Programming environment

Load raw data

Table 1. Raw data names and paths.
dataset name path
Modeling demographic_surfactant_growth inst/extdata/2011-202312_GA_22-30_838/0_Demographic+surfactant+Growth_838_DR_Su_20240813.xlsx
ventilation_breathing_o2_daily_42d inst/extdata/2011-202312_GA_22-30_838/1_Ventilation 1_呼吸與氧氣_42d_daily_838_DR_Su_20240813.xlsx
ventilation_breathing_o2_steroid_6w inst/extdata/2011-202312_GA_22-30_838/1_Ventilation 2_呼吸與氧氣_steroid_6w_838_DR_Su_20240813.xlsx
hemodynamics_42d inst/extdata/2011-202312_GA_22-30_838/2_Hemodynamics_42d_838_DR_Su_20240813.xlsx
infection_42d inst/extdata/2011-202312_GA_22-30_838/3_Infection 1_42d_838_DR_Su_20240813.xlsx
gi_tract_feeding_42d inst/extdata/2011-202312_GA_22-30_838/4_Gl_tract1_feeding_42d_DR_Su_20240813.xlsx
growth_hc_bw_6w inst/extdata/2011-202312_GA_22-30_838/5_Growth2_HC_BW_6w_838_DR_Su_20240813.xlsx
morbidities_42d inst/extdata/2011-202312_GA_22-30_838/6_Morbidities1_42day_838_DR_Su_20240813.xlsx
outcomes inst/extdata/2011-202312_GA_22-30_838/7_Outcome_Morbidity_Outcomes_838_DR_Su_20240813.xlsx
Independent test demographic_surfactant_growth inst/extdata/2011-202312_GA_22-30_838/0_Demographic+surfactant+Growth_838_DR_Su_20240813.xlsx
ventilation_breathing_o2_daily_42d inst/extdata/2011-202312_GA_22-30_838/1_Ventilation 1_呼吸與氧氣_42d_daily_838_DR_Su_20240813.xlsx
ventilation_breathing_o2_steroid_6w inst/extdata/2011-202312_GA_22-30_838/1_Ventilation 2_呼吸與氧氣_steroid_6w_838_DR_Su_20240813.xlsx
hemodynamics_42d inst/extdata/2011-202312_GA_22-30_838/2_Hemodynamics_42d_838_DR_Su_20240813.xlsx
infection_42d inst/extdata/2011-202312_GA_22-30_838/3_Infection 1_42d_838_DR_Su_20240813.xlsx
gi_tract_feeding_42d inst/extdata/2011-202312_GA_22-30_838/4_Gl_tract1_feeding_42d_DR_Su_20240813.xlsx
growth_hc_bw_6w inst/extdata/2011-202312_GA_22-30_838/5_Growth2_HC_BW_6w_838_DR_Su_20240813.xlsx
morbidities_42d inst/extdata/2011-202312_GA_22-30_838/6_Morbidities1_42day_838_DR_Su_20240813.xlsx
outcomes inst/extdata/2011-202312_GA_22-30_838/7_Outcome_Morbidity_Outcomes_838_DR_Su_20240813.xlsx

Data preprocessing

Data cleaning

Table 2. Raw data old and new column names.
dataset table old_colname new_colname
Modeling demographic_surfactant_growth ID id
Family_Socioeconomic_status socioeconomic_status
Maternal_education_level education_status
Maternal_age maternal_age
IVF ivf
Preeclampsia pe
Gestational_diabetes gdm
CS cs
Gravida gravida
BBW bbw_g
GA ga_wk
Male sex
Multiple_gestation multiple_gestation
AS1 as1
AS5 as5
Resuscitation_at_birth resuscitation_at_birth
birthtime_scoring birthtime_scoring
Antenatal_steroid steroid_antenatal
Chorioamnionitis chorioamnionitis
surfactant surfactant
BBWZ bbw_z
BHCZ bhc_z
ventilation_breathing_o2_daily_42d ID id
Age_D t_day
Resp_Support_raw resp_supp_raw
FiO2_raw fio2_raw
ventilation_breathing_o2_steroid_6w ID id
GA ga_wk
Age_W t_wk
Cumulative_Aggressive_Resp_Support_days_QW resp_supp_agg_cum_day_qw
Cumulative_FiO2_Support_days_QW fio2_cum_day_qw
Cumulative_FiO2_Support_concentration_QW fio2_cum_level_qw
Cumulative_Aggressive_Resp_Support_percentile resp_supp_agg_cum_day_pct
Cumulative_FiO2_days_percentile fio2_cum_day_pct
Cumulative_FiO2_concentration_percentile fio2_cum_level_pct
postnatal_steroid steroid_postnatal
hemodynamics_42d ID id
Age_D t_day
Inotropic inotropic
Blood_Volume blood_volume
Transfusion transfusion
infection_42d ID id
Age_D t_day
blood_culture blood_culture
Thrombocytopenia_severity plt
Leukopenia_severity wbc
gi_tract_feeding_42d ID id
Age_D t_day
Feeding feeding
growth_hc_bw_6w ID id
Age_W t_wk
Postnatal_BW_z_score_QW bw_z_qw
Postnatal_HC_z_score_QW hc_z_qw
morbidities_42d ID id
Age_D t_day
IVH ivh
PVL pvl
cerebellar_hemorrhage cerebellar_hemorrhage
ischaemic_stroke ischaemic_stroke
hs-PDArequiring_intervention hs_pda_iv
NEC nec
NonNEC_surgical_abdomen non_nec_surg_abd
AKI aki
outcomes ID id
Survival_at_discharge survive
age_of_death death_age
severe_ROP rop_severe
BPD_grade bpd_grade
EUGR_HC eugr_hc
EUGR_BW eugr_bw
discharge_hearing_outcome hearing
Independent test demographic_surfactant_growth ID id
Family_Socioeconomic_status socioeconomic_status
Maternal_education_level education_status
Maternal_age maternal_age
IVF ivf
Preeclampsia pe
Gestational_diabetes gdm
CS cs
Gravida gravida
BBW bbw_g
GA ga_wk
Male sex
Multiple_gestation multiple_gestation
AS1 as1
AS5 as5
Resuscitation_at_birth resuscitation_at_birth
birthtime_scoring birthtime_scoring
Antenatal_steroid steroid_antenatal
Chorioamnionitis chorioamnionitis
surfactant surfactant
BBWZ bbw_z
BHCZ bhc_z
ventilation_breathing_o2_daily_42d ID id
Age_D t_day
Resp_Support_raw resp_supp_raw
FiO2_raw fio2_raw
ventilation_breathing_o2_steroid_6w ID id
GA ga_wk
Age_W t_wk
Cumulative_Aggressive_Resp_Support_days_QW resp_supp_agg_cum_day_qw
Cumulative_FiO2_Support_days_QW fio2_cum_day_qw
Cumulative_FiO2_Support_concentration_QW fio2_cum_level_qw
Cumulative_Aggressive_Resp_Support_percentile resp_supp_agg_cum_day_pct
Cumulative_FiO2_days_percentile fio2_cum_day_pct
Cumulative_FiO2_concentration_percentile fio2_cum_level_pct
postnatal_steroid steroid_postnatal
hemodynamics_42d ID id
Age_D t_day
Inotropic inotropic
Blood_Volume blood_volume
Transfusion transfusion
infection_42d ID id
Age_D t_day
blood_culture blood_culture
Thrombocytopenia_severity plt
Leukopenia_severity wbc
gi_tract_feeding_42d ID id
Age_D t_day
Feeding feeding
growth_hc_bw_6w ID id
Age_W t_wk
Postnatal_BW_z_score_QW bw_z_qw
Postnatal_HC_z_score_QW hc_z_qw
morbidities_42d ID id
Age_D t_day
IVH ivh
PVL pvl
cerebellar_hemorrhage cerebellar_hemorrhage
ischaemic_stroke ischaemic_stroke
hs-PDArequiring_intervention hs_pda_iv
NEC nec
NonNEC_surgical_abdomen non_nec_surg_abd
AKI aki
outcomes ID id
Survival_at_discharge survive
age_of_death death_age
severe_ROP rop_severe
BPD_grade bpd_grade
EUGR_HC eugr_hc
EUGR_BW eugr_bw
discharge_hearing_outcome hearing
Table 3. Raw data old and new variable types.
variable old_type new_type
id numeric character
t numeric numeric
socioeconomic_status numeric factor
education_status numeric factor
maternal_age numeric numeric
ivf numeric factor
pe numeric factor
gdm numeric factor
cs numeric factor
gravida numeric numeric
bbw_g numeric numeric
ga_wk numeric numeric
sex numeric factor
multiple_gestation numeric factor
as1 numeric numeric
as5 numeric numeric
resuscitation_at_birth numeric numeric
birthtime_scoring numeric factor
steroid_antenatal numeric numeric
chorioamnionitis numeric factor
surfactant numeric numeric
bbw_z numeric numeric
bhc_z numeric numeric
survive numeric factor
death_age numeric numeric
rop_severe numeric factor
bpd_grade numeric factor
eugr_hc numeric factor
eugr_bw numeric factor
hearing numeric factor
resp_supp_agg_cum_day_qw numeric numeric
fio2_cum_day_qw numeric numeric
fio2_cum_level_qw numeric numeric
resp_supp_agg_cum_day_pct numeric numeric
fio2_cum_day_pct numeric numeric
fio2_cum_level_pct numeric numeric
steroid_postnatal numeric numeric
bw_z_qw numeric factor
hc_z_qw numeric factor
resp_supp_raw numeric factor
fio2_raw numeric numeric
inotropic numeric numeric
blood_volume numeric numeric
transfusion numeric numeric
blood_culture numeric numeric
plt numeric numeric
wbc numeric numeric
feeding numeric numeric
ivh numeric factor
pvl numeric factor
cerebellar_hemorrhage numeric factor
ischaemic_stroke numeric factor
hs_pda_iv numeric factor
nec numeric numeric
non_nec_surg_abd numeric factor
aki numeric numeric
Table 4. Raw data old and new categories.
colname old_cat new_cat
socioeconomic_status 1 5-lowest
socioeconomic_status 2 4-second lowest
socioeconomic_status 3 3-medium
socioeconomic_status 4 2-second highest
socioeconomic_status 5 1-highest
education_status 1 7-elementary school
education_status 2 6-junior high school
education_status 3 5-high school, vocational
education_status 4 4-high school
education_status 5 3-college, vocational
education_status 6 2-college
education_status 7 1-postgraduate
ivf 0 0-no
ivf 1 1-yes
pe 0 0-no
pe 1 1-yes
gdm 0 0-no
gdm 1 1-yes
cs 0 0-no
cs 1 1-yes
sex 0 0-female
sex 1 1-male
multiple_gestation 0 0-no
multiple_gestation 1 1-yes
birthtime_scoring 1 1-born 08:00-16:59
birthtime_scoring 2 2-born 17:00-23:59
birthtime_scoring 3 3-born 00:00-07:59
chorioamnionitis 0 0-no
chorioamnionitis 1 1-yes
survive 0 0-no
survive 1 1-yes
rop_severe 0 0-none/stage I/stage II
rop_severe 1 1-stage II+
bpd_grade 0 0-no BPD
bpd_grade 1 1-mild BPD
bpd_grade 2 2-moderate/severe BPD
eugr_hc 0 0-HC z-score at birth >=-1.5
eugr_hc 1 1-HC z-score at birth <-1.5
eugr_bw 0 0-BW z-score at birth >=-1.5
eugr_bw 1 1-BW z-score at birth <-1.5
hearing 0 0-passed
hearing 1 1-failed
bw_z_qw 0 4-BW z-score <=-3
bw_z_qw 1 3-BW z-score >-3 & <=-2
bw_z_qw 2 2-BW z-score >-2 & <=-1
bw_z_qw 3 1-BW z-score >-1
hc_z_qw 0 4-HC z-score <=-3
hc_z_qw 1 3-HC z-score >-3 & <=-2
hc_z_qw 2 2-HC z-score >-2 & <=-1
hc_z_qw 3 1-HC z-score >-1
resp_supp_raw 1 1-room air
resp_supp_raw 2 2-nasal canula with oxygen
resp_supp_raw 3 3-CPAP
resp_supp_raw 4 4-N-IPPV
resp_supp_raw 5 5-IMV
resp_supp_raw 6 6-IMV+iNO/HFOV/HFOV+iNO
ivh 0 1-no IVH
ivh 1 2-IVH grade I
ivh 2 3-IVH grade II
ivh 4 4-IVH grade III
ivh 5 5-IVH grade IV, unilateral
ivh 6 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus
pvl 0 1-no PVL
pvl 2 2-PVL focal, unilateral
pvl 4 3-PVL focal, bilateral
pvl 6 4-PVL extensive, bilateral
cerebellar_hemorrhage 0 1-no bleeding
cerebellar_hemorrhage 1 2-minimal bleeding
cerebellar_hemorrhage 2 3-severe bleeding
ischaemic_stroke 0 1-no ischemia
ischaemic_stroke 1 2-ischemia, unilateral
ischaemic_stroke 2 3-ischemia, bilateral
ischaemic_stroke 3 4-ischemia, multiple
hs_pda_iv 0 1-no PDA/PDA, no intervention
hs_pda_iv 1 2-PDA, medical intervention
hs_pda_iv 2 3-PDA, surgical intervention
non_nec_surg_abd 0 1-no NEC/NEC, no surgery
non_nec_surg_abd 4 2-SIP/meconium ileus/volvulus/obstruction
non_nec_surg_abd 6 3-SIP/meconium ileus/volvulus/obstruction with stomy
Table 5. Consistency check - survival and age of death.
dataset survive ms_death_age n
Modeling 0-no FALSE 119
1-yes TRUE 719
Independent test 0-no FALSE 12
1-yes TRUE 75
Table 6. Consistency check - other outcomes and age of death.
dataset ms_death_age variable missing non-missing
Modeling missing ms_bpd_grade 0 719
ms_eugr_bw 0 719
ms_eugr_hc 0 719
ms_hearing 14 705
ms_rop_severe 0 719
non-missing ms_bpd_grade 109 10
ms_eugr_bw 110 9
ms_eugr_hc 110 9
ms_hearing 119 0
ms_rop_severe 109 10
Independent test missing ms_bpd_grade 0 75
ms_eugr_bw 0 75
ms_eugr_hc 0 75
ms_hearing 0 75
ms_rop_severe 0 75
non-missing ms_bpd_grade 12 0
ms_eugr_bw 12 0
ms_eugr_hc 12 0
ms_hearing 12 0
ms_rop_severe 12 0
Table 7. Consistency check - time-dependent variables and age of death.
t_death_age_def t_alive variable missing non-missing
ceiled 0-no ms_resp_supp_agg_cum_day_qw 458 4
ms_fio2_cum_day_qw 458 4
ms_fio2_cum_level_qw 458 4
ms_resp_supp_agg_cum_day_pct 458 4
ms_fio2_cum_day_pct 458 4
ms_fio2_cum_level_pct 458 4
ms_steroid_postnatal 458 4
ms_bw_z_qw 460 2
ms_hc_z_qw 460 2
ms_resp_supp_raw 3648 33
ms_fio2_raw 3648 33
ms_inotropic 3648 33
ms_blood_volume 3648 33
ms_transfusion 3648 33
ms_blood_culture 3648 33
ms_plt 3675 6
ms_wbc 3675 6
ms_feeding 3648 33
1-yes ms_resp_supp_agg_cum_day_qw 1 251
ms_fio2_cum_day_qw 1 251
ms_fio2_cum_level_qw 1 251
ms_resp_supp_agg_cum_day_pct 1 251
ms_fio2_cum_day_pct 1 251
ms_fio2_cum_level_pct 1 251
ms_steroid_postnatal 0 252
ms_bw_z_qw 5 247
ms_hc_z_qw 23 229
ms_resp_supp_raw 5 1312
ms_fio2_raw 5 1312
ms_inotropic 0 1317
ms_blood_volume 0 1317
ms_transfusion 0 1317
ms_blood_culture 0 1317
ms_plt 986 331
ms_wbc 995 322
ms_feeding 0 1317
rounded_plus1 0-no ms_resp_supp_agg_cum_day_qw 458 1
ms_fio2_cum_day_qw 458 1
ms_fio2_cum_level_qw 458 1
ms_resp_supp_agg_cum_day_pct 458 1
ms_fio2_cum_day_pct 458 1
ms_fio2_cum_level_pct 458 1
ms_steroid_postnatal 458 1
ms_bw_z_qw 459 0
ms_hc_z_qw 459 0
ms_resp_supp_raw 3633 8
ms_fio2_raw 3633 8
ms_inotropic 3633 8
ms_blood_volume 3633 8
ms_transfusion 3633 8
ms_blood_culture 3633 8
ms_plt 3641 0
ms_wbc 3641 0
ms_feeding 3633 8
1-yes ms_resp_supp_agg_cum_day_qw 1 254
ms_fio2_cum_day_qw 1 254
ms_fio2_cum_level_qw 1 254
ms_resp_supp_agg_cum_day_pct 1 254
ms_fio2_cum_day_pct 1 254
ms_fio2_cum_level_pct 1 254
ms_steroid_postnatal 0 255
ms_bw_z_qw 6 249
ms_hc_z_qw 24 231
ms_resp_supp_raw 20 1337
ms_fio2_raw 20 1337
ms_inotropic 15 1342
ms_blood_volume 15 1342
ms_transfusion 15 1342
ms_blood_culture 15 1342
ms_plt 1020 337
ms_wbc 1029 328
ms_feeding 15 1342
floored_plus1 0-no ms_resp_supp_agg_cum_day_qw 458 4
ms_fio2_cum_day_qw 458 4
ms_fio2_cum_level_qw 458 4
ms_resp_supp_agg_cum_day_pct 458 4
ms_fio2_cum_day_pct 458 4
ms_fio2_cum_level_pct 458 4
ms_steroid_postnatal 458 4
ms_bw_z_qw 460 2
ms_hc_z_qw 460 2
ms_resp_supp_raw 3648 33
ms_fio2_raw 3648 33
ms_inotropic 3648 33
ms_blood_volume 3648 33
ms_transfusion 3648 33
ms_blood_culture 3648 33
ms_plt 3675 6
ms_wbc 3675 6
ms_feeding 3648 33
1-yes ms_resp_supp_agg_cum_day_qw 1 251
ms_fio2_cum_day_qw 1 251
ms_fio2_cum_level_qw 1 251
ms_resp_supp_agg_cum_day_pct 1 251
ms_fio2_cum_day_pct 1 251
ms_fio2_cum_level_pct 1 251
ms_steroid_postnatal 0 252
ms_bw_z_qw 5 247
ms_hc_z_qw 23 229
ms_resp_supp_raw 5 1312
ms_fio2_raw 5 1312
ms_inotropic 0 1317
ms_blood_volume 0 1317
ms_transfusion 0 1317
ms_blood_culture 0 1317
ms_plt 986 331
ms_wbc 995 322
ms_feeding 0 1317

Data partition

Figure 1. GA (week) distribution for each partition and independent test. GA, gestational week.

Numerical data transformation

Figure 2. QQ plot of numerical variables. QQ, quantile-to-quantile.

## t, maternal_age, gravida, ga_wk, as1, as5, resuscitation_at_birth, steroid_antenatal, surfactant, bbw_z, bhc_z, resp_supp_agg_cum_day_qw, fio2_cum_day_qw, fio2_cum_level_qw, resp_supp_agg_cum_day_pct, fio2_cum_day_pct, fio2_cum_level_pct, steroid_postnatal, inotropic, blood_volume, transfusion, blood_culture, plt, wbc, feeding, nec, aki
Table 8. Normality test.
variable statistic p.value alternative
death_age* 0.261 <0.001 two-sided
Note:
*, p-value <=0.05, Shapiro-Wilk normality test.
## death_age
## log, sqrt, inv, log2, exp, asinh, bct
Table 9. Normality test after transformation.
variable best_trans p.value log sqrt inv log2 exp asinh bct
death_age* bct <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
Note:
*, p-value <=0.05, Shapiro-Wilk normality test.
## death_age

Outlier analysis

Correlation matrix

## ms_fio2_cum_day_pct, ms_fio2_cum_day_qw, ms_fio2_cum_level_pct, ms_fio2_cum_level_qw, ms_resp_supp_agg_cum_day_pct, ms_resp_supp_agg_cum_day_qw, pvl
Table 10. Categorical variables with pair-wise perfect separation.
V1 V1_value V2 V2_value n
ms_death_age yes ms_rop_severe yes 0
ms_death_age yes ms_bpd_grade yes 0
ms_death_age yes ms_eugr_hc yes 0
ms_death_age yes ms_eugr_bw yes 0
ms_death_age no ms_hearing no 0
ms_death_age yes ms_inotropic yes 0
ms_death_age yes ms_blood_volume yes 0
ms_death_age yes ms_transfusion yes 0
ms_death_age yes ms_blood_culture yes 0
ms_death_age yes ms_feeding yes 0
ms_death_age yes ms_ivh yes 0
ms_death_age yes ms_pvl yes 0
ms_death_age yes ms_cerebellar_hemorrhage yes 0
ms_death_age yes ms_ischaemic_stroke yes 0
ms_death_age yes ms_hs_pda_iv yes 0
ms_death_age yes ms_nec yes 0
ms_death_age yes ms_non_nec_surg_abd yes 0
ms_death_age yes ms_aki yes 0
ms_death_age yes survive 0-no 0
ms_death_age no survive 1-yes 0
ms_death_age yes rop_severe NA 0
ms_death_age yes bpd_grade NA 0
ms_death_age no bpd_grade 1-mild BPD 0
ms_death_age yes eugr_hc NA 0
ms_death_age yes eugr_bw NA 0
ms_death_age no hearing 0-passed 0
ms_death_age no hearing 1-failed 0
ms_death_age no bw_z_qw 4-BW z-score <=-3 0
ms_death_age yes ivh NA 0
ms_death_age yes cerebellar_hemorrhage NA 0
ms_death_age yes ischaemic_stroke NA 0
ms_death_age no ischaemic_stroke 4-ischemia, multiple 0
ms_death_age yes hs_pda_iv NA 0
ms_death_age yes non_nec_surg_abd NA 0
ms_death_age no non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_rop_severe yes ms_bpd_grade no 0
ms_rop_severe no ms_bpd_grade yes 0
ms_rop_severe yes ms_eugr_hc no 0
ms_rop_severe yes ms_eugr_bw no 0
ms_rop_severe yes ms_hearing no 0
ms_rop_severe no ms_inotropic yes 0
ms_rop_severe no ms_blood_volume yes 0
ms_rop_severe no ms_transfusion yes 0
ms_rop_severe no ms_blood_culture yes 0
ms_rop_severe no ms_feeding yes 0
ms_rop_severe no ms_ivh yes 0
ms_rop_severe no ms_pvl yes 0
ms_rop_severe no ms_cerebellar_hemorrhage yes 0
ms_rop_severe no ms_ischaemic_stroke yes 0
ms_rop_severe no ms_hs_pda_iv yes 0
ms_rop_severe no ms_nec yes 0
ms_rop_severe no ms_non_nec_surg_abd yes 0
ms_rop_severe no ms_aki yes 0
ms_rop_severe yes survive 1-yes 0
ms_rop_severe yes rop_severe 0-none/stage I/stage II 0
ms_rop_severe yes rop_severe 1-stage II+ 0
ms_rop_severe no rop_severe NA 0
ms_rop_severe yes bpd_grade 0-no BPD 0
ms_rop_severe yes bpd_grade 1-mild BPD 0
ms_rop_severe yes bpd_grade 2-moderate/severe BPD 0
ms_rop_severe no bpd_grade NA 0
ms_rop_severe yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_rop_severe yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_rop_severe yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_rop_severe yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_rop_severe yes hearing 0-passed 0
ms_rop_severe yes hearing 1-failed 0
ms_rop_severe yes bw_z_qw 4-BW z-score <=-3 0
ms_rop_severe yes hc_z_qw 4-HC z-score <=-3 0
ms_rop_severe yes ivh 2-IVH grade I 0
ms_rop_severe no ivh NA 0
ms_rop_severe no cerebellar_hemorrhage NA 0
ms_rop_severe yes ischaemic_stroke 2-ischemia, unilateral 0
ms_rop_severe yes ischaemic_stroke 4-ischemia, multiple 0
ms_rop_severe no ischaemic_stroke NA 0
ms_rop_severe no hs_pda_iv NA 0
ms_rop_severe yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_rop_severe no non_nec_surg_abd NA 0
ms_bpd_grade yes ms_eugr_hc no 0
ms_bpd_grade yes ms_eugr_bw no 0
ms_bpd_grade yes ms_hearing no 0
ms_bpd_grade no ms_inotropic yes 0
ms_bpd_grade no ms_blood_volume yes 0
ms_bpd_grade no ms_transfusion yes 0
ms_bpd_grade no ms_blood_culture yes 0
ms_bpd_grade no ms_feeding yes 0
ms_bpd_grade no ms_ivh yes 0
ms_bpd_grade no ms_pvl yes 0
ms_bpd_grade no ms_cerebellar_hemorrhage yes 0
ms_bpd_grade no ms_ischaemic_stroke yes 0
ms_bpd_grade no ms_hs_pda_iv yes 0
ms_bpd_grade no ms_nec yes 0
ms_bpd_grade no ms_non_nec_surg_abd yes 0
ms_bpd_grade no ms_aki yes 0
ms_bpd_grade yes survive 1-yes 0
ms_bpd_grade yes rop_severe 0-none/stage I/stage II 0
ms_bpd_grade yes rop_severe 1-stage II+ 0
ms_bpd_grade no rop_severe NA 0
ms_bpd_grade yes bpd_grade 0-no BPD 0
ms_bpd_grade yes bpd_grade 1-mild BPD 0
ms_bpd_grade yes bpd_grade 2-moderate/severe BPD 0
ms_bpd_grade no bpd_grade NA 0
ms_bpd_grade yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_bpd_grade yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_bpd_grade yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_bpd_grade yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_bpd_grade yes hearing 0-passed 0
ms_bpd_grade yes hearing 1-failed 0
ms_bpd_grade yes bw_z_qw 4-BW z-score <=-3 0
ms_bpd_grade yes hc_z_qw 4-HC z-score <=-3 0
ms_bpd_grade yes ivh 2-IVH grade I 0
ms_bpd_grade no ivh NA 0
ms_bpd_grade no cerebellar_hemorrhage NA 0
ms_bpd_grade yes ischaemic_stroke 2-ischemia, unilateral 0
ms_bpd_grade yes ischaemic_stroke 4-ischemia, multiple 0
ms_bpd_grade no ischaemic_stroke NA 0
ms_bpd_grade no hs_pda_iv NA 0
ms_bpd_grade yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_bpd_grade no non_nec_surg_abd NA 0
ms_eugr_hc yes ms_eugr_bw no 0
ms_eugr_hc no ms_eugr_bw yes 0
ms_eugr_hc yes ms_hearing no 0
ms_eugr_hc no ms_inotropic yes 0
ms_eugr_hc no ms_blood_volume yes 0
ms_eugr_hc no ms_transfusion yes 0
ms_eugr_hc no ms_blood_culture yes 0
ms_eugr_hc no ms_feeding yes 0
ms_eugr_hc no ms_ivh yes 0
ms_eugr_hc no ms_pvl yes 0
ms_eugr_hc no ms_cerebellar_hemorrhage yes 0
ms_eugr_hc no ms_ischaemic_stroke yes 0
ms_eugr_hc no ms_hs_pda_iv yes 0
ms_eugr_hc no ms_nec yes 0
ms_eugr_hc no ms_non_nec_surg_abd yes 0
ms_eugr_hc no ms_aki yes 0
ms_eugr_hc yes survive 1-yes 0
ms_eugr_hc yes rop_severe 1-stage II+ 0
ms_eugr_hc no rop_severe NA 0
ms_eugr_hc yes bpd_grade 1-mild BPD 0
ms_eugr_hc yes bpd_grade 2-moderate/severe BPD 0
ms_eugr_hc no bpd_grade NA 0
ms_eugr_hc yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_eugr_hc yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_eugr_hc no eugr_hc NA 0
ms_eugr_hc yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_eugr_hc yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_eugr_hc no eugr_bw NA 0
ms_eugr_hc yes hearing 0-passed 0
ms_eugr_hc yes hearing 1-failed 0
ms_eugr_hc yes bw_z_qw 4-BW z-score <=-3 0
ms_eugr_hc yes hc_z_qw 4-HC z-score <=-3 0
ms_eugr_hc yes ivh 2-IVH grade I 0
ms_eugr_hc no ivh NA 0
ms_eugr_hc no cerebellar_hemorrhage NA 0
ms_eugr_hc yes ischaemic_stroke 2-ischemia, unilateral 0
ms_eugr_hc yes ischaemic_stroke 4-ischemia, multiple 0
ms_eugr_hc no ischaemic_stroke NA 0
ms_eugr_hc no hs_pda_iv NA 0
ms_eugr_hc yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_eugr_hc no non_nec_surg_abd NA 0
ms_eugr_bw yes ms_hearing no 0
ms_eugr_bw no ms_inotropic yes 0
ms_eugr_bw no ms_blood_volume yes 0
ms_eugr_bw no ms_transfusion yes 0
ms_eugr_bw no ms_blood_culture yes 0
ms_eugr_bw no ms_feeding yes 0
ms_eugr_bw no ms_ivh yes 0
ms_eugr_bw no ms_pvl yes 0
ms_eugr_bw no ms_cerebellar_hemorrhage yes 0
ms_eugr_bw no ms_ischaemic_stroke yes 0
ms_eugr_bw no ms_hs_pda_iv yes 0
ms_eugr_bw no ms_nec yes 0
ms_eugr_bw no ms_non_nec_surg_abd yes 0
ms_eugr_bw no ms_aki yes 0
ms_eugr_bw yes survive 1-yes 0
ms_eugr_bw yes rop_severe 1-stage II+ 0
ms_eugr_bw no rop_severe NA 0
ms_eugr_bw yes bpd_grade 1-mild BPD 0
ms_eugr_bw yes bpd_grade 2-moderate/severe BPD 0
ms_eugr_bw no bpd_grade NA 0
ms_eugr_bw yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_eugr_bw yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_eugr_bw no eugr_hc NA 0
ms_eugr_bw yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_eugr_bw yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_eugr_bw no eugr_bw NA 0
ms_eugr_bw yes hearing 0-passed 0
ms_eugr_bw yes hearing 1-failed 0
ms_eugr_bw yes bw_z_qw 4-BW z-score <=-3 0
ms_eugr_bw yes hc_z_qw 4-HC z-score <=-3 0
ms_eugr_bw yes ivh 2-IVH grade I 0
ms_eugr_bw no ivh NA 0
ms_eugr_bw no cerebellar_hemorrhage NA 0
ms_eugr_bw yes ischaemic_stroke 2-ischemia, unilateral 0
ms_eugr_bw yes ischaemic_stroke 4-ischemia, multiple 0
ms_eugr_bw no ischaemic_stroke NA 0
ms_eugr_bw no hs_pda_iv NA 0
ms_eugr_bw yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_eugr_bw no non_nec_surg_abd NA 0
ms_hearing no ms_inotropic yes 0
ms_hearing no ms_blood_volume yes 0
ms_hearing no ms_transfusion yes 0
ms_hearing no ms_blood_culture yes 0
ms_hearing no ms_feeding yes 0
ms_hearing no ms_ivh yes 0
ms_hearing no ms_pvl yes 0
ms_hearing no ms_cerebellar_hemorrhage yes 0
ms_hearing no ms_ischaemic_stroke yes 0
ms_hearing no ms_hs_pda_iv yes 0
ms_hearing no ms_nec yes 0
ms_hearing no ms_non_nec_surg_abd yes 0
ms_hearing no ms_aki yes 0
ms_hearing no survive 0-no 0
ms_hearing no rop_severe NA 0
ms_hearing yes bpd_grade 1-mild BPD 0
ms_hearing no bpd_grade NA 0
ms_hearing no eugr_hc NA 0
ms_hearing no eugr_bw NA 0
ms_hearing yes hearing 0-passed 0
ms_hearing yes hearing 1-failed 0
ms_hearing no hearing NA 0
ms_hearing yes bw_z_qw 4-BW z-score <=-3 0
ms_hearing no ivh NA 0
ms_hearing no cerebellar_hemorrhage NA 0
ms_hearing no ischaemic_stroke NA 0
ms_hearing no hs_pda_iv NA 0
ms_hearing yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_hearing no non_nec_surg_abd NA 0
ms_bw_z_qw yes socioeconomic_status 1-highest 0
ms_bw_z_qw yes education_status 4-high school 0
ms_bw_z_qw yes education_status 7-elementary school 0
ms_bw_z_qw yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_bw_z_qw yes bw_z_qw 1-BW z-score >-1 0
ms_bw_z_qw yes bw_z_qw 2-BW z-score >-2 & <=-1 0
ms_bw_z_qw yes bw_z_qw 3-BW z-score >-3 & <=-2 0
ms_bw_z_qw yes bw_z_qw 4-BW z-score <=-3 0
ms_bw_z_qw no bw_z_qw NA 0
ms_bw_z_qw yes hc_z_qw 1-HC z-score >-1 0
ms_bw_z_qw yes hc_z_qw 2-HC z-score >-2 & <=-1 0
ms_bw_z_qw yes hc_z_qw 3-HC z-score >-3 & <=-2 0
ms_bw_z_qw yes ivh 2-IVH grade I 0
ms_bw_z_qw yes ivh 3-IVH grade II 0
ms_bw_z_qw yes ivh 4-IVH grade III 0
ms_bw_z_qw yes ivh 5-IVH grade IV, unilateral 0
ms_bw_z_qw yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
ms_bw_z_qw yes cerebellar_hemorrhage 3-severe bleeding 0
ms_bw_z_qw yes ischaemic_stroke 2-ischemia, unilateral 0
ms_bw_z_qw yes ischaemic_stroke 4-ischemia, multiple 0
ms_bw_z_qw yes hs_pda_iv 3-PDA, surgical intervention 0
ms_bw_z_qw yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ms_bw_z_qw yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_hc_z_qw yes bw_z_qw 4-BW z-score <=-3 0
ms_hc_z_qw yes hc_z_qw 1-HC z-score >-1 0
ms_hc_z_qw yes hc_z_qw 2-HC z-score >-2 & <=-1 0
ms_hc_z_qw yes hc_z_qw 3-HC z-score >-3 & <=-2 0
ms_hc_z_qw yes hc_z_qw 4-HC z-score <=-3 0
ms_hc_z_qw no hc_z_qw NA 0
ms_hc_z_qw yes ivh 2-IVH grade I 0
ms_hc_z_qw yes ivh 3-IVH grade II 0
ms_hc_z_qw yes ivh 4-IVH grade III 0
ms_hc_z_qw yes ivh 5-IVH grade IV, unilateral 0
ms_hc_z_qw yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
ms_hc_z_qw yes cerebellar_hemorrhage 3-severe bleeding 0
ms_hc_z_qw yes ischaemic_stroke 4-ischemia, multiple 0
ms_hc_z_qw yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ms_hc_z_qw yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_inotropic yes ms_blood_volume no 0
ms_inotropic no ms_blood_volume yes 0
ms_inotropic yes ms_transfusion no 0
ms_inotropic no ms_transfusion yes 0
ms_inotropic yes ms_blood_culture no 0
ms_inotropic no ms_blood_culture yes 0
ms_inotropic yes ms_plt no 0
ms_inotropic yes ms_wbc no 0
ms_inotropic yes ms_feeding no 0
ms_inotropic no ms_feeding yes 0
ms_inotropic yes ms_ivh no 0
ms_inotropic no ms_ivh yes 0
ms_inotropic yes ms_pvl no 0
ms_inotropic no ms_pvl yes 0
ms_inotropic yes ms_cerebellar_hemorrhage no 0
ms_inotropic no ms_cerebellar_hemorrhage yes 0
ms_inotropic yes ms_ischaemic_stroke no 0
ms_inotropic no ms_ischaemic_stroke yes 0
ms_inotropic yes ms_hs_pda_iv no 0
ms_inotropic no ms_hs_pda_iv yes 0
ms_inotropic yes ms_nec no 0
ms_inotropic no ms_nec yes 0
ms_inotropic yes ms_non_nec_surg_abd no 0
ms_inotropic no ms_non_nec_surg_abd yes 0
ms_inotropic yes ms_aki no 0
ms_inotropic no ms_aki yes 0
ms_inotropic yes socioeconomic_status 1-highest 0
ms_inotropic yes education_status 1-postgraduate 0
ms_inotropic yes education_status 4-high school 0
ms_inotropic yes education_status 6-junior high school 0
ms_inotropic yes education_status 7-elementary school 0
ms_inotropic yes birthtime_scoring 2-born 17:00-23:59 0
ms_inotropic yes survive 1-yes 0
ms_inotropic yes rop_severe 0-none/stage I/stage II 0
ms_inotropic yes rop_severe 1-stage II+ 0
ms_inotropic yes bpd_grade 0-no BPD 0
ms_inotropic yes bpd_grade 1-mild BPD 0
ms_inotropic yes bpd_grade 2-moderate/severe BPD 0
ms_inotropic yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_inotropic yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_inotropic yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_inotropic yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_inotropic yes hearing 0-passed 0
ms_inotropic yes hearing 1-failed 0
ms_inotropic yes bw_z_qw 4-BW z-score <=-3 0
ms_inotropic yes hc_z_qw 3-HC z-score >-3 & <=-2 0
ms_inotropic yes hc_z_qw 4-HC z-score <=-3 0
ms_inotropic yes ivh 1-no IVH 0
ms_inotropic yes ivh 2-IVH grade I 0
ms_inotropic yes ivh 3-IVH grade II 0
ms_inotropic yes ivh 4-IVH grade III 0
ms_inotropic yes ivh 5-IVH grade IV, unilateral 0
ms_inotropic yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
ms_inotropic no ivh NA 0
ms_inotropic yes cerebellar_hemorrhage 1-no bleeding 0
ms_inotropic yes cerebellar_hemorrhage 3-severe bleeding 0
ms_inotropic no cerebellar_hemorrhage NA 0
ms_inotropic yes ischaemic_stroke 1-no ischemia 0
ms_inotropic yes ischaemic_stroke 2-ischemia, unilateral 0
ms_inotropic yes ischaemic_stroke 3-ischemia, bilateral 0
ms_inotropic yes ischaemic_stroke 4-ischemia, multiple 0
ms_inotropic no ischaemic_stroke NA 0
ms_inotropic yes hs_pda_iv 1-no PDA/PDA, no intervention 0
ms_inotropic yes hs_pda_iv 2-PDA, medical intervention 0
ms_inotropic yes hs_pda_iv 3-PDA, surgical intervention 0
ms_inotropic no hs_pda_iv NA 0
ms_inotropic yes non_nec_surg_abd 1-no NEC/NEC, no surgery 0
ms_inotropic yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ms_inotropic yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_inotropic no non_nec_surg_abd NA 0
ms_blood_volume yes ms_transfusion no 0
ms_blood_volume no ms_transfusion yes 0
ms_blood_volume yes ms_blood_culture no 0
ms_blood_volume no ms_blood_culture yes 0
ms_blood_volume yes ms_plt no 0
ms_blood_volume yes ms_wbc no 0
ms_blood_volume yes ms_feeding no 0
ms_blood_volume no ms_feeding yes 0
ms_blood_volume yes ms_ivh no 0
ms_blood_volume no ms_ivh yes 0
ms_blood_volume yes ms_pvl no 0
ms_blood_volume no ms_pvl yes 0
ms_blood_volume yes ms_cerebellar_hemorrhage no 0
ms_blood_volume no ms_cerebellar_hemorrhage yes 0
ms_blood_volume yes ms_ischaemic_stroke no 0
ms_blood_volume no ms_ischaemic_stroke yes 0
ms_blood_volume yes ms_hs_pda_iv no 0
ms_blood_volume no ms_hs_pda_iv yes 0
ms_blood_volume yes ms_nec no 0
ms_blood_volume no ms_nec yes 0
ms_blood_volume yes ms_non_nec_surg_abd no 0
ms_blood_volume no ms_non_nec_surg_abd yes 0
ms_blood_volume yes ms_aki no 0
ms_blood_volume no ms_aki yes 0
ms_blood_volume yes socioeconomic_status 1-highest 0
ms_blood_volume yes education_status 1-postgraduate 0
ms_blood_volume yes education_status 4-high school 0
ms_blood_volume yes education_status 6-junior high school 0
ms_blood_volume yes education_status 7-elementary school 0
ms_blood_volume yes birthtime_scoring 2-born 17:00-23:59 0
ms_blood_volume yes survive 1-yes 0
ms_blood_volume yes rop_severe 0-none/stage I/stage II 0
ms_blood_volume yes rop_severe 1-stage II+ 0
ms_blood_volume yes bpd_grade 0-no BPD 0
ms_blood_volume yes bpd_grade 1-mild BPD 0
ms_blood_volume yes bpd_grade 2-moderate/severe BPD 0
ms_blood_volume yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_blood_volume yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_blood_volume yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_blood_volume yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_blood_volume yes hearing 0-passed 0
ms_blood_volume yes hearing 1-failed 0
ms_blood_volume yes bw_z_qw 4-BW z-score <=-3 0
ms_blood_volume yes hc_z_qw 3-HC z-score >-3 & <=-2 0
ms_blood_volume yes hc_z_qw 4-HC z-score <=-3 0
ms_blood_volume yes ivh 1-no IVH 0
ms_blood_volume yes ivh 2-IVH grade I 0
ms_blood_volume yes ivh 3-IVH grade II 0
ms_blood_volume yes ivh 4-IVH grade III 0
ms_blood_volume yes ivh 5-IVH grade IV, unilateral 0
ms_blood_volume yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
ms_blood_volume no ivh NA 0
ms_blood_volume yes cerebellar_hemorrhage 1-no bleeding 0
ms_blood_volume yes cerebellar_hemorrhage 3-severe bleeding 0
ms_blood_volume no cerebellar_hemorrhage NA 0
ms_blood_volume yes ischaemic_stroke 1-no ischemia 0
ms_blood_volume yes ischaemic_stroke 2-ischemia, unilateral 0
ms_blood_volume yes ischaemic_stroke 3-ischemia, bilateral 0
ms_blood_volume yes ischaemic_stroke 4-ischemia, multiple 0
ms_blood_volume no ischaemic_stroke NA 0
ms_blood_volume yes hs_pda_iv 1-no PDA/PDA, no intervention 0
ms_blood_volume yes hs_pda_iv 2-PDA, medical intervention 0
ms_blood_volume yes hs_pda_iv 3-PDA, surgical intervention 0
ms_blood_volume no hs_pda_iv NA 0
ms_blood_volume yes non_nec_surg_abd 1-no NEC/NEC, no surgery 0
ms_blood_volume yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ms_blood_volume yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_blood_volume no non_nec_surg_abd NA 0
ms_transfusion yes ms_blood_culture no 0
ms_transfusion no ms_blood_culture yes 0
ms_transfusion yes ms_plt no 0
ms_transfusion yes ms_wbc no 0
ms_transfusion yes ms_feeding no 0
ms_transfusion no ms_feeding yes 0
ms_transfusion yes ms_ivh no 0
ms_transfusion no ms_ivh yes 0
ms_transfusion yes ms_pvl no 0
ms_transfusion no ms_pvl yes 0
ms_transfusion yes ms_cerebellar_hemorrhage no 0
ms_transfusion no ms_cerebellar_hemorrhage yes 0
ms_transfusion yes ms_ischaemic_stroke no 0
ms_transfusion no ms_ischaemic_stroke yes 0
ms_transfusion yes ms_hs_pda_iv no 0
ms_transfusion no ms_hs_pda_iv yes 0
ms_transfusion yes ms_nec no 0
ms_transfusion no ms_nec yes 0
ms_transfusion yes ms_non_nec_surg_abd no 0
ms_transfusion no ms_non_nec_surg_abd yes 0
ms_transfusion yes ms_aki no 0
ms_transfusion no ms_aki yes 0
ms_transfusion yes socioeconomic_status 1-highest 0
ms_transfusion yes education_status 1-postgraduate 0
ms_transfusion yes education_status 4-high school 0
ms_transfusion yes education_status 6-junior high school 0
ms_transfusion yes education_status 7-elementary school 0
ms_transfusion yes birthtime_scoring 2-born 17:00-23:59 0
ms_transfusion yes survive 1-yes 0
ms_transfusion yes rop_severe 0-none/stage I/stage II 0
ms_transfusion yes rop_severe 1-stage II+ 0
ms_transfusion yes bpd_grade 0-no BPD 0
ms_transfusion yes bpd_grade 1-mild BPD 0
ms_transfusion yes bpd_grade 2-moderate/severe BPD 0
ms_transfusion yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_transfusion yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_transfusion yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_transfusion yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_transfusion yes hearing 0-passed 0
ms_transfusion yes hearing 1-failed 0
ms_transfusion yes bw_z_qw 4-BW z-score <=-3 0
ms_transfusion yes hc_z_qw 3-HC z-score >-3 & <=-2 0
ms_transfusion yes hc_z_qw 4-HC z-score <=-3 0
ms_transfusion yes ivh 1-no IVH 0
ms_transfusion yes ivh 2-IVH grade I 0
ms_transfusion yes ivh 3-IVH grade II 0
ms_transfusion yes ivh 4-IVH grade III 0
ms_transfusion yes ivh 5-IVH grade IV, unilateral 0
ms_transfusion yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
ms_transfusion no ivh NA 0
ms_transfusion yes cerebellar_hemorrhage 1-no bleeding 0
ms_transfusion yes cerebellar_hemorrhage 3-severe bleeding 0
ms_transfusion no cerebellar_hemorrhage NA 0
ms_transfusion yes ischaemic_stroke 1-no ischemia 0
ms_transfusion yes ischaemic_stroke 2-ischemia, unilateral 0
ms_transfusion yes ischaemic_stroke 3-ischemia, bilateral 0
ms_transfusion yes ischaemic_stroke 4-ischemia, multiple 0
ms_transfusion no ischaemic_stroke NA 0
ms_transfusion yes hs_pda_iv 1-no PDA/PDA, no intervention 0
ms_transfusion yes hs_pda_iv 2-PDA, medical intervention 0
ms_transfusion yes hs_pda_iv 3-PDA, surgical intervention 0
ms_transfusion no hs_pda_iv NA 0
ms_transfusion yes non_nec_surg_abd 1-no NEC/NEC, no surgery 0
ms_transfusion yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ms_transfusion yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_transfusion no non_nec_surg_abd NA 0
ms_blood_culture yes ms_plt no 0
ms_blood_culture yes ms_wbc no 0
ms_blood_culture yes ms_feeding no 0
ms_blood_culture no ms_feeding yes 0
ms_blood_culture yes ms_ivh no 0
ms_blood_culture no ms_ivh yes 0
ms_blood_culture yes ms_pvl no 0
ms_blood_culture no ms_pvl yes 0
ms_blood_culture yes ms_cerebellar_hemorrhage no 0
ms_blood_culture no ms_cerebellar_hemorrhage yes 0
ms_blood_culture yes ms_ischaemic_stroke no 0
ms_blood_culture no ms_ischaemic_stroke yes 0
ms_blood_culture yes ms_hs_pda_iv no 0
ms_blood_culture no ms_hs_pda_iv yes 0
ms_blood_culture yes ms_nec no 0
ms_blood_culture no ms_nec yes 0
ms_blood_culture yes ms_non_nec_surg_abd no 0
ms_blood_culture no ms_non_nec_surg_abd yes 0
ms_blood_culture yes ms_aki no 0
ms_blood_culture no ms_aki yes 0
ms_blood_culture yes socioeconomic_status 1-highest 0
ms_blood_culture yes education_status 1-postgraduate 0
ms_blood_culture yes education_status 4-high school 0
ms_blood_culture yes education_status 6-junior high school 0
ms_blood_culture yes education_status 7-elementary school 0
ms_blood_culture yes birthtime_scoring 2-born 17:00-23:59 0
ms_blood_culture yes survive 1-yes 0
ms_blood_culture yes rop_severe 0-none/stage I/stage II 0
ms_blood_culture yes rop_severe 1-stage II+ 0
ms_blood_culture yes bpd_grade 0-no BPD 0
ms_blood_culture yes bpd_grade 1-mild BPD 0
ms_blood_culture yes bpd_grade 2-moderate/severe BPD 0
ms_blood_culture yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_blood_culture yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_blood_culture yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_blood_culture yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_blood_culture yes hearing 0-passed 0
ms_blood_culture yes hearing 1-failed 0
ms_blood_culture yes bw_z_qw 4-BW z-score <=-3 0
ms_blood_culture yes hc_z_qw 3-HC z-score >-3 & <=-2 0
ms_blood_culture yes hc_z_qw 4-HC z-score <=-3 0
ms_blood_culture yes ivh 1-no IVH 0
ms_blood_culture yes ivh 2-IVH grade I 0
ms_blood_culture yes ivh 3-IVH grade II 0
ms_blood_culture yes ivh 4-IVH grade III 0
ms_blood_culture yes ivh 5-IVH grade IV, unilateral 0
ms_blood_culture yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
ms_blood_culture no ivh NA 0
ms_blood_culture yes cerebellar_hemorrhage 1-no bleeding 0
ms_blood_culture yes cerebellar_hemorrhage 3-severe bleeding 0
ms_blood_culture no cerebellar_hemorrhage NA 0
ms_blood_culture yes ischaemic_stroke 1-no ischemia 0
ms_blood_culture yes ischaemic_stroke 2-ischemia, unilateral 0
ms_blood_culture yes ischaemic_stroke 3-ischemia, bilateral 0
ms_blood_culture yes ischaemic_stroke 4-ischemia, multiple 0
ms_blood_culture no ischaemic_stroke NA 0
ms_blood_culture yes hs_pda_iv 1-no PDA/PDA, no intervention 0
ms_blood_culture yes hs_pda_iv 2-PDA, medical intervention 0
ms_blood_culture yes hs_pda_iv 3-PDA, surgical intervention 0
ms_blood_culture no hs_pda_iv NA 0
ms_blood_culture yes non_nec_surg_abd 1-no NEC/NEC, no surgery 0
ms_blood_culture yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ms_blood_culture yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_blood_culture no non_nec_surg_abd NA 0
ms_plt yes ms_wbc no 0
ms_plt no ms_feeding yes 0
ms_plt no ms_ivh yes 0
ms_plt no ms_pvl yes 0
ms_plt no ms_cerebellar_hemorrhage yes 0
ms_plt no ms_ischaemic_stroke yes 0
ms_plt no ms_hs_pda_iv yes 0
ms_plt no ms_nec yes 0
ms_plt no ms_non_nec_surg_abd yes 0
ms_plt no ms_aki yes 0
ms_plt no ivh NA 0
ms_plt no cerebellar_hemorrhage NA 0
ms_plt yes ischaemic_stroke 4-ischemia, multiple 0
ms_plt no ischaemic_stroke 2-ischemia, unilateral 0
ms_plt no ischaemic_stroke NA 0
ms_plt no hs_pda_iv NA 0
ms_plt no non_nec_surg_abd NA 0
ms_wbc no ms_feeding yes 0
ms_wbc no ms_ivh yes 0
ms_wbc no ms_pvl yes 0
ms_wbc no ms_cerebellar_hemorrhage yes 0
ms_wbc no ms_ischaemic_stroke yes 0
ms_wbc no ms_hs_pda_iv yes 0
ms_wbc no ms_nec yes 0
ms_wbc no ms_non_nec_surg_abd yes 0
ms_wbc no ms_aki yes 0
ms_wbc no ivh NA 0
ms_wbc no cerebellar_hemorrhage NA 0
ms_wbc yes ischaemic_stroke 4-ischemia, multiple 0
ms_wbc no ischaemic_stroke 2-ischemia, unilateral 0
ms_wbc no ischaemic_stroke NA 0
ms_wbc no hs_pda_iv NA 0
ms_wbc no non_nec_surg_abd NA 0
ms_feeding yes ms_ivh no 0
ms_feeding no ms_ivh yes 0
ms_feeding yes ms_pvl no 0
ms_feeding no ms_pvl yes 0
ms_feeding yes ms_cerebellar_hemorrhage no 0
ms_feeding no ms_cerebellar_hemorrhage yes 0
ms_feeding yes ms_ischaemic_stroke no 0
ms_feeding no ms_ischaemic_stroke yes 0
ms_feeding yes ms_hs_pda_iv no 0
ms_feeding no ms_hs_pda_iv yes 0
ms_feeding yes ms_nec no 0
ms_feeding no ms_nec yes 0
ms_feeding yes ms_non_nec_surg_abd no 0
ms_feeding no ms_non_nec_surg_abd yes 0
ms_feeding yes ms_aki no 0
ms_feeding no ms_aki yes 0
ms_feeding yes socioeconomic_status 1-highest 0
ms_feeding yes education_status 1-postgraduate 0
ms_feeding yes education_status 4-high school 0
ms_feeding yes education_status 6-junior high school 0
ms_feeding yes education_status 7-elementary school 0
ms_feeding yes birthtime_scoring 2-born 17:00-23:59 0
ms_feeding yes survive 1-yes 0
ms_feeding yes rop_severe 0-none/stage I/stage II 0
ms_feeding yes rop_severe 1-stage II+ 0
ms_feeding yes bpd_grade 0-no BPD 0
ms_feeding yes bpd_grade 1-mild BPD 0
ms_feeding yes bpd_grade 2-moderate/severe BPD 0
ms_feeding yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_feeding yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_feeding yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_feeding yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_feeding yes hearing 0-passed 0
ms_feeding yes hearing 1-failed 0
ms_feeding yes bw_z_qw 4-BW z-score <=-3 0
ms_feeding yes hc_z_qw 3-HC z-score >-3 & <=-2 0
ms_feeding yes hc_z_qw 4-HC z-score <=-3 0
ms_feeding yes ivh 1-no IVH 0
ms_feeding yes ivh 2-IVH grade I 0
ms_feeding yes ivh 3-IVH grade II 0
ms_feeding yes ivh 4-IVH grade III 0
ms_feeding yes ivh 5-IVH grade IV, unilateral 0
ms_feeding yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
ms_feeding no ivh NA 0
ms_feeding yes cerebellar_hemorrhage 1-no bleeding 0
ms_feeding yes cerebellar_hemorrhage 3-severe bleeding 0
ms_feeding no cerebellar_hemorrhage NA 0
ms_feeding yes ischaemic_stroke 1-no ischemia 0
ms_feeding yes ischaemic_stroke 2-ischemia, unilateral 0
ms_feeding yes ischaemic_stroke 3-ischemia, bilateral 0
ms_feeding yes ischaemic_stroke 4-ischemia, multiple 0
ms_feeding no ischaemic_stroke NA 0
ms_feeding yes hs_pda_iv 1-no PDA/PDA, no intervention 0
ms_feeding yes hs_pda_iv 2-PDA, medical intervention 0
ms_feeding yes hs_pda_iv 3-PDA, surgical intervention 0
ms_feeding no hs_pda_iv NA 0
ms_feeding yes non_nec_surg_abd 1-no NEC/NEC, no surgery 0
ms_feeding yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ms_feeding yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_feeding no non_nec_surg_abd NA 0
ms_ivh yes ms_pvl no 0
ms_ivh no ms_pvl yes 0
ms_ivh yes ms_cerebellar_hemorrhage no 0
ms_ivh no ms_cerebellar_hemorrhage yes 0
ms_ivh yes ms_ischaemic_stroke no 0
ms_ivh no ms_ischaemic_stroke yes 0
ms_ivh yes ms_hs_pda_iv no 0
ms_ivh no ms_hs_pda_iv yes 0
ms_ivh yes ms_nec no 0
ms_ivh no ms_nec yes 0
ms_ivh yes ms_non_nec_surg_abd no 0
ms_ivh no ms_non_nec_surg_abd yes 0
ms_ivh yes ms_aki no 0
ms_ivh no ms_aki yes 0
ms_ivh yes socioeconomic_status 1-highest 0
ms_ivh yes education_status 1-postgraduate 0
ms_ivh yes education_status 4-high school 0
ms_ivh yes education_status 6-junior high school 0
ms_ivh yes education_status 7-elementary school 0
ms_ivh yes birthtime_scoring 2-born 17:00-23:59 0
ms_ivh yes survive 1-yes 0
ms_ivh yes rop_severe 0-none/stage I/stage II 0
ms_ivh yes rop_severe 1-stage II+ 0
ms_ivh yes bpd_grade 0-no BPD 0
ms_ivh yes bpd_grade 1-mild BPD 0
ms_ivh yes bpd_grade 2-moderate/severe BPD 0
ms_ivh yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_ivh yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_ivh yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_ivh yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_ivh yes hearing 0-passed 0
ms_ivh yes hearing 1-failed 0
ms_ivh yes bw_z_qw 4-BW z-score <=-3 0
ms_ivh yes hc_z_qw 3-HC z-score >-3 & <=-2 0
ms_ivh yes hc_z_qw 4-HC z-score <=-3 0
ms_ivh yes ivh 1-no IVH 0
ms_ivh yes ivh 2-IVH grade I 0
ms_ivh yes ivh 3-IVH grade II 0
ms_ivh yes ivh 4-IVH grade III 0
ms_ivh yes ivh 5-IVH grade IV, unilateral 0
ms_ivh yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
ms_ivh no ivh NA 0
ms_ivh yes cerebellar_hemorrhage 1-no bleeding 0
ms_ivh yes cerebellar_hemorrhage 3-severe bleeding 0
ms_ivh no cerebellar_hemorrhage NA 0
ms_ivh yes ischaemic_stroke 1-no ischemia 0
ms_ivh yes ischaemic_stroke 2-ischemia, unilateral 0
ms_ivh yes ischaemic_stroke 3-ischemia, bilateral 0
ms_ivh yes ischaemic_stroke 4-ischemia, multiple 0
ms_ivh no ischaemic_stroke NA 0
ms_ivh yes hs_pda_iv 1-no PDA/PDA, no intervention 0
ms_ivh yes hs_pda_iv 2-PDA, medical intervention 0
ms_ivh yes hs_pda_iv 3-PDA, surgical intervention 0
ms_ivh no hs_pda_iv NA 0
ms_ivh yes non_nec_surg_abd 1-no NEC/NEC, no surgery 0
ms_ivh yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ms_ivh yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_ivh no non_nec_surg_abd NA 0
ms_pvl yes ms_cerebellar_hemorrhage no 0
ms_pvl no ms_cerebellar_hemorrhage yes 0
ms_pvl yes ms_ischaemic_stroke no 0
ms_pvl no ms_ischaemic_stroke yes 0
ms_pvl yes ms_hs_pda_iv no 0
ms_pvl no ms_hs_pda_iv yes 0
ms_pvl yes ms_nec no 0
ms_pvl no ms_nec yes 0
ms_pvl yes ms_non_nec_surg_abd no 0
ms_pvl no ms_non_nec_surg_abd yes 0
ms_pvl yes ms_aki no 0
ms_pvl no ms_aki yes 0
ms_pvl yes socioeconomic_status 1-highest 0
ms_pvl yes education_status 1-postgraduate 0
ms_pvl yes education_status 4-high school 0
ms_pvl yes education_status 6-junior high school 0
ms_pvl yes education_status 7-elementary school 0
ms_pvl yes birthtime_scoring 2-born 17:00-23:59 0
ms_pvl yes survive 1-yes 0
ms_pvl yes rop_severe 0-none/stage I/stage II 0
ms_pvl yes rop_severe 1-stage II+ 0
ms_pvl yes bpd_grade 0-no BPD 0
ms_pvl yes bpd_grade 1-mild BPD 0
ms_pvl yes bpd_grade 2-moderate/severe BPD 0
ms_pvl yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_pvl yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_pvl yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_pvl yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_pvl yes hearing 0-passed 0
ms_pvl yes hearing 1-failed 0
ms_pvl yes bw_z_qw 4-BW z-score <=-3 0
ms_pvl yes hc_z_qw 3-HC z-score >-3 & <=-2 0
ms_pvl yes hc_z_qw 4-HC z-score <=-3 0
ms_pvl yes ivh 1-no IVH 0
ms_pvl yes ivh 2-IVH grade I 0
ms_pvl yes ivh 3-IVH grade II 0
ms_pvl yes ivh 4-IVH grade III 0
ms_pvl yes ivh 5-IVH grade IV, unilateral 0
ms_pvl yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
ms_pvl no ivh NA 0
ms_pvl yes cerebellar_hemorrhage 1-no bleeding 0
ms_pvl yes cerebellar_hemorrhage 3-severe bleeding 0
ms_pvl no cerebellar_hemorrhage NA 0
ms_pvl yes ischaemic_stroke 1-no ischemia 0
ms_pvl yes ischaemic_stroke 2-ischemia, unilateral 0
ms_pvl yes ischaemic_stroke 3-ischemia, bilateral 0
ms_pvl yes ischaemic_stroke 4-ischemia, multiple 0
ms_pvl no ischaemic_stroke NA 0
ms_pvl yes hs_pda_iv 1-no PDA/PDA, no intervention 0
ms_pvl yes hs_pda_iv 2-PDA, medical intervention 0
ms_pvl yes hs_pda_iv 3-PDA, surgical intervention 0
ms_pvl no hs_pda_iv NA 0
ms_pvl yes non_nec_surg_abd 1-no NEC/NEC, no surgery 0
ms_pvl yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ms_pvl yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_pvl no non_nec_surg_abd NA 0
ms_cerebellar_hemorrhage yes ms_ischaemic_stroke no 0
ms_cerebellar_hemorrhage no ms_ischaemic_stroke yes 0
ms_cerebellar_hemorrhage yes ms_hs_pda_iv no 0
ms_cerebellar_hemorrhage no ms_hs_pda_iv yes 0
ms_cerebellar_hemorrhage yes ms_nec no 0
ms_cerebellar_hemorrhage no ms_nec yes 0
ms_cerebellar_hemorrhage yes ms_non_nec_surg_abd no 0
ms_cerebellar_hemorrhage no ms_non_nec_surg_abd yes 0
ms_cerebellar_hemorrhage yes ms_aki no 0
ms_cerebellar_hemorrhage no ms_aki yes 0
ms_cerebellar_hemorrhage yes socioeconomic_status 1-highest 0
ms_cerebellar_hemorrhage yes education_status 1-postgraduate 0
ms_cerebellar_hemorrhage yes education_status 4-high school 0
ms_cerebellar_hemorrhage yes education_status 6-junior high school 0
ms_cerebellar_hemorrhage yes education_status 7-elementary school 0
ms_cerebellar_hemorrhage yes birthtime_scoring 2-born 17:00-23:59 0
ms_cerebellar_hemorrhage yes survive 1-yes 0
ms_cerebellar_hemorrhage yes rop_severe 0-none/stage I/stage II 0
ms_cerebellar_hemorrhage yes rop_severe 1-stage II+ 0
ms_cerebellar_hemorrhage yes bpd_grade 0-no BPD 0
ms_cerebellar_hemorrhage yes bpd_grade 1-mild BPD 0
ms_cerebellar_hemorrhage yes bpd_grade 2-moderate/severe BPD 0
ms_cerebellar_hemorrhage yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_cerebellar_hemorrhage yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_cerebellar_hemorrhage yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_cerebellar_hemorrhage yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_cerebellar_hemorrhage yes hearing 0-passed 0
ms_cerebellar_hemorrhage yes hearing 1-failed 0
ms_cerebellar_hemorrhage yes bw_z_qw 4-BW z-score <=-3 0
ms_cerebellar_hemorrhage yes hc_z_qw 3-HC z-score >-3 & <=-2 0
ms_cerebellar_hemorrhage yes hc_z_qw 4-HC z-score <=-3 0
ms_cerebellar_hemorrhage yes ivh 1-no IVH 0
ms_cerebellar_hemorrhage yes ivh 2-IVH grade I 0
ms_cerebellar_hemorrhage yes ivh 3-IVH grade II 0
ms_cerebellar_hemorrhage yes ivh 4-IVH grade III 0
ms_cerebellar_hemorrhage yes ivh 5-IVH grade IV, unilateral 0
ms_cerebellar_hemorrhage yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
ms_cerebellar_hemorrhage no ivh NA 0
ms_cerebellar_hemorrhage yes cerebellar_hemorrhage 1-no bleeding 0
ms_cerebellar_hemorrhage yes cerebellar_hemorrhage 3-severe bleeding 0
ms_cerebellar_hemorrhage no cerebellar_hemorrhage NA 0
ms_cerebellar_hemorrhage yes ischaemic_stroke 1-no ischemia 0
ms_cerebellar_hemorrhage yes ischaemic_stroke 2-ischemia, unilateral 0
ms_cerebellar_hemorrhage yes ischaemic_stroke 3-ischemia, bilateral 0
ms_cerebellar_hemorrhage yes ischaemic_stroke 4-ischemia, multiple 0
ms_cerebellar_hemorrhage no ischaemic_stroke NA 0
ms_cerebellar_hemorrhage yes hs_pda_iv 1-no PDA/PDA, no intervention 0
ms_cerebellar_hemorrhage yes hs_pda_iv 2-PDA, medical intervention 0
ms_cerebellar_hemorrhage yes hs_pda_iv 3-PDA, surgical intervention 0
ms_cerebellar_hemorrhage no hs_pda_iv NA 0
ms_cerebellar_hemorrhage yes non_nec_surg_abd 1-no NEC/NEC, no surgery 0
ms_cerebellar_hemorrhage yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ms_cerebellar_hemorrhage yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_cerebellar_hemorrhage no non_nec_surg_abd NA 0
ms_ischaemic_stroke yes ms_hs_pda_iv no 0
ms_ischaemic_stroke no ms_hs_pda_iv yes 0
ms_ischaemic_stroke yes ms_nec no 0
ms_ischaemic_stroke no ms_nec yes 0
ms_ischaemic_stroke yes ms_non_nec_surg_abd no 0
ms_ischaemic_stroke no ms_non_nec_surg_abd yes 0
ms_ischaemic_stroke yes ms_aki no 0
ms_ischaemic_stroke no ms_aki yes 0
ms_ischaemic_stroke yes socioeconomic_status 1-highest 0
ms_ischaemic_stroke yes education_status 1-postgraduate 0
ms_ischaemic_stroke yes education_status 4-high school 0
ms_ischaemic_stroke yes education_status 6-junior high school 0
ms_ischaemic_stroke yes education_status 7-elementary school 0
ms_ischaemic_stroke yes birthtime_scoring 2-born 17:00-23:59 0
ms_ischaemic_stroke yes survive 1-yes 0
ms_ischaemic_stroke yes rop_severe 0-none/stage I/stage II 0
ms_ischaemic_stroke yes rop_severe 1-stage II+ 0
ms_ischaemic_stroke yes bpd_grade 0-no BPD 0
ms_ischaemic_stroke yes bpd_grade 1-mild BPD 0
ms_ischaemic_stroke yes bpd_grade 2-moderate/severe BPD 0
ms_ischaemic_stroke yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_ischaemic_stroke yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_ischaemic_stroke yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_ischaemic_stroke yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_ischaemic_stroke yes hearing 0-passed 0
ms_ischaemic_stroke yes hearing 1-failed 0
ms_ischaemic_stroke yes bw_z_qw 4-BW z-score <=-3 0
ms_ischaemic_stroke yes hc_z_qw 3-HC z-score >-3 & <=-2 0
ms_ischaemic_stroke yes hc_z_qw 4-HC z-score <=-3 0
ms_ischaemic_stroke yes ivh 1-no IVH 0
ms_ischaemic_stroke yes ivh 2-IVH grade I 0
ms_ischaemic_stroke yes ivh 3-IVH grade II 0
ms_ischaemic_stroke yes ivh 4-IVH grade III 0
ms_ischaemic_stroke yes ivh 5-IVH grade IV, unilateral 0
ms_ischaemic_stroke yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
ms_ischaemic_stroke no ivh NA 0
ms_ischaemic_stroke yes cerebellar_hemorrhage 1-no bleeding 0
ms_ischaemic_stroke yes cerebellar_hemorrhage 3-severe bleeding 0
ms_ischaemic_stroke no cerebellar_hemorrhage NA 0
ms_ischaemic_stroke yes ischaemic_stroke 1-no ischemia 0
ms_ischaemic_stroke yes ischaemic_stroke 2-ischemia, unilateral 0
ms_ischaemic_stroke yes ischaemic_stroke 3-ischemia, bilateral 0
ms_ischaemic_stroke yes ischaemic_stroke 4-ischemia, multiple 0
ms_ischaemic_stroke no ischaemic_stroke NA 0
ms_ischaemic_stroke yes hs_pda_iv 1-no PDA/PDA, no intervention 0
ms_ischaemic_stroke yes hs_pda_iv 2-PDA, medical intervention 0
ms_ischaemic_stroke yes hs_pda_iv 3-PDA, surgical intervention 0
ms_ischaemic_stroke no hs_pda_iv NA 0
ms_ischaemic_stroke yes non_nec_surg_abd 1-no NEC/NEC, no surgery 0
ms_ischaemic_stroke yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ms_ischaemic_stroke yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_ischaemic_stroke no non_nec_surg_abd NA 0
ms_hs_pda_iv yes ms_nec no 0
ms_hs_pda_iv no ms_nec yes 0
ms_hs_pda_iv yes ms_non_nec_surg_abd no 0
ms_hs_pda_iv no ms_non_nec_surg_abd yes 0
ms_hs_pda_iv yes ms_aki no 0
ms_hs_pda_iv no ms_aki yes 0
ms_hs_pda_iv yes socioeconomic_status 1-highest 0
ms_hs_pda_iv yes education_status 1-postgraduate 0
ms_hs_pda_iv yes education_status 4-high school 0
ms_hs_pda_iv yes education_status 6-junior high school 0
ms_hs_pda_iv yes education_status 7-elementary school 0
ms_hs_pda_iv yes birthtime_scoring 2-born 17:00-23:59 0
ms_hs_pda_iv yes survive 1-yes 0
ms_hs_pda_iv yes rop_severe 0-none/stage I/stage II 0
ms_hs_pda_iv yes rop_severe 1-stage II+ 0
ms_hs_pda_iv yes bpd_grade 0-no BPD 0
ms_hs_pda_iv yes bpd_grade 1-mild BPD 0
ms_hs_pda_iv yes bpd_grade 2-moderate/severe BPD 0
ms_hs_pda_iv yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_hs_pda_iv yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_hs_pda_iv yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_hs_pda_iv yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_hs_pda_iv yes hearing 0-passed 0
ms_hs_pda_iv yes hearing 1-failed 0
ms_hs_pda_iv yes bw_z_qw 4-BW z-score <=-3 0
ms_hs_pda_iv yes hc_z_qw 3-HC z-score >-3 & <=-2 0
ms_hs_pda_iv yes hc_z_qw 4-HC z-score <=-3 0
ms_hs_pda_iv yes ivh 1-no IVH 0
ms_hs_pda_iv yes ivh 2-IVH grade I 0
ms_hs_pda_iv yes ivh 3-IVH grade II 0
ms_hs_pda_iv yes ivh 4-IVH grade III 0
ms_hs_pda_iv yes ivh 5-IVH grade IV, unilateral 0
ms_hs_pda_iv yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
ms_hs_pda_iv no ivh NA 0
ms_hs_pda_iv yes cerebellar_hemorrhage 1-no bleeding 0
ms_hs_pda_iv yes cerebellar_hemorrhage 3-severe bleeding 0
ms_hs_pda_iv no cerebellar_hemorrhage NA 0
ms_hs_pda_iv yes ischaemic_stroke 1-no ischemia 0
ms_hs_pda_iv yes ischaemic_stroke 2-ischemia, unilateral 0
ms_hs_pda_iv yes ischaemic_stroke 3-ischemia, bilateral 0
ms_hs_pda_iv yes ischaemic_stroke 4-ischemia, multiple 0
ms_hs_pda_iv no ischaemic_stroke NA 0
ms_hs_pda_iv yes hs_pda_iv 1-no PDA/PDA, no intervention 0
ms_hs_pda_iv yes hs_pda_iv 2-PDA, medical intervention 0
ms_hs_pda_iv yes hs_pda_iv 3-PDA, surgical intervention 0
ms_hs_pda_iv no hs_pda_iv NA 0
ms_hs_pda_iv yes non_nec_surg_abd 1-no NEC/NEC, no surgery 0
ms_hs_pda_iv yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ms_hs_pda_iv yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_hs_pda_iv no non_nec_surg_abd NA 0
ms_nec yes ms_non_nec_surg_abd no 0
ms_nec no ms_non_nec_surg_abd yes 0
ms_nec yes ms_aki no 0
ms_nec no ms_aki yes 0
ms_nec yes socioeconomic_status 1-highest 0
ms_nec yes education_status 1-postgraduate 0
ms_nec yes education_status 4-high school 0
ms_nec yes education_status 6-junior high school 0
ms_nec yes education_status 7-elementary school 0
ms_nec yes birthtime_scoring 2-born 17:00-23:59 0
ms_nec yes survive 1-yes 0
ms_nec yes rop_severe 0-none/stage I/stage II 0
ms_nec yes rop_severe 1-stage II+ 0
ms_nec yes bpd_grade 0-no BPD 0
ms_nec yes bpd_grade 1-mild BPD 0
ms_nec yes bpd_grade 2-moderate/severe BPD 0
ms_nec yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_nec yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_nec yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_nec yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_nec yes hearing 0-passed 0
ms_nec yes hearing 1-failed 0
ms_nec yes bw_z_qw 4-BW z-score <=-3 0
ms_nec yes hc_z_qw 3-HC z-score >-3 & <=-2 0
ms_nec yes hc_z_qw 4-HC z-score <=-3 0
ms_nec yes ivh 1-no IVH 0
ms_nec yes ivh 2-IVH grade I 0
ms_nec yes ivh 3-IVH grade II 0
ms_nec yes ivh 4-IVH grade III 0
ms_nec yes ivh 5-IVH grade IV, unilateral 0
ms_nec yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
ms_nec no ivh NA 0
ms_nec yes cerebellar_hemorrhage 1-no bleeding 0
ms_nec yes cerebellar_hemorrhage 3-severe bleeding 0
ms_nec no cerebellar_hemorrhage NA 0
ms_nec yes ischaemic_stroke 1-no ischemia 0
ms_nec yes ischaemic_stroke 2-ischemia, unilateral 0
ms_nec yes ischaemic_stroke 3-ischemia, bilateral 0
ms_nec yes ischaemic_stroke 4-ischemia, multiple 0
ms_nec no ischaemic_stroke NA 0
ms_nec yes hs_pda_iv 1-no PDA/PDA, no intervention 0
ms_nec yes hs_pda_iv 2-PDA, medical intervention 0
ms_nec yes hs_pda_iv 3-PDA, surgical intervention 0
ms_nec no hs_pda_iv NA 0
ms_nec yes non_nec_surg_abd 1-no NEC/NEC, no surgery 0
ms_nec yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ms_nec yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_nec no non_nec_surg_abd NA 0
ms_non_nec_surg_abd yes ms_aki no 0
ms_non_nec_surg_abd no ms_aki yes 0
ms_non_nec_surg_abd yes socioeconomic_status 1-highest 0
ms_non_nec_surg_abd yes education_status 1-postgraduate 0
ms_non_nec_surg_abd yes education_status 4-high school 0
ms_non_nec_surg_abd yes education_status 6-junior high school 0
ms_non_nec_surg_abd yes education_status 7-elementary school 0
ms_non_nec_surg_abd yes birthtime_scoring 2-born 17:00-23:59 0
ms_non_nec_surg_abd yes survive 1-yes 0
ms_non_nec_surg_abd yes rop_severe 0-none/stage I/stage II 0
ms_non_nec_surg_abd yes rop_severe 1-stage II+ 0
ms_non_nec_surg_abd yes bpd_grade 0-no BPD 0
ms_non_nec_surg_abd yes bpd_grade 1-mild BPD 0
ms_non_nec_surg_abd yes bpd_grade 2-moderate/severe BPD 0
ms_non_nec_surg_abd yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_non_nec_surg_abd yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_non_nec_surg_abd yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_non_nec_surg_abd yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_non_nec_surg_abd yes hearing 0-passed 0
ms_non_nec_surg_abd yes hearing 1-failed 0
ms_non_nec_surg_abd yes bw_z_qw 4-BW z-score <=-3 0
ms_non_nec_surg_abd yes hc_z_qw 3-HC z-score >-3 & <=-2 0
ms_non_nec_surg_abd yes hc_z_qw 4-HC z-score <=-3 0
ms_non_nec_surg_abd yes ivh 1-no IVH 0
ms_non_nec_surg_abd yes ivh 2-IVH grade I 0
ms_non_nec_surg_abd yes ivh 3-IVH grade II 0
ms_non_nec_surg_abd yes ivh 4-IVH grade III 0
ms_non_nec_surg_abd yes ivh 5-IVH grade IV, unilateral 0
ms_non_nec_surg_abd yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
ms_non_nec_surg_abd no ivh NA 0
ms_non_nec_surg_abd yes cerebellar_hemorrhage 1-no bleeding 0
ms_non_nec_surg_abd yes cerebellar_hemorrhage 3-severe bleeding 0
ms_non_nec_surg_abd no cerebellar_hemorrhage NA 0
ms_non_nec_surg_abd yes ischaemic_stroke 1-no ischemia 0
ms_non_nec_surg_abd yes ischaemic_stroke 2-ischemia, unilateral 0
ms_non_nec_surg_abd yes ischaemic_stroke 3-ischemia, bilateral 0
ms_non_nec_surg_abd yes ischaemic_stroke 4-ischemia, multiple 0
ms_non_nec_surg_abd no ischaemic_stroke NA 0
ms_non_nec_surg_abd yes hs_pda_iv 1-no PDA/PDA, no intervention 0
ms_non_nec_surg_abd yes hs_pda_iv 2-PDA, medical intervention 0
ms_non_nec_surg_abd yes hs_pda_iv 3-PDA, surgical intervention 0
ms_non_nec_surg_abd no hs_pda_iv NA 0
ms_non_nec_surg_abd yes non_nec_surg_abd 1-no NEC/NEC, no surgery 0
ms_non_nec_surg_abd yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ms_non_nec_surg_abd yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_non_nec_surg_abd no non_nec_surg_abd NA 0
ms_aki yes socioeconomic_status 1-highest 0
ms_aki yes education_status 1-postgraduate 0
ms_aki yes education_status 4-high school 0
ms_aki yes education_status 6-junior high school 0
ms_aki yes education_status 7-elementary school 0
ms_aki yes birthtime_scoring 2-born 17:00-23:59 0
ms_aki yes survive 1-yes 0
ms_aki yes rop_severe 0-none/stage I/stage II 0
ms_aki yes rop_severe 1-stage II+ 0
ms_aki yes bpd_grade 0-no BPD 0
ms_aki yes bpd_grade 1-mild BPD 0
ms_aki yes bpd_grade 2-moderate/severe BPD 0
ms_aki yes eugr_hc 0-HC z-score at birth >=-1.5 0
ms_aki yes eugr_hc 1-HC z-score at birth <-1.5 0
ms_aki yes eugr_bw 0-BW z-score at birth >=-1.5 0
ms_aki yes eugr_bw 1-BW z-score at birth <-1.5 0
ms_aki yes hearing 0-passed 0
ms_aki yes hearing 1-failed 0
ms_aki yes bw_z_qw 4-BW z-score <=-3 0
ms_aki yes hc_z_qw 3-HC z-score >-3 & <=-2 0
ms_aki yes hc_z_qw 4-HC z-score <=-3 0
ms_aki yes ivh 1-no IVH 0
ms_aki yes ivh 2-IVH grade I 0
ms_aki yes ivh 3-IVH grade II 0
ms_aki yes ivh 4-IVH grade III 0
ms_aki yes ivh 5-IVH grade IV, unilateral 0
ms_aki yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
ms_aki no ivh NA 0
ms_aki yes cerebellar_hemorrhage 1-no bleeding 0
ms_aki yes cerebellar_hemorrhage 3-severe bleeding 0
ms_aki no cerebellar_hemorrhage NA 0
ms_aki yes ischaemic_stroke 1-no ischemia 0
ms_aki yes ischaemic_stroke 2-ischemia, unilateral 0
ms_aki yes ischaemic_stroke 3-ischemia, bilateral 0
ms_aki yes ischaemic_stroke 4-ischemia, multiple 0
ms_aki no ischaemic_stroke NA 0
ms_aki yes hs_pda_iv 1-no PDA/PDA, no intervention 0
ms_aki yes hs_pda_iv 2-PDA, medical intervention 0
ms_aki yes hs_pda_iv 3-PDA, surgical intervention 0
ms_aki no hs_pda_iv NA 0
ms_aki yes non_nec_surg_abd 1-no NEC/NEC, no surgery 0
ms_aki yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ms_aki yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ms_aki no non_nec_surg_abd NA 0
socioeconomic_status 4-second lowest education_status 1-postgraduate 0
socioeconomic_status 5-lowest education_status 1-postgraduate 0
socioeconomic_status 5-lowest education_status 2-college 0
socioeconomic_status 1-highest education_status 3-college, vocational 0
socioeconomic_status 5-lowest education_status 3-college, vocational 0
socioeconomic_status 1-highest education_status 4-high school 0
socioeconomic_status 1-highest education_status 5-high school, vocational 0
socioeconomic_status 1-highest education_status 6-junior high school 0
socioeconomic_status 1-highest education_status 7-elementary school 0
socioeconomic_status 2-second highest education_status 7-elementary school 0
socioeconomic_status 5-lowest ivf 1-yes 0
socioeconomic_status 1-highest pe 1-yes 0
socioeconomic_status 1-highest gdm 1-yes 0
socioeconomic_status 5-lowest gdm 1-yes 0
socioeconomic_status 1-highest chorioamnionitis 1-yes 0
socioeconomic_status 5-lowest chorioamnionitis 1-yes 0
socioeconomic_status 1-highest bpd_grade 1-mild BPD 0
socioeconomic_status 5-lowest bpd_grade 1-mild BPD 0
socioeconomic_status 1-highest bw_z_qw 3-BW z-score >-3 & <=-2 0
socioeconomic_status 1-highest bw_z_qw NA 0
socioeconomic_status 1-highest bw_z_qw 4-BW z-score <=-3 0
socioeconomic_status 2-second highest bw_z_qw 4-BW z-score <=-3 0
socioeconomic_status 5-lowest bw_z_qw 4-BW z-score <=-3 0
socioeconomic_status 1-highest hc_z_qw 3-HC z-score >-3 & <=-2 0
socioeconomic_status 1-highest hc_z_qw 4-HC z-score <=-3 0
socioeconomic_status 4-second lowest ivh 4-IVH grade III 0
socioeconomic_status 5-lowest ivh 4-IVH grade III 0
socioeconomic_status 1-highest ivh 5-IVH grade IV, unilateral 0
socioeconomic_status 1-highest ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
socioeconomic_status 5-lowest ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
socioeconomic_status 1-highest ivh NA 0
socioeconomic_status 1-highest cerebellar_hemorrhage 3-severe bleeding 0
socioeconomic_status 4-second lowest cerebellar_hemorrhage 3-severe bleeding 0
socioeconomic_status 5-lowest cerebellar_hemorrhage 3-severe bleeding 0
socioeconomic_status 1-highest cerebellar_hemorrhage NA 0
socioeconomic_status 1-highest ischaemic_stroke 2-ischemia, unilateral 0
socioeconomic_status 3-medium ischaemic_stroke 2-ischemia, unilateral 0
socioeconomic_status 5-lowest ischaemic_stroke 2-ischemia, unilateral 0
socioeconomic_status 1-highest ischaemic_stroke 3-ischemia, bilateral 0
socioeconomic_status 5-lowest ischaemic_stroke 3-ischemia, bilateral 0
socioeconomic_status 1-highest ischaemic_stroke NA 0
socioeconomic_status 1-highest ischaemic_stroke 4-ischemia, multiple 0
socioeconomic_status 2-second highest ischaemic_stroke 4-ischemia, multiple 0
socioeconomic_status 3-medium ischaemic_stroke 4-ischemia, multiple 0
socioeconomic_status 1-highest hs_pda_iv NA 0
socioeconomic_status 1-highest non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
socioeconomic_status 1-highest non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
socioeconomic_status 4-second lowest non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
socioeconomic_status 5-lowest non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
socioeconomic_status 1-highest non_nec_surg_abd NA 0
education_status 7-elementary school ivf 1-yes 0
education_status 7-elementary school pe 1-yes 0
education_status 6-junior high school gdm 1-yes 0
education_status 7-elementary school gdm 1-yes 0
education_status 7-elementary school birthtime_scoring 3-born 00:00-07:59 0
education_status 7-elementary school chorioamnionitis 1-yes 0
education_status 7-elementary school rop_severe 1-stage II+ 0
education_status 7-elementary school bpd_grade 1-mild BPD 0
education_status 7-elementary school eugr_hc 1-HC z-score at birth <-1.5 0
education_status 7-elementary school hearing 1-failed 0
education_status 7-elementary school bw_z_qw 3-BW z-score >-3 & <=-2 0
education_status 4-high school bw_z_qw NA 0
education_status 7-elementary school bw_z_qw NA 0
education_status 1-postgraduate bw_z_qw 4-BW z-score <=-3 0
education_status 4-high school bw_z_qw 4-BW z-score <=-3 0
education_status 6-junior high school bw_z_qw 4-BW z-score <=-3 0
education_status 7-elementary school bw_z_qw 4-BW z-score <=-3 0
education_status 7-elementary school hc_z_qw 4-HC z-score <=-3 0
education_status 7-elementary school ivh 2-IVH grade I 0
education_status 4-high school ivh 4-IVH grade III 0
education_status 5-high school, vocational ivh 4-IVH grade III 0
education_status 6-junior high school ivh 4-IVH grade III 0
education_status 7-elementary school ivh 4-IVH grade III 0
education_status 5-high school, vocational ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
education_status 6-junior high school ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
education_status 7-elementary school ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
education_status 1-postgraduate ivh 5-IVH grade IV, unilateral 0
education_status 3-college, vocational ivh 5-IVH grade IV, unilateral 0
education_status 1-postgraduate ivh NA 0
education_status 4-high school ivh NA 0
education_status 6-junior high school ivh NA 0
education_status 7-elementary school ivh NA 0
education_status 3-college, vocational cerebellar_hemorrhage 3-severe bleeding 0
education_status 4-high school cerebellar_hemorrhage 3-severe bleeding 0
education_status 6-junior high school cerebellar_hemorrhage 3-severe bleeding 0
education_status 7-elementary school cerebellar_hemorrhage 3-severe bleeding 0
education_status 1-postgraduate cerebellar_hemorrhage NA 0
education_status 4-high school cerebellar_hemorrhage NA 0
education_status 6-junior high school cerebellar_hemorrhage NA 0
education_status 7-elementary school cerebellar_hemorrhage NA 0
education_status 1-postgraduate ischaemic_stroke 2-ischemia, unilateral 0
education_status 3-college, vocational ischaemic_stroke 2-ischemia, unilateral 0
education_status 4-high school ischaemic_stroke 2-ischemia, unilateral 0
education_status 6-junior high school ischaemic_stroke 2-ischemia, unilateral 0
education_status 7-elementary school ischaemic_stroke 2-ischemia, unilateral 0
education_status 1-postgraduate ischaemic_stroke 3-ischemia, bilateral 0
education_status 3-college, vocational ischaemic_stroke 3-ischemia, bilateral 0
education_status 4-high school ischaemic_stroke 3-ischemia, bilateral 0
education_status 6-junior high school ischaemic_stroke 3-ischemia, bilateral 0
education_status 7-elementary school ischaemic_stroke 3-ischemia, bilateral 0
education_status 1-postgraduate ischaemic_stroke NA 0
education_status 4-high school ischaemic_stroke NA 0
education_status 6-junior high school ischaemic_stroke NA 0
education_status 7-elementary school ischaemic_stroke NA 0
education_status 1-postgraduate ischaemic_stroke 4-ischemia, multiple 0
education_status 2-college ischaemic_stroke 4-ischemia, multiple 0
education_status 3-college, vocational ischaemic_stroke 4-ischemia, multiple 0
education_status 6-junior high school ischaemic_stroke 4-ischemia, multiple 0
education_status 7-elementary school ischaemic_stroke 4-ischemia, multiple 0
education_status 7-elementary school hs_pda_iv 3-PDA, surgical intervention 0
education_status 1-postgraduate hs_pda_iv NA 0
education_status 4-high school hs_pda_iv NA 0
education_status 6-junior high school hs_pda_iv NA 0
education_status 7-elementary school hs_pda_iv NA 0
education_status 1-postgraduate non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
education_status 4-high school non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
education_status 6-junior high school non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
education_status 7-elementary school non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
education_status 1-postgraduate non_nec_surg_abd NA 0
education_status 4-high school non_nec_surg_abd NA 0
education_status 6-junior high school non_nec_surg_abd NA 0
education_status 7-elementary school non_nec_surg_abd NA 0
ivf 1-yes ischaemic_stroke 2-ischemia, unilateral 0
ivf 1-yes ischaemic_stroke 4-ischemia, multiple 0
pe 1-yes ischaemic_stroke 4-ischemia, multiple 0
gdm 1-yes bpd_grade 1-mild BPD 0
gdm 1-yes bw_z_qw 3-BW z-score >-3 & <=-2 0
gdm 1-yes bw_z_qw 4-BW z-score <=-3 0
gdm 1-yes ivh 4-IVH grade III 0
gdm 1-yes ischaemic_stroke 2-ischemia, unilateral 0
gdm 1-yes ischaemic_stroke 3-ischemia, bilateral 0
gdm 1-yes ischaemic_stroke 4-ischemia, multiple 0
gdm 1-yes non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
gdm 1-yes non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
cs 0-no bw_z_qw 4-BW z-score <=-3 0
cs 0-no ischaemic_stroke 3-ischemia, bilateral 0
cs 0-no ischaemic_stroke 4-ischemia, multiple 0
sex 0-female cerebellar_hemorrhage 3-severe bleeding 0
sex 0-female non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
multiple_gestation 1-yes ischaemic_stroke 2-ischemia, unilateral 0
multiple_gestation 0-no ischaemic_stroke 3-ischemia, bilateral 0
birthtime_scoring 2-born 17:00-23:59 ivh NA 0
birthtime_scoring 2-born 17:00-23:59 cerebellar_hemorrhage NA 0
birthtime_scoring 3-born 00:00-07:59 ischaemic_stroke 2-ischemia, unilateral 0
birthtime_scoring 3-born 00:00-07:59 ischaemic_stroke 3-ischemia, bilateral 0
birthtime_scoring 2-born 17:00-23:59 ischaemic_stroke NA 0
birthtime_scoring 1-born 08:00-16:59 ischaemic_stroke 4-ischemia, multiple 0
birthtime_scoring 3-born 00:00-07:59 ischaemic_stroke 4-ischemia, multiple 0
birthtime_scoring 2-born 17:00-23:59 hs_pda_iv NA 0
birthtime_scoring 2-born 17:00-23:59 non_nec_surg_abd NA 0
chorioamnionitis 1-yes bw_z_qw 4-BW z-score <=-3 0
chorioamnionitis 1-yes ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
chorioamnionitis 1-yes ischaemic_stroke 2-ischemia, unilateral 0
chorioamnionitis 1-yes ischaemic_stroke 3-ischemia, bilateral 0
chorioamnionitis 1-yes ischaemic_stroke 4-ischemia, multiple 0
survive 1-yes rop_severe NA 0
survive 1-yes bpd_grade NA 0
survive 0-no bpd_grade 1-mild BPD 0
survive 1-yes eugr_hc NA 0
survive 1-yes eugr_bw NA 0
survive 0-no hearing 0-passed 0
survive 0-no hearing 1-failed 0
survive 0-no bw_z_qw 4-BW z-score <=-3 0
survive 1-yes ivh NA 0
survive 1-yes cerebellar_hemorrhage NA 0
survive 1-yes ischaemic_stroke NA 0
survive 0-no ischaemic_stroke 4-ischemia, multiple 0
survive 1-yes hs_pda_iv NA 0
survive 1-yes non_nec_surg_abd NA 0
survive 0-no non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
rop_severe NA bpd_grade 0-no BPD 0
rop_severe NA bpd_grade 1-mild BPD 0
rop_severe NA bpd_grade 2-moderate/severe BPD 0
rop_severe 0-none/stage I/stage II bpd_grade NA 0
rop_severe 1-stage II+ bpd_grade NA 0
rop_severe NA eugr_hc 0-HC z-score at birth >=-1.5 0
rop_severe NA eugr_hc 1-HC z-score at birth <-1.5 0
rop_severe 1-stage II+ eugr_hc NA 0
rop_severe NA eugr_bw 0-BW z-score at birth >=-1.5 0
rop_severe NA eugr_bw 1-BW z-score at birth <-1.5 0
rop_severe 1-stage II+ eugr_bw NA 0
rop_severe NA hearing 0-passed 0
rop_severe NA hearing 1-failed 0
rop_severe 1-stage II+ bw_z_qw 4-BW z-score <=-3 0
rop_severe NA bw_z_qw 4-BW z-score <=-3 0
rop_severe NA hc_z_qw 4-HC z-score <=-3 0
rop_severe NA ivh 2-IVH grade I 0
rop_severe 0-none/stage I/stage II ivh NA 0
rop_severe 1-stage II+ ivh NA 0
rop_severe 1-stage II+ cerebellar_hemorrhage 3-severe bleeding 0
rop_severe 0-none/stage I/stage II cerebellar_hemorrhage NA 0
rop_severe 1-stage II+ cerebellar_hemorrhage NA 0
rop_severe 1-stage II+ ischaemic_stroke 2-ischemia, unilateral 0
rop_severe NA ischaemic_stroke 2-ischemia, unilateral 0
rop_severe 1-stage II+ ischaemic_stroke 3-ischemia, bilateral 0
rop_severe NA ischaemic_stroke 4-ischemia, multiple 0
rop_severe 0-none/stage I/stage II ischaemic_stroke NA 0
rop_severe 1-stage II+ ischaemic_stroke NA 0
rop_severe 0-none/stage I/stage II hs_pda_iv NA 0
rop_severe 1-stage II+ hs_pda_iv NA 0
rop_severe NA non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
rop_severe 0-none/stage I/stage II non_nec_surg_abd NA 0
rop_severe 1-stage II+ non_nec_surg_abd NA 0
bpd_grade NA eugr_hc 0-HC z-score at birth >=-1.5 0
bpd_grade NA eugr_hc 1-HC z-score at birth <-1.5 0
bpd_grade 1-mild BPD eugr_hc NA 0
bpd_grade 2-moderate/severe BPD eugr_hc NA 0
bpd_grade NA eugr_bw 0-BW z-score at birth >=-1.5 0
bpd_grade NA eugr_bw 1-BW z-score at birth <-1.5 0
bpd_grade 1-mild BPD eugr_bw NA 0
bpd_grade 2-moderate/severe BPD eugr_bw NA 0
bpd_grade NA hearing 0-passed 0
bpd_grade NA hearing 1-failed 0
bpd_grade 1-mild BPD hearing NA 0
bpd_grade 1-mild BPD bw_z_qw 4-BW z-score <=-3 0
bpd_grade NA bw_z_qw 4-BW z-score <=-3 0
bpd_grade NA hc_z_qw 4-HC z-score <=-3 0
bpd_grade 1-mild BPD ivh 2-IVH grade I 0
bpd_grade NA ivh 2-IVH grade I 0
bpd_grade 1-mild BPD ivh 5-IVH grade IV, unilateral 0
bpd_grade 1-mild BPD ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
bpd_grade 0-no BPD ivh NA 0
bpd_grade 1-mild BPD ivh NA 0
bpd_grade 2-moderate/severe BPD ivh NA 0
bpd_grade 0-no BPD cerebellar_hemorrhage 3-severe bleeding 0
bpd_grade 1-mild BPD cerebellar_hemorrhage 3-severe bleeding 0
bpd_grade 0-no BPD cerebellar_hemorrhage NA 0
bpd_grade 1-mild BPD cerebellar_hemorrhage NA 0
bpd_grade 2-moderate/severe BPD cerebellar_hemorrhage NA 0
bpd_grade 1-mild BPD ischaemic_stroke 2-ischemia, unilateral 0
bpd_grade NA ischaemic_stroke 2-ischemia, unilateral 0
bpd_grade 1-mild BPD ischaemic_stroke 3-ischemia, bilateral 0
bpd_grade 0-no BPD ischaemic_stroke 4-ischemia, multiple 0
bpd_grade 1-mild BPD ischaemic_stroke 4-ischemia, multiple 0
bpd_grade NA ischaemic_stroke 4-ischemia, multiple 0
bpd_grade 0-no BPD ischaemic_stroke NA 0
bpd_grade 1-mild BPD ischaemic_stroke NA 0
bpd_grade 2-moderate/severe BPD ischaemic_stroke NA 0
bpd_grade 0-no BPD hs_pda_iv NA 0
bpd_grade 1-mild BPD hs_pda_iv NA 0
bpd_grade 2-moderate/severe BPD hs_pda_iv NA 0
bpd_grade 1-mild BPD non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
bpd_grade 1-mild BPD non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
bpd_grade NA non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
bpd_grade 0-no BPD non_nec_surg_abd NA 0
bpd_grade 1-mild BPD non_nec_surg_abd NA 0
bpd_grade 2-moderate/severe BPD non_nec_surg_abd NA 0
eugr_hc NA eugr_bw 0-BW z-score at birth >=-1.5 0
eugr_hc NA eugr_bw 1-BW z-score at birth <-1.5 0
eugr_hc 0-HC z-score at birth >=-1.5 eugr_bw NA 0
eugr_hc 1-HC z-score at birth <-1.5 eugr_bw NA 0
eugr_hc NA hearing 0-passed 0
eugr_hc NA hearing 1-failed 0
eugr_hc NA bw_z_qw 4-BW z-score <=-3 0
eugr_hc NA hc_z_qw 4-HC z-score <=-3 0
eugr_hc NA ivh 2-IVH grade I 0
eugr_hc 0-HC z-score at birth >=-1.5 ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
eugr_hc 0-HC z-score at birth >=-1.5 ivh NA 0
eugr_hc 1-HC z-score at birth <-1.5 ivh NA 0
eugr_hc 0-HC z-score at birth >=-1.5 cerebellar_hemorrhage 3-severe bleeding 0
eugr_hc 0-HC z-score at birth >=-1.5 cerebellar_hemorrhage NA 0
eugr_hc 1-HC z-score at birth <-1.5 cerebellar_hemorrhage NA 0
eugr_hc NA ischaemic_stroke 2-ischemia, unilateral 0
eugr_hc 0-HC z-score at birth >=-1.5 ischaemic_stroke 3-ischemia, bilateral 0
eugr_hc 0-HC z-score at birth >=-1.5 ischaemic_stroke 4-ischemia, multiple 0
eugr_hc NA ischaemic_stroke 4-ischemia, multiple 0
eugr_hc 0-HC z-score at birth >=-1.5 ischaemic_stroke NA 0
eugr_hc 1-HC z-score at birth <-1.5 ischaemic_stroke NA 0
eugr_hc 0-HC z-score at birth >=-1.5 hs_pda_iv NA 0
eugr_hc 1-HC z-score at birth <-1.5 hs_pda_iv NA 0
eugr_hc NA non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
eugr_hc 0-HC z-score at birth >=-1.5 non_nec_surg_abd NA 0
eugr_hc 1-HC z-score at birth <-1.5 non_nec_surg_abd NA 0
eugr_bw NA hearing 0-passed 0
eugr_bw NA hearing 1-failed 0
eugr_bw NA bw_z_qw 4-BW z-score <=-3 0
eugr_bw 1-BW z-score at birth <-1.5 bw_z_qw NA 0
eugr_bw NA hc_z_qw 4-HC z-score <=-3 0
eugr_bw NA ivh 2-IVH grade I 0
eugr_bw 0-BW z-score at birth >=-1.5 ivh NA 0
eugr_bw 1-BW z-score at birth <-1.5 ivh NA 0
eugr_bw 0-BW z-score at birth >=-1.5 cerebellar_hemorrhage 3-severe bleeding 0
eugr_bw 0-BW z-score at birth >=-1.5 cerebellar_hemorrhage NA 0
eugr_bw 1-BW z-score at birth <-1.5 cerebellar_hemorrhage NA 0
eugr_bw NA ischaemic_stroke 2-ischemia, unilateral 0
eugr_bw 1-BW z-score at birth <-1.5 ischaemic_stroke 3-ischemia, bilateral 0
eugr_bw 1-BW z-score at birth <-1.5 ischaemic_stroke 4-ischemia, multiple 0
eugr_bw NA ischaemic_stroke 4-ischemia, multiple 0
eugr_bw 0-BW z-score at birth >=-1.5 ischaemic_stroke NA 0
eugr_bw 1-BW z-score at birth <-1.5 ischaemic_stroke NA 0
eugr_bw 0-BW z-score at birth >=-1.5 hs_pda_iv NA 0
eugr_bw 1-BW z-score at birth <-1.5 hs_pda_iv NA 0
eugr_bw NA non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
eugr_bw 0-BW z-score at birth >=-1.5 non_nec_surg_abd NA 0
eugr_bw 1-BW z-score at birth <-1.5 non_nec_surg_abd NA 0
hearing NA bw_z_qw 4-BW z-score <=-3 0
hearing 0-passed ivh NA 0
hearing 1-failed ivh NA 0
hearing 1-failed cerebellar_hemorrhage 3-severe bleeding 0
hearing 0-passed cerebellar_hemorrhage NA 0
hearing 1-failed cerebellar_hemorrhage NA 0
hearing 1-failed ischaemic_stroke 3-ischemia, bilateral 0
hearing 1-failed ischaemic_stroke 4-ischemia, multiple 0
hearing 0-passed ischaemic_stroke NA 0
hearing 1-failed ischaemic_stroke NA 0
hearing 0-passed hs_pda_iv NA 0
hearing 1-failed hs_pda_iv NA 0
hearing NA non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
hearing 0-passed non_nec_surg_abd NA 0
hearing 1-failed non_nec_surg_abd NA 0
bw_z_qw 4-BW z-score <=-3 hc_z_qw 1-HC z-score >-1 0
bw_z_qw NA hc_z_qw 1-HC z-score >-1 0
bw_z_qw 4-BW z-score <=-3 hc_z_qw 2-HC z-score >-2 & <=-1 0
bw_z_qw NA hc_z_qw 2-HC z-score >-2 & <=-1 0
bw_z_qw 4-BW z-score <=-3 hc_z_qw 3-HC z-score >-3 & <=-2 0
bw_z_qw NA hc_z_qw 3-HC z-score >-3 & <=-2 0
bw_z_qw 4-BW z-score <=-3 hc_z_qw NA 0
bw_z_qw 4-BW z-score <=-3 ivh 2-IVH grade I 0
bw_z_qw NA ivh 2-IVH grade I 0
bw_z_qw 4-BW z-score <=-3 ivh 3-IVH grade II 0
bw_z_qw NA ivh 3-IVH grade II 0
bw_z_qw 4-BW z-score <=-3 ivh 4-IVH grade III 0
bw_z_qw NA ivh 4-IVH grade III 0
bw_z_qw 4-BW z-score <=-3 ivh 5-IVH grade IV, unilateral 0
bw_z_qw NA ivh 5-IVH grade IV, unilateral 0
bw_z_qw 4-BW z-score <=-3 ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
bw_z_qw NA ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
bw_z_qw 4-BW z-score <=-3 ivh NA 0
bw_z_qw 3-BW z-score >-3 & <=-2 cerebellar_hemorrhage 3-severe bleeding 0
bw_z_qw 4-BW z-score <=-3 cerebellar_hemorrhage 3-severe bleeding 0
bw_z_qw NA cerebellar_hemorrhage 3-severe bleeding 0
bw_z_qw 4-BW z-score <=-3 cerebellar_hemorrhage NA 0
bw_z_qw 4-BW z-score <=-3 ischaemic_stroke 2-ischemia, unilateral 0
bw_z_qw NA ischaemic_stroke 2-ischemia, unilateral 0
bw_z_qw 2-BW z-score >-2 & <=-1 ischaemic_stroke 3-ischemia, bilateral 0
bw_z_qw 3-BW z-score >-3 & <=-2 ischaemic_stroke 3-ischemia, bilateral 0
bw_z_qw 4-BW z-score <=-3 ischaemic_stroke 3-ischemia, bilateral 0
bw_z_qw 2-BW z-score >-2 & <=-1 ischaemic_stroke 4-ischemia, multiple 0
bw_z_qw 3-BW z-score >-3 & <=-2 ischaemic_stroke 4-ischemia, multiple 0
bw_z_qw 4-BW z-score <=-3 ischaemic_stroke 4-ischemia, multiple 0
bw_z_qw NA ischaemic_stroke 4-ischemia, multiple 0
bw_z_qw 4-BW z-score <=-3 ischaemic_stroke NA 0
bw_z_qw 4-BW z-score <=-3 hs_pda_iv 2-PDA, medical intervention 0
bw_z_qw 4-BW z-score <=-3 hs_pda_iv 3-PDA, surgical intervention 0
bw_z_qw NA hs_pda_iv 3-PDA, surgical intervention 0
bw_z_qw 4-BW z-score <=-3 hs_pda_iv NA 0
bw_z_qw 4-BW z-score <=-3 non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
bw_z_qw NA non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
bw_z_qw 4-BW z-score <=-3 non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
bw_z_qw NA non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
bw_z_qw 4-BW z-score <=-3 non_nec_surg_abd NA 0
hc_z_qw 4-HC z-score <=-3 ivh 2-IVH grade I 0
hc_z_qw NA ivh 2-IVH grade I 0
hc_z_qw NA ivh 3-IVH grade II 0
hc_z_qw 4-HC z-score <=-3 ivh 4-IVH grade III 0
hc_z_qw NA ivh 4-IVH grade III 0
hc_z_qw 4-HC z-score <=-3 ivh 5-IVH grade IV, unilateral 0
hc_z_qw NA ivh 5-IVH grade IV, unilateral 0
hc_z_qw 4-HC z-score <=-3 ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
hc_z_qw NA ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 0
hc_z_qw 3-HC z-score >-3 & <=-2 ivh NA 0
hc_z_qw 4-HC z-score <=-3 ivh NA 0
hc_z_qw 2-HC z-score >-2 & <=-1 cerebellar_hemorrhage 3-severe bleeding 0
hc_z_qw 3-HC z-score >-3 & <=-2 cerebellar_hemorrhage 3-severe bleeding 0
hc_z_qw 4-HC z-score <=-3 cerebellar_hemorrhage 3-severe bleeding 0
hc_z_qw NA cerebellar_hemorrhage 3-severe bleeding 0
hc_z_qw 3-HC z-score >-3 & <=-2 cerebellar_hemorrhage NA 0
hc_z_qw 4-HC z-score <=-3 cerebellar_hemorrhage NA 0
hc_z_qw 2-HC z-score >-2 & <=-1 ischaemic_stroke 3-ischemia, bilateral 0
hc_z_qw 3-HC z-score >-3 & <=-2 ischaemic_stroke 3-ischemia, bilateral 0
hc_z_qw 4-HC z-score <=-3 ischaemic_stroke 3-ischemia, bilateral 0
hc_z_qw 3-HC z-score >-3 & <=-2 ischaemic_stroke 4-ischemia, multiple 0
hc_z_qw 4-HC z-score <=-3 ischaemic_stroke 4-ischemia, multiple 0
hc_z_qw NA ischaemic_stroke 4-ischemia, multiple 0
hc_z_qw 3-HC z-score >-3 & <=-2 ischaemic_stroke NA 0
hc_z_qw 4-HC z-score <=-3 ischaemic_stroke NA 0
hc_z_qw 1-HC z-score >-1 ischaemic_stroke 2-ischemia, unilateral 0
hc_z_qw 3-HC z-score >-3 & <=-2 ischaemic_stroke 2-ischemia, unilateral 0
hc_z_qw 3-HC z-score >-3 & <=-2 hs_pda_iv NA 0
hc_z_qw 4-HC z-score <=-3 hs_pda_iv NA 0
hc_z_qw 4-HC z-score <=-3 non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
hc_z_qw NA non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
hc_z_qw 3-HC z-score >-3 & <=-2 non_nec_surg_abd NA 0
hc_z_qw 4-HC z-score <=-3 non_nec_surg_abd NA 0
hc_z_qw 1-HC z-score >-1 non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
hc_z_qw NA non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ivh NA cerebellar_hemorrhage 1-no bleeding 0
ivh 2-IVH grade I cerebellar_hemorrhage 3-severe bleeding 0
ivh 3-IVH grade II cerebellar_hemorrhage 3-severe bleeding 0
ivh 4-IVH grade III cerebellar_hemorrhage 3-severe bleeding 0
ivh 5-IVH grade IV, unilateral cerebellar_hemorrhage 3-severe bleeding 0
ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus cerebellar_hemorrhage 3-severe bleeding 0
ivh NA cerebellar_hemorrhage 3-severe bleeding 0
ivh 1-no IVH cerebellar_hemorrhage NA 0
ivh 2-IVH grade I cerebellar_hemorrhage NA 0
ivh 3-IVH grade II cerebellar_hemorrhage NA 0
ivh 4-IVH grade III cerebellar_hemorrhage NA 0
ivh 5-IVH grade IV, unilateral cerebellar_hemorrhage NA 0
ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus cerebellar_hemorrhage NA 0
ivh NA ischaemic_stroke 1-no ischemia 0
ivh 2-IVH grade I ischaemic_stroke 2-ischemia, unilateral 0
ivh 3-IVH grade II ischaemic_stroke 2-ischemia, unilateral 0
ivh 4-IVH grade III ischaemic_stroke 2-ischemia, unilateral 0
ivh 5-IVH grade IV, unilateral ischaemic_stroke 2-ischemia, unilateral 0
ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus ischaemic_stroke 2-ischemia, unilateral 0
ivh NA ischaemic_stroke 2-ischemia, unilateral 0
ivh 2-IVH grade I ischaemic_stroke 3-ischemia, bilateral 0
ivh 3-IVH grade II ischaemic_stroke 3-ischemia, bilateral 0
ivh 4-IVH grade III ischaemic_stroke 3-ischemia, bilateral 0
ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus ischaemic_stroke 3-ischemia, bilateral 0
ivh NA ischaemic_stroke 3-ischemia, bilateral 0
ivh 2-IVH grade I ischaemic_stroke 4-ischemia, multiple 0
ivh 3-IVH grade II ischaemic_stroke 4-ischemia, multiple 0
ivh 4-IVH grade III ischaemic_stroke 4-ischemia, multiple 0
ivh 5-IVH grade IV, unilateral ischaemic_stroke 4-ischemia, multiple 0
ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus ischaemic_stroke 4-ischemia, multiple 0
ivh NA ischaemic_stroke 4-ischemia, multiple 0
ivh 1-no IVH ischaemic_stroke NA 0
ivh 2-IVH grade I ischaemic_stroke NA 0
ivh 3-IVH grade II ischaemic_stroke NA 0
ivh 4-IVH grade III ischaemic_stroke NA 0
ivh 5-IVH grade IV, unilateral ischaemic_stroke NA 0
ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus ischaemic_stroke NA 0
ivh NA hs_pda_iv 1-no PDA/PDA, no intervention 0
ivh 4-IVH grade III hs_pda_iv 2-PDA, medical intervention 0
ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus hs_pda_iv 2-PDA, medical intervention 0
ivh NA hs_pda_iv 2-PDA, medical intervention 0
ivh 2-IVH grade I hs_pda_iv 3-PDA, surgical intervention 0
ivh 3-IVH grade II hs_pda_iv 3-PDA, surgical intervention 0
ivh 4-IVH grade III hs_pda_iv 3-PDA, surgical intervention 0
ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus hs_pda_iv 3-PDA, surgical intervention 0
ivh NA hs_pda_iv 3-PDA, surgical intervention 0
ivh 1-no IVH hs_pda_iv NA 0
ivh 2-IVH grade I hs_pda_iv NA 0
ivh 3-IVH grade II hs_pda_iv NA 0
ivh 4-IVH grade III hs_pda_iv NA 0
ivh 5-IVH grade IV, unilateral hs_pda_iv NA 0
ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus hs_pda_iv NA 0
ivh NA non_nec_surg_abd 1-no NEC/NEC, no surgery 0
ivh 2-IVH grade I non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ivh 3-IVH grade II non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ivh 4-IVH grade III non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ivh 5-IVH grade IV, unilateral non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ivh NA non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ivh 2-IVH grade I non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ivh 3-IVH grade II non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ivh 4-IVH grade III non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ivh 5-IVH grade IV, unilateral non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ivh NA non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ivh 1-no IVH non_nec_surg_abd NA 0
ivh 2-IVH grade I non_nec_surg_abd NA 0
ivh 3-IVH grade II non_nec_surg_abd NA 0
ivh 4-IVH grade III non_nec_surg_abd NA 0
ivh 5-IVH grade IV, unilateral non_nec_surg_abd NA 0
ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus non_nec_surg_abd NA 0
cerebellar_hemorrhage NA ischaemic_stroke 1-no ischemia 0
cerebellar_hemorrhage 3-severe bleeding ischaemic_stroke 2-ischemia, unilateral 0
cerebellar_hemorrhage NA ischaemic_stroke 2-ischemia, unilateral 0
cerebellar_hemorrhage 3-severe bleeding ischaemic_stroke 3-ischemia, bilateral 0
cerebellar_hemorrhage NA ischaemic_stroke 3-ischemia, bilateral 0
cerebellar_hemorrhage 3-severe bleeding ischaemic_stroke 4-ischemia, multiple 0
cerebellar_hemorrhage NA ischaemic_stroke 4-ischemia, multiple 0
cerebellar_hemorrhage 1-no bleeding ischaemic_stroke NA 0
cerebellar_hemorrhage 3-severe bleeding ischaemic_stroke NA 0
cerebellar_hemorrhage NA hs_pda_iv 1-no PDA/PDA, no intervention 0
cerebellar_hemorrhage 3-severe bleeding hs_pda_iv 2-PDA, medical intervention 0
cerebellar_hemorrhage NA hs_pda_iv 2-PDA, medical intervention 0
cerebellar_hemorrhage 3-severe bleeding hs_pda_iv 3-PDA, surgical intervention 0
cerebellar_hemorrhage NA hs_pda_iv 3-PDA, surgical intervention 0
cerebellar_hemorrhage 1-no bleeding hs_pda_iv NA 0
cerebellar_hemorrhage 3-severe bleeding hs_pda_iv NA 0
cerebellar_hemorrhage NA non_nec_surg_abd 1-no NEC/NEC, no surgery 0
cerebellar_hemorrhage 3-severe bleeding non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
cerebellar_hemorrhage NA non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
cerebellar_hemorrhage 3-severe bleeding non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
cerebellar_hemorrhage NA non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
cerebellar_hemorrhage 1-no bleeding non_nec_surg_abd NA 0
cerebellar_hemorrhage 3-severe bleeding non_nec_surg_abd NA 0
ischaemic_stroke NA hs_pda_iv 1-no PDA/PDA, no intervention 0
ischaemic_stroke 2-ischemia, unilateral hs_pda_iv 2-PDA, medical intervention 0
ischaemic_stroke 3-ischemia, bilateral hs_pda_iv 2-PDA, medical intervention 0
ischaemic_stroke 4-ischemia, multiple hs_pda_iv 2-PDA, medical intervention 0
ischaemic_stroke NA hs_pda_iv 2-PDA, medical intervention 0
ischaemic_stroke 2-ischemia, unilateral hs_pda_iv 3-PDA, surgical intervention 0
ischaemic_stroke 3-ischemia, bilateral hs_pda_iv 3-PDA, surgical intervention 0
ischaemic_stroke 4-ischemia, multiple hs_pda_iv 3-PDA, surgical intervention 0
ischaemic_stroke NA hs_pda_iv 3-PDA, surgical intervention 0
ischaemic_stroke 1-no ischemia hs_pda_iv NA 0
ischaemic_stroke 2-ischemia, unilateral hs_pda_iv NA 0
ischaemic_stroke 3-ischemia, bilateral hs_pda_iv NA 0
ischaemic_stroke 4-ischemia, multiple hs_pda_iv NA 0
ischaemic_stroke NA non_nec_surg_abd 1-no NEC/NEC, no surgery 0
ischaemic_stroke 2-ischemia, unilateral non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ischaemic_stroke 3-ischemia, bilateral non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ischaemic_stroke 4-ischemia, multiple non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ischaemic_stroke NA non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
ischaemic_stroke 2-ischemia, unilateral non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ischaemic_stroke 3-ischemia, bilateral non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ischaemic_stroke 4-ischemia, multiple non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ischaemic_stroke NA non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
ischaemic_stroke 1-no ischemia non_nec_surg_abd NA 0
ischaemic_stroke 2-ischemia, unilateral non_nec_surg_abd NA 0
ischaemic_stroke 3-ischemia, bilateral non_nec_surg_abd NA 0
ischaemic_stroke 4-ischemia, multiple non_nec_surg_abd NA 0
hs_pda_iv NA non_nec_surg_abd 1-no NEC/NEC, no surgery 0
hs_pda_iv 2-PDA, medical intervention non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
hs_pda_iv 3-PDA, surgical intervention non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
hs_pda_iv NA non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 0
hs_pda_iv 3-PDA, surgical intervention non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
hs_pda_iv NA non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 0
hs_pda_iv 1-no PDA/PDA, no intervention non_nec_surg_abd NA 0
hs_pda_iv 2-PDA, medical intervention non_nec_surg_abd NA 0
hs_pda_iv 3-PDA, surgical intervention non_nec_surg_abd NA 0

Figure 3. Correlation matrix. *, based on p-value (frequentist) or 95% CI (Bayesian); †, pair of variable and its missingness; ‡, at least 1 variable was a categorical variable with a category of 1 value; §, insufficient sample size.

Missing value imputation

Descriptive statistics

Table 11. Sample characteristics by survival.
unit N variable value survive 0-no survive 1-yes cor.p.value
id|t 20551 total (prevalence) n (%) 811 (3.95) 19740 (96.05)
resp_supp_agg_cum_day_qw average (SD) 9.24 (8.86) 3.44 (6.83) <0.001
fio2_cum_day_qw average (SD) 15.68 (11.54) 8.53 (10.87) <0.001
fio2_cum_level_qw average (SD) 290.99 (257.82) 91.98 (183.55) <0.001
resp_supp_agg_cum_day_pct average (SD) 62.36 (32.78) 49.99 (23.82) <0.001
fio2_cum_day_pct average (SD) 65.22 (31.36) 50.47 (28.21) <0.001
fio2_cum_level_pct average (SD) 73.29 (29.8) 49.36 (28.33) <0.001
steroid_postnatal 0 % (n) 96 (776) 99 (19446) <0.001
2 % (n) 4 (35) 1 (294)
bw_z_qw 1-BW z-score >-1 % (n) 55 (445) 58 (11459) <0.001
2-BW z-score >-2 & <=-1 % (n) 29 (237) 37 (7358)
3-BW z-score >-3 & <=-2 % (n) 16 (126) 4 (839)
4-BW z-score <=-3 % (n) 0 (3) 0 (84)
hc_z_qw 1-HC z-score >-1 % (n) 40 (325) 42 (8356) <0.001
2-HC z-score >-2 & <=-1 % (n) 34 (279) 37 (7346)
3-HC z-score >-3 & <=-2 % (n) 13 (106) 16 (3112)
4-HC z-score <=-3 % (n) 12 (101) 5 (926)
inotropic 0 % (n) 63 (511) 93 (18360) <0.001
2 % (n) 15 (121) 4 (799)
4 % (n) 10 (83) 2 (443)
6 % (n) 12 (96) 1 (138)
blood_volume 0 % (n) 81 (659) 98 (19291) <0.001
4 % (n) 16 (130) 2 (427)
6 % (n) 3 (22) 0 (22)
transfusion 0 % (n) 80 (645) 95 (18673) <0.001
2 % (n) 20 (166) 5 (1067)
blood_culture 0 % (n) 89 (718) 95 (18724) <0.001
2 % (n) 9 (76) 5 (901)
6 % (n) 2 (17) 1 (115)
plt 0 % (n) 62 (505) 88 (17324) <0.001
1 % (n) 16 (126) 7 (1306)
2 % (n) 14 (112) 4 (704)
4 % (n) 8 (67) 2 (364)
6 % (n) 0 (1) 0 (42)
wbc 0 % (n) 94 (766) 97 (19105) >0.05
2 % (n) 4 (35) 2 (478)
4 % (n) 1 (10) 1 (157)
feeding 0 % (n) 50 (406) 14 (2824) <0.001
1 % (n) 31 (252) 24 (4834)
2 % (n) 6 (46) 8 (1586)
3 % (n) 7 (58) 8 (1489)
4 % (n) 2 (20) 4 (754)
5 % (n) 1 (11) 4 (716)
6 % (n) 2 (18) 38 (7537)
ivh 1-no IVH % (n) 97 (783) 99 (19617) <0.001
2-IVH grade I % (n) 0 (1) 0 (43)
3-IVH grade II % (n) 1 (9) 0 (60)
4-IVH grade III % (n) 0 (4) 0 (8)
5-IVH grade IV, unilateral % (n) 1 (9) 0 (8)
6-IVH grade IV, bilateral/IVH grade III with hydrocephalus % (n) 1 (5) 0 (4)
cerebellar_hemorrhage 1-no bleeding % (n) 100 (808) 100 (19739) <0.001
3-severe bleeding % (n) 0 (3) 0 (1)
ischaemic_stroke 1-no ischemia % (n) 100 (807) 100 (19735) <0.001
2-ischemia, unilateral % (n) 0 (1) 0 (2)
3-ischemia, bilateral % (n) 0 (3) 0 (1)
4-ischemia, multiple % (n) 0 (0) 0 (2)
hs_pda_iv 1-no PDA/PDA, no intervention % (n) 95 (774) 97 (19220) <0.001
2-PDA, medical intervention % (n) 4 (34) 2 (466)
3-PDA, surgical intervention % (n) 0 (3) 0 (54)
nec 0 % (n) 100 (811) 100 (19684) <0.001
2 % (n) 0 (0) 0 (38)
3 % (n) 0 (0) 0 (11)
4 % (n) 0 (0) 0 (4)
5 % (n) 0 (0) 0 (1)
6 % (n) 0 (0) 0 (2)
non_nec_surg_abd 1-no NEC/NEC, no surgery % (n) 100 (808) 100 (19722) <0.001
2-SIP/meconium ileus/volvulus/obstruction % (n) 0 (3) 0 (10)
3-SIP/meconium ileus/volvulus/obstruction with stomy % (n) 0 (0) 0 (8)
aki 0 % (n) 96 (780) 100 (19681) <0.001
2 % (n) 1 (8) 0 (33)
4 % (n) 1 (5) 0 (14)
6 % (n) 2 (18) 0 (12)
id 537 total (prevalence) n (%) 67 (12.48) 470 (87.52)
socioeconomic_status 1-highest % (n) 3 (2) 1 (7) <0.001
2-second highest % (n) 16 (11) 23 (107)
3-medium % (n) 42 (28) 50 (236)
4-second lowest % (n) 30 (20) 23 (108)
5-lowest % (n) 9 (6) 3 (12)
education_status 1-postgraduate % (n) 10 (7) 8 (38) <0.001
2-college % (n) 36 (24) 44 (208)
3-college, vocational % (n) 12 (8) 12 (57)
4-high school % (n) 6 (4) 6 (26)
5-high school, vocational % (n) 27 (18) 23 (110)
6-junior high school % (n) 7 (5) 6 (27)
7-elementary school % (n) 1 (1) 1 (4)
maternal_age average (SD) 31.33 (5.75) 33.05 (5.17) >0.05
ivf 0-no % (n) 82 (55) 76 (355) <0.001
1-yes % (n) 18 (12) 24 (115)
pe 0-no % (n) 78 (52) 79 (373) <0.001
1-yes % (n) 22 (15) 21 (97)
gdm 0-no % (n) 94 (63) 95 (448) <0.001
1-yes % (n) 6 (4) 5 (22)
cs 0-no % (n) 40 (27) 35 (166) 0.025
1-yes % (n) 60 (40) 65 (304)
gravida average (SD) 2.33 (1.45) 2.4 (1.4) <0.001
ga_wk average (SD) 24.67 (2.08) 27.39 (2.11) <0.001
sex 0-female % (n) 40 (27) 44 (207) >0.05
1-male % (n) 60 (40) 56 (263)
multiple_gestation 0-no % (n) 67 (45) 70 (327) 0.004
1-yes % (n) 33 (22) 30 (143)
as1 0 % (n) 75 (50) 21 (99) <0.001
1 % (n) 21 (14) 30 (139)
2 % (n) 4 (3) 42 (197)
4 % (n) 0 (0) 7 (35)
as5 0 % (n) 31 (21) 4 (20) <0.001
1 % (n) 24 (16) 9 (41)
2 % (n) 34 (23) 29 (134)
4 % (n) 10 (7) 59 (275)
resuscitation_at_birth 0 % (n) 40 (27) 87 (407) <0.001
6 % (n) 60 (40) 13 (63)
birthtime_scoring 1-born 08:00-16:59 % (n) 52 (35) 51 (239) <0.001
2-born 17:00-23:59 % (n) 18 (12) 28 (131)
3-born 00:00-07:59 % (n) 30 (20) 21 (100)
steroid_antenatal 0 % (n) 16 (11) 5 (25) <0.001
2 % (n) 36 (24) 28 (130)
4 % (n) 48 (32) 67 (315)
chorioamnionitis 0-no % (n) 85 (57) 88 (413) <0.001
1-yes % (n) 15 (10) 12 (57)
surfactant 0 % (n) 19 (13) 66 (312) <0.001
2 % (n) 81 (54) 34 (158)
bbw_z 0 % (n) 7 (5) 1 (6) <0.001
2 % (n) 15 (10) 8 (37)
4 % (n) 78 (52) 91 (427)
bhc_z 0 % (n) 9 (6) 5 (24) <0.001
2 % (n) 13 (9) 9 (41)
4 % (n) 78 (52) 86 (405)
death_age average (SD) 19.95 (41.99) N/A
546 total (prevalence) n (%) 67 (12.27) 479 (87.73)
pvl 1-no PVL % (n) 100 (67) 98 (470)
2-PVL focal, unilateral % (n) 0 (0) 0 (1)
3-PVL focal, bilateral % (n) 0 (0) 1 (6)
4-PVL extensive, bilateral % (n) 0 (0) 0 (2)
Table 12. Sample characteristics by other outcomes.
unit N variable value rop_severe 0-none/stage I/stage II rop_severe 1-stage II+ rop_severe (missing) bpd_grade 0-no BPD bpd_grade 1-mild BPD bpd_grade 2-moderate/severe BPD bpd_grade (missing) eugr_hc 0-HC z-score at birth >=-1.5 eugr_hc 1-HC z-score at birth <-1.5 eugr_hc (missing) eugr_bw 0-BW z-score at birth >=-1.5 eugr_bw 1-BW z-score at birth <-1.5 eugr_bw (missing) hearing 0-passed hearing 1-failed hearing (missing)
id|t 20551 total (prevalence) n (%) 17598 (85.63) 2394 (11.65) 559 (2.72) 13272 (64.58) 714 (3.47) 6006 (29.22) 559 (2.72) 15456 (75.21) 4494 (21.87) 601 (2.92) 16044 (78.07) 3906 (19.01) 601 (2.92) 17724 (86.24) 1554 (7.56) 1273 (6.19)
resp_supp_agg_cum_day_qw average (SD) 2.49 (5.41) 10.82 (10.92) 10.17 (8.35) 0.99 (2.53) 3.32 (4.95) 9.03 (9.81) 10.17 (8.35) 2.22 (5.16) 7.87 (9.73) 9.6 (8.32) 2.66 (6.08) 6.93 (8.72) 9.6 (8.32) 3.06 (6.5) 7.77 (8.89) 7.12 (8.52)
fio2_cum_day_qw average (SD) 7.45 (10.11) 17.99 (12.67) 12.5 (9.74) 4.76 (7.61) 12.9 (11.21) 16.95 (12.46) 12.5 (9.74) 6.97 (9.8) 14.57 (12.65) 13.13 (10.17) 7.5 (10.39) 13.53 (11.95) 13.13 (10.17) 7.97 (10.54) 14.73 (12.57) 13.36 (11.54)
fio2_cum_level_qw average (SD) 73.19 (160.55) 257.73 (271.11) 262.22 (244.45) 31.88 (59.45) 112.96 (133.38) 233.3 (280.85) 262.22 (244.45) 63.49 (135.77) 202.7 (277.05) 265.17 (243.41) 77.01 (165.14) 168.14 (244.61) 265.17 (243.41) 84.91 (178.57) 173.89 (229.85) 217.15 (238.78)
resp_supp_agg_cum_day_pct average (SD) 49.54 (23.22) 54.45 (28.82) 63.07 (32.12) 45.36 (19.7) 53.86 (24.62) 60.2 (28.92) 63.07 (32.12) 48.02 (21.77) 57.1 (29.38) 64.11 (31.21) 48.33 (22.09) 57.2 (29.58) 64.11 (31.21) 49.41 (22.99) 56.25 (30.95) 58.3 (30.56)
fio2_cum_day_pct average (SD) 50.54 (28.31) 53.71 (29.09) 55.98 (30.5) 44.22 (26.83) 67.3 (22.89) 63.76 (27.2) 55.98 (30.5) 49.22 (27.88) 56.36 (29.39) 58.59 (30.95) 49.63 (28.16) 55.75 (28.75) 58.59 (30.95) 49.87 (28.5) 53.29 (23.99) 64.85 (29.54)
fio2_cum_level_pct average (SD) 49.68 (28.53) 50.48 (28.27) 69.37 (31.64) 43.79 (27.07) 64.54 (23.63) 61.25 (27.96) 69.37 (31.64) 47.82 (27.84) 56.11 (29.61) 70.94 (31.27) 48.03 (28.09) 56.49 (28.96) 70.94 (31.27) 49.1 (28.47) 47.97 (26.09) 69.94 (28.94)
steroid_postnatal 0 % (n) 99 (17451) 93 (2233) 96 (538) 100 (13244) 99 (707) 95 (5733) 96 (538) 99 (15288) 97 (4354) 97 (580) 99 (15841) 97 (3801) 97 (580) 99 (17472) 97 (1512) 97 (1238)
2 % (n) 1 (147) 7 (161) 4 (21) 0 (28) 1 (7) 5 (273) 4 (21) 1 (168) 3 (140) 3 (21) 1 (203) 3 (105) 3 (21) 1 (252) 3 (42) 3 (35)
bw_z_qw 1-BW z-score >-1 % (n) 60 (10514) 43 (1022) 66 (368) 65 (8674) 68 (482) 40 (2380) 66 (368) 59 (9165) 52 (2350) 65 (389) 60 (9618) 49 (1897) 65 (389) 60 (10603) 38 (590) 56 (711)
2-BW z-score >-2 & <=-1 % (n) 35 (6155) 54 (1289) 27 (151) 32 (4199) 28 (197) 51 (3048) 27 (151) 36 (5531) 42 (1899) 27 (165) 36 (5729) 44 (1701) 27 (165) 36 (6352) 53 (817) 33 (426)
3-BW z-score >-3 & <=-2 % (n) 5 (842) 3 (83) 7 (40) 3 (371) 5 (35) 9 (519) 7 (40) 4 (680) 5 (238) 8 (47) 4 (666) 6 (252) 8 (47) 4 (699) 9 (133) 10 (133)
4-BW z-score <=-3 % (n) 0 (87) 0 (0) 0 (0) 0 (28) 0 (0) 1 (59) 0 (0) 1 (80) 0 (7) 0 (0) 0 (31) 1 (56) 0 (0) 0 (70) 1 (14) 0 (3)
hc_z_qw 1-HC z-score >-1 % (n) 45 (7857) 23 (556) 48 (268) 51 (6755) 27 (193) 24 (1465) 48 (268) 44 (6826) 35 (1551) 51 (304) 45 (7249) 29 (1128) 51 (304) 44 (7785) 23 (356) 42 (540)
2-HC z-score >-2 & <=-1 % (n) 37 (6496) 38 (919) 38 (210) 37 (4907) 45 (324) 36 (2184) 38 (210) 38 (5930) 33 (1482) 35 (213) 37 (5971) 37 (1441) 35 (213) 37 (6643) 37 (571) 32 (411)
3-HC z-score >-3 & <=-2 % (n) 14 (2438) 29 (700) 14 (80) 10 (1319) 26 (183) 27 (1636) 14 (80) 13 (2050) 24 (1085) 14 (83) 14 (2182) 24 (953) 14 (83) 15 (2633) 24 (368) 17 (217)
4-HC z-score <=-3 % (n) 5 (807) 9 (219) 0 (1) 2 (291) 2 (14) 12 (721) 0 (1) 4 (650) 8 (376) 0 (1) 4 (642) 10 (384) 0 (1) 4 (663) 17 (259) 8 (105)
inotropic 0 % (n) 94 (16629) 81 (1943) 53 (299) 97 (12817) 95 (679) 85 (5076) 53 (299) 95 (14745) 84 (3785) 57 (341) 95 (15187) 86 (3343) 57 (341) 94 (16617) 85 (1319) 73 (935)
2 % (n) 3 (563) 11 (261) 17 (96) 2 (282) 3 (19) 9 (523) 17 (96) 3 (464) 8 (360) 16 (96) 3 (541) 7 (283) 16 (96) 4 (633) 9 (144) 11 (143)
4 % (n) 2 (310) 6 (143) 13 (73) 1 (150) 2 (15) 5 (288) 13 (73) 1 (201) 6 (252) 12 (73) 2 (243) 5 (210) 12 (73) 2 (370) 4 (63) 7 (93)
6 % (n) 1 (96) 2 (47) 16 (91) 0 (23) 0 (1) 2 (119) 16 (91) 0 (46) 2 (97) 15 (91) 0 (73) 2 (70) 15 (91) 1 (104) 2 (28) 8 (102)
blood_volume 0 % (n) 98 (17276) 94 (2261) 74 (413) 98 (13053) 97 (696) 96 (5788) 74 (413) 99 (15232) 95 (4263) 76 (455) 98 (15803) 95 (3692) 76 (455) 98 (17363) 95 (1482) 87 (1105)
4 % (n) 2 (313) 5 (120) 22 (124) 2 (213) 2 (17) 3 (203) 22 (124) 1 (216) 5 (217) 21 (124) 1 (231) 5 (202) 21 (124) 2 (345) 4 (66) 11 (146)
6 % (n) 0 (9) 1 (13) 4 (22) 0 (6) 0 (1) 0 (15) 4 (22) 0 (8) 0 (14) 4 (22) 0 (10) 0 (12) 4 (22) 0 (16) 0 (6) 2 (22)
transfusion 0 % (n) 95 (16800) 88 (2098) 75 (420) 97 (12844) 94 (668) 90 (5386) 75 (420) 96 (14793) 90 (4063) 77 (462) 95 (15309) 91 (3547) 77 (462) 95 (16853) 89 (1383) 85 (1082)
2 % (n) 5 (798) 12 (296) 25 (139) 3 (428) 6 (46) 10 (620) 25 (139) 4 (663) 10 (431) 23 (139) 5 (735) 9 (359) 23 (139) 5 (871) 11 (171) 15 (191)
blood_culture 0 % (n) 95 (16798) 90 (2154) 88 (490) 96 (12783) 93 (667) 92 (5502) 88 (490) 96 (14824) 91 (4089) 88 (529) 96 (15344) 91 (3569) 88 (529) 95 (16887) 90 (1395) 91 (1160)
2 % (n) 4 (716) 9 (207) 10 (54) 3 (445) 6 (42) 7 (436) 10 (54) 4 (580) 8 (341) 9 (56) 4 (631) 7 (290) 9 (56) 4 (754) 8 (127) 8 (96)
6 % (n) 0 (84) 1 (33) 3 (15) 0 (44) 1 (5) 1 (68) 3 (15) 0 (52) 1 (64) 3 (16) 0 (69) 1 (47) 3 (16) 0 (83) 2 (32) 1 (17)
plt 0 % (n) 89 (15586) 78 (1877) 65 (366) 91 (12055) 91 (652) 79 (4756) 65 (366) 91 (14018) 76 (3411) 67 (400) 90 (14440) 77 (2989) 67 (400) 89 (15776) 72 (1122) 73 (931)
1 % (n) 6 (1099) 11 (257) 14 (76) 5 (722) 4 (31) 10 (603) 14 (76) 5 (838) 11 (514) 13 (80) 6 (919) 11 (433) 13 (80) 6 (1084) 13 (198) 12 (150)
2 % (n) 3 (584) 7 (161) 13 (71) 2 (315) 3 (19) 7 (411) 13 (71) 3 (394) 8 (348) 12 (74) 3 (443) 8 (299) 12 (74) 3 (540) 10 (157) 9 (119)
4 % (n) 2 (291) 4 (95) 8 (45) 1 (156) 1 (9) 4 (221) 8 (45) 1 (179) 5 (206) 8 (46) 1 (213) 4 (172) 8 (46) 2 (284) 5 (75) 6 (72)
6 % (n) 0 (38) 0 (4) 0 (1) 0 (24) 0 (3) 0 (15) 0 (1) 0 (27) 0 (15) 0 (1) 0 (29) 0 (13) 0 (1) 0 (40) 0 (2) 0 (1)
wbc 0 % (n) 97 (17076) 95 (2272) 94 (523) 98 (12954) 93 (662) 95 (5732) 94 (523) 97 (15017) 95 (4291) 94 (563) 97 (15582) 95 (3726) 94 (563) 97 (17192) 95 (1469) 95 (1210)
2 % (n) 2 (388) 4 (96) 5 (29) 2 (239) 5 (34) 4 (211) 5 (29) 2 (331) 3 (152) 5 (30) 2 (344) 4 (139) 5 (30) 2 (398) 4 (63) 4 (52)
4 % (n) 1 (134) 1 (26) 1 (7) 1 (79) 3 (18) 1 (63) 1 (7) 1 (108) 1 (51) 1 (8) 1 (118) 1 (41) 1 (8) 1 (134) 1 (22) 1 (11)
feeding 0 % (n) 13 (2252) 26 (623) 64 (355) 10 (1393) 15 (106) 23 (1376) 64 (355) 11 (1695) 26 (1173) 60 (362) 11 (1793) 28 (1075) 60 (362) 13 (2322) 29 (447) 36 (461)
1 % (n) 23 (4035) 37 (897) 28 (154) 22 (2901) 30 (211) 30 (1820) 28 (154) 23 (3503) 31 (1405) 30 (178) 22 (3578) 34 (1330) 30 (178) 24 (4209) 34 (536) 27 (341)
2 % (n) 8 (1405) 9 (209) 3 (18) 8 (1019) 11 (79) 9 (516) 3 (18) 8 (1256) 8 (354) 4 (22) 8 (1309) 8 (301) 4 (22) 8 (1424) 8 (131) 6 (77)
3 % (n) 8 (1340) 7 (178) 5 (29) 7 (965) 10 (73) 8 (480) 5 (29) 8 (1196) 7 (317) 6 (34) 8 (1235) 7 (278) 6 (34) 8 (1337) 8 (131) 6 (79)
4 % (n) 4 (695) 3 (76) 1 (3) 4 (502) 5 (36) 4 (233) 1 (3) 4 (613) 3 (156) 1 (5) 4 (660) 3 (109) 1 (5) 4 (688) 3 (53) 3 (33)
5 % (n) 4 (662) 3 (65) 0 (0) 4 (514) 3 (19) 3 (194) 0 (0) 4 (603) 3 (124) 0 (0) 4 (611) 3 (116) 0 (0) 4 (670) 2 (36) 2 (21)
6 % (n) 41 (7209) 14 (346) 0 (0) 45 (5978) 27 (190) 23 (1387) 0 (0) 43 (6590) 21 (965) 0 (0) 43 (6858) 18 (697) 0 (0) 40 (7074) 14 (220) 21 (261)
ivh 1-no IVH % (n) 99 (17505) 99 (2363) 95 (532) 100 (13216) 99 (710) 99 (5942) 95 (532) 99 (15376) 99 (4450) 96 (574) 99 (15949) 99 (3877) 96 (574) 99 (17617) 99 (1539) 98 (1244)
2-IVH grade I % (n) 0 (40) 0 (4) 0 (0) 0 (33) 0 (0) 0 (11) 0 (0) 0 (34) 0 (10) 0 (0) 0 (37) 0 (7) 0 (0) 0 (42) 0 (1) 0 (1)
3-IVH grade II % (n) 0 (43) 1 (17) 2 (9) 0 (20) 0 (3) 1 (37) 2 (9) 0 (41) 0 (19) 1 (9) 0 (46) 0 (14) 1 (9) 0 (52) 1 (8) 1 (9)
4-IVH grade III % (n) 0 (5) 0 (3) 1 (4) 0 (1) 0 (1) 0 (6) 1 (4) 0 (4) 0 (4) 1 (4) 0 (5) 0 (3) 1 (4) 0 (6) 0 (2) 0 (4)
5-IVH grade IV, unilateral % (n) 0 (3) 0 (5) 2 (9) 0 (1) 0 (0) 0 (7) 2 (9) 0 (1) 0 (7) 1 (9) 0 (5) 0 (3) 1 (9) 0 (5) 0 (2) 1 (10)
6-IVH grade IV, bilateral/IVH grade III with hydrocephalus % (n) 0 (2) 0 (2) 1 (5) 0 (1) 0 (0) 0 (3) 1 (5) 0 (0) 0 (4) 1 (5) 0 (2) 0 (2) 1 (5) 0 (2) 0 (2) 0 (5)
cerebellar_hemorrhage 1-no bleeding % (n) 100 (17597) 100 (2394) 99 (556) 100 (13272) 100 (714) 100 (6005) 99 (556) 100 (15456) 100 (4493) 100 (598) 100 (16044) 100 (3905) 100 (598) 100 (17723) 100 (1554) 100 (1270)
3-severe bleeding % (n) 0 (1) 0 (0) 1 (3) 0 (0) 0 (0) 0 (1) 1 (3) 0 (0) 0 (1) 0 (3) 0 (0) 0 (1) 0 (3) 0 (1) 0 (0) 0 (3)
ischaemic_stroke 1-no ischemia % (n) 100 (17592) 100 (2393) 100 (557) 100 (13270) 100 (714) 100 (6001) 100 (557) 100 (15454) 100 (4489) 100 (599) 100 (16038) 100 (3905) 100 (599) 100 (17721) 100 (1553) 100 (1268)
2-ischemia, unilateral % (n) 0 (3) 0 (0) 0 (0) 0 (1) 0 (0) 0 (2) 0 (0) 0 (2) 0 (1) 0 (0) 0 (2) 0 (1) 0 (0) 0 (1) 0 (1) 0 (1)
3-ischemia, bilateral % (n) 0 (2) 0 (0) 0 (2) 0 (1) 0 (0) 0 (1) 0 (2) 0 (0) 0 (2) 0 (2) 0 (2) 0 (0) 0 (2) 0 (1) 0 (0) 0 (3)
4-ischemia, multiple % (n) 0 (1) 0 (1) 0 (0) 0 (0) 0 (0) 0 (2) 0 (0) 0 (0) 0 (2) 0 (0) 0 (2) 0 (0) 0 (0) 0 (1) 0 (0) 0 (1)
hs_pda_iv 1-no PDA/PDA, no intervention % (n) 98 (17181) 96 (2287) 94 (526) 98 (13061) 98 (700) 95 (5707) 94 (526) 98 (15102) 96 (4324) 95 (568) 98 (15668) 96 (3758) 95 (568) 98 (17289) 95 (1474) 97 (1231)
2-PDA, medical intervention % (n) 2 (377) 4 (93) 5 (30) 1 (191) 2 (13) 4 (266) 5 (30) 2 (320) 3 (150) 5 (30) 2 (340) 3 (130) 5 (30) 2 (390) 5 (72) 3 (38)
3-PDA, surgical intervention % (n) 0 (40) 1 (14) 1 (3) 0 (20) 0 (1) 1 (33) 1 (3) 0 (34) 0 (20) 0 (3) 0 (36) 0 (18) 0 (3) 0 (45) 1 (8) 0 (4)
nec 0 % (n) 100 (17548) 100 (2388) 100 (559) 100 (13231) 100 (712) 100 (5993) 100 (559) 100 (15411) 100 (4483) 100 (601) 100 (16002) 100 (3892) 100 (601) 100 (17672) 100 (1551) 100 (1272)
2 % (n) 0 (34) 0 (4) 0 (0) 0 (30) 0 (2) 0 (6) 0 (0) 0 (32) 0 (6) 0 (0) 0 (30) 0 (8) 0 (0) 0 (38) 0 (0) 0 (0)
3 % (n) 0 (10) 0 (1) 0 (0) 0 (7) 0 (0) 0 (4) 0 (0) 0 (9) 0 (2) 0 (0) 0 (9) 0 (2) 0 (0) 0 (10) 0 (1) 0 (0)
4 % (n) 0 (3) 0 (1) 0 (0) 0 (2) 0 (0) 0 (2) 0 (0) 0 (3) 0 (1) 0 (0) 0 (2) 0 (2) 0 (0) 0 (3) 0 (0) 0 (1)
5 % (n) 0 (1) 0 (0) 0 (0) 0 (0) 0 (0) 0 (1) 0 (0) 0 (0) 0 (1) 0 (0) 0 (0) 0 (1) 0 (0) 0 (0) 0 (1) 0 (0)
6 % (n) 0 (2) 0 (0) 0 (0) 0 (2) 0 (0) 0 (0) 0 (0) 0 (1) 0 (1) 0 (0) 0 (1) 0 (1) 0 (0) 0 (1) 0 (1) 0 (0)
non_nec_surg_abd 1-no NEC/NEC, no surgery % (n) 100 (17586) 100 (2388) 99 (556) 100 (13267) 100 (714) 100 (5993) 99 (556) 100 (15450) 100 (4482) 100 (598) 100 (16035) 100 (3897) 100 (598) 100 (17710) 100 (1550) 100 (1270)
2-SIP/meconium ileus/volvulus/obstruction % (n) 0 (7) 0 (3) 1 (3) 0 (4) 0 (0) 0 (6) 1 (3) 0 (4) 0 (6) 0 (3) 0 (5) 0 (5) 0 (3) 0 (7) 0 (3) 0 (3)
3-SIP/meconium ileus/volvulus/obstruction with stomy % (n) 0 (5) 0 (3) 0 (0) 0 (1) 0 (0) 0 (7) 0 (0) 0 (2) 0 (6) 0 (0) 0 (4) 0 (4) 0 (0) 0 (7) 0 (1) 0 (0)
aki 0 % (n) 100 (17554) 99 (2378) 95 (529) 100 (13252) 100 (711) 99 (5969) 95 (529) 100 (15419) 99 (4471) 95 (571) 100 (16007) 99 (3883) 95 (571) 100 (17676) 100 (1547) 97 (1238)
2 % (n) 0 (26) 0 (7) 1 (8) 0 (12) 0 (1) 0 (20) 1 (8) 0 (23) 0 (10) 1 (8) 0 (23) 0 (10) 1 (8) 0 (29) 0 (3) 1 (9)
4 % (n) 0 (11) 0 (3) 1 (5) 0 (4) 0 (2) 0 (8) 1 (5) 0 (8) 0 (6) 1 (5) 0 (6) 0 (8) 1 (5) 0 (10) 0 (3) 0 (6)
6 % (n) 0 (7) 0 (6) 3 (17) 0 (4) 0 (0) 0 (9) 3 (17) 0 (6) 0 (7) 3 (17) 0 (8) 0 (5) 3 (17) 0 (9) 0 (1) 2 (20)
id 537 total (prevalence) n (%) 419 (78.03) 57 (10.61) 61 (11.36) 316 (58.85) 17 (3.17) 143 (26.63) 61 (11.36) 368 (68.53) 107 (19.93) 62 (11.55) 382 (71.14) 93 (17.32) 62 (11.55) 422 (78.58) 37 (6.89) 78 (14.53)
socioeconomic_status 1-highest % (n) 1 (6) 2 (1) 3 (2) 2 (6) 0 (0) 1 (1) 3 (2) 2 (6) 1 (1) 3 (2) 2 (6) 1 (1) 3 (2) 1 (6) 3 (1) 3 (2)
2-second highest % (n) 21 (89) 32 (18) 18 (11) 20 (64) 29 (5) 27 (38) 18 (11) 21 (76) 29 (31) 18 (11) 22 (84) 25 (23) 18 (11) 22 (94) 27 (10) 18 (14)
3-medium % (n) 50 (211) 49 (28) 41 (25) 49 (154) 41 (7) 55 (78) 41 (25) 51 (189) 46 (49) 42 (26) 52 (197) 44 (41) 42 (26) 52 (218) 49 (18) 36 (28)
4-second lowest % (n) 25 (103) 14 (8) 28 (17) 26 (82) 29 (5) 17 (24) 28 (17) 24 (87) 22 (24) 27 (17) 22 (85) 28 (26) 27 (17) 22 (93) 19 (7) 36 (28)
5-lowest % (n) 2 (10) 4 (2) 10 (6) 3 (10) 0 (0) 1 (2) 10 (6) 3 (10) 2 (2) 10 (6) 3 (10) 2 (2) 10 (6) 3 (11) 3 (1) 8 (6)
education_status 1-postgraduate % (n) 8 (33) 9 (5) 11 (7) 8 (25) 6 (1) 8 (12) 11 (7) 8 (28) 9 (10) 11 (7) 8 (30) 9 (8) 11 (7) 8 (34) 8 (3) 10 (8)
2-college % (n) 44 (183) 47 (27) 36 (22) 43 (136) 35 (6) 48 (68) 36 (22) 44 (163) 43 (46) 37 (23) 46 (174) 38 (35) 37 (23) 46 (194) 35 (13) 32 (25)
3-college, vocational % (n) 12 (51) 11 (6) 13 (8) 13 (41) 6 (1) 10 (15) 13 (8) 11 (41) 15 (16) 13 (8) 12 (46) 12 (11) 13 (8) 12 (50) 16 (6) 12 (9)
4-high school % (n) 5 (19) 12 (7) 7 (4) 6 (18) 12 (2) 4 (6) 7 (4) 5 (20) 6 (6) 6 (4) 5 (21) 5 (5) 6 (4) 5 (19) 16 (6) 6 (5)
5-high school, vocational % (n) 25 (105) 16 (9) 23 (14) 24 (76) 35 (6) 22 (32) 23 (14) 24 (89) 23 (25) 23 (14) 23 (88) 28 (26) 23 (14) 23 (97) 22 (8) 29 (23)
6-junior high school % (n) 6 (24) 5 (3) 8 (5) 5 (17) 6 (1) 6 (9) 8 (5) 6 (23) 4 (4) 8 (5) 5 (20) 8 (7) 8 (5) 6 (25) 3 (1) 8 (6)
7-elementary school % (n) 1 (4) 0 (0) 2 (1) 1 (3) 0 (0) 1 (1) 2 (1) 1 (4) 0 (0) 2 (1) 1 (3) 1 (1) 2 (1) 1 (3) 0 (0) 3 (2)
maternal_age average (SD) 33.14 (5.14) 32.51 (5.41) 31.08 (5.75) 32.8 (5.2) 33.41 (5.35) 33.59 (5.08) 31.08 (5.75) 33.11 (5.17) 32.95 (5.2) 31.05 (5.71) 33.05 (5.09) 33.14 (5.5) 31.05 (5.71) 33.18 (5.18) 32.16 (4.75) 31.29 (5.71)
ivf 0-no % (n) 77 (323) 65 (37) 82 (50) 77 (244) 59 (10) 74 (106) 82 (50) 76 (281) 73 (78) 82 (51) 75 (288) 76 (71) 82 (51) 76 (319) 73 (27) 82 (64)
1-yes % (n) 23 (96) 35 (20) 18 (11) 23 (72) 41 (7) 26 (37) 18 (11) 24 (87) 27 (29) 18 (11) 25 (94) 24 (22) 18 (11) 24 (103) 27 (10) 18 (14)
pe 0-no % (n) 77 (322) 93 (53) 82 (50) 76 (239) 88 (15) 85 (121) 82 (50) 78 (288) 81 (87) 81 (50) 80 (305) 75 (70) 81 (50) 79 (332) 89 (33) 77 (60)
1-yes % (n) 23 (97) 7 (4) 18 (11) 24 (77) 12 (2) 15 (22) 18 (11) 22 (80) 19 (20) 19 (12) 20 (77) 25 (23) 19 (12) 21 (90) 11 (4) 23 (18)
gdm 0-no % (n) 95 (399) 96 (55) 93 (57) 94 (298) 100 (17) 97 (139) 93 (57) 95 (350) 96 (103) 94 (58) 95 (364) 96 (89) 94 (58) 95 (403) 92 (34) 95 (74)
1-yes % (n) 5 (20) 4 (2) 7 (4) 6 (18) 0 (0) 3 (4) 7 (4) 5 (18) 4 (4) 6 (4) 5 (18) 4 (4) 6 (4) 5 (19) 8 (3) 5 (4)
cs 0-no % (n) 35 (145) 40 (23) 41 (25) 37 (116) 24 (4) 34 (48) 41 (25) 36 (132) 34 (36) 40 (25) 35 (135) 35 (33) 40 (25) 36 (151) 35 (13) 37 (29)
1-yes % (n) 65 (274) 60 (34) 59 (36) 63 (200) 76 (13) 66 (95) 59 (36) 64 (236) 66 (71) 60 (37) 65 (247) 65 (60) 60 (37) 64 (271) 65 (24) 63 (49)
gravida average (SD) 2.4 (1.4) 2.4 (1.49) 2.31 (1.37) 2.27 (1.35) 2.35 (1.41) 2.68 (1.52) 2.31 (1.37) 2.41 (1.44) 2.36 (1.33) 2.31 (1.36) 2.4 (1.4) 2.39 (1.47) 2.31 (1.36) 2.4 (1.44) 2.22 (1.03) 2.41 (1.39)
ga_wk average (SD) 27.75 (1.86) 24.56 (1.64) 24.52 (2.05) 28.11 (1.63) 27.24 (1.75) 25.75 (2.17) 24.52 (2.05) 27.8 (1.94) 25.87 (2) 24.58 (2.08) 27.66 (2) 26.16 (2.13) 24.58 (2.08) 27.53 (2.03) 25.59 (2.23) 25.13 (2.32)
sex 0-female % (n) 47 (196) 26 (15) 38 (23) 47 (149) 41 (7) 38 (55) 38 (23) 45 (164) 44 (47) 37 (23) 46 (175) 39 (36) 37 (23) 45 (189) 41 (15) 38 (30)
1-male % (n) 53 (223) 74 (42) 62 (38) 53 (167) 59 (10) 62 (88) 62 (38) 55 (204) 56 (60) 63 (39) 54 (207) 61 (57) 63 (39) 55 (233) 59 (22) 62 (48)
multiple_gestation 0-no % (n) 70 (295) 63 (36) 67 (41) 72 (227) 47 (8) 67 (96) 67 (41) 72 (264) 62 (66) 68 (42) 70 (268) 67 (62) 68 (42) 70 (295) 68 (25) 67 (52)
1-yes % (n) 30 (124) 37 (21) 33 (20) 28 (89) 53 (9) 33 (47) 33 (20) 28 (104) 38 (41) 32 (20) 30 (114) 33 (31) 32 (20) 30 (127) 32 (12) 33 (26)
as1 0 % (n) 19 (80) 42 (24) 74 (45) 16 (49) 41 (7) 34 (48) 74 (45) 18 (67) 34 (36) 74 (46) 20 (75) 30 (28) 74 (46) 21 (87) 27 (10) 67 (52)
1 % (n) 30 (125) 25 (14) 23 (14) 28 (90) 18 (3) 32 (46) 23 (14) 28 (104) 33 (35) 23 (14) 29 (112) 29 (27) 23 (14) 29 (122) 35 (13) 23 (18)
2 % (n) 43 (182) 28 (16) 3 (2) 47 (148) 41 (7) 30 (43) 3 (2) 46 (168) 28 (30) 3 (2) 43 (164) 37 (34) 3 (2) 43 (180) 32 (12) 10 (8)
4 % (n) 8 (32) 5 (3) 0 (0) 9 (29) 0 (0) 4 (6) 0 (0) 8 (29) 6 (6) 0 (0) 8 (31) 4 (4) 0 (0) 8 (33) 5 (2) 0 (0)
as5 0 % (n) 4 (17) 7 (4) 33 (20) 3 (11) 0 (0) 7 (10) 33 (20) 4 (14) 7 (7) 32 (20) 3 (11) 11 (10) 32 (20) 4 (17) 8 (3) 27 (21)
1 % (n) 7 (31) 19 (11) 25 (15) 5 (17) 6 (1) 17 (24) 25 (15) 6 (23) 18 (19) 24 (15) 8 (31) 12 (11) 24 (15) 9 (37) 11 (4) 21 (16)
2 % (n) 27 (115) 40 (23) 31 (19) 24 (77) 41 (7) 38 (54) 31 (19) 27 (98) 36 (39) 32 (20) 28 (106) 33 (31) 32 (20) 28 (120) 27 (10) 35 (27)
4 % (n) 61 (256) 33 (19) 11 (7) 67 (211) 53 (9) 38 (55) 11 (7) 63 (233) 39 (42) 11 (7) 61 (234) 44 (41) 11 (7) 59 (248) 54 (20) 18 (14)
resuscitation_at_birth 0 % (n) 89 (371) 70 (40) 38 (23) 90 (284) 94 (16) 78 (111) 38 (23) 88 (323) 81 (87) 39 (24) 89 (340) 75 (70) 39 (24) 87 (367) 81 (30) 47 (37)
6 % (n) 11 (48) 30 (17) 62 (38) 10 (32) 6 (1) 22 (32) 62 (38) 12 (45) 19 (20) 61 (38) 11 (42) 25 (23) 61 (38) 13 (55) 19 (7) 53 (41)
birthtime_scoring 1-born 08:00-16:59 % (n) 52 (219) 42 (24) 51 (31) 52 (163) 47 (8) 50 (72) 51 (31) 49 (182) 56 (60) 52 (32) 51 (196) 49 (46) 52 (32) 51 (215) 51 (19) 51 (40)
2-born 17:00-23:59 % (n) 27 (115) 30 (17) 18 (11) 27 (84) 41 (7) 29 (41) 18 (11) 30 (109) 21 (23) 18 (11) 27 (103) 31 (29) 18 (11) 27 (115) 27 (10) 23 (18)
3-born 00:00-07:59 % (n) 20 (85) 28 (16) 31 (19) 22 (69) 12 (2) 21 (30) 31 (19) 21 (77) 22 (24) 31 (19) 22 (83) 19 (18) 31 (19) 22 (92) 22 (8) 26 (20)
steroid_antenatal 0 % (n) 6 (24) 4 (2) 16 (10) 7 (21) 0 (0) 3 (5) 16 (10) 5 (19) 7 (7) 16 (10) 5 (20) 6 (6) 16 (10) 5 (22) 5 (2) 15 (12)
2 % (n) 28 (118) 25 (14) 36 (22) 29 (92) 29 (5) 24 (35) 36 (22) 26 (95) 34 (36) 37 (23) 28 (106) 27 (25) 37 (23) 27 (116) 27 (10) 36 (28)
4 % (n) 66 (277) 72 (41) 48 (29) 64 (203) 71 (12) 72 (103) 48 (29) 69 (254) 60 (64) 47 (29) 67 (256) 67 (62) 47 (29) 67 (284) 68 (25) 49 (38)
chorioamnionitis 0-no % (n) 89 (372) 82 (47) 84 (51) 90 (284) 82 (14) 85 (121) 84 (51) 87 (321) 91 (97) 84 (52) 88 (335) 89 (83) 84 (52) 87 (369) 95 (35) 85 (66)
1-yes % (n) 11 (47) 18 (10) 16 (10) 10 (32) 18 (3) 15 (22) 16 (10) 13 (47) 9 (10) 16 (10) 12 (47) 11 (10) 16 (10) 13 (53) 5 (2) 15 (12)
surfactant 0 % (n) 69 (290) 42 (24) 18 (11) 77 (244) 59 (10) 42 (60) 18 (11) 73 (269) 41 (44) 19 (12) 70 (267) 49 (46) 19 (12) 67 (284) 54 (20) 27 (21)
2 % (n) 31 (129) 58 (33) 82 (50) 23 (72) 41 (7) 58 (83) 82 (50) 27 (99) 59 (63) 81 (50) 30 (115) 51 (47) 81 (50) 33 (138) 46 (17) 73 (57)
bbw_z 0 % (n) 2 (7) 2 (1) 5 (3) 1 (2) 0 (0) 4 (6) 5 (3) 1 (5) 3 (3) 5 (3) 1 (5) 3 (3) 5 (3) 1 (4) 5 (2) 6 (5)
2 % (n) 8 (34) 5 (3) 16 (10) 6 (20) 6 (1) 11 (16) 16 (10) 8 (29) 7 (8) 16 (10) 8 (30) 8 (7) 16 (10) 8 (32) 14 (5) 13 (10)
4 % (n) 90 (378) 93 (53) 79 (48) 93 (294) 94 (16) 85 (121) 79 (48) 91 (334) 90 (96) 79 (49) 91 (347) 89 (83) 79 (49) 91 (386) 81 (30) 81 (63)
bhc_z 0 % (n) 6 (24) 4 (2) 7 (4) 3 (11) 6 (1) 10 (14) 7 (4) 6 (22) 4 (4) 6 (4) 4 (17) 10 (9) 6 (4) 4 (18) 16 (6) 8 (6)
2 % (n) 8 (35) 12 (7) 13 (8) 7 (23) 12 (2) 12 (17) 13 (8) 10 (36) 6 (6) 13 (8) 9 (35) 8 (7) 13 (8) 9 (37) 11 (4) 12 (9)
4 % (n) 86 (360) 84 (48) 80 (49) 89 (282) 82 (14) 78 (112) 80 (49) 84 (310) 91 (97) 81 (50) 86 (330) 83 (77) 81 (50) 87 (367) 73 (27) 81 (63)
death_age average (SD) N/A N/A 8.79 (13.64) N/A N/A N/A 8.79 (13.64) N/A N/A 9.5 (14.61) N/A N/A 9.5 (14.61) N/A N/A N/A
546 total (prevalence) n (%) 427 (78.21) 58 (10.62) 61 (11.17) 322 (58.97) 17 (3.11) 146 (26.74) 61 (11.17) 375 (68.68) 109 (19.96) 62 (11.36) 389 (71.25) 95 (17.4) 62 (11.36) 429 (78.57) 38 (6.96) 79 (14.47)
pvl 1-no PVL % (n) 98 (419) 98 (57) 100 (61) 98 (316) 100 (17) 98 (143) 100 (61) 98 (368) 98 (107) 100 (62) 98 (382) 98 (93) 100 (62) 98 (422) 97 (37) 99 (78)
2-PVL focal, unilateral % (n) 0 (0) 2 (1) 0 (0) 0 (0) 0 (0) 1 (1) 0 (0) 0 (0) 1 (1) 0 (0) 0 (0) 1 (1) 0 (0) 0 (0) 3 (1) 0 (0)
3-PVL focal, bilateral % (n) 1 (6) 0 (0) 0 (0) 1 (4) 0 (0) 1 (2) 0 (0) 1 (5) 1 (1) 0 (0) 1 (5) 1 (1) 0 (0) 1 (5) 0 (0) 1 (1)
4-PVL extensive, bilateral % (n) 0 (2) 0 (0) 0 (0) 1 (2) 0 (0) 0 (0) 0 (0) 1 (2) 0 (0) 0 (0) 1 (2) 0 (0) 0 (0) 0 (2) 0 (0) 0 (0)

Feature extraction

Table 13. Processed data old and new categories.
colname old_cat new_cat
socioeconomic_status 1-highest 1-high
socioeconomic_status 2-second highest 1-high
socioeconomic_status 3-medium 2-medium
socioeconomic_status 4-second lowest 3-low
socioeconomic_status 5-lowest 3-low
education_status 1-postgraduate 0-high
education_status 2-college 0-high
education_status 3-college, vocational 0-high
education_status 4-high school 1-low
education_status 5-high school, vocational 1-low
education_status 6-junior high school 1-low
education_status 7-elementary school 1-low
ivf 0-no 0-no
ivf 1-yes 1-yes
pe 0-no 0-no
pe 1-yes 1-yes
gdm 0-no 0-no
gdm 1-yes 1-yes
cs 0-no 0-no
cs 1-yes 1-yes
sex 0-female 0-female
sex 1-male 1-male
multiple_gestation 0-no 0-no
multiple_gestation 1-yes 1-yes
birthtime_scoring 1-born 08:00-16:59 birthtime_day
birthtime_scoring 2-born 17:00-23:59 birthtime_evening
birthtime_scoring 3-born 00:00-07:59 birthtime_night
chorioamnionitis 0-no 0-no
chorioamnionitis 1-yes 1-yes
survive 0-no 0-no
survive 1-yes 1-yes
rop_severe 0-none/stage I/stage II 0-none/stage I/stage II
rop_severe 1-stage II+ 1-stage II+
rop_severe NA NA
bpd_grade 0-no BPD bpd*
bpd_grade 1-mild BPD (removed)
bpd_grade 2-moderate/severe BPD bpd_moderate_severe
bpd_grade NA (missing)
eugr_hc 0-HC z-score at birth >=-1.5 0-HC z-score at birth >=-1.5
eugr_hc 1-HC z-score at birth <-1.5 1-HC z-score at birth <-1.5
eugr_hc NA NA
eugr_bw 0-BW z-score at birth >=-1.5 0-BW z-score at birth >=-1.5
eugr_bw 1-BW z-score at birth <-1.5 1-BW z-score at birth <-1.5
eugr_bw NA NA
hearing 0-passed 0-passed
hearing 1-failed 1-failed
hearing NA NA
bw_z_qw 1-BW z-score >-1 0-BW z-score >-1
bw_z_qw 2-BW z-score >-2 & <=-1 1-BW z-score <=-1
bw_z_qw 3-BW z-score >-3 & <=-2 1-BW z-score <=-1
bw_z_qw 4-BW z-score <=-3 1-BW z-score <=-1
hc_z_qw 1-HC z-score >-1 0-HC z-score >-1
hc_z_qw 2-HC z-score >-2 & <=-1 1-HC z-score <=-1
hc_z_qw 3-HC z-score >-3 & <=-2 1-HC z-score <=-1
hc_z_qw 4-HC z-score <=-3 1-HC z-score <=-1
ivh 1-no IVH 0-no IVH
ivh 2-IVH grade I 1-IVH
ivh 3-IVH grade II 1-IVH
ivh 4-IVH grade III 1-IVH
ivh 5-IVH grade IV, unilateral 1-IVH
ivh 6-IVH grade IV, bilateral/IVH grade III with hydrocephalus 1-IVH
pvl 1-no PVL 0-no PVL
pvl 2-PVL focal, unilateral 1-PVL
pvl 3-PVL focal, bilateral 1-PVL
pvl 4-PVL extensive, bilateral 1-PVL
cerebellar_hemorrhage 1-no bleeding 1-no bleeding
cerebellar_hemorrhage 3-severe bleeding 3-severe bleeding
ischaemic_stroke 1-no ischemia 0-no ischemia
ischaemic_stroke 2-ischemia, unilateral 1-ischemia
ischaemic_stroke 3-ischemia, bilateral 1-ischemia
ischaemic_stroke 4-ischemia, multiple 1-ischemia
hs_pda_iv 1-no PDA/PDA, no intervention (removed)
hs_pda_iv 2-PDA, medical intervention pda_medical
hs_pda_iv 3-PDA, surgical intervention pda_surgical
non_nec_surg_abd 1-no NEC/NEC, no surgery 0-no NEC/NEC, no surgery
non_nec_surg_abd 2-SIP/meconium ileus/volvulus/obstruction 1-NEC with surgery
non_nec_surg_abd 3-SIP/meconium ileus/volvulus/obstruction with stomy 1-NEC with surgery
Note:
*, inversed nominal category.

Univariate regression analysis

Table 14. Univariate regression analysis.
outcome variable term OR LB UB p.value
survive fio2_cum_level_qw* value 1.002000e+00 1.001 1.003 <0.001
survive ga_wk* value 1.740000e+00 1.518 1.995 <0.001
survive as1* value 5.449000e+00 3.453 8.600 <0.001
survive as5* value 2.507000e+00 1.996 3.149 <0.001
survive resuscitation_at_birth* value 6.860000e-01 0.626 0.753 <0.001
survive steroid_antenatal* value 1.416000e+00 1.177 1.704 <0.001
survive surfactant* value 3.490000e-01 0.254 0.480 <0.001
survive bbw_z* value 1.566000e+00 1.223 2.005 <0.001
survive fio2_cum_day_qw* value 1.185000e+00 1.041 1.349 0.01
survive maternal_age* value 1.062000e+00 1.013 1.114 0.013
survive resp_supp_agg_cum_day_qw* value 1.054000e+00 1.010 1.101 0.017
survive fio2_cum_day_pct* value 1.029000e+00 1.001 1.058 0.039
survive fio2_cum_level_pct* value 1.027000e+00 1.000 1.055 0.046
survive plt value 1.684000e+00 0.971 2.919 0.064
survive bhc_z value 1.209000e+00 0.982 1.488 0.074
survive socioeconomic_status 3-low 5.260000e-01 0.258 1.074 0.078
survive birthtime_evening 1-yes 1.771000e+00 0.919 3.414 0.088
survive birthtime_night 1-yes 6.350000e-01 0.360 1.121 0.117
survive ivf 1-yes 1.485000e+00 0.768 2.869 0.24
survive feeding value 8.440000e-01 0.636 1.122 0.244
survive education_status 1-low 7.680000e-01 0.456 1.292 0.32
survive cs 1-yes 1.236000e+00 0.732 2.087 0.427
survive chorioamnionitis 1-yes 7.870000e-01 0.380 1.627 0.518
survive sex 1-male 8.580000e-01 0.509 1.444 0.563
survive transfusion value 1.325000e+00 0.469 3.748 0.595
survive resp_supp_agg_cum_day_pct value 1.007000e+00 0.981 1.033 0.601
survive gdm 1-yes 7.730000e-01 0.258 2.318 0.646
survive multiple_gestation 1-yes 8.940000e-01 0.518 1.545 0.689
survive gravida value 1.036000e+00 0.859 1.248 0.713
survive pe 1-yes 9.020000e-01 0.487 1.670 0.742
survive birthtime_day 1-yes 9.460000e-01 0.567 1.579 0.832
survive socioeconomic_status 2-medium 9.610000e-01 0.480 1.925 0.911
survive bw_z_qw 1-BW z-score <=-1 1.036000e+00 0.278 3.857 0.958
survive pvl 1-PVL 2.231151e+06 0.000 Inf 0.985
survive steroid_postnatal value 0.000000e+00 0.000 Inf 0.998
survive hc_z_qw 1-HC z-score <=-1 3.082449e+08 0.000 Inf 0.998
survive inotropic value 1.000000e-03 0.000 Inf 0.998
survive blood_culture value 0.000000e+00 0.000 Inf 0.998
survive wbc value 0.000000e+00 0.000 Inf 0.998
survive blood_volume value 3.000000e-02 0.000 Inf 0.999
survive pda_surgical 1-yes 0.000000e+00 0.000 Inf 0.999
survive ivhNA 1-IVH NA NA NA NA
survive cerebellar_hemorrhageNA 3-severe bleeding NA NA NA NA
survive ischaemic_strokeNA 1-ischemia NA NA NA NA
survive pda_medicalNA 1-yes NA NA NA NA
survive necNA value NA NA NA NA
survive non_nec_surg_abdNA 1-NEC with surgery NA NA NA NA
survive akiNA value NA NA NA NA
rop_severe resp_supp_agg_cum_day_qw* value 1.102000e+00 1.098 1.107 <0.001
rop_severe fio2_cum_day_qw* value 1.120000e+00 1.114 1.127 <0.001
rop_severe fio2_cum_level_qw* value 1.002000e+00 1.002 1.002 <0.001
rop_severe steroid_postnatal* value 2.451000e+00 2.260 2.657 <0.001
rop_severe ga_wk* value 4.360000e-01 0.359 0.528 <0.001
rop_severe as5* value 6.590000e-01 0.536 0.811 <0.001
rop_severe resuscitation_at_birth* value 1.219000e+00 1.095 1.357 <0.001
rop_severe surfactant* value 1.758000e+00 1.325 2.332 <0.001
rop_severe hc_z_qw* 1-HC z-score <=-1 2.940000e+00 2.653 3.258 <0.001
rop_severe inotropic* value 1.385000e+00 1.346 1.425 <0.001
rop_severe blood_volume* value 1.318000e+00 1.261 1.378 <0.001
rop_severe transfusion* value 1.643000e+00 1.545 1.747 <0.001
rop_severe blood_culture* value 1.267000e+00 1.215 1.322 <0.001
rop_severe plt* value 1.276000e+00 1.228 1.325 <0.001
rop_severe wbc* value 1.182000e+00 1.105 1.265 <0.001
rop_severe feeding* value 6.950000e-01 0.680 0.709 <0.001
rop_severe ivh* 1-IVH 2.388000e+00 1.647 3.462 <0.001
rop_severe cerebellar_hemorrhage 3-severe bleeding 0.000000e+00 0.000 Inf <0.001
rop_severe pda_medical* 1-yes 1.789000e+00 1.447 2.212 <0.001
rop_severe pda_surgical* 1-yes 2.358000e+00 1.391 3.995 <0.001
rop_severe aki* value 1.280000e+00 1.139 1.438 <0.001
rop_severe as1* value 6.310000e-01 0.468 0.851 0.003
rop_severe bw_z_qw* 1-BW z-score <=-1 1.964000e+00 1.808 2.134 0.003
rop_severe non_nec_surg_abd* 1-NEC with surgery 3.163000e+00 1.415 7.067 0.003
rop_severe sex* 1-male 2.461000e+00 1.324 4.575 0.004
rop_severe pe* 1-yes 2.510000e-01 0.088 0.710 0.009
rop_severe ivf* 1-yes 1.819000e+00 1.008 3.280 0.047
rop_severe socioeconomic_status* 3-low 4.420000e-01 0.196 0.998 0.049
rop_severe birthtime_day 1-yes 6.640000e-01 0.380 1.162 0.152
rop_severe resp_supp_agg_cum_day_pct value 1.008000e+00 1.006 1.009 0.16
rop_severe chorioamnionitis 1-yes 1.684000e+00 0.798 3.554 0.171
rop_severe birthtime_night 1-yes 1.533000e+00 0.821 2.864 0.18
rop_severe socioeconomic_status 2-medium 6.640000e-01 0.353 1.247 0.203
rop_severe multiple_gestation 1-yes 1.388000e+00 0.779 2.473 0.266
rop_severe steroid_antenatal value 1.133000e+00 0.879 1.460 0.335
rop_severe maternal_age value 9.770000e-01 0.926 1.030 0.388
rop_severe cs 1-yes 7.820000e-01 0.444 1.378 0.395
rop_severe fio2_cum_day_pct value 1.004000e+00 1.002 1.005 0.412
rop_severe bbw_z value 1.119000e+00 0.732 1.713 0.603
rop_severe education_status 1-low 8.780000e-01 0.489 1.577 0.664
rop_severe gdm 1-yes 7.250000e-01 0.165 3.188 0.671
rop_severe birthtime_evening 1-yes 1.123000e+00 0.612 2.061 0.707
rop_severe nec value 9.550000e-01 0.706 1.290 0.746
rop_severe fio2_cum_level_pct value 1.001000e+00 1.000 1.002 0.827
rop_severe ischaemic_stroke 1-ischemia 1.208000e+00 0.170 8.601 0.849
rop_severe pvl 1-PVL 9.190000e-01 0.113 7.482 0.937
rop_severe bhc_z value 1.010000e+00 0.771 1.323 0.944
rop_severe gravida value 1.004000e+00 0.825 1.221 0.971
bpd fio2_cum_level_qw* value 1.007000e+00 1.005 1.008 <0.001
bpd fio2_cum_level_pct* value 1.009000e+00 1.005 1.013 <0.001
bpd resp_supp_agg_cum_day_qw* value 1.082000e+00 1.024 1.143 0.005
bpd fio2_cum_day_pct value 1.004000e+00 1.000 1.009 0.074
bpd ga_wk value 8.350000e-01 0.542 1.287 0.415
bpd maternal_age value 1.018000e+00 0.955 1.085 0.583
bpd fio2_cum_day_qw value 1.007000e+00 0.972 1.043 0.713
bpd resp_supp_agg_cum_day_pct value 9.990000e-01 0.994 1.005 0.824
bpd nec value 9.440000e-01 0.485 1.837 0.866
bpd cerebellar_hemorrhage 3-severe bleeding 3.143660e+08 0.000 Inf 0.999
bpd steroid_postnatal value 1.000000e+00 0.141 7.099 1
bpd socioeconomic_status 2-medium 1.000000e+00 0.020 50.397 1
bpd socioeconomic_status 3-low 1.000000e+00 0.020 50.397 1
bpd education_status 1-low 1.000000e+00 0.020 50.397 1
bpd ivf 1-yes 1.000000e+00 0.020 50.397 1
bpd pe 1-yes 1.000000e+00 0.020 50.397 1
bpd gdm 1-yes 1.000000e+00 0.020 50.397 1
bpd cs 1-yes 1.000000e+00 0.020 50.397 1
bpd gravida value 1.000000e+00 0.592 1.688 1
bpd sex 1-male 1.000000e+00 0.020 50.397 1
bpd multiple_gestation 1-yes 1.000000e+00 0.020 50.397 1
bpd as1 value 1.000000e+00 0.392 2.552 1
bpd as5 value 1.000000e+00 0.392 2.552 1
bpd resuscitation_at_birth value 1.000000e+00 0.520 1.922 1
bpd birthtime_day 1-yes 1.000000e+00 0.020 50.397 1
bpd birthtime_evening 1-yes 1.000000e+00 0.020 50.397 1
bpd birthtime_night 1-yes 1.000000e+00 0.020 50.397 1
bpd steroid_antenatal value 1.000000e+00 0.375 2.664 1
bpd chorioamnionitis 1-yes 1.000000e+00 0.020 50.397 1
bpd surfactant value 1.000000e+00 0.141 7.099 1
bpd bbw_z value 1.000000e+00 0.375 2.664 1
bpd bhc_z value 1.000000e+00 0.375 2.664 1
bpd bw_z_qw 1-BW z-score <=-1 1.000000e+00 0.020 50.397 1
bpd hc_z_qw 1-HC z-score <=-1 1.000000e+00 0.020 50.397 1
bpd inotropic value 1.000000e+00 0.538 1.859 1
bpd blood_volume value 1.000000e+00 0.526 1.899 1
bpd transfusion value 1.000000e+00 0.141 7.099 1
bpd blood_culture value 1.000000e+00 0.526 1.899 1
bpd plt value 1.000000e+00 0.562 1.778 1
bpd wbc value 1.000000e+00 0.375 2.664 1
bpd feeding value 1.000000e+00 0.592 1.688 1
bpd ivh 1-IVH 1.000000e+00 0.020 50.397 1
bpd pvl 1-PVL 1.000000e+00 0.020 50.397 1
bpd ischaemic_stroke 1-ischemia 1.000000e+00 0.020 50.397 1
bpd pda_medical 1-yes 1.000000e+00 0.020 50.397 1
bpd pda_surgical 1-yes 1.000000e+00 0.020 50.397 1
bpd non_nec_surg_abd 1-NEC with surgery 1.000000e+00 0.020 50.397 1
bpd aki value 1.000000e+00 0.538 1.859 1
bpd_moderate_severe fio2_cum_level_qw* value 1.005000e+00 1.004 1.007 <0.001
bpd_moderate_severe fio2_cum_level_pct* value 1.008000e+00 1.004 1.012 <0.001
bpd_moderate_severe resp_supp_agg_cum_day_qw* value 1.074000e+00 1.020 1.132 0.007
bpd_moderate_severe fio2_cum_day_pct value 1.002000e+00 0.998 1.007 0.327
bpd_moderate_severe ga_wk value 8.350000e-01 0.542 1.287 0.415
bpd_moderate_severe resp_supp_agg_cum_day_pct value 9.980000e-01 0.992 1.003 0.441
bpd_moderate_severe maternal_age value 1.018000e+00 0.955 1.085 0.583
bpd_moderate_severe fio2_cum_day_qw value 1.003000e+00 0.969 1.038 0.865
bpd_moderate_severe nec value 9.440000e-01 0.485 1.837 0.866
bpd_moderate_severe cerebellar_hemorrhage 3-severe bleeding 3.143660e+08 0.000 Inf 0.999
bpd_moderate_severe steroid_postnatal value 1.000000e+00 0.141 7.099 1
bpd_moderate_severe socioeconomic_status 2-medium 1.000000e+00 0.020 50.397 1
bpd_moderate_severe socioeconomic_status 3-low 1.000000e+00 0.020 50.397 1
bpd_moderate_severe education_status 1-low 1.000000e+00 0.020 50.397 1
bpd_moderate_severe ivf 1-yes 1.000000e+00 0.020 50.397 1
bpd_moderate_severe pe 1-yes 1.000000e+00 0.020 50.397 1
bpd_moderate_severe gdm 1-yes 1.000000e+00 0.020 50.397 1
bpd_moderate_severe cs 1-yes 1.000000e+00 0.020 50.397 1
bpd_moderate_severe gravida value 1.000000e+00 0.592 1.688 1
bpd_moderate_severe sex 1-male 1.000000e+00 0.020 50.397 1
bpd_moderate_severe multiple_gestation 1-yes 1.000000e+00 0.020 50.397 1
bpd_moderate_severe as1 value 1.000000e+00 0.392 2.552 1
bpd_moderate_severe as5 value 1.000000e+00 0.392 2.552 1
bpd_moderate_severe resuscitation_at_birth value 1.000000e+00 0.520 1.922 1
bpd_moderate_severe birthtime_day 1-yes 1.000000e+00 0.020 50.397 1
bpd_moderate_severe birthtime_evening 1-yes 1.000000e+00 0.020 50.397 1
bpd_moderate_severe birthtime_night 1-yes 1.000000e+00 0.020 50.397 1
bpd_moderate_severe steroid_antenatal value 1.000000e+00 0.375 2.664 1
bpd_moderate_severe chorioamnionitis 1-yes 1.000000e+00 0.020 50.397 1
bpd_moderate_severe surfactant value 1.000000e+00 0.141 7.099 1
bpd_moderate_severe bbw_z value 1.000000e+00 0.375 2.664 1
bpd_moderate_severe bhc_z value 1.000000e+00 0.375 2.664 1
bpd_moderate_severe bw_z_qw 1-BW z-score <=-1 1.000000e+00 0.020 50.397 1
bpd_moderate_severe hc_z_qw 1-HC z-score <=-1 1.000000e+00 0.020 50.397 1
bpd_moderate_severe inotropic value 1.000000e+00 0.538 1.859 1
bpd_moderate_severe blood_volume value 1.000000e+00 0.526 1.899 1
bpd_moderate_severe transfusion value 1.000000e+00 0.141 7.099 1
bpd_moderate_severe blood_culture value 1.000000e+00 0.526 1.899 1
bpd_moderate_severe plt value 1.000000e+00 0.562 1.778 1
bpd_moderate_severe wbc value 1.000000e+00 0.375 2.664 1
bpd_moderate_severe feeding value 1.000000e+00 0.592 1.688 1
bpd_moderate_severe ivh 1-IVH 1.000000e+00 0.020 50.397 1
bpd_moderate_severe pvl 1-PVL 1.000000e+00 0.020 50.397 1
bpd_moderate_severe ischaemic_stroke 1-ischemia 1.000000e+00 0.020 50.397 1
bpd_moderate_severe pda_medical 1-yes 1.000000e+00 0.020 50.397 1
bpd_moderate_severe pda_surgical 1-yes 1.000000e+00 0.020 50.397 1
bpd_moderate_severe non_nec_surg_abd 1-NEC with surgery 1.000000e+00 0.020 50.397 1
bpd_moderate_severe aki value 1.000000e+00 0.538 1.859 1
eugr_hc resp_supp_agg_cum_day_qw* value 1.076000e+00 1.072 1.079 <0.001
eugr_hc fio2_cum_day_qw* value 1.070000e+00 1.066 1.073 <0.001
eugr_hc fio2_cum_level_qw* value 1.002000e+00 1.002 1.002 <0.001
eugr_hc steroid_postnatal* value 1.545000e+00 1.420 1.682 <0.001
eugr_hc ga_wk* value 6.400000e-01 0.571 0.717 <0.001
eugr_hc as5* value 6.820000e-01 0.578 0.804 <0.001
eugr_hc surfactant* value 1.972000e+00 1.576 2.469 <0.001
eugr_hc inotropic* value 1.386000e+00 1.356 1.418 <0.001
eugr_hc blood_volume* value 1.310000e+00 1.267 1.355 <0.001
eugr_hc transfusion* value 1.435000e+00 1.365 1.509 <0.001
eugr_hc blood_culture* value 1.267000e+00 1.226 1.309 <0.001
eugr_hc plt* value 1.390000e+00 1.355 1.425 <0.001
eugr_hc wbc* value 1.155000e+00 1.097 1.217 <0.001
eugr_hc feeding* value 7.470000e-01 0.736 0.758 <0.001
eugr_hc ivh* 1-IVH 1.767000e+00 1.298 2.405 <0.001
eugr_hc cerebellar_hemorrhage* 3-severe bleeding 8.200000e+00 1.142 58.898 <0.001
eugr_hc ischaemic_stroke* 1-ischemia 4.469000e+00 1.853 10.777 <0.001
eugr_hc non_nec_surg_abd* 1-NEC with surgery 4.023000e+00 2.277 7.106 <0.001
eugr_hc aki* value 1.201000e+00 1.087 1.328 <0.001
eugr_hc resp_supp_agg_cum_day_pct* value 1.014000e+00 1.013 1.015 0.001
eugr_hc as1* value 6.770000e-01 0.540 0.848 0.001
eugr_hc pda_medical* 1-yes 1.538000e+00 1.302 1.816 0.001
eugr_hc pda_surgical* 1-yes 1.805000e+00 1.162 2.804 0.004
eugr_hc hc_z_qw* 1-HC z-score <=-1 1.508000e+00 1.411 1.611 0.006
eugr_hc fio2_cum_level_pct* value 1.009000e+00 1.008 1.010 0.007
eugr_hc fio2_cum_day_pct* value 1.008000e+00 1.007 1.009 0.02
eugr_hc multiple_gestation* 1-yes 1.577000e+00 1.005 2.476 0.048
eugr_hc resuscitation_at_birth value 1.087000e+00 0.987 1.197 0.089
eugr_hc birthtime_evening 1-yes 6.510000e-01 0.390 1.086 0.1
eugr_hc steroid_antenatal value 8.650000e-01 0.726 1.030 0.103
eugr_hc socioeconomic_status 2-medium 6.640000e-01 0.397 1.112 0.12
eugr_hc bw_z_qw 1-BW z-score <=-1 1.296000e+00 1.221 1.376 0.12
eugr_hc bhc_z value 1.207000e+00 0.944 1.543 0.133
eugr_hc socioeconomic_status 3-low 6.870000e-01 0.379 1.246 0.216
eugr_hc birthtime_day 1-yes 1.305000e+00 0.846 2.012 0.229
eugr_hc chorioamnionitis 1-yes 7.040000e-01 0.343 1.446 0.339
eugr_hc education_status 1-low 8.290000e-01 0.526 1.308 0.421
eugr_hc ivf 1-yes 1.201000e+00 0.736 1.959 0.464
eugr_hc pe 1-yes 8.280000e-01 0.480 1.428 0.497
eugr_hc bbw_z value 9.150000e-01 0.692 1.211 0.536
eugr_hc gdm 1-yes 7.550000e-01 0.250 2.281 0.618
eugr_hc cs 1-yes 1.103000e+00 0.701 1.737 0.672
eugr_hc gravida value 9.720000e-01 0.833 1.135 0.722
eugr_hc birthtime_night 1-yes 1.093000e+00 0.650 1.836 0.738
eugr_hc maternal_age value 9.940000e-01 0.954 1.037 0.788
eugr_hc sex 1-male 1.026000e+00 0.665 1.583 0.907
eugr_hc nec value 1.013000e+00 0.826 1.242 0.907
eugr_hc pvl 1-PVL 9.830000e-01 0.201 4.800 0.983
eugr_bw resp_supp_agg_cum_day_qw* value 1.058000e+00 1.054 1.061 <0.001
eugr_bw fio2_cum_day_qw* value 1.053000e+00 1.050 1.056 <0.001
eugr_bw fio2_cum_level_qw* value 1.002000e+00 1.001 1.002 <0.001
eugr_bw ga_wk* value 7.190000e-01 0.644 0.802 <0.001
eugr_bw as5* value 7.300000e-01 0.615 0.867 <0.001
eugr_bw surfactant* value 1.540000e+00 1.223 1.940 <0.001
eugr_bw hc_z_qw* 1-HC z-score <=-1 2.084000e+00 1.935 2.246 <0.001
eugr_bw inotropic* value 1.317000e+00 1.285 1.350 <0.001
eugr_bw blood_volume* value 1.328000e+00 1.282 1.375 <0.001
eugr_bw transfusion* value 1.382000e+00 1.308 1.460 <0.001
eugr_bw blood_culture* value 1.224000e+00 1.180 1.269 <0.001
eugr_bw plt* value 1.362000e+00 1.325 1.400 <0.001
eugr_bw wbc* value 1.151000e+00 1.089 1.217 <0.001
eugr_bw feeding* value 7.080000e-01 0.696 0.719 <0.001
eugr_bw cerebellar_hemorrhage* 3-severe bleeding 9.548000e+00 1.327 68.706 <0.001
eugr_bw non_nec_surg_abd* 1-NEC with surgery 3.110000e+00 1.613 5.997 <0.001
eugr_bw aki* value 1.223000e+00 1.105 1.353 <0.001
eugr_bw resuscitation_at_birth* value 1.177000e+00 1.070 1.294 0.001
eugr_bw resp_supp_agg_cum_day_pct* value 1.014000e+00 1.012 1.015 0.002
eugr_bw pda_medical* 1-yes 1.517000e+00 1.270 1.814 0.002
eugr_bw pda_surgical* 1-yes 1.857000e+00 1.167 2.954 0.004
eugr_bw fio2_cum_level_pct* value 1.009000e+00 1.008 1.011 0.007
eugr_bw steroid_postnatal* value 1.390000e+00 1.261 1.532 0.012
eugr_bw bw_z_qw* 1-BW z-score <=-1 1.534000e+00 1.439 1.636 0.014
eugr_bw as1* value 7.640000e-01 0.608 0.961 0.022
eugr_bw fio2_cum_day_pct* value 1.007000e+00 1.006 1.008 0.05
eugr_bw nec value 1.165000e+00 0.977 1.390 0.074
eugr_bw bhc_z value 8.630000e-01 0.708 1.052 0.144
eugr_bw education_status 1-low 1.368000e+00 0.861 2.173 0.185
eugr_bw ivh 1-IVH 1.235000e+00 0.849 1.796 0.199
eugr_bw sex 1-male 1.339000e+00 0.842 2.127 0.217
eugr_bw pe 1-yes 1.301000e+00 0.764 2.218 0.333
eugr_bw socioeconomic_status 2-medium 7.800000e-01 0.445 1.369 0.387
eugr_bw bbw_z value 8.860000e-01 0.665 1.180 0.407
eugr_bw birthtime_evening 1-yes 1.227000e+00 0.749 2.011 0.416
eugr_bw multiple_gestation 1-yes 1.175000e+00 0.725 1.907 0.512
eugr_bw birthtime_night 1-yes 8.650000e-01 0.489 1.527 0.616
eugr_bw chorioamnionitis 1-yes 8.590000e-01 0.416 1.771 0.68
eugr_bw ischaemic_stroke 1-ischemia 7.080000e-01 0.100 5.033 0.728
eugr_bw birthtime_day 1-yes 9.290000e-01 0.590 1.461 0.749
eugr_bw socioeconomic_status 3-low 1.105000e+00 0.597 2.048 0.75
eugr_bw steroid_antenatal value 9.780000e-01 0.808 1.183 0.818
eugr_bw pvl 1-PVL 1.174000e+00 0.240 5.742 0.843
eugr_bw ivf 1-yes 9.490000e-01 0.558 1.616 0.848
eugr_bw gdm 1-yes 9.090000e-01 0.300 2.752 0.866
eugr_bw maternal_age value 1.003000e+00 0.960 1.048 0.887
eugr_bw gravida value 9.930000e-01 0.845 1.167 0.934
eugr_bw cs 1-yes 9.940000e-01 0.619 1.596 0.979
hearing resp_supp_agg_cum_day_qw* value 1.064000e+00 1.059 1.070 <0.001
hearing fio2_cum_day_qw* value 1.066000e+00 1.061 1.072 <0.001
hearing fio2_cum_level_qw* value 1.002000e+00 1.001 1.002 <0.001
hearing ga_wk* value 6.670000e-01 0.568 0.782 <0.001
hearing hc_z_qw* 1-HC z-score <=-1 2.971000e+00 2.614 3.376 <0.001
hearing blood_volume* value 1.234000e+00 1.163 1.310 <0.001
hearing transfusion* value 1.514000e+00 1.397 1.640 <0.001
hearing blood_culture* value 1.307000e+00 1.244 1.373 <0.001
hearing plt* value 1.409000e+00 1.354 1.467 <0.001
hearing wbc* value 1.227000e+00 1.134 1.329 <0.001
hearing feeding* value 6.950000e-01 0.677 0.713 <0.001
hearing cerebellar_hemorrhage 3-severe bleeding 0.000000e+00 0.000 Inf <0.001
hearing pda_medical* 1-yes 2.120000e+00 1.663 2.703 <0.001
hearing inotropic* value 1.281000e+00 1.230 1.333 0.001
hearing bw_z_qw* 1-BW z-score <=-1 2.439000e+00 2.196 2.708 0.004
hearing bhc_z* value 7.050000e-01 0.553 0.899 0.005
hearing bbw_z* value 6.610000e-01 0.468 0.932 0.018
hearing non_nec_surg_abd* 1-NEC with surgery 2.993000e+00 1.118 8.015 0.021
hearing ivh 1-IVH 1.605000e+00 0.948 2.716 0.03
hearing pda_surgical 1-yes 1.954000e+00 0.973 3.924 0.035
hearing surfactant value 1.323000e+00 0.942 1.856 0.106
hearing steroid_postnatal value 1.364000e+00 1.169 1.591 0.114
hearing resp_supp_agg_cum_day_pct value 1.011000e+00 1.009 1.013 0.133
hearing pe 1-yes 4.470000e-01 0.154 1.295 0.138
hearing aki value 1.144000e+00 0.943 1.388 0.175
hearing as1 value 7.980000e-01 0.569 1.119 0.19
hearing ischaemic_stroke 1-ischemia 3.415000e+00 0.478 24.417 0.212
hearing chorioamnionitis 1-yes 3.980000e-01 0.093 1.701 0.214
hearing maternal_age value 9.630000e-01 0.903 1.027 0.248
hearing resuscitation_at_birth value 1.077000e+00 0.931 1.245 0.319
hearing gdm 1-yes 1.872000e+00 0.527 6.644 0.332
hearing as5 value 8.900000e-01 0.690 1.148 0.369
hearing fio2_cum_day_pct value 1.004000e+00 1.002 1.006 0.388
hearing education_status 1-low 1.316000e+00 0.663 2.615 0.433
hearing gravida value 9.060000e-01 0.701 1.171 0.452
hearing socioeconomic_status 3-low 6.990000e-01 0.270 1.810 0.461
hearing socioeconomic_status 2-medium 7.510000e-01 0.342 1.648 0.475
hearing sex 1-male 1.190000e+00 0.600 2.357 0.619
hearing pvl 1-PVL 1.629000e+00 0.195 13.602 0.652
hearing nec value 1.090000e+00 0.799 1.486 0.656
hearing ivf 1-yes 1.147000e+00 0.537 2.450 0.723
hearing multiple_gestation 1-yes 1.115000e+00 0.543 2.288 0.767
hearing fio2_cum_level_pct value 9.990000e-01 0.997 1.000 0.786
hearing cs 1-yes 1.029000e+00 0.509 2.079 0.937
hearing birthtime_day 1-yes 1.016000e+00 0.519 1.991 0.962
hearing birthtime_evening 1-yes 9.890000e-01 0.464 2.107 0.977
hearing birthtime_night 1-yes 9.900000e-01 0.438 2.238 0.98
hearing steroid_antenatal value 1.001000e+00 0.750 1.336 0.994
Note:
*, either LB > 1 or UB < 1 and p-value <= 0.05.

Covariate selection

Multivariate regression analysis

Table 15. Multivariate regression analysis.
outcome variable term OR LB UB p.value covariates
survive ga_wk* value 1.740 1.518 1.995 <0.001
survive as1* value 2.976 1.671 5.299 <0.001 as5
survive steroid_antenatal* value 1.416 1.177 1.704 <0.001
survive bbw_z* value 1.566 1.223 2.005 <0.001
survive fio2_cum_level_qw* value 1.002 1.001 1.003 <0.001
survive as5* value 1.607 1.186 2.178 0.002 as1
survive surfactant* value 0.612 0.428 0.875 0.007 ga_wk, as5
survive fio2_cum_day_qw* value 1.185 1.041 1.349 0.01
survive maternal_age* value 1.062 1.013 1.114 0.013
survive resp_supp_agg_cum_day_qw* value 1.054 1.010 1.101 0.017
survive resuscitation_at_birth* value 0.872 0.774 0.983 0.025 as5, as1
survive fio2_cum_day_pct* value 1.029 1.001 1.058 0.039
survive fio2_cum_level_pct* value 1.027 1.000 1.055 0.046
rop_severe transfusion* value 1.118 1.049 1.191 <0.001 resp_supp_agg_cum_day_qw, feeding, inotropic, fio2_cum_level_qw, fio2_cum_day_qw, as5, surfactant, resuscitation_at_birth
rop_severe ga_wk* value 0.550 0.533 0.567 <0.001 transfusion, resp_supp_agg_cum_day_qw, steroid_postnatal, feeding, inotropic, fio2_cum_level_qw, blood_culture, blood_volume, ivh, fio2_cum_day_qw, plt, hc_z_qw, aki, pda_medical, pda_surgical, non_nec_surg_abd, bw_z_qw
rop_severe ivh* 1-IVH 2.388 1.647 3.462 <0.001
rop_severe aki* value 1.280 1.139 1.438 <0.001
rop_severe wbc* value 1.182 1.105 1.265 <0.001
rop_severe pda_surgical* 1-yes 2.358 1.391 3.995 <0.001
rop_severe non_nec_surg_abd* 1-NEC with surgery 3.163 1.415 7.067 0.003
rop_severe steroid_postnatal* value 1.225 1.128 1.331 0.013 resp_supp_agg_cum_day_qw, ga_wk, feeding, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, as5, surfactant, as1, bw_z_qw
rop_severe feeding* value 0.890 0.869 0.911 0.018 resp_supp_agg_cum_day_qw, ga_wk, inotropic, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, as5, surfactant, resuscitation_at_birth
rop_severe sex* 1-male 1.998 1.824 2.190 0.018 resp_supp_agg_cum_day_qw, feeding, fio2_cum_level_qw, fio2_cum_day_qw
rop_severe pe* 1-yes 0.324 0.277 0.379 0.031 resp_supp_agg_cum_day_qw, fio2_cum_day_qw
rop_severe blood_culture value 1.064 1.015 1.116 0.116 transfusion, resp_supp_agg_cum_day_qw, feeding, inotropic, fio2_cum_level_qw, fio2_cum_day_qw
rop_severe hc_z_qw 1-HC z-score <=-1 1.364 1.204 1.546 0.147 resp_supp_agg_cum_day_qw, ga_wk, feeding, fio2_cum_level_qw, fio2_cum_day_qw, as5, surfactant, resuscitation_at_birth, as1, bw_z_qw
rop_severe ivf 1-yes 1.462 1.344 1.591 0.159 resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw
rop_severe blood_volume value 1.054 1.006 1.104 0.198 transfusion, resp_supp_agg_cum_day_qw, ga_wk, feeding, inotropic, fio2_cum_day_qw, as5, surfactant
rop_severe pda_medical 1-yes 1.218 0.985 1.506 0.225 resp_supp_agg_cum_day_qw, feeding, inotropic, surfactant
rop_severe socioeconomic_status 3-low 0.677 0.601 0.763 0.301 resp_supp_agg_cum_day_qw, feeding, fio2_cum_level_qw, fio2_cum_day_qw
rop_severe socioeconomic_status 2-medium 0.762 0.696 0.835 0.336 resp_supp_agg_cum_day_qw, feeding, fio2_cum_level_qw, fio2_cum_day_qw
rop_severe resuscitation_at_birth value 1.045 1.029 1.061 0.338 transfusion, resp_supp_agg_cum_day_qw, steroid_postnatal, feeding, inotropic, fio2_cum_level_qw, blood_culture, blood_volume, ivh, fio2_cum_day_qw, plt, hc_z_qw, aki, pda_medical, pda_surgical, bw_z_qw
rop_severe plt value 1.032 0.989 1.077 0.363 resp_supp_agg_cum_day_qw, ga_wk, feeding, inotropic, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, as5, surfactant, resuscitation_at_birth, bw_z_qw
rop_severe as5 value 0.943 0.914 0.972 0.518 transfusion, resp_supp_agg_cum_day_qw, steroid_postnatal, feeding, inotropic, fio2_cum_level_qw, blood_culture, blood_volume, ivh, fio2_cum_day_qw, plt, hc_z_qw, aki, pda_medical, pda_surgical, non_nec_surg_abd, bw_z_qw
rop_severe resp_supp_agg_cum_day_qw value 1.007 1.001 1.014 0.663 ga_wk, feeding, fio2_cum_day_qw, hc_z_qw, as5, surfactant, resuscitation_at_birth, as1
rop_severe surfactant value 1.051 1.002 1.104 0.746 transfusion, resp_supp_agg_cum_day_qw, steroid_postnatal, feeding, inotropic, fio2_cum_level_qw, blood_culture, blood_volume, ivh, plt, hc_z_qw, aki, pda_medical, pda_surgical, bw_z_qw
rop_severe bw_z_qw 1-BW z-score <=-1 1.050 0.955 1.155 0.83 resp_supp_agg_cum_day_qw, ga_wk, feeding, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, as5, as1
rop_severe as1 value 0.969 0.928 1.013 0.837 resp_supp_agg_cum_day_qw, steroid_postnatal, feeding, inotropic, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, bw_z_qw
rop_severe fio2_cum_day_qw value 0.996 0.989 1.004 0.85 resp_supp_agg_cum_day_qw, ga_wk, feeding, hc_z_qw, as5, resuscitation_at_birth
rop_severe inotropic value 1.008 0.976 1.041 0.877 transfusion, resp_supp_agg_cum_day_qw, ga_wk, feeding, fio2_cum_level_qw, fio2_cum_day_qw, as5, surfactant, resuscitation_at_birth, as1
rop_severe fio2_cum_level_qw value 1.000 1.000 1.000 0.962 steroid_postnatal, feeding, fio2_cum_day_qw, hc_z_qw, as5, surfactant, resuscitation_at_birth, as1, bw_z_qw
bpd fio2_cum_level_qw* value 1.004 1.003 1.005 <0.001 resp_supp_agg_cum_day_qw
bpd fio2_cum_level_pct* value 1.009 1.005 1.013 <0.001
bpd resp_supp_agg_cum_day_qw* value 1.082 1.024 1.143 0.005
bpd_moderate_severe fio2_cum_level_qw* value 1.003 1.002 1.004 <0.001 resp_supp_agg_cum_day_qw
bpd_moderate_severe fio2_cum_level_pct* value 1.008 1.004 1.012 <0.001
bpd_moderate_severe resp_supp_agg_cum_day_qw* value 1.074 1.020 1.132 0.007
eugr_hc cerebellar_hemorrhage* 3-severe bleeding 8.200 1.142 58.898 <0.001
eugr_hc plt* value 1.193 1.160 1.227 <0.001 inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, feeding, ga_wk, fio2_cum_day_qw, surfactant, as5, resp_supp_agg_cum_day_pct
eugr_hc feeding* value 0.876 0.862 0.891 <0.001 plt, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, ga_wk, fio2_cum_day_qw, surfactant, as5, as1, resp_supp_agg_cum_day_pct
eugr_hc ga_wk* value 0.744 0.727 0.761 <0.001 plt, inotropic, blood_culture, resp_supp_agg_cum_day_qw, transfusion, fio2_cum_level_qw, feeding, blood_volume, fio2_cum_day_qw, non_nec_surg_abd, ivh, steroid_postnatal, aki, pda_medical, pda_surgical, hc_z_qw, fio2_cum_level_pct
eugr_hc ivh* 1-IVH 1.767 1.298 2.405 <0.001
eugr_hc ischaemic_stroke* 1-ischemia 4.469 1.853 10.777 <0.001
eugr_hc aki* value 1.201 1.087 1.328 <0.001
eugr_hc non_nec_surg_abd* 1-NEC with surgery 2.003 1.134 3.540 0.002 feeding
eugr_hc blood_culture* value 1.079 1.041 1.119 0.003 inotropic, resp_supp_agg_cum_day_qw, transfusion, fio2_cum_level_qw, feeding, ga_wk, fio2_cum_day_qw, surfactant
eugr_hc pda_surgical* 1-yes 1.805 1.162 2.804 0.004
eugr_hc inotropic* value 1.087 1.060 1.115 0.01 plt, resp_supp_agg_cum_day_qw, transfusion, fio2_cum_level_qw, feeding, blood_volume, ga_wk, fio2_cum_day_qw, surfactant, as5, as1, resp_supp_agg_cum_day_pct, fio2_cum_level_pct, fio2_cum_day_pct
eugr_hc surfactant* value 1.390 1.336 1.446 0.012 cerebellar_hemorrhage, plt, inotropic, blood_culture, resp_supp_agg_cum_day_qw, transfusion, fio2_cum_level_qw, feeding, blood_volume, fio2_cum_day_qw, non_nec_surg_abd, ivh, ischaemic_stroke, steroid_postnatal, aki, pda_medical, resp_supp_agg_cum_day_pct, pda_surgical, hc_z_qw, fio2_cum_level_pct
eugr_hc blood_volume value 1.051 1.014 1.088 0.055 plt, inotropic, resp_supp_agg_cum_day_qw, transfusion, fio2_cum_level_qw, feeding, ga_wk, fio2_cum_day_qw, surfactant, as5, resp_supp_agg_cum_day_pct
eugr_hc transfusion value 0.960 0.910 1.013 0.062 inotropic, blood_culture, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, feeding, blood_volume, ga_wk, fio2_cum_day_qw, surfactant, as5, resp_supp_agg_cum_day_pct
eugr_hc steroid_postnatal value 1.173 1.077 1.277 0.11 feeding, surfactant, as5, as1, resp_supp_agg_cum_day_pct, fio2_cum_level_pct
eugr_hc multiple_gestation 1-yes 1.345 1.266 1.429 0.112 transfusion, fio2_cum_level_qw, feeding, blood_volume, fio2_cum_day_qw, ischaemic_stroke, resp_supp_agg_cum_day_pct, fio2_cum_level_pct, fio2_cum_day_pct
eugr_hc as1 value 0.879 0.851 0.908 0.214 cerebellar_hemorrhage, plt, inotropic, blood_culture, resp_supp_agg_cum_day_qw, transfusion, fio2_cum_level_qw, feeding, blood_volume, fio2_cum_day_qw, non_nec_surg_abd, ivh, steroid_postnatal, aki, pda_medical, resp_supp_agg_cum_day_pct, pda_surgical, hc_z_qw, fio2_cum_level_pct, fio2_cum_day_pct
eugr_hc pda_medical 1-yes 1.126 0.955 1.329 0.281 resp_supp_agg_cum_day_qw, feeding, fio2_cum_day_qw
eugr_hc as5 value 0.941 0.919 0.965 0.433 plt, inotropic, blood_culture, resp_supp_agg_cum_day_qw, transfusion, fio2_cum_level_qw, feeding, blood_volume, ga_wk, fio2_cum_day_qw, non_nec_surg_abd, ivh, steroid_postnatal, aki, pda_medical, resp_supp_agg_cum_day_pct, pda_surgical, hc_z_qw, fio2_cum_level_pct, fio2_cum_day_pct
eugr_hc resp_supp_agg_cum_day_qw value 1.008 1.003 1.014 0.584 plt, inotropic, fio2_cum_level_qw, feeding, ga_wk, fio2_cum_day_qw, surfactant, as5, as1
eugr_hc wbc value 1.016 0.963 1.071 0.635 plt, feeding
eugr_hc hc_z_qw 1-HC z-score <=-1 0.939 0.874 1.008 0.68 plt, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, feeding, surfactant, as5, as1
eugr_hc resp_supp_agg_cum_day_pct value 1.001 1.000 1.002 0.81 plt, inotropic, feeding, surfactant, as5, as1, fio2_cum_level_pct, fio2_cum_day_pct
eugr_hc fio2_cum_level_pct value 1.001 0.999 1.002 0.836 inotropic, feeding, as5, as1, resp_supp_agg_cum_day_pct
eugr_hc fio2_cum_level_qw value 1.000 1.000 1.000 0.9 plt, inotropic, resp_supp_agg_cum_day_qw, feeding, ga_wk, fio2_cum_day_qw, surfactant, as5, as1
eugr_hc fio2_cum_day_pct value 1.000 0.998 1.001 0.909 inotropic, feeding, as5, as1, resp_supp_agg_cum_day_pct
eugr_hc fio2_cum_day_qw value 0.999 0.994 1.004 0.95 inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, feeding, ga_wk, surfactant, as5, as1
eugr_bw cerebellar_hemorrhage* 3-severe bleeding 9.548 1.327 68.706 <0.001
eugr_bw feeding* value 0.782 0.768 0.796 <0.001 resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, ga_wk, surfactant, as5, resp_supp_agg_cum_day_pct
eugr_bw plt* value 1.146 1.111 1.182 <0.001 feeding, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, ga_wk, hc_z_qw, surfactant, as5, resuscitation_at_birth, resp_supp_agg_cum_day_pct
eugr_bw ga_wk* value 0.781 0.761 0.800 <0.001 feeding, plt, blood_volume, transfusion, blood_culture, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, aki, non_nec_surg_abd, pda_medical, pda_surgical, fio2_cum_level_pct, steroid_postnatal, bw_z_qw
eugr_bw aki* value 1.223 1.105 1.353 <0.001
eugr_bw non_nec_surg_abd* 1-NEC with surgery 3.110 1.613 5.997 <0.001
eugr_bw pda_surgical* 1-yes 1.857 1.167 2.954 0.004
eugr_bw blood_volume* value 1.084 1.045 1.124 0.006 feeding, plt, transfusion, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_day_qw, ga_wk, surfactant, as5, resp_supp_agg_cum_day_pct
eugr_bw wbc value 1.073 1.015 1.135 0.065 plt
eugr_bw hc_z_qw 1-HC z-score <=-1 1.378 1.271 1.494 0.068 feeding, plt, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, ga_wk, surfactant, as5, resuscitation_at_birth, as1
eugr_bw transfusion value 0.958 0.903 1.016 0.075 feeding, blood_volume, blood_culture, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, ga_wk, surfactant, as5, resuscitation_at_birth, resp_supp_agg_cum_day_pct
eugr_bw blood_culture value 1.045 1.004 1.088 0.102 feeding, transfusion, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_day_qw, ga_wk
eugr_bw resuscitation_at_birth value 1.057 1.043 1.071 0.185 feeding, plt, blood_volume, transfusion, blood_culture, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, aki, pda_medical, resp_supp_agg_cum_day_pct, pda_surgical, fio2_cum_level_pct, steroid_postnatal, bw_z_qw, fio2_cum_day_pct
eugr_bw as5 value 0.905 0.882 0.928 0.223 feeding, plt, blood_volume, transfusion, blood_culture, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, aki, non_nec_surg_abd, pda_medical, resp_supp_agg_cum_day_pct, pda_surgical, fio2_cum_level_pct, steroid_postnatal, bw_z_qw, fio2_cum_day_pct
eugr_bw steroid_postnatal value 1.160 1.052 1.280 0.249 surfactant, as5, resp_supp_agg_cum_day_pct, fio2_cum_level_pct
eugr_bw fio2_cum_level_qw value 0.999 0.999 1.000 0.3 feeding, plt, inotropic, ga_wk, hc_z_qw, surfactant, as5, resuscitation_at_birth, as1
eugr_bw pda_medical 1-yes 1.118 0.936 1.336 0.345 feeding, fio2_cum_day_qw, surfactant
eugr_bw inotropic value 1.032 1.004 1.061 0.457 feeding, plt, blood_volume, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, ga_wk, surfactant, as5, resuscitation_at_birth, resp_supp_agg_cum_day_pct, fio2_cum_level_pct, as1
eugr_bw bw_z_qw 1-BW z-score <=-1 1.103 1.026 1.186 0.586 feeding, plt, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, ga_wk, hc_z_qw, surfactant, as5, resuscitation_at_birth, as1
eugr_bw as1 value 0.956 0.925 0.989 0.663 feeding, plt, blood_volume, transfusion, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, resp_supp_agg_cum_day_pct, fio2_cum_level_pct, steroid_postnatal, bw_z_qw, fio2_cum_day_pct
eugr_bw surfactant value 1.055 1.013 1.098 0.669 cerebellar_hemorrhage, feeding, plt, blood_volume, transfusion, blood_culture, inotropic, resp_supp_agg_cum_day_qw, fio2_cum_level_qw, fio2_cum_day_qw, hc_z_qw, aki, non_nec_surg_abd, pda_medical, resp_supp_agg_cum_day_pct, pda_surgical, fio2_cum_level_pct, steroid_postnatal, bw_z_qw, fio2_cum_day_pct
eugr_bw fio2_cum_day_pct value 1.001 1.000 1.002 0.733 feeding, inotropic, as5, resuscitation_at_birth, as1
eugr_bw resp_supp_agg_cum_day_qw value 0.996 0.991 1.001 0.78 feeding, plt, inotropic, fio2_cum_day_qw, ga_wk, hc_z_qw, surfactant, as5, resuscitation_at_birth, as1
eugr_bw fio2_cum_level_pct value 1.001 0.999 1.002 0.85 feeding, inotropic, surfactant, as5, resuscitation_at_birth, resp_supp_agg_cum_day_pct, as1
eugr_bw resp_supp_agg_cum_day_pct value 1.001 0.999 1.002 0.864 feeding, plt, inotropic, surfactant, as5, resuscitation_at_birth, fio2_cum_level_pct, as1
eugr_bw fio2_cum_day_qw value 0.998 0.993 1.004 0.902 feeding, inotropic, resp_supp_agg_cum_day_qw, ga_wk, hc_z_qw, surfactant, as5, resuscitation_at_birth
hearing plt* value 1.153 1.100 1.208 <0.001 feeding, resp_supp_agg_cum_day_qw, ga_wk, hc_z_qw, fio2_cum_day_qw, fio2_cum_level_qw, bw_z_qw, bhc_z, bbw_z
hearing feeding* value 0.787 0.765 0.811 0.001 resp_supp_agg_cum_day_qw, ga_wk, fio2_cum_day_qw
hearing ga_wk* value 0.752 0.728 0.777 0.002 plt, transfusion, feeding, blood_culture, resp_supp_agg_cum_day_qw, hc_z_qw, fio2_cum_day_qw, pda_medical, blood_volume, inotropic, bw_z_qw, non_nec_surg_abd
hearing non_nec_surg_abd* 1-NEC with surgery 2.993 1.118 8.015 0.021
hearing wbc* value 1.103 1.017 1.197 0.041 feeding
hearing blood_culture* value 1.113 1.053 1.175 0.043 transfusion, feeding, resp_supp_agg_cum_day_qw, ga_wk, fio2_cum_day_qw
hearing pda_medical 1-yes 1.308 1.026 1.669 0.126 ga_wk, fio2_cum_day_qw
hearing bhc_z value 0.825 0.794 0.857 0.135 plt, feeding, resp_supp_agg_cum_day_qw, hc_z_qw, bw_z_qw
hearing fio2_cum_level_qw value 1.001 1.000 1.001 0.324 feeding, hc_z_qw, bw_z_qw
hearing bbw_z value 0.845 0.800 0.892 0.34 plt, feeding, resp_supp_agg_cum_day_qw, hc_z_qw, bw_z_qw
hearing hc_z_qw 1-HC z-score <=-1 1.238 1.060 1.446 0.371 feeding, resp_supp_agg_cum_day_qw, ga_wk, fio2_cum_day_qw, bw_z_qw, bhc_z, bbw_z
hearing bw_z_qw 1-BW z-score <=-1 1.312 1.155 1.492 0.435 resp_supp_agg_cum_day_qw, ga_wk, hc_z_qw, fio2_cum_day_qw, bhc_z, bbw_z
hearing transfusion value 1.024 0.941 1.115 0.563 feeding, blood_culture, resp_supp_agg_cum_day_qw, ga_wk, fio2_cum_day_qw, fio2_cum_level_qw, inotropic
hearing inotropic value 1.036 0.993 1.081 0.607 feeding, resp_supp_agg_cum_day_qw, ga_wk, fio2_cum_day_qw, fio2_cum_level_qw
hearing blood_volume value 1.028 0.967 1.093 0.648 feeding, resp_supp_agg_cum_day_qw, ga_wk, fio2_cum_day_qw, inotropic
hearing resp_supp_agg_cum_day_qw value 1.007 0.999 1.014 0.759 plt, feeding, hc_z_qw, fio2_cum_day_qw, bw_z_qw
hearing fio2_cum_day_qw value 1.000 0.992 1.009 0.985 feeding, resp_supp_agg_cum_day_qw, ga_wk, hc_z_qw, bw_z_qw
Note:
*, either LB > 1 or UB < 1 and p-value <= 0.05.

Figure 4. Effect size changes before and after adjustment for confounders.

Feature selection

Dimensional reduction

Table 16. Dimensional reduction needed for regression training.
outcome type min_epv cat n pred epv max_pred
survive* baseline 20 0 67 8 9 2
survive residual 20 0 811 7 116 38
survive* residual 150 0 811 7 116 3
survive* residual 200 0 811 7 116 2
rop_severe residual 20 1 2394 10 240 117
rop_severe residual 150 1 2394 10 240 13
rop_severe* residual 200 1 2394 10 240 9
bpd baseline 20 1 160 0 Inf 7
bpd residual 20 1 6720 4 1680 334
bpd residual 150 1 6720 4 1680 42
bpd residual 200 1 6720 4 1680 31
bpd_moderate_severe baseline 20 1 143 0 Inf 6
bpd_moderate_severe residual 20 1 6006 4 1502 298
bpd_moderate_severe residual 150 1 6006 4 1502 38
bpd_moderate_severe residual 200 1 6006 4 1502 28
eugr_hc baseline 20 1 107 2 54 4
eugr_hc residual 20 1 4494 12 375 222
eugr_hc residual 150 1 4494 12 375 27
eugr_hc residual 200 1 4494 12 375 20
eugr_bw baseline 20 1 93 1 93 3
eugr_bw residual 20 1 3906 9 434 193
eugr_bw residual 150 1 3906 9 434 24
eugr_bw residual 200 1 3906 9 434 17
hearing residual 20 1 1554 7 222 75
hearing residual 150 1 1554 7 222 8
hearing* residual 200 1 1554 7 222 5
Note:
*, require dimensional reduction.

Figure 5. Dimensional reduction model weights for predictors of: (A) survival baseline prediction (min. 20 EPV); (B) survival residual prediction (min. 150 EPV); (C) survival residual prediction (min. 200 EPV); (D) hearing residual prediction (min. 200 EPV); and (E) severe ROP residual prediction (min. 200 EPV). PVE, proportion of variance explained

Predictive modeling

## survive: survive
## rop_severe: survive -> rop_severe
## bpd: survive -> bpd
## bpd_moderate_severe: survive -> bpd -> bpd_moderate_severe
## eugr_hc: survive -> eugr_hc
## eugr_bw: survive -> eugr_bw
## rop_severe: survive -> hearing
Table 17. List of model stacks and algorithms.
outcome type pred min_epv algorithm
survive baseline 8 20 rr
residual 7 20 rr
150 rf
gbm
200 dnn
rop_severe residual 10 20 rr
150 rf
gbm
200 dnn
bpd residual 4 20 rr
150 rf
gbm
200 dnn
bpd_moderate_severe residual 4 20 rr
150 rf
gbm
200 dnn
eugr_hc baseline 2 20 rr
residual 12 20 rr
150 rf
gbm
200 dnn
eugr_bw baseline 1 20 rr
residual 9 20 rr
150 rf
gbm
200 dnn
hearing residual 7 20 rr
150 rf
gbm
200 dnn
Note:
EPV, event per variable

Survival prediction

Severe ROP prediction

BPD prediction

Moderate/severe BPD prediction

EUGR-HC prediction

EUGR-BW prediction

Failed hearing test prediction

Model evaluation

Evaluation metrics

Survival baseline

Figure 6. Survival baseline prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.

Survival stack

Figure 7. Survival stacked prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.

Severe ROP stack

Figure 8. Severe ROP stacked prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.

BPD stack

Figure 9. BPD stacked prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.

Moderate/severe BPD stack

Figure 10. Moderate/severe BPD stacked prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.

EUGR-HC baseline

Figure 11. EUGR-HC baseline prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.

EUGR-HC stack

Figure 12. EUGR-HC stacked prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.

EUGR-BW baseline

Figure 13. EUGR-BW baseline prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.

EUGR-BW stack

Figure 14. EUGR-BW stacked prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.

Failed hearing test stack

Figure 15. Failed hearing test stacked prediction model evaluation using test set for: (A) calibration plot; (B) decision curve; (C) ROC curve; and (D) SHAP beeswarm plot. Vertical dashed line in panels A and B indicates the chosen threshold. ROC, receiver operating characteristics; SHAP, the Shapley additive explanation.

Predictive performance

Table 18. Predictive performance using test sets.
model dataset AUC-ROC TH F1 TNR TPR PPV NPV
bpd_moderate_severe_stack_rf Modeling 0.86 ( 0.86, 0.86) 0.32 0.69 ( 0.69, 0.70) 83.28 (83.09, 83.46) 75.82 (75.51, 76.14) 64.15 (63.84, 64.46) 89.72 (89.55, 89.89)
Independent test 0.69 ( 0.69, 0.69) 0.32 0.57 ( 0.56, 0.57) 77.34 (76.97, 77.71) 56.70 (56.15, 57.24) 57.02 (56.45, 57.59) 77.11 (76.78, 77.44)
bpd_stack_rf Modeling 0.87 ( 0.87, 0.87) 0.31 0.70 ( 0.70, 0.70) 80.55 (80.36, 80.74) 73.96 (73.56, 74.36) 66.12 (65.83, 66.41) 85.77 (85.53, 86.01)
Independent test 0.73 ( 0.73, 0.73) 0.31 0.58 ( 0.57, 0.58) 75.81 (75.48, 76.14) 54.56 (54.07, 55.04) 61.44 (60.99, 61.89) 70.25 (69.93, 70.57)
eugr_bw_baseline2_rr Modeling 0.82 ( 0.80, 0.84) 0.21 0.58 ( 0.55, 0.60) 82.19 (80.93, 83.46) 69.25 (65.69, 72.81) 49.67 (46.57, 52.76) 91.24 (90.11, 92.38)
Independent test 0.67 ( 0.64, 0.69) 0.21 0.42 ( 0.38, 0.45) 74.37 (72.50, 76.25) 51.95 (47.94, 55.97) 35.30 (31.68, 38.92) 85.45 (84.12, 86.77)
eugr_bw_stack_rr Modeling 0.90 ( 0.90, 0.90) 0.17 0.61 ( 0.61, 0.61) 74.87 (74.63, 75.10) 86.89 (86.57, 87.20) 46.87 (46.46, 47.28) 95.72 (95.61, 95.83)
Independent test 0.77 ( 0.77, 0.77) 0.17 0.50 ( 0.49, 0.51) 73.26 (72.93, 73.58) 69.19 (68.48, 69.90) 39.18 (38.60, 39.77) 90.52 (90.26, 90.77)
eugr_hc_baseline2_rr Modeling 0.88 ( 0.87, 0.89) 0.18 0.65 ( 0.64, 0.67) 73.98 (73.00, 74.95) 88.32 (86.55, 90.10) 52.20 (50.39, 54.01) 95.08 (94.28, 95.88)
Independent test 0.83 ( 0.81, 0.85) 0.18 0.56 ( 0.53, 0.60) 75.12 (73.47, 76.77) 83.17 (78.95, 87.39) 43.35 (39.63, 47.06) 95.11 (93.72, 96.49)
eugr_hc_stack_rr Modeling 0.91 ( 0.91, 0.91) 0.25 0.73 ( 0.72, 0.73) 88.51 (88.34, 88.68) 77.93 (77.49, 78.38) 67.89 (67.50, 68.27) 92.79 (92.63, 92.94)
Independent test 0.85 ( 0.85, 0.86) 0.25 0.67 ( 0.66, 0.67) 85.61 (85.38, 85.84) 81.97 (81.44, 82.50) 56.42 (55.77, 57.07) 95.43 (95.29, 95.57)
hearing_stack_rr Modeling 0.78 ( 0.78, 0.79) 0.07 0.35 ( 0.34, 0.35) 71.79 (71.58, 72.00) 73.76 (73.13, 74.39) 22.55 (22.16, 22.95) 96.09 (95.98, 96.20)
Independent test 0.71 ( 0.70, 0.72) 0.07 0.30 ( 0.30, 0.31) 71.91 (71.62, 72.20) 66.69 (65.66, 67.72) 19.72 (19.27, 20.17) 95.43 (95.27, 95.58)
rop_severe_stack_rr Modeling 0.87 ( 0.87, 0.88) 0.13 0.53 ( 0.53, 0.53) 82.84 (82.67, 83.00) 81.67 (81.21, 82.13) 39.28 (38.84, 39.72) 97.08 (96.99, 97.16)
Independent test 0.90 ( 0.90, 0.91) 0.13 0.47 ( 0.46, 0.48) 79.07 (78.75, 79.40) 85.09 (84.39, 85.80) 32.47 (31.86, 33.09) 97.82 (97.72, 97.92)
survive_baseline1_rr Modeling 0.84 ( 0.83, 0.86) 0.82 0.87 ( 0.86, 0.88) 76.69 (73.76, 79.62) 80.81 (79.37, 82.25) 94.65 (93.92, 95.38) 44.07 (41.79, 46.35)
Independent test 0.81 ( 0.79, 0.83) 0.82 0.91 ( 0.90, 0.92) 58.81 (53.24, 64.38) 88.58 (87.48, 89.69) 93.04 (91.86, 94.22) 44.94 (40.43, 49.46)
survive_stack_dnn Modeling 0.85 ( 0.84, 0.86) 0.93 0.93 ( 0.93, 0.93) 67.15 (66.03, 68.28) 88.18 (88.04, 88.33) 98.64 (98.59, 98.69) 17.39 (16.97, 17.81)
Independent test 0.92 ( 0.91, 0.92) 0.93 0.94 ( 0.94, 0.94) 75.05 (73.13, 76.97) 89.73 (89.51, 89.96) 99.45 (99.39, 99.50) 12.77 (12.10, 13.45)
Note:
AUC-ROC, area under the curve - receiver operating characteristics; TH, the chosen threshold, balanced sensitivity and specificity; F1, the F1-score; TNR, true negative rate (specificity); TPR, true positive rate (sensitivity/recall); PPV, positive predictive value (precision); NPV, negative predictive value.
mutate(cm_selected_time_summary_val, set = "Validation") |>
  rbind(mutate(cm_selected_time_summary, set = "Test")) |>
  timing_selection_plot("survive", "t_7")

Figure 16. Performance for predicting survival at particular time using the chosen threshold. The best timing was selected according to TPR and PPV using validation set. PPV, positive predictive value or precision; TPR, true positive rate or sensitivity.

mutate(cm_selected_time_summary_val, set = "Validation") |>
  rbind(mutate(cm_selected_time_summary, set = "Test")) |>
  timing_selection_plot("rop_severe", "t_14")

Figure 17. Performance for predicting severe ROP at particular time using the chosen threshold. The best timing was selected according to TPR, TNR, and NPV using validation set. NPV, negative predictive value; ROP, retinopathy of prematurity; TNR, true negative rate or specificity; TPR, true positive rate or sensitivity.

mutate(cm_selected_time_summary_val, set = "Validation") |>
  rbind(mutate(cm_selected_time_summary, set = "Test")) |>
  timing_selection_plot("bpd", "t_28")

Figure 18. Performance for predicting BPD at particular time using the chosen threshold. The best timing was selected according to TPR, TNR, and NPV using validation set. BPD, bronchopulmonary disease; NPV, negative predictive value; TNR, true negative rate or specificity; TPR, true positive rate or sensitivity.

mutate(cm_selected_time_summary_val, set = "Validation") |>
  rbind(mutate(cm_selected_time_summary, set = "Test")) |>
  timing_selection_plot("bpd_moderate_severe", "t_28")

Figure 19. Performance for predicting moderate-to-severe BPD at particular time using the chosen threshold. The best timing was selected according to TPR, TNR, and NPV using validation set. BPD, bronchopulmonary disease; NPV, negative predictive value; TNR, true negative rate or specificity; TPR, true positive rate or sensitivity.

mutate(cm_selected_time_summary_val, set = "Validation") |>
  rbind(mutate(cm_selected_time_summary, set = "Test")) |>
  timing_selection_plot("eugr_hc", "t_28")

Figure 20. Performance for predicting EUGR-HC at particular time using the chosen threshold. The best timing was selected according to TPR, PPV, TNR, and NPV using validation set. EUGR-HC, extrauterine growth restriction by head circumference; NPV, negative predictive value; PPV, positive predictive value or precision; TNR, true negative rate or specificity; TPR, true positive rate or sensitivity.

mutate(cm_selected_time_summary_val, set = "Validation") |>
  rbind(mutate(cm_selected_time_summary, set = "Test")) |>
  timing_selection_plot("eugr_bw", "t_14")

Figure 21. Performance for predicting EUGR-BW at particular time using the chosen threshold. The best timing was selected according to TPR and NPV using validation set. EUGR-BW, extrauterine growth restriction by body weight; NPV, negative predictive value; TPR, true positive rate or sensitivity.

mutate(cm_selected_time_summary_val, set = "Validation") |>
  rbind(mutate(cm_selected_time_summary, set = "Test")) |>
  timing_selection_plot("hearing", "t_14")

Figure 22. Performance for predicting failed hearing test at particular time using the chosen threshold. The best timing was selected according to TPR, TNR, and NPV using validation set. NPV, negative predictive value; TNR, true negative rate or specificity; TPR, true positive rate or sensitivity.

Figure 23. Predictive performance using independent test sets at particular time.

Table 19. Predictive performance using test set at particular time.
outcome timing TH dataset F1 TNR TPR PPV NPV
survive 1 0.93 Independent test 0.84 ( 0.82, 0.85) 74.10 ( 67.98, 80.21) 73.75 ( 71.59, 75.92) 96.72 ( 95.90, 97.54) 22.89 ( 19.29, 26.49)
Modeling 0.89 ( 0.89, 0.90) 75.66 ( 69.80, 81.52) 81.91 ( 80.83, 82.99) 98.34 ( 97.91, 98.76) 19.53 ( 17.14, 21.92)
rop_severe 2 0.13 Independent test 0.58 ( 0.55, 0.61) 71.19 ( 68.55, 73.84) 92.90 ( 89.99, 95.82) 42.56 ( 39.42, 45.71) 97.73 ( 96.81, 98.66)
Modeling 0.50 ( 0.47, 0.52) 82.37 ( 81.32, 83.41) 79.70 ( 75.95, 83.45) 36.30 ( 33.87, 38.73) 96.98 ( 96.42, 97.55)
bpd 3 0.31 Independent test 0.79 ( 0.77, 0.81) 68.36 ( 66.32, 70.41) 94.02 ( 92.41, 95.63) 68.49 ( 66.16, 70.83) 93.75 ( 92.00, 95.50)
Modeling 0.73 ( 0.71, 0.75) 78.36 ( 76.59, 80.14) 81.96 ( 80.07, 83.85) 65.79 ( 63.56, 68.02) 89.58 ( 88.39, 90.76)
bpd_moderate_severe 3 0.32 Independent test 0.70 ( 0.68, 0.73) 63.99 ( 62.00, 65.99) 89.16 ( 87.20, 91.12) 58.62 ( 56.01, 61.23) 90.94 ( 89.15, 92.72)
Modeling 0.73 ( 0.71, 0.75) 85.69 ( 84.32, 87.05) 78.30 ( 75.93, 80.67) 68.28 ( 65.67, 70.89) 90.95 ( 89.86, 92.05)
eugr_hc 3 0.25 Independent test 0.75 ( 0.73, 0.76) 82.60 ( 80.37, 84.83) 86.87 ( 84.21, 89.52) 66.11 ( 63.48, 68.73) 94.32 ( 93.25, 95.40)
Modeling 0.77 ( 0.75, 0.78) 89.59 ( 88.73, 90.44) 82.76 ( 80.50, 85.02) 71.91 ( 69.81, 74.02) 94.17 ( 93.39, 94.95)
eugr_bw 2 0.17 Independent test 0.76 ( 0.73, 0.78) 67.81 ( 65.61, 70.00) 100.00 (100.00, 100.00) 61.00 ( 58.27, 63.73) 100.00 (100.00, 100.00)
Modeling 0.60 ( 0.57, 0.62) 73.47 ( 71.90, 75.04) 87.15 ( 84.82, 89.48) 45.58 ( 43.16, 48.00) 95.55 ( 94.59, 96.50)
hearing 2 0.07 Independent test 0.40 ( 0.36, 0.43) 63.64 ( 61.58, 65.70) 100.00 (100.00, 100.00) 25.06 ( 22.54, 27.58) 100.00 (100.00, 100.00)
Modeling 0.29 ( 0.26, 0.32) 67.83 ( 66.22, 69.44) 69.88 ( 64.57, 75.19) 18.61 ( 16.46, 20.76) 95.57 ( 94.75, 96.39)
Note:
*, No positives or no predicted positives; †, No negatives; ‡, No positives; §, No predicted positives; ¶, No predicted negatives; TH, the chosen threshold, balanced sensitivity and specificity; F1, the F1-score; TNR, true negative rate (specificity); TPR, true positive rate (sensitivity/recall); PPV, positive predictive value (precision); NPV, negative predictive value.

Figure 24. Predictive performance of BPD prediction models in our study versus previous studies. *, Kwok TC et al. (2023) did not summarize the estimates; hence, each individual’s c-statistics are shown (n=6); BPD, bronchopulmonary disease; CI, confidence interval; PI, prediction interval.

Figure 25. Predictive performance of moderate/severe BPD prediction models in our study versus previous studies. BPD, bronchopulmonary disease; CI, confidence interval.

Model deployment

Figure 26. A case with ~50% truly-predicted survive and ~20% truly-predicted positives for other outcomes.

Figure 27. Survival trajectories with ~90% truly and 1+ falsely predicted deaths and ~20% falsely predicted survive. Vertical dashed line indicates death age.

Figure 28. Other outcome trajectories with ~20% truly and ~20% falsely predicted outcomes among ~50% truly predicted survive.

Table 20. Required features.
outcome at_birth during_care
Survival_at_discharge 7 features: GA, AS1, Antenatal_steroid, BBWZ, AS5, surfactant, Maternal_age, Resuscitation_at_birth 1 + 6 features: GA, Cumulative_FiO2_Support_concentration_QW, Cumulative_FiO2_Support_days_QW, Cumulative_Aggressive_Resp_Support_days_QW, Cumulative_FiO2_days_percentile, Cumulative_FiO2_concentration_percentile, Age_D
severe_ROP 7 features: GA, AS1, Antenatal_steroid, BBWZ, AS5, surfactant, Maternal_age, Resuscitation_at_birth 1 + 14 features: GA, Cumulative_FiO2_Support_concentration_QW, Cumulative_FiO2_Support_days_QW, Cumulative_Aggressive_Resp_Support_days_QW, Cumulative_FiO2_days_percentile, Cumulative_FiO2_concentration_percentile, IVH, Transfusion, AKI, Leukopenia_severity, pda_surgical, NonNEC_surgical_abdomen, postnatal_steroid, Feeding, Age_D
BPD 7 features: GA, AS1, Antenatal_steroid, BBWZ, AS5, surfactant, Maternal_age, Resuscitation_at_birth 1 + 6 features: GA, Cumulative_FiO2_Support_concentration_QW, Cumulative_FiO2_Support_days_QW, Cumulative_Aggressive_Resp_Support_days_QW, Cumulative_FiO2_days_percentile, Cumulative_FiO2_concentration_percentile, Age_D
BPD_moderate_severe 7 features: GA, AS1, Antenatal_steroid, BBWZ, AS5, surfactant, Maternal_age, Resuscitation_at_birth 1 + 6 features: GA, Cumulative_FiO2_Support_concentration_QW, Cumulative_FiO2_Support_days_QW, Cumulative_Aggressive_Resp_Support_days_QW, Cumulative_FiO2_days_percentile, Cumulative_FiO2_concentration_percentile, Age_D
EUGR_HC 7 features: GA, AS1, Antenatal_steroid, BBWZ, AS5, surfactant, Maternal_age, Resuscitation_at_birth 1 + 16 features: GA, Cumulative_FiO2_Support_concentration_QW, Cumulative_FiO2_Support_days_QW, Cumulative_Aggressive_Resp_Support_days_QW, Cumulative_FiO2_days_percentile, Cumulative_FiO2_concentration_percentile, IVH, AKI, pda_surgical, NonNEC_surgical_abdomen, Feeding, cerebellar_hemorrhage, Thrombocytopenia_severity, ischaemic_stroke, blood_culture, Inotropic, Age_D
EUGR_BW 7 features: GA, AS1, Antenatal_steroid, BBWZ, AS5, surfactant, Maternal_age, Resuscitation_at_birth 1 + 13 features: GA, Cumulative_FiO2_Support_concentration_QW, Cumulative_FiO2_Support_days_QW, Cumulative_Aggressive_Resp_Support_days_QW, Cumulative_FiO2_days_percentile, Cumulative_FiO2_concentration_percentile, AKI, pda_surgical, NonNEC_surgical_abdomen, Feeding, cerebellar_hemorrhage, Thrombocytopenia_severity, Blood_Volume, Age_D
discharge_hearing_outcome 7 features: GA, AS1, Antenatal_steroid, BBWZ, AS5, surfactant, Maternal_age, Resuscitation_at_birth 1 + 11 features: GA, Cumulative_FiO2_Support_concentration_QW, Cumulative_FiO2_Support_days_QW, Cumulative_Aggressive_Resp_Support_days_QW, Cumulative_FiO2_days_percentile, Cumulative_FiO2_concentration_percentile, Leukopenia_severity, NonNEC_surgical_abdomen, Feeding, Thrombocytopenia_severity, blood_culture, Age_D

Severe ROP

EUGR-HC

Failed hearing test