 | 2.752 | 0.866 |
| eugr_bw | maternal_age | value | 1.003000e+00 | 0.960 | 1.048 | 0.887 |
| eugr_bw | gravida | value | 9.930000e-01 | 0.845 | 1.167 | 0.934 |
| eugr_bw | cs | 1-yes | 9.940000e-01 | 0.619 | 1.596 | 0.979 |
| hearing | resp_supp_agg_cum_day_qw* | value | 1.064000e+00 | 1.059 | 1.070 | <0.001 |
| hearing | fio2_cum_day_qw* | value | 1.066000e+00 | 1.061 | 1.072 | <0.001 |
| hearing | fio2_cum_level_qw* | value | 1.002000e+00 | 1.001 | 1.002 | <0.001 |
| hearing | ga_wk* | value | 6.670000e-01 | 0.568 | 0.782 | <0.001 |
| hearing | hc_z_qw* | 1-HC z-score <=-1 | 2.971000e+00 | 2.614 | 3.376 | <0.001 |
| hearing | blood_volume* | value | 1.234000e+00 | 1.163 | 1.310 | <0.001 |
| hearing | transfusion* | value | 1.514000e+00 | 1.397 | 1.640 | <0.001 |
| hearing | blood_culture* | value | 1.307000e+00 | 1.244 | 1.373 | <0.001 |
| hearing | plt* | value | 1.409000e+00 | 1.354 | 1.467 | <0.001 |
| hearing | wbc* | value | 1.227000e+00 | 1.134 | 1.329 | <0.001 |
| hearing | feeding* | value | 6.950000e-01 | 0.677 | 0.713 | <0.001 |
| hearing | cerebellar_hemorrhage | 3-severe bleeding | 0.000000e+00 | 0.000 | Inf | <0.001 |
| hearing | pda_medical* | 1-yes | 2.120000e+00 | 1.663 | 2.703 | <0.001 |
| hearing | inotropic* | value | 1.281000e+00 | 1.230 | 1.333 | 0.001 |
| hearing | bw_z_qw* | 1-BW z-score <=-1 | 2.439000e+00 | 2.196 | 2.708 | 0.004 |
| hearing | bhc_z* | value | 7.050000e-01 | 0.553 | 0.899 | 0.005 |
| hearing | bbw_z* | value | 6.610000e-01 | 0.468 | 0.932 | 0.018 |
| hearing | non_nec_surg_abd* | 1-NEC with surgery | 2.993000e+00 | 1.118 | 8.015 | 0.021 |
| hearing | ivh | 1-IVH | 1.605000e+00 | 0.948 | 2.716 | 0.03 |
| hearing | pda_surgical | 1-yes | 1.954000e+00 | 0.973 | 3.924 | 0.035 |
| hearing | surfactant | value | 1.323000e+00 | 0.942 | 1.856 | 0.106 |
| hearing | steroid_postnatal | value | 1.364000e+00 | 1.169 | 1.591 | 0.114 |
| hearing | resp_supp_agg_cum_day_pct | value | 1.011000e+00 | 1.009 | 1.013 | 0.133 |
| hearing | pe | 1-yes | 4.470000e-01 | 0.154 | 1.295 | 0.138 |
| hearing | aki | value | 1.144000e+00 | 0.943 | 1.388 | 0.175 |
| hearing | as1 | value | 7.980000e-01 | 0.569 | 1.119 | 0.19 |
| hearing | ischaemic_stroke | 1-ischemia | 3.415000e+00 | 0.478 | 24.417 | 0.212 |
| hearing | chorioamnionitis | 1-yes | 3.980000e-01 | 0.093 | 1.701 | 0.214 |
| hearing | maternal_age | value | 9.630000e-01 | 0.903 | 1.027 | 0.248 |
| hearing | resuscitation_at_birth | value | 1.077000e+00 | 0.931 | 1.245 | 0.319 |
| hearing | gdm | 1-yes | 1.872000e+00 | 0.527 | 6.644 | 0.332 |
| hearing | as5 | value | 8.900000e-01 | 0.690 | 1.148 | 0.369 |
| hearing | fio2_cum_day_pct | value | 1.004000e+00 | 1.002 | 1.006 | 0.388 |
| hearing | education_status | 1-low | 1.316000e+00 | 0.663 | 2.615 | 0.433 |
| hearing | gravida | value | 9.060000e-01 | 0.701 | 1.171 | 0.452 |
| hearing | socioeconomic_status | 3-low | 6.990000e-01 | 0.270 | 1.810 | 0.461 |
| hearing | socioeconomic_status | 2-medium | 7.510000e-01 | 0.342 | 1.648 | 0.475 |
| hearing | sex | 1-male | 1.190000e+00 | 0.600 | 2.357 | 0.619 |
| hearing | pvl | 1-PVL | 1.629000e+00 | 0.195 | 13.602 | 0.652 |
| hearing | nec | value | 1.090000e+00 | 0.799 | 1.486 | 0.656 |
| hearing | ivf | 1-yes | 1.147000e+00 | 0.537 | 2.450 | 0.723 |
| hearing | multiple_gestation | 1-yes | 1.115000e+00 | 0.543 | 2.288 | 0.767 |
| hearing | fio2_cum_level_pct | value | 9.990000e-01 | 0.997 | 1.000 | 0.786 |
| hearing | cs | 1-yes | 1.029000e+00 | 0.509 | 2.079 | 0.937 |
| hearing | birthtime_day | 1-yes | 1.016000e+00 | 0.519 | 1.991 | 0.962 |
| hearing | birthtime_evening | 1-yes | 9.890000e-01 | 0.464 | 2.107 | 0.977 |
| hearing | birthtime_night | 1-yes | 9.900000e-01 | 0.438 | 2.238 | 0.98 |
| hearing | steroid_antenatal | value | 1.001000e+00 | 0.750 | 1.336 | 0.994 |
| Note: | ||||||
| *, either LB > 1 or UB < 1 and p-value <= 0.05. |
Covariate selection
Multivariate regression analysis
| outcome | variable | term | OR | LB | UB | p.value | covariates |
|---|---|---|---|---|---|---|---|
| survive | ga_wk* | value | 1.740 | 1.518 | 1.995 | <0.001 | |
| survive | as1* | value | 2.976 | 1.671 | 5.299 | <0.001 | as5 |
| survive | steroid_antenatal* | value | 1.416 | 1.177 | 1.704 | <0.001 | |
| survive | bbw_z* | value | 1.566 | 1.223 | 2.005 | <0.001 | |
| survive | fio2_cum_level_qw* | value | 1.002 | 1.001 | 1.003 | <0.001 | |
| survive | as5* | value | 1.607 | 1.186 | 2.178 | 0.002 | as1 |
| survive | surfactant* | value | 0.612 | 0.428 | 0.875 | 0.007 | ga_wk, as5 |
| survive | fio2_cum_day_qw* | value | 1.185 | 1.041 | 1.349 | 0.01 | |
| survive | maternal_age* | value | 1.062 | 1.013 | 1.114 | 0.013 | |
| survive | resp_supp_agg_cum_day_qw* | value | 1.054 | 1.010 | 1.101 | 0.017 | |
| survive | resuscitation_at_birth* | value | 0.872 | 0.774 | 0.983 | 0.025 | as5, as1 |
| survive | fio2_cum_day_pct* | value | 1.029 | 1.001 | 1.058 | 0.039 | |
| survive | fio2_cum_level_pct* | value | 1.027 | 1.000 | 1.055 | 0.046 | |
| rop_severe | transfusion* | value | 1.118 | 1.049 | 1.191 | <0.001 | resp_supp_agg_cum_day_qw, feeding, inotropic, fio2_cum_level_qw, fio2_cum_day_qw, as5, surfactant, resuscitation_at_birth |
| rop_severe | ga_wk* | value | 0.550 | 0.533 | 0.567 | <0.001 | transfusion, resp_supp_agg_cum_day_qw, steroid_postnatal, feeding, inotropic, fio2_cum_level_qw, blood_culture, blood_volume, ivh, fio2_cum_day_qw, plt, hc_z_qw, aki, pda_medical, pda_surgical, non_nec_surg_abd, bw_z_qw |
| rop_severe | ivh* | 1-IVH | 2.388 | 1.647 | 3.462 | <0.001 | |
| rop_severe | aki* | value | 1.280 | 1.139 | 1.438 | <0.001 | |
| rop_severe | wbc* | value | 1.182 | 1.105 | 1.265 | <0.001 | |
| rop_severe | pda_surgical* | 1-yes | 2.358 | 1.391 | 3.995 | <0.001 | |
| rop_severe | non_nec_surg_abd* | 1-NEC with surgery | 3.163 | 1.415 | 7.067 | 0.003 | |
| rop_severe | steroid_postnatal* | value | 1.225 | 1.128 | 1.331 | 0.013 | resp_supp_agg_cum_day_qw, ga_wk, feeding, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, as5, surfactant, as1, bw_z_qw |
| rop_severe | feeding* | value | 0.890 | 0.869 | 0.911 | 0.018 | resp_supp_agg_cum_day_qw, ga_wk, inotropic, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, as5, surfactant, resuscitation_at_birth |
| rop_severe | sex* | 1-male | 1.998 | 1.824 | 2.190 | 0.018 | resp_supp_agg_cum_day_qw, feeding, fio2_cum_level_qw, fio2_cum_day_qw |
| rop_severe | pe* | 1-yes | 0.324 | 0.277 | 0.379 | 0.031 | resp_supp_agg_cum_day_qw, fio2_cum_day_qw |
| rop_severe | blood_culture | value | 1.064 | 1.015 | 1.116 | 0.116 | transfusion, resp_supp_agg_cum_day_qw, feeding, inotropic, fio2_cum_level_qw, fio2_cum_day_qw |
| rop_severe | hc_z_qw | 1-HC z-score <=-1 | 1.364 | 1.204 | 1.546 | 0.147 | resp_supp_agg_cum_day_qw, ga_wk, feeding, fio2_cum_level_qw, fio2_cum_day_qw, as5, surfactant, resuscitation_at_birth, as1, bw_z_qw |
| rop_severe | ivf | 1-yes | 1.462 | 1.344 | 1.591 | 0.159 | resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw |
| rop_severe | blood_volume | value | 1.054 | 1.006 | 1.104 | 0.198 | transfusion, resp_supp_agg_cum_day_qw, ga_wk, feeding, inotropic, fio2_cum_day_qw, as5, surfactant |
| rop_severe | pda_medical | 1-yes | 1.218 | 0.985 | 1.506 | 0.225 | resp_supp_agg_cum_day_qw, feeding, inotropic, surfactant |
| rop_severe | socioeconomic_status | 3-low | 0.677 | 0.601 | 0.763 | 0.301 | resp_supp_agg_cum_day_qw, feeding, fio2_cum_level_qw, fio2_cum_day_qw |
| rop_severe | socioeconomic_status | 2-medium | 0.762 | 0.696 | 0.835 | 0.336 | resp_supp_agg_cum_day_qw, feeding, fio2_cum_level_qw, fio2_cum_day_qw |
| rop_severe | resuscitation_at_birth | value | 1.045 | 1.029 | 1.061 | 0.338 | transfusion, resp_supp_agg_cum_day_qw, steroid_postnatal, feeding, inotropic, fio2_cum_level_qw, blood_culture, blood_volume, ivh, fio2_cum_day_qw, plt, hc_z_qw, aki, pda_medical, pda_surgical, bw_z_qw |
| rop_severe | plt | value | 1.032 | 0.989 | 1.077 | 0.363 | resp_supp_agg_cum_day_qw, ga_wk, feeding, inotropic, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, as5, surfactant, resuscitation_at_birth, bw_z_qw |
| rop_severe | as5 | value | 0.943 | 0.914 | 0.972 | 0.518 | transfusion, resp_supp_agg_cum_day_qw, steroid_postnatal, feeding, inotropic, fio2_cum_level_qw, blood_culture, blood_volume, ivh, fio2_cum_day_qw, plt, hc_z_qw, aki, pda_medical, pda_surgical, non_nec_surg_abd, bw_z_qw |
| rop_severe | resp_supp_agg_cum_day_qw | value | 1.007 | 1.001 | 1.014 | 0.663 | ga_wk, feeding, fio2_cum_day_qw, hc_z_qw, as5, surfactant, resuscitation_at_birth, as1 |
| rop_severe | surfactant | value | 1.051 | 1.002 | 1.104 | 0.746 | transfusion, resp_supp_agg_cum_day_qw, steroid_postnatal, feeding, inotropic, fio2_cum_level_qw, blood_culture, blood_volume, ivh, plt, hc_z_qw, aki, pda_medical, pda_surgical, bw_z_qw |
| rop_severe | bw_z_qw | 1-BW z-score <=-1 | 1.050 | 0.955 | 1.155 | 0.83 | resp_supp_agg_cum_day_qw, ga_wk, feeding, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, as5, as1 |
| rop_severe | as1 | value | 0.969 | 0.928 | 1.013 | 0.837 | resp_supp_agg_cum_day_qw, steroid_postnatal, feeding, inotropic, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, bw_z_qw |
| rop_severe | fio2_cum_day_qw | value | 0.996 | 0.989 | 1.004 | 0.85 | resp_supp_agg_cum_day_qw, ga_wk, feeding, hc_z_qw, as5, resuscitation_at_birth |
| rop_severe | inotropic | value | 1.008 | 0.976 | 1.041 | 0.877 | transfusion, resp_supp_agg_cum_day_qw, ga_wk, feeding, fio2_cum_level_qw, fio2_cum_day_qw, as5, surfactant, resuscitation_at_birth, as1 |
| rop_severe | fio2_cum_level_qw | value | 1.000 | 1.000 | 1.000 | 0.962 | steroid_postnatal, feeding, fio2_cum_day_qw, hc_z_qw, as5, surfactant, resuscitation_at_birth, as1, bw_z_qw |
| bpd | fio2_cum_level_qw* | value | 1.004 | 1.003 | 1.005 | <0.001 | resp_supp_agg_cum_day_qw |
| bpd | fio2_cum_level_pct* | value | 1.009 | 1.005 | 1.013 | <0.001 | |
| bpd | resp_supp_agg_cum_day_qw* | value | 1.082 | 1.024 | 1.143 | 0.005 | |
| bpd_moderate_severe | fio2_cum_level_qw* | value | 1.003 | 1.002 | 1.004 | <0.001 | resp_supp_agg_cum_day_qw |
| bpd_moderate_severe | fio2_cum_level_pct* | value | 1.008 | 1.004 | 1.012 | <0.001 | |
| bpd_moderate_severe | resp_supp_agg_cum_day_qw* | value | 1.074 | 1.020 | 1.132 | 0.007 | |
| eugr_hc | cerebellar_hemorrhage* | 3-severe bleeding | 8.200 | 1.142 | 58.898 | <0.001 | |
| eugr_hc | plt* | value | 1.193 | 1.160 | 1.227 | <0.001 | inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, feeding, ga_wk, fio2_cum_day_qw, surfactant, as5, resp_supp_agg_cum_day_pct |
| eugr_hc | feeding* | value | 0.876 | 0.862 | 0.891 | <0.001 | plt, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, ga_wk, fio2_cum_day_qw, surfactant, as5, as1, resp_supp_agg_cum_day_pct |
| eugr_hc | ga_wk* | value | 0.744 | 0.727 | 0.761 | <0.001 | plt, inotropic, blood_culture, resp_supp_agg_cum_day_qw, transfusion, fio2_cum_level_qw, feeding, blood_volume, fio2_cum_day_qw, non_nec_surg_abd, ivh, steroid_postnatal, aki, pda_medical, pda_surgical, hc_z_qw, fio2_cum_level_pct |
| eugr_hc | ivh* | 1-IVH | 1.767 | 1.298 | 2.405 | <0.001 | |
| eugr_hc | ischaemic_stroke* | 1-ischemia | 4.469 | 1.853 | 10.777 | <0.001 | |
| eugr_hc | aki* | value | 1.201 | 1.087 | 1.328 | <0.001 | |
| eugr_hc | non_nec_surg_abd* | 1-NEC with surgery | 2.003 | 1.134 | 3.540 | 0.002 | feeding |
| eugr_hc | blood_culture* | value | 1.079 | 1.041 | 1.119 | 0.003 | inotropic, resp_supp_agg_cum_day_qw, transfusion, fio2_cum_level_qw, feeding, ga_wk, fio2_cum_day_qw, surfactant |
| eugr_hc | pda_surgical* | 1-yes | 1.805 | 1.162 | 2.804 | 0.004 | |
| eugr_hc | inotropic* | value | 1.087 | 1.060 | 1.115 | 0.01 | plt, resp_supp_agg_cum_day_qw, transfusion, fio2_cum_level_qw, feeding, blood_volume, ga_wk, fio2_cum_day_qw, surfactant, as5, as1, resp_supp_agg_cum_day_pct, fio2_cum_level_pct, fio2_cum_day_pct |
| eugr_hc | surfactant* | value | 1.390 | 1.336 | 1.446 | 0.012 | cerebellar_hemorrhage, plt, inotropic, blood_culture, resp_supp_agg_cum_day_qw, transfusion, fio2_cum_level_qw, feeding, blood_volume, fio2_cum_day_qw, non_nec_surg_abd, ivh, ischaemic_stroke, steroid_postnatal, aki, pda_medical, resp_supp_agg_cum_day_pct, pda_surgical, hc_z_qw, fio2_cum_level_pct |
| eugr_hc | blood_volume | value | 1.051 | 1.014 | 1.088 | 0.055 | plt, inotropic, resp_supp_agg_cum_day_qw, transfusion, fio2_cum_level_qw, feeding, ga_wk, fio2_cum_day_qw, surfactant, as5, resp_supp_agg_cum_day_pct |
| eugr_hc | transfusion | value | 0.960 | 0.910 | 1.013 | 0.062 | inotropic, blood_culture, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, feeding, blood_volume, ga_wk, fio2_cum_day_qw, surfactant, as5, resp_supp_agg_cum_day_pct |
| eugr_hc | steroid_postnatal | value | 1.173 | 1.077 | 1.277 | 0.11 | feeding, surfactant, as5, as1, resp_supp_agg_cum_day_pct, fio2_cum_level_pct |
| eugr_hc | multiple_gestation | 1-yes | 1.345 | 1.266 | 1.429 | 0.112 | transfusion, fio2_cum_level_qw, feeding, blood_volume, fio2_cum_day_qw, ischaemic_stroke, resp_supp_agg_cum_day_pct, fio2_cum_level_pct, fio2_cum_day_pct |
| eugr_hc | as1 | value | 0.879 | 0.851 | 0.908 | 0.214 | cerebellar_hemorrhage, plt, inotropic, blood_culture, resp_supp_agg_cum_day_qw, transfusion, fio2_cum_level_qw, feeding, blood_volume, fio2_cum_day_qw, non_nec_surg_abd, ivh, steroid_postnatal, aki, pda_medical, resp_supp_agg_cum_day_pct, pda_surgical, hc_z_qw, fio2_cum_level_pct, fio2_cum_day_pct |
| eugr_hc | pda_medical | 1-yes | 1.126 | 0.955 | 1.329 | 0.281 | resp_supp_agg_cum_day_qw, feeding, fio2_cum_day_qw |
| eugr_hc | as5 | value | 0.941 | 0.919 | 0.965 | 0.433 | plt, inotropic, blood_culture, resp_supp_agg_cum_day_qw, transfusion, fio2_cum_level_qw, feeding, blood_volume, ga_wk, fio2_cum_day_qw, non_nec_surg_abd, ivh, steroid_postnatal, aki, pda_medical, resp_supp_agg_cum_day_pct, pda_surgical, hc_z_qw, fio2_cum_level_pct, fio2_cum_day_pct |
| eugr_hc | resp_supp_agg_cum_day_qw | value | 1.008 | 1.003 | 1.014 | 0.584 | plt, inotropic, fio2_cum_level_qw, feeding, ga_wk, fio2_cum_day_qw, surfactant, as5, as1 |
| eugr_hc | wbc | value | 1.016 | 0.963 | 1.071 | 0.635 | plt, feeding |
| eugr_hc | hc_z_qw | 1-HC z-score <=-1 | 0.939 | 0.874 | 1.008 | 0.68 | plt, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, feeding, surfactant, as5, as1 |
| eugr_hc | resp_supp_agg_cum_day_pct | value | 1.001 | 1.000 | 1.002 | 0.81 | plt, inotropic, feeding, surfactant, as5, as1, fio2_cum_level_pct, fio2_cum_day_pct |
| eugr_hc | fio2_cum_level_pct | value | 1.001 | 0.999 | 1.002 | 0.836 | inotropic, feeding, as5, as1, resp_supp_agg_cum_day_pct |
| eugr_hc | fio2_cum_level_qw | value | 1.000 | 1.000 | 1.000 | 0.9 | plt, inotropic, resp_supp_agg_cum_day_qw, feeding, ga_wk, fio2_cum_day_qw, surfactant, as5, as1 |
| eugr_hc | fio2_cum_day_pct | value | 1.000 | 0.998 | 1.001 | 0.909 | inotropic, feeding, as5, as1, resp_supp_agg_cum_day_pct |
| eugr_hc | fio2_cum_day_qw | value | 0.999 | 0.994 | 1.004 | 0.95 | inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, feeding, ga_wk, surfactant, as5, as1 |
| eugr_bw | cerebellar_hemorrhage* | 3-severe bleeding | 9.548 | 1.327 | 68.706 | <0.001 | |
| eugr_bw | feeding* | value | 0.782 | 0.768 | 0.796 | <0.001 | resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, ga_wk, surfactant, as5, resp_supp_agg_cum_day_pct |
| eugr_bw | plt* | value | 1.146 | 1.111 | 1.182 | <0.001 | feeding, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, ga_wk, hc_z_qw, surfactant, as5, resuscitation_at_birth, resp_supp_agg_cum_day_pct |
| eugr_bw | ga_wk* | value | 0.781 | 0.761 | 0.800 | <0.001 | feeding, plt, blood_volume, transfusion, blood_culture, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, aki, non_nec_surg_abd, pda_medical, pda_surgical, fio2_cum_level_pct, steroid_postnatal, bw_z_qw |
| eugr_bw | aki* | value | 1.223 | 1.105 | 1.353 | <0.001 | |
| eugr_bw | non_nec_surg_abd* | 1-NEC with surgery | 3.110 | 1.613 | 5.997 | <0.001 | |
| eugr_bw | pda_surgical* | 1-yes | 1.857 | 1.167 | 2.954 | 0.004 | |
| eugr_bw | blood_volume* | value | 1.084 | 1.045 | 1.124 | 0.006 | feeding, plt, transfusion, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_day_qw, ga_wk, surfactant, as5, resp_supp_agg_cum_day_pct |
| eugr_bw | wbc | value | 1.073 | 1.015 | 1.135 | 0.065 | plt |
| eugr_bw | hc_z_qw | 1-HC z-score <=-1 | 1.378 | 1.271 | 1.494 | 0.068 | feeding, plt, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, ga_wk, surfactant, as5, resuscitation_at_birth, as1 |
| eugr_bw | transfusion | value | 0.958 | 0.903 | 1.016 | 0.075 | feeding, blood_volume, blood_culture, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, ga_wk, surfactant, as5, resuscitation_at_birth, resp_supp_agg_cum_day_pct |
| eugr_bw | blood_culture | value | 1.045 | 1.004 | 1.088 | 0.102 | feeding, transfusion, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_day_qw, ga_wk |
| eugr_bw | resuscitation_at_birth | value | 1.057 | 1.043 | 1.071 | 0.185 | feeding, plt, blood_volume, transfusion, blood_culture, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, aki, pda_medical, resp_supp_agg_cum_day_pct, pda_surgical, fio2_cum_level_pct, steroid_postnatal, bw_z_qw, fio2_cum_day_pct |
| eugr_bw | as5 | value | 0.905 | 0.882 | 0.928 | 0.223 | feeding, plt, blood_volume, transfusion, blood_culture, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, aki, non_nec_surg_abd, pda_medical, resp_supp_agg_cum_day_pct, pda_surgical, fio2_cum_level_pct, steroid_postnatal, bw_z_qw, fio2_cum_day_pct |
| eugr_bw | steroid_postnatal | value | 1.160 | 1.052 | 1.280 | 0.249 | surfactant, as5, resp_supp_agg_cum_day_pct, fio2_cum_level_pct |
| eugr_bw | fio2_cum_level_qw | value | 0.999 | 0.999 | 1.000 | 0.3 | feeding, plt, inotropic, ga_wk, hc_z_qw, surfactant, as5, resuscitation_at_birth, as1 |
| eugr_bw | pda_medical | 1-yes | 1.118 | 0.936 | 1.336 | 0.345 | feeding, fio2_cum_day_qw, surfactant |
| eugr_bw | inotropic | value | 1.032 | 1.004 | 1.061 | 0.457 | feeding, plt, blood_volume, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, ga_wk, surfactant, as5, resuscitation_at_birth, resp_supp_agg_cum_day_pct, fio2_cum_level_pct, as1 |
| eugr_bw | bw_z_qw | 1-BW z-score <=-1 | 1.103 | 1.026 | 1.186 | 0.586 | feeding, plt, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, ga_wk, hc_z_qw, surfactant, as5, resuscitation_at_birth, as1 |
| eugr_bw | as1 | value | 0.956 | 0.925 | 0.989 | 0.663 | feeding, plt, blood_volume, transfusion, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, resp_supp_agg_cum_day_pct, fio2_cum_level_pct, steroid_postnatal, bw_z_qw, fio2_cum_day_pct |
| eugr_bw | surfactant | value | 1.055 | 1.013 | 1.098 | 0.669 | cerebellar_hemorrhage, feeding, plt, blood_volume, transfusion, blood_culture, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, aki, non_nec_surg_abd, pda_medical, resp_supp_agg_cum_day_pct, pda_surgical, fio2_cum_level_pct, steroid_postnatal, bw_z_qw, fio2_cum_day_pct |
| eugr_bw | fio2_cum_day_pct | value | 1.001 | 1.000 | 1.002 | 0.733 | feeding, inotropic, as5, resuscitation_at_birth, as1 |
| eugr_bw | resp_supp_agg_cum_day_qw | value | 0.996 | 0.991 | 1.001 | 0.78 | feeding, plt, inotropic, fio2_cum_day_qw, ga_wk, hc_z_qw, surfactant, as5, resuscitation_at_birth, as1 |
| eugr_bw | fio2_cum_level_pct | value | 1.001 | 0.999 | 1.002 | 0.85 | feeding, inotropic, surfactant, as5, resuscitation_at_birth, resp_supp_agg_cum_day_pct, as1 |
| eugr_bw | resp_supp_agg_cum_day_pct | value | 1.001 | 0.999 | 1.002 | 0.864 | feeding, plt, inotropic, surfactant, as5, resuscitation_at_birth, fio2_cum_level_pct, as1 |
| eugr_bw | fio2_cum_day_qw | value | 0.998 | 0.993 | 1.004 | 0.902 | feeding, inotropic, resp_supp_agg_cum_day_qw, ga_wk, hc_z_qw, surfactant, as5, resuscitation_at_birth |
| hearing | plt* | value | 1.153 | 1.100 | 1.208 | <0.001 | feeding, resp_supp_agg_cum_day_qw, ga_wk, hc_z_qw, fio2_cum_day_qw, fio2_cum_level_qw, bw_z_qw, bhc_z, bbw_z |
| hearing | feeding* | value | 0.787 | 0.765 | 0.811 | 0.001 | resp_supp_agg_cum_day_qw, ga_wk, fio2_cum_day_qw |
| hearing | ga_wk* | value | 0.752 | 0.728 | 0.777 | 0.002 | plt, transfusion, feeding, blood_culture, resp_supp_agg_cum_day_qw, hc_z_qw, fio2_cum_day_qw, pda_medical, blood_volume, inotropic, bw_z_qw, non_nec_surg_abd |
| hearing | non_nec_surg_abd* | 1-NEC with surgery | 2.993 | 1.118 | 8.015 | 0.021 | |
| hearing | wbc* | value | 1.103 | 1.017 | 1.197 | 0.041 | feeding |
| hearing | blood_culture* | value | 1.113 | 1.053 | 1.175 | 0.043 | transfusion, feeding, resp_supp_agg_cum_day_qw, ga_wk, fio2_cum_day_qw |
| hearing | pda_medical | 1-yes | 1.308 | 1.026 | 1.669 | 0.126 | ga_wk, fio2_cum_day_qw |
| hearing | bhc_z | value | 0.825 | 0.794 | 0.857 | 0.135 | plt, feeding, resp_supp_agg_cum_day_qw, hc_z_qw, bw_z_qw |
| hearing | fio2_cum_level_qw | value | 1.001 | 1.000 | 1.001 | 0.324 | feeding, hc_z_qw, bw_z_qw |
| hearing | bbw_z | value | 0.845 | 0.800 | 0.892 | 0.34 | plt, feeding, resp_supp_agg_cum_day_qw, hc_z_qw, bw_z_qw |
| hearing | hc_z_qw | 1-HC z-score <=-1 | 1.238 | 1.060 | 1.446 | 0.371 | feeding, resp_supp_agg_cum_day_qw, ga_wk, fio2_cum_day_qw, bw_z_qw, bhc_z, bbw_z |
| hearing | bw_z_qw | 1-BW z-score <=-1 | 1.312 | 1.155 | 1.492 | 0.435 | resp_supp_agg_cum_day_qw, ga_wk, hc_z_qw, fio2_cum_day_qw, bhc_z, bbw_z |
| hearing | transfusion | value | 1.024 | 0.941 | 1.115 | 0.563 | feeding, blood_culture, resp_supp_agg_cum_day_qw, ga_wk, fio2_cum_day_qw, fio2_cum_level_qw, inotropic |
| hearing | inotropic | value | 1.036 | 0.993 | 1.081 | 0.607 | feeding, resp_supp_agg_cum_day_qw, ga_wk, fio2_cum_day_qw, fio2_cum_level_qw |
| hearing | blood_volume | value | 1.028 | 0.967 | 1.093 | 0.648 | feeding, resp_supp_agg_cum_day_qw, ga_wk, fio2_cum_day_qw, inotropic |
| hearing | resp_supp_agg_cum_day_qw | value | 1.007 | 0.999 | 1.014 | 0.759 | plt, feeding, hc_z_qw, fio2_cum_day_qw, bw_z_qw |
| hearing | fio2_cum_day_qw | value | 1.000 | 0.992 | 1.009 | 0.985 | feeding, resp_supp_agg_cum_day_qw, ga_wk, hc_z_qw, bw_z_qw |
| Note: | |||||||
| *, either LB > 1 or UB < 1 and p-value <= 0.05. |
Figure 4. Effect size changes before and after adjustment for confounders.
Feature selection
Dimensional reduction
| outcome | type | min_epv | cat | n | pred | epv | max_pred |
|---|---|---|---|---|---|---|---|
| survive* | baseline | 20 | 0 | 67 | 8 | 9 | 2 |
| survive | residual | 20 | 0 | 811 | 7 | 116 | 38 |
| survive* | residual | 150 | 0 | 811 | 7 | 116 | 3 |
| survive* | residual | 200 | 0 | 811 | 7 | 116 | 2 |
| rop_severe | residual | 20 | 1 | 2394 | 10 | 240 | 117 |
| rop_severe | residual | 150 | 1 | 2394 | 10 | 240 | 13 |
| rop_severe* | residual | 200 | 1 | 2394 | 10 | 240 | 9 |
| bpd | baseline | 20 | 1 | 160 | 0 | Inf | 7 |
| bpd | residual | 20 | 1 | 6720 | 4 | 1680 | 334 |
| bpd | residual | 150 | 1 | 6720 | 4 | 1680 | 42 |
| bpd | residual | 200 | 1 | 6720 | 4 | 1680 | 31 |
| bpd_moderate_severe | baseline | 20 | 1 | 143 | 0 | Inf | 6 |
| bpd_moderate_severe | residual | 20 | 1 | 6006 | 4 | 1502 | 298 |
| bpd_moderate_severe | residual | 150 | 1 | 6006 | 4 | 1502 | 38 |
| bpd_moderate_severe | residual | 200 | 1 | 6006 | 4 | 1502 | 28 |
| eugr_hc | baseline | 20 | 1 | 107 | 2 | 54 | 4 |
| eugr_hc | residual | 20 | 1 | 4494 | 12 | 375 | 222 |
| eugr_hc | residual | 150 | 1 | 4494 | 12 | 375 | 27 |
| eugr_hc | residual | 200 | 1 | 4494 | 12 | 375 | 20 |
| eugr_bw | baseline | 20 | 1 | 93 | 1 | 93 | 3 |
| eugr_bw | residual | 20 | 1 | 3906 | 9 | 434 | 193 |
| eugr_bw | residual | 150 | 1 | 3906 | 9 | 434 | 24 |
| eugr_bw | residual | 200 | 1 | 3906 | 9 | 434 | 17 |
| hearing | residual | 20 | 1 | 1554 | 7 | 222 | 75 |
| hearing | residual | 150 | 1 | 1554 | 7 | 222 | 8 |
| hearing* | residual | 200 | 1 | 1554 | 7 | 222 | 5 |
| Note: | |||||||
| *, require dimensional reduction. |
Figure 5. Dimensional reduction model weights for predictors of: (A) survival baseline prediction (min. 20 EPV); (B) survival residual prediction (min. 150 EPV); (C) survival residual prediction (min. 200 EPV); (D) hearing residual prediction (min. 200 EPV); and (E) severe ROP residual prediction (min. 200 EPV). PVE, proportion of variance explained
Predictive modeling
## survive: survive
## rop_severe: survive -> rop_severe
## bpd: survive -> bpd
## bpd_moderate_severe: survive -> bpd -> bpd_moderate_severe
## eugr_hc: survive -> eugr_hc
## eugr_bw: survive -> eugr_bw
## rop_severe: survive -> hearing| outcome | type | pred | min_epv | algorithm |
|---|---|---|---|---|
| survive | baseline | 8 | 20 | rr |
| residual | 7 | 20 | rr | |
| 150 | rf | |||
| gbm | ||||
| 200 | dnn | |||
| rop_severe | residual | 10 | 20 | rr |
| 150 | rf | |||
| gbm | ||||
| 200 | dnn | |||
| bpd | residual | 4 | 20 | rr |
| 150 | rf | |||
| gbm | ||||
| 200 | dnn | |||
| bpd_moderate_severe | residual | 4 | 20 | rr |
| 150 | rf | |||
| gbm | ||||
| 200 | dnn | |||
| eugr_hc | baseline | 2 | 20 | rr |
| residual | 12 | 20 | rr | |
| 150 | rf | |||
| gbm | ||||
| 200 | dnn | |||
| eugr_bw | baseline | 1 | 20 | rr |
| residual | 9 | 20 | rr | |
| 150 | rf | |||
| gbm | ||||
| 200 | dnn | |||
| hearing | residual | 7 | 20 | rr |
| 150 | rf | |||
| gbm | ||||
| 200 | dnn | |||
| Note: | ||||
| EPV, event per variable |
Survival prediction
Severe ROP prediction
BPD prediction
Moderate/severe BPD prediction
EUGR-HC prediction
EUGR-BW prediction
Failed hearing test prediction
Model evaluation
Evaluation metrics
Survival baseline
Figure 6. Survival baseline prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.
Survival stack
Figure 7. Survival stacked prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.
Severe ROP stack
Figure 8. Severe ROP stacked prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.
BPD stack
Figure 9. BPD stacked prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.
Moderate/severe BPD stack
Figure 10. Moderate/severe BPD stacked prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.
EUGR-HC baseline
Figure 11. EUGR-HC baseline prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.
EUGR-HC stack
Figure 12. EUGR-HC stacked prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.
EUGR-BW baseline
Figure 13. EUGR-BW baseline prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.
EUGR-BW stack
Figure 14. EUGR-BW stacked prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.
Failed hearing test stack
Figure 15. Failed hearing test stacked prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.
Predictive performance
| model | dataset | AUC-ROC | TH | F1 | TNR | TPR | PPV | NPV |
|---|---|---|---|---|---|---|---|---|
| bpd_moderate_severe_stack_rf | Modeling | 0.86 ( 0.86, 0.86) | 0.32 | 0.69 ( 0.69, 0.70) | 83.28 (83.09, 83.46) | 75.82 (75.51, 76.14) | 64.15 (63.84, 64.46) | 89.72 (89.55, 89.89) |
| Independent test | 0.69 ( 0.69, 0.69) | 0.32 | 0.57 ( 0.56, 0.57) | 77.34 (76.97, 77.71) | 56.70 (56.15, 57.24) | 57.02 (56.45, 57.59) | 77.11 (76.78, 77.44) | |
| bpd_stack_rf | Modeling | 0.87 ( 0.87, 0.87) | 0.31 | 0.70 ( 0.70, 0.70) | 80.55 (80.36, 80.74) | 73.96 (73.56, 74.36) | 66.12 (65.83, 66.41) | 85.77 (85.53, 86.01) |
| Independent test | 0.73 ( 0.73, 0.73) | 0.31 | 0.58 ( 0.57, 0.58) | 75.81 (75.48, 76.14) | 54.56 (54.07, 55.04) | 61.44 (60.99, 61.89) | 70.25 (69.93, 70.57) | |
| eugr_bw_baseline2_rr | Modeling | 0.82 ( 0.80, 0.84) | 0.21 | 0.58 ( 0.55, 0.60) | 82.19 (80.93, 83.46) | 69.25 (65.69, 72.81) | 49.67 (46.57, 52.76) | 91.24 (90.11, 92.38) |
| Independent test | 0.67 ( 0.64, 0.69) | 0.21 | 0.42 ( 0.38, 0.45) | 74.37 (72.50, 76.25) | 51.95 (47.94, 55.97) | 35.30 (31.68, 38.92) | 85.45 (84.12, 86.77) | |
| eugr_bw_stack_rr | Modeling | 0.90 ( 0.90, 0.90) | 0.17 | 0.61 ( 0.61, 0.61) | 74.87 (74.63, 75.10) | 86.89 (86.57, 87.20) | 46.87 (46.46, 47.28) | 95.72 (95.61, 95.83) |
| Independent test | 0.77 ( 0.77, 0.77) | 0.17 | 0.50 ( 0.49, 0.51) | 73.26 (72.93, 73.58) | 69.19 (68.48, 69.90) | 39.18 (38.60, 39.77) | 90.52 (90.26, 90.77) | |
| eugr_hc_baseline2_rr | Modeling | 0.88 ( 0.87, 0.89) | 0.18 | 0.65 ( 0.64, 0.67) | 73.98 (73.00, 74.95) | 88.32 (86.55, 90.10) | 52.20 (50.39, 54.01) | 95.08 (94.28, 95.88) |
| Independent test | 0.83 ( 0.81, 0.85) | 0.18 | 0.56 ( 0.53, 0.60) | 75.12 (73.47, 76.77) | 83.17 (78.95, 87.39) | 43.35 (39.63, 47.06) | 95.11 (93.72, 96.49) | |
| eugr_hc_stack_rr | Modeling | 0.91 ( 0.91, 0.91) | 0.25 | 0.73 ( 0.72, 0.73) | 88.51 (88.34, 88.68) | 77.93 (77.49, 78.38) | 67.89 (67.50, 68.27) | 92.79 (92.63, 92.94) |
| Independent test | 0.85 ( 0.85, 0.86) | 0.25 | 0.67 ( 0.66, 0.67) | 85.61 (85.38, 85.84) | 81.97 (81.44, 82.50) | 56.42 (55.77, 57.07) | 95.43 (95.29, 95.57) | |
| hearing_stack_rr | Modeling | 0.78 ( 0.78, 0.79) | 0.07 | 0.35 ( 0.34, 0.35) | 71.79 (71.58, 72.00) | 73.76 (73.13, 74.39) | 22.55 (22.16, 22.95) | 96.09 (95.98, 96.20) |
| Independent test | 0.71 ( 0.70, 0.72) | 0.07 | 0.30 ( 0.30, 0.31) | 71.91 (71.62, 72.20) | 66.69 (65.66, 67.72) | 19.72 (19.27, 20.17) | 95.43 (95.27, 95.58) | |
| rop_severe_stack_rr | Modeling | 0.87 ( 0.87, 0.88) | 0.13 | 0.53 ( 0.53, 0.53) | 82.84 (82.67, 83.00) | 81.67 (81.21, 82.13) | 39.28 (38.84, 39.72) | 97.08 (96.99, 97.16) |
| Independent test | 0.90 ( 0.90, 0.91) | 0.13 | 0.47 ( 0.46, 0.48) | 79.07 (78.75, 79.40) | 85.09 (84.39, 85.80) | 32.47 (31.86, 33.09) | 97.82 (97.72, 97.92) | |
| survive_baseline1_rr | Modeling | 0.84 ( 0.83, 0.86) | 0.82 | 0.87 ( 0.86, 0.88) | 76.69 (73.76, 79.62) | 80.81 (79.37, 82.25) | 94.65 (93.92, 95.38) | 44.07 (41.79, 46.35) |
| Independent test | 0.81 ( 0.79, 0.83) | 0.82 | 0.91 ( 0.90, 0.92) | 58.81 (53.24, 64.38) | 88.58 (87.48, 89.69) | 93.04 (91.86, 94.22) | 44.94 (40.43, 49.46) | |
| survive_stack_dnn | Modeling | 0.85 ( 0.84, 0.86) | 0.93 | 0.93 ( 0.93, 0.93) | 67.15 (66.03, 68.28) | 88.18 (88.04, 88.33) | 98.64 (98.59, 98.69) | 17.39 (16.97, 17.81) |
| Independent test | 0.92 ( 0.91, 0.92) | 0.93 | 0.94 ( 0.94, 0.94) | 75.05 (73.13, 76.97) | 89.73 (89.51, 89.96) | 99.45 (99.39, 99.50) | 12.77 (12.10, 13.45) | |
| Note: | ||||||||
| AUC-ROC, area under the curve - receiver operating characteristics; TH, the chosen threshold, balanced sensitivity and specificity; F1, the F1-score; TNR, true negative rate (specificity); TPR, true positive rate (sensitivity/recall); PPV, positive predictive value (precision); NPV, negative predictive value. |
mutate(cm_selected_time_summary_val, set = "Validation") |>
rbind(mutate(cm_selected_time_summary, set = "Test")) |>
timing_selection_plot("survive", "t_7")
Figure 16. Performance for predicting survival at particular time using the chosen threshold. The best timing was selected according to TPR and PPV using validation set. PPV, positive predictive value or precision; TPR, true positive rate or sensitivity.
mutate(cm_selected_time_summary_val, set = "Validation") |>
rbind(mutate(cm_selected_time_summary, set = "Test")) |>
timing_selection_plot("rop_severe", "t_14")
Figure 17. Performance for predicting severe ROP at particular time using the chosen threshold. The best timing was selected according to TPR, TNR, and NPV using validation set. NPV, negative predictive value; ROP, retinopathy of prematurity; TNR, true negative rate or specificity; TPR, true positive rate or sensitivity.
mutate(cm_selected_time_summary_val, set = "Validation") |>
rbind(mutate(cm_selected_time_summary, set = "Test")) |>
timing_selection_plot("bpd", "t_28")
Figure 18. Performance for predicting BPD at particular time using the chosen threshold. The best timing was selected according to TPR, TNR, and NPV using validation set. BPD, bronchopulmonary disease; NPV, negative predictive value; TNR, true negative rate or specificity; TPR, true positive rate or sensitivity.
mutate(cm_selected_time_summary_val, set = "Validation") |>
rbind(mutate(cm_selected_time_summary, set = "Test")) |>
timing_selection_plot("bpd_moderate_severe", "t_28")
Figure 19. Performance for predicting moderate-to-severe BPD at particular time using the chosen threshold. The best timing was selected according to TPR, TNR, and NPV using validation set. BPD, bronchopulmonary disease; NPV, negative predictive value; TNR, true negative rate or specificity; TPR, true positive rate or sensitivity.
mutate(cm_selected_time_summary_val, set = "Validation") |>
rbind(mutate(cm_selected_time_summary, set = "Test")) |>
timing_selection_plot("eugr_hc", "t_28")
Figure 20. Performance for predicting EUGR-HC at particular time using the chosen threshold. The best timing was selected according to TPR, PPV, TNR, and NPV using validation set. EUGR-HC, extrauterine growth restriction by head circumference; NPV, negative predictive value; PPV, positive predictive value or precision; TNR, true negative rate or specificity; TPR, true positive rate or sensitivity.
mutate(cm_selected_time_summary_val, set = "Validation") |>
rbind(mutate(cm_selected_time_summary, set = "Test")) |>
timing_selection_plot("eugr_bw", "t_14")
Figure 21. Performance for predicting EUGR-BW at particular time using the chosen threshold. The best timing was selected according to TPR and NPV using validation set. EUGR-BW, extrauterine growth restriction by body weight; NPV, negative predictive value; TPR, true positive rate or sensitivity.
mutate(cm_selected_time_summary_val, set = "Validation") |>
rbind(mutate(cm_selected_time_summary, set = "Test")) |>
timing_selection_plot("hearing", "t_14")
Figure 22. Performance for predicting failed hearing test at particular time using the chosen threshold. The best timing was selected according to TPR, TNR, and NPV using validation set. NPV, negative predictive value; TNR, true negative rate or specificity; TPR, true positive rate or sensitivity.
Figure 23. Predictive performance using independent test sets at particular time.
| outcome | timing | TH | dataset | F1 | TNR | TPR | PPV | NPV |
|---|---|---|---|---|---|---|---|---|
| survive | 1 | 0.93 | Independent test | 0.84 ( 0.82, 0.85) | 74.10 ( 67.98, 80.21) | 73.75 ( 71.59, 75.92) | 96.72 ( 95.90, 97.54) | 22.89 ( 19.29, 26.49) |
| Modeling | 0.89 ( 0.89, 0.90) | 75.66 ( 69.80, 81.52) | 81.91 ( 80.83, 82.99) | 98.34 ( 97.91, 98.76) | 19.53 ( 17.14, 21.92) | |||
| rop_severe | 2 | 0.13 | Independent test | 0.58 ( 0.55, 0.61) | 71.19 ( 68.55, 73.84) | 92.90 ( 89.99, 95.82) | 42.56 ( 39.42, 45.71) | 97.73 ( 96.81, 98.66) |
| Modeling | 0.50 ( 0.47, 0.52) | 82.37 ( 81.32, 83.41) | 79.70 ( 75.95, 83.45) | 36.30 ( 33.87, 38.73) | 96.98 ( 96.42, 97.55) | |||
| bpd | 3 | 0.31 | Independent test | 0.79 ( 0.77, 0.81) | 68.36 ( 66.32, 70.41) | 94.02 ( 92.41, 95.63) | 68.49 ( 66.16, 70.83) | 93.75 ( 92.00, 95.50) |
| Modeling | 0.73 ( 0.71, 0.75) | 78.36 ( 76.59, 80.14) | 81.96 ( 80.07, 83.85) | 65.79 ( 63.56, 68.02) | 89.58 ( 88.39, 90.76) | |||
| bpd_moderate_severe | 3 | 0.32 | Independent test | 0.70 ( 0.68, 0.73) | 63.99 ( 62.00, 65.99) | 89.16 ( 87.20, 91.12) | 58.62 ( 56.01, 61.23) | 90.94 ( 89.15, 92.72) |
| Modeling | 0.73 ( 0.71, 0.75) | 85.69 ( 84.32, 87.05) | 78.30 ( 75.93, 80.67) | 68.28 ( 65.67, 70.89) | 90.95 ( 89.86, 92.05) | |||
| eugr_hc | 3 | 0.25 | Independent test | 0.75 ( 0.73, 0.76) | 82.60 ( 80.37, 84.83) | 86.87 ( 84.21, 89.52) | 66.11 ( 63.48, 68.73) | 94.32 ( 93.25, 95.40) |
| Modeling | 0.77 ( 0.75, 0.78) | 89.59 ( 88.73, 90.44) | 82.76 ( 80.50, 85.02) | 71.91 ( 69.81, 74.02) | 94.17 ( 93.39, 94.95) | |||
| eugr_bw | 2 | 0.17 | Independent test | 0.76 ( 0.73, 0.78) | 67.81 ( 65.61, 70.00) | 100.00 (100.00, 100.00) | 61.00 ( 58.27, 63.73) | 100.00 (100.00, 100.00) |
| Modeling | 0.60 ( 0.57, 0.62) | 73.47 ( 71.90, 75.04) | 87.15 ( 84.82, 89.48) | 45.58 ( 43.16, 48.00) | 95.55 ( 94.59, 96.50) | |||
| hearing | 2 | 0.07 | Independent test | 0.40 ( 0.36, 0.43) | 63.64 ( 61.58, 65.70) | 100.00 (100.00, 100.00) | 25.06 ( 22.54, 27.58) | 100.00 (100.00, 100.00) |
| Modeling | 0.29 ( 0.26, 0.32) | 67.83 ( 66.22, 69.44) | 69.88 ( 64.57, 75.19) | 18.61 ( 16.46, 20.76) | 95.57 ( 94.75, 96.39) | |||
| Note: | ||||||||
| *, No positives or no predicted positives; †, No negatives; ‡, No positives; §, No predicted positives; ¶, No predicted negatives; TH, the chosen threshold, balanced sensitivity and specificity; F1, the F1-score; TNR, true negative rate (specificity); TPR, true positive rate (sensitivity/recall); PPV, positive predictive value (precision); NPV, negative predictive value. |
Figure 24. Predictive performance of BPD prediction models in our study versus previous studies. *, Kwok TC et al. (2023) did not summarize the estimates; hence, each individual’s c-statistics are shown (n=6); BPD, bronchopulmonary disease; CI, confidence interval; PI, prediction interval.
Figure 25. Predictive performance of moderate/severe BPD prediction models in our study versus previous studies. BPD, bronchopulmonary disease; CI, confidence interval.
Model deployment
Figure 26. A case with ~50% truly-predicted survive and ~20% truly-predicted positives for other outcomes.
Figure 27. Survival trajectories with ~90% truly and 1+ falsely predicted deaths and ~20% falsely predicted survive. Vertical dashed line indicates death age.
Figure 28. Other outcome trajectories with ~20% truly and ~20% falsely predicted outcomes among ~50% truly predicted survive.
| outcome | at_birth | during_care |
|---|---|---|
| Survival_at_discharge | 7 features: GA, AS1, Antenatal_steroid, BBWZ, AS5, surfactant, Maternal_age, Resuscitation_at_birth | 1 + 6 features: GA, Cumulative_FiO2_Support_concentration_QW, Cumulative_FiO2_Support_days_QW, Cumulative_Aggressive_Resp_Support_days_QW, Cumulative_FiO2_days_percentile, Cumulative_FiO2_concentration_percentile, Age_D |
| severe_ROP | 7 features: GA, AS1, Antenatal_steroid, BBWZ, AS5, surfactant, Maternal_age, Resuscitation_at_birth | 1 + 14 features: GA, Cumulative_FiO2_Support_concentration_QW, Cumulative_FiO2_Support_days_QW, Cumulative_Aggressive_Resp_Support_days_QW, Cumulative_FiO2_days_percentile, Cumulative_FiO2_concentration_percentile, IVH, Transfusion, AKI, Leukopenia_severity, pda_surgical, NonNEC_surgical_abdomen, postnatal_steroid, Feeding, Age_D |
| BPD | 7 features: GA, AS1, Antenatal_steroid, BBWZ, AS5, surfactant, Maternal_age, Resuscitation_at_birth | 1 + 6 features: GA, Cumulative_FiO2_Support_concentration_QW, Cumulative_FiO2_Support_days_QW, Cumulative_Aggressive_Resp_Support_days_QW, Cumulative_FiO2_days_percentile, Cumulative_FiO2_concentration_percentile, Age_D |
| BPD_moderate_severe | 7 features: GA, AS1, Antenatal_steroid, BBWZ, AS5, surfactant, Maternal_age, Resuscitation_at_birth | 1 + 6 features: GA, Cumulative_FiO2_Support_concentration_QW, Cumulative_FiO2_Support_days_QW, Cumulative_Aggressive_Resp_Support_days_QW, Cumulative_FiO2_days_percentile, Cumulative_FiO2_concentration_percentile, Age_D |
| EUGR_HC | 7 features: GA, AS1, Antenatal_steroid, BBWZ, AS5, surfactant, Maternal_age, Resuscitation_at_birth | 1 + 16 features: GA, Cumulative_FiO2_Support_concentration_QW, Cumulative_FiO2_Support_days_QW, Cumulative_Aggressive_Resp_Support_days_QW, Cumulative_FiO2_days_percentile, Cumulative_FiO2_concentration_percentile, IVH, AKI, pda_surgical, NonNEC_surgical_abdomen, Feeding, cerebellar_hemorrhage, Thrombocytopenia_severity, ischaemic_stroke, blood_culture, Inotropic, Age_D |
| EUGR_BW | 7 features: GA, AS1, Antenatal_steroid, BBWZ, AS5, surfactant, Maternal_age, Resuscitation_at_birth | 1 + 13 features: GA, Cumulative_FiO2_Support_concentration_QW, Cumulative_FiO2_Support_days_QW, Cumulative_Aggressive_Resp_Support_days_QW, Cumulative_FiO2_days_percentile, Cumulative_FiO2_concentration_percentile, AKI, pda_surgical, NonNEC_surgical_abdomen, Feeding, cerebellar_hemorrhage, Thrombocytopenia_severity, Blood_Volume, Age_D |
| discharge_hearing_outcome | 7 features: GA, AS1, Antenatal_steroid, BBWZ, AS5, surfactant, Maternal_age, Resuscitation_at_birth | 1 + 11 features: GA, Cumulative_FiO2_Support_concentration_QW, Cumulative_FiO2_Support_days_QW, Cumulative_Aggressive_Resp_Support_days_QW, Cumulative_FiO2_days_percentile, Cumulative_FiO2_concentration_percentile, Leukopenia_severity, NonNEC_surgical_abdomen, Feeding, Thrombocytopenia_severity, blood_culture, Age_D |